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The map label for this gene is gcvPB [H]

Identifier: 118580016

GI number: 118580016

Start: 1701349

End: 1702785

Strand: Direct

Name: gcvPB [H]

Synonym: Ppro_1593

Alternate gene names: 118580016

Gene position: 1701349-1702785 (Clockwise)

Preceding gene: 118580015

Following gene: 118580022

Centisome position: 42.45

GC content: 63.33

Gene sequence:

>1437_bases
ATGCGGCTGATCTACGAAGAGTCGGTTGCCGGGCGGCGCGGTGTGGCCTTGCCCGCCTCGGACGTGCCCGTCTCGGAATC
GCTGCCTGAGGAGCTTCTGCGTGTAGTACCGGCGGAACTGCCCCAGCTCTCGGAGCTGGACCTGGTGCGGCACTTCACCA
ACCTCTCCCGGCGCAACTTCTCGGTGGACACCCATTTCTATCCCCTGGGTTCCTGCACCATGAAGTACAACCCCAGGGTG
CTGGAGGACGCGGCTCTGCTGTTCGAGGCGTTTCATCCCATGACGGCGCTCCTGCCGGGCGGCGAGGAGCTCTGTCAGGG
GAGCCTGGGGCTGCTCTACGACCTGGGGCAGCTCCTGGCCGACATCACCGGCATGGACGAGGTCTGCACCCAGCCGCTGG
CGGGCGCCCAGGGGGAGATGACCGGCATCATGCTGATCGCCGCCTACCACCGGGCCCGGGGCAAGCGCAAGCGCTACGTT
CTGGTGCCGGATTCGTCCCACGGCACCAATCCCGCCTCGGCGGCCATGGCGGGCTATGAGATCATCACCGTTGCCTCCGG
TACCCAGGGGGACATGGACATGGAGCTGTTCAGGCAGGCCATGAACGATCAGGTGGCGGCGGTCATGATGACCTGCCCCA
ACACCCTGGGGCTGTTCAATCCACGCATCCGGGAGATCTGCGACATCGCCCACTCCCATGATGCCCTCATGTACTACGAC
GGCGCCAACCTGAACGCCATCCTGGGTAGGGTGCGGCCGGGTGATATCGGCTTTGACGTGGTGCATGTAAACCTGCACAA
AACCTTTGCCACGCCCCACGGTGGCGGCGGTCCCGGCGCCGGGCCATTGGGGGTCAGGCAGGCGCTGATCCCCTTCTTGC
CGCTGCCACGCGTCCGAATGGACGAGCATGGCCGTTTGTGTCTGGAAACGGAATCGGAACTCTCCATCGGGCGTTGTGCC
AACTTCTTCGGTAATTTCGGCGTGCTGGCAAGGGCCTACGCCTACATAACCATGCTCGGTCGCCAAGGGCTGATGCGGGT
GTCCGAAGCTGCGGTGCTGAACGCCAACTACATCAAAGAGCGACTTAAAGGGCATTACGAACTCCCCCATGATCTTCCCT
GCATGCACGAGTGCGTGTTCTCGGCCTCCCGGCAGCTGGCCCAGGGTGTCCATGCCATCGACATCGCCAAGTACCTCATT
GACCGCGGATTCCACCCGCCCACGGTCTATTTCCCCCTGAACGTCAGGGAAGCCATCATGATCGAGCCGACTGAAACCGA
GAGCAGGGCGACACTGGATGGGTTTATCGATGCCATGATCGAGGCGTCCGGACTGGCGGAGAGCAATCCCCGGGTGTTAC
TGGATGCGCCGCTGACCATGCCGGTTTCTCGGTTGGACGAGACCAAGGCTGCCCGGGAGTTGAAGGTGTGCTGGTGA

Upstream 100 bases:

>100_bases
CCTACTACCGGGATTCGGAGCGGCTGATGGTGGTGACCGTGACCGAGAAGCGGAGCCGTCGGGAGATCGATCACCTGGCT
CGGCAACTGGAGGTGGCGTT

Downstream 100 bases:

>100_bases
TGAGTGATGAGTGATGGGAGCCTTATGATATGCTTACGTCGATGCGGAACTGGGTGCCGTTGCCGGTGTTCATGACCTCC
AGGCTGCCCCCCATGCTCTT

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MRLIYEESVAGRRGVALPASDVPVSESLPEELLRVVPAELPQLSELDLVRHFTNLSRRNFSVDTHFYPLGSCTMKYNPRV
LEDAALLFEAFHPMTALLPGGEELCQGSLGLLYDLGQLLADITGMDEVCTQPLAGAQGEMTGIMLIAAYHRARGKRKRYV
LVPDSSHGTNPASAAMAGYEIITVASGTQGDMDMELFRQAMNDQVAAVMMTCPNTLGLFNPRIREICDIAHSHDALMYYD
GANLNAILGRVRPGDIGFDVVHVNLHKTFATPHGGGGPGAGPLGVRQALIPFLPLPRVRMDEHGRLCLETESELSIGRCA
NFFGNFGVLARAYAYITMLGRQGLMRVSEAAVLNANYIKERLKGHYELPHDLPCMHECVFSASRQLAQGVHAIDIAKYLI
DRGFHPPTVYFPLNVREAIMIEPTETESRATLDGFIDAMIEASGLAESNPRVLLDAPLTMPVSRLDETKAARELKVCW

Sequences:

>Translated_478_residues
MRLIYEESVAGRRGVALPASDVPVSESLPEELLRVVPAELPQLSELDLVRHFTNLSRRNFSVDTHFYPLGSCTMKYNPRV
LEDAALLFEAFHPMTALLPGGEELCQGSLGLLYDLGQLLADITGMDEVCTQPLAGAQGEMTGIMLIAAYHRARGKRKRYV
LVPDSSHGTNPASAAMAGYEIITVASGTQGDMDMELFRQAMNDQVAAVMMTCPNTLGLFNPRIREICDIAHSHDALMYYD
GANLNAILGRVRPGDIGFDVVHVNLHKTFATPHGGGGPGAGPLGVRQALIPFLPLPRVRMDEHGRLCLETESELSIGRCA
NFFGNFGVLARAYAYITMLGRQGLMRVSEAAVLNANYIKERLKGHYELPHDLPCMHECVFSASRQLAQGVHAIDIAKYLI
DRGFHPPTVYFPLNVREAIMIEPTETESRATLDGFIDAMIEASGLAESNPRVLLDAPLTMPVSRLDETKAARELKVCW
>Mature_478_residues
MRLIYEESVAGRRGVALPASDVPVSESLPEELLRVVPAELPQLSELDLVRHFTNLSRRNFSVDTHFYPLGSCTMKYNPRV
LEDAALLFEAFHPMTALLPGGEELCQGSLGLLYDLGQLLADITGMDEVCTQPLAGAQGEMTGIMLIAAYHRARGKRKRYV
LVPDSSHGTNPASAAMAGYEIITVASGTQGDMDMELFRQAMNDQVAAVMMTCPNTLGLFNPRIREICDIAHSHDALMYYD
GANLNAILGRVRPGDIGFDVVHVNLHKTFATPHGGGGPGAGPLGVRQALIPFLPLPRVRMDEHGRLCLETESELSIGRCA
NFFGNFGVLARAYAYITMLGRQGLMRVSEAAVLNANYIKERLKGHYELPHDLPCMHECVFSASRQLAQGVHAIDIAKYLI
DRGFHPPTVYFPLNVREAIMIEPTETESRATLDGFIDAMIEASGLAESNPRVLLDAPLTMPVSRLDETKAARELKVCW

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=437, Percent_Identity=41.1899313501144, Blast_Score=256, Evalue=3e-68,
Organism=Escherichia coli, GI1789269, Length=408, Percent_Identity=40.4411764705882, Blast_Score=261, Evalue=7e-71,
Organism=Caenorhabditis elegans, GI17535605, Length=406, Percent_Identity=39.6551724137931, Blast_Score=248, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI32564013, Length=361, Percent_Identity=39.8891966759003, Blast_Score=226, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6323843, Length=460, Percent_Identity=40.4347826086956, Blast_Score=271, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24645648, Length=410, Percent_Identity=39.5121951219512, Blast_Score=247, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 52416; Mature: 52416

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIYEESVAGRRGVALPASDVPVSESLPEELLRVVPAELPQLSELDLVRHFTNLSRRNF
CCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
SVDTHFYPLGSCTMKYNPRVLEDAALLFEAFHPMTALLPGGEELCQGSLGLLYDLGQLLA
CCCCEEEECCCEEEECCCCHHHHHHHHHHHHCCHHHCCCCCHHHHCCCHHHHHHHHHHHH
DITGMDEVCTQPLAGAQGEMTGIMLIAAYHRARGKRKRYVLVPDSSHGTNPASAAMAGYE
HHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCCEE
IITVASGTQGDMDMELFRQAMNDQVAAVMMTCPNTLGLFNPRIREICDIAHSHDALMYYD
EEEEECCCCCCCCHHHHHHHHCCHHEEHEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEC
GANLNAILGRVRPGDIGFDVVHVNLHKTFATPHGGGGPGAGPLGVRQALIPFLPLPRVRM
CCCHHHHHCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
DEHGRLCLETESELSIGRCANFFGNFGVLARAYAYITMLGRQGLMRVSEAAVLNANYIKE
CCCCCEEEECCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLKGHYELPHDLPCMHECVFSASRQLAQGVHAIDIAKYLIDRGFHPPTVYFPLNVREAIM
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCEEEE
IEPTETESRATLDGFIDAMIEASGLAESNPRVLLDAPLTMPVSRLDETKAARELKVCW
ECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRLIYEESVAGRRGVALPASDVPVSESLPEELLRVVPAELPQLSELDLVRHFTNLSRRNF
CCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
SVDTHFYPLGSCTMKYNPRVLEDAALLFEAFHPMTALLPGGEELCQGSLGLLYDLGQLLA
CCCCEEEECCCEEEECCCCHHHHHHHHHHHHCCHHHCCCCCHHHHCCCHHHHHHHHHHHH
DITGMDEVCTQPLAGAQGEMTGIMLIAAYHRARGKRKRYVLVPDSSHGTNPASAAMAGYE
HHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCCEE
IITVASGTQGDMDMELFRQAMNDQVAAVMMTCPNTLGLFNPRIREICDIAHSHDALMYYD
EEEEECCCCCCCCHHHHHHHHCCHHEEHEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEC
GANLNAILGRVRPGDIGFDVVHVNLHKTFATPHGGGGPGAGPLGVRQALIPFLPLPRVRM
CCCHHHHHCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
DEHGRLCLETESELSIGRCANFFGNFGVLARAYAYITMLGRQGLMRVSEAAVLNANYIKE
CCCCCEEEECCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLKGHYELPHDLPCMHECVFSASRQLAQGVHAIDIAKYLIDRGFHPPTVYFPLNVREAIM
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCEEEE
IEPTETESRATLDGFIDAMIEASGLAESNPRVLLDAPLTMPVSRLDETKAARELKVCW
ECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA