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The map label for this gene is gcvPA [H]

Identifier: 118580015

GI number: 118580015

Start: 1700012

End: 1701358

Strand: Direct

Name: gcvPA [H]

Synonym: Ppro_1592

Alternate gene names: 118580015

Gene position: 1700012-1701358 (Clockwise)

Preceding gene: 118580014

Following gene: 118580016

Centisome position: 42.42

GC content: 64.22

Gene sequence:

>1347_bases
ATGGATGACAGCCATTATTGTCCCCACACGCCGGAGGAGAGGGGGGAGATGCTCGACCTGATCGGCGTCGCCAGTGTGGA
TGATCTGTTCGCGTCCATCCCCGAAGAGCTGCGGGCCAGGACCTTCAACATCCCTCCCGGCATGTCGGAGTTCGAAGCTT
TGGCCAGGATGCGGGAACTGGCCGCTGAAAACGGACAGGGGATCGTCCCCTTCATCGGCGGAGGTTACTTCGACCACCTG
GTCCCCTCCGTCGTCTCTCACCTGGCCGGCAGGTCGGAGTTTTATACCGCCTATACCCCCTATCAGCCGGAGTGCTCCCA
GGGTACTCTGCAGGCGCTGTTCGAATACCAGACCGCCATCTGCCGCTTGACCGATCTGGATGTTTCCAATGCCTCGCTCT
ACGACGGCGCCACCGCCTGCGCCGAGGCTGCTATGATGGCCCTGCGCGTCACCGGGCGCAGGAGGATCGTGGTGGACGGC
TGCGTCAACCCCTTCTCCCGCCAGGTGCTGAAAACCTATCTGGGGAATCTGGATGTGGAGGTTTTGGAGATCGAACCTCT
GGACGGATTGCTGAACCGCGGGGAACTTGAAACTGTACTGGACGACGGCGTGGCCGGCCTGCTGGTGCAGAACCCCACTT
TCTTCGGCACGGTGGATGATTACTCGTCTCTGGCCGACCTGCTCCACGCCAGGGGGGCGCTACTGATCAGTTCGGTCTAC
CCCGTCTCCCTGGGACTGCTGAAGACGCCAGGGGAGATGGGCGTGGATATCGCCGTGGGGGATGGCCAGAGCCTGGGCAA
CCCGCTCTCCTTCGGCGGCCCCTCATTCGGCTTCATGGCGGCGCGTAAGGCCCTGGTACGCAACATGCCCGGTCGCATGG
TGGGCGAAACCGTGGACGGACAGGGGAGGCGCGGCTATGTGCTGACCCTGCAGGCCCGCGAACAACACATCAAGCGCCAC
CGGGCCACCTCCAACATCTGCAGCAACCAGAGCCTCTGCGCCCTGCGGGGGCTGATCTTCCTCTCTTCACTGGGCAGGGA
TGGGCTGACGGAGTTGGCTCGTCTGAACCGGGACAAGTCCGAGTACGCCAAGGCGCGCCTGGAGGAAATCCCCGGAGTGT
CCGTCCTGCGCTCGGCCCCCACCTTCAACGAATTCACCGTCTCGCTCCCCGCACCGGCCGGCATTGCCGTAGCGGCGCTG
CTGGGGCAGGGGGTGGCGGCCGGAGTGCCGCTCTCCACCTACTACCGGGATTCGGAGCGGCTGATGGTGGTGACCGTGAC
CGAGAAGCGGAGCCGTCGGGAGATCGATCACCTGGCTCGGCAACTGGAGGTGGCGTTATGCGGCTGA

Upstream 100 bases:

>100_bases
GTGGATGGCCTGGCTGGAACTGGATGACGCAACCGAACTGGAGAAACTGATGACGGAAGAACAGTACGCCTGCTACCTGA
AAAGCCTGTAGGAGTCAGCC

Downstream 100 bases:

>100_bases
TCTACGAAGAGTCGGTTGCCGGGCGGCGCGGTGTGGCCTTGCCCGCCTCGGACGTGCCCGTCTCGGAATCGCTGCCTGAG
GAGCTTCTGCGTGTAGTACC

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MDDSHYCPHTPEERGEMLDLIGVASVDDLFASIPEELRARTFNIPPGMSEFEALARMRELAAENGQGIVPFIGGGYFDHL
VPSVVSHLAGRSEFYTAYTPYQPECSQGTLQALFEYQTAICRLTDLDVSNASLYDGATACAEAAMMALRVTGRRRIVVDG
CVNPFSRQVLKTYLGNLDVEVLEIEPLDGLLNRGELETVLDDGVAGLLVQNPTFFGTVDDYSSLADLLHARGALLISSVY
PVSLGLLKTPGEMGVDIAVGDGQSLGNPLSFGGPSFGFMAARKALVRNMPGRMVGETVDGQGRRGYVLTLQAREQHIKRH
RATSNICSNQSLCALRGLIFLSSLGRDGLTELARLNRDKSEYAKARLEEIPGVSVLRSAPTFNEFTVSLPAPAGIAVAAL
LGQGVAAGVPLSTYYRDSERLMVVTVTEKRSRREIDHLARQLEVALCG

Sequences:

>Translated_448_residues
MDDSHYCPHTPEERGEMLDLIGVASVDDLFASIPEELRARTFNIPPGMSEFEALARMRELAAENGQGIVPFIGGGYFDHL
VPSVVSHLAGRSEFYTAYTPYQPECSQGTLQALFEYQTAICRLTDLDVSNASLYDGATACAEAAMMALRVTGRRRIVVDG
CVNPFSRQVLKTYLGNLDVEVLEIEPLDGLLNRGELETVLDDGVAGLLVQNPTFFGTVDDYSSLADLLHARGALLISSVY
PVSLGLLKTPGEMGVDIAVGDGQSLGNPLSFGGPSFGFMAARKALVRNMPGRMVGETVDGQGRRGYVLTLQAREQHIKRH
RATSNICSNQSLCALRGLIFLSSLGRDGLTELARLNRDKSEYAKARLEEIPGVSVLRSAPTFNEFTVSLPAPAGIAVAAL
LGQGVAAGVPLSTYYRDSERLMVVTVTEKRSRREIDHLARQLEVALCG
>Mature_448_residues
MDDSHYCPHTPEERGEMLDLIGVASVDDLFASIPEELRARTFNIPPGMSEFEALARMRELAAENGQGIVPFIGGGYFDHL
VPSVVSHLAGRSEFYTAYTPYQPECSQGTLQALFEYQTAICRLTDLDVSNASLYDGATACAEAAMMALRVTGRRRIVVDG
CVNPFSRQVLKTYLGNLDVEVLEIEPLDGLLNRGELETVLDDGVAGLLVQNPTFFGTVDDYSSLADLLHARGALLISSVY
PVSLGLLKTPGEMGVDIAVGDGQSLGNPLSFGGPSFGFMAARKALVRNMPGRMVGETVDGQGRRGYVLTLQAREQHIKRH
RATSNICSNQSLCALRGLIFLSSLGRDGLTELARLNRDKSEYAKARLEEIPGVSVLRSAPTFNEFTVSLPAPAGIAVAAL
LGQGVAAGVPLSTYYRDSERLMVVTVTEKRSRREIDHLARQLEVALCG

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=356, Percent_Identity=39.6067415730337, Blast_Score=234, Evalue=1e-61,
Organism=Escherichia coli, GI1789269, Length=403, Percent_Identity=33.7468982630273, Blast_Score=180, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17535605, Length=360, Percent_Identity=39.1666666666667, Blast_Score=233, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6323843, Length=356, Percent_Identity=34.5505617977528, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24645648, Length=340, Percent_Identity=39.4117647058824, Blast_Score=230, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 48460; Mature: 48460

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDSHYCPHTPEERGEMLDLIGVASVDDLFASIPEELRARTFNIPPGMSEFEALARMREL
CCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHH
AAENGQGIVPFIGGGYFDHLVPSVVSHLAGRSEFYTAYTPYQPECSQGTLQALFEYQTAI
HHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
CRLTDLDVSNASLYDGATACAEAAMMALRVTGRRRIVVDGCVNPFSRQVLKTYLGNLDVE
HEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCEE
VLEIEPLDGLLNRGELETVLDDGVAGLLVQNPTFFGTVDDYSSLADLLHARGALLISSVY
EEEECCCHHHHCCCCHHHHHHCCCEEEEEECCEEEECHHHHHHHHHHHHHCCHHHHHHHH
PVSLGLLKTPGEMGVDIAVGDGQSLGNPLSFGGPSFGFMAARKALVRNMPGRMVGETVDG
HHHCCEEECCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
QGRRGYVLTLQAREQHIKRHRATSNICSNQSLCALRGLIFLSSLGRDGLTELARLNRDKS
CCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHH
EYAKARLEEIPGVSVLRSAPTFNEFTVSLPAPAGIAVAALLGQGVAAGVPLSTYYRDSER
HHHHHHHHHCCCHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCHHHEEECCCC
LMVVTVTEKRSRREIDHLARQLEVALCG
EEEEEECCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDDSHYCPHTPEERGEMLDLIGVASVDDLFASIPEELRARTFNIPPGMSEFEALARMREL
CCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHH
AAENGQGIVPFIGGGYFDHLVPSVVSHLAGRSEFYTAYTPYQPECSQGTLQALFEYQTAI
HHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
CRLTDLDVSNASLYDGATACAEAAMMALRVTGRRRIVVDGCVNPFSRQVLKTYLGNLDVE
HEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCEE
VLEIEPLDGLLNRGELETVLDDGVAGLLVQNPTFFGTVDDYSSLADLLHARGALLISSVY
EEEECCCHHHHCCCCHHHHHHCCCEEEEEECCEEEECHHHHHHHHHHHHHCCHHHHHHHH
PVSLGLLKTPGEMGVDIAVGDGQSLGNPLSFGGPSFGFMAARKALVRNMPGRMVGETVDG
HHHCCEEECCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
QGRRGYVLTLQAREQHIKRHRATSNICSNQSLCALRGLIFLSSLGRDGLTELARLNRDKS
CCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHH
EYAKARLEEIPGVSVLRSAPTFNEFTVSLPAPAGIAVAALLGQGVAAGVPLSTYYRDSER
HHHHHHHHHCCCHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCHHHEEECCCC
LMVVTVTEKRSRREIDHLARQLEVALCG
EEEEEECCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA