Click here to switch to the map view.

The map label for this gene is ndhS [H]

Identifier: 118579869

GI number: 118579869

Start: 1545443

End: 1545919

Strand: Reverse

Name: ndhS [H]

Synonym: Ppro_1445

Alternate gene names: 118579869

Gene position: 1545919-1545443 (Counterclockwise)

Preceding gene: 118579870

Following gene: 118579868

Centisome position: 38.57

GC content: 63.73

Gene sequence:

>477_bases
GTGCTGATTGATGTTACCTTTGAGCTGAATGGCAAAACCGTCACCATCACCACCCATCCCCTGCGGCGTCTGCTGGACAT
CTTGCGGGATGACCTGCGGCTCACCGGAACCAAGGAGGGGTGCGGCGAAGGGGAGTGCGGGGCCTGCGCCGTGCTGCTGG
ACCGGCACTTGGTCAACGCCTGCCTGATAGCGGCGGCTTCCCTGGAGGGAAAGAGCGTGCTGACCATCGAGGGGTACCGG
GAGACGGAGCGTTTCGCAGTCTTGAGCAAGGCTTTTGCCCGGGCCGGGAGCGTGCAGTGCGGCTTCTGCACGCCGGGCAT
GGTCATGGCCGCCGAGGCCCTGCTGCGACGCACTCCCCATCCCACGGAAGAACAGGTGCGGGAGGGGTTGACGGGGAATC
TCTGCCGCTGCACCGGGTATAACATGATCGTGGATGGAATCATGCTGGCGGCACAAGAGGGGGACGGATTATGGTAG

Upstream 100 bases:

>100_bases
GGGGCAGCGCCGGCCCTGGCCTTGGCGGTGCAAAACGCCATCGGCCGCGACCTACGCCAGCTGCCGGTCACGCCGGAACT
GATACGGGAGGCAATGCAAC

Downstream 100 bases:

>100_bases
GAGCATTCAGACCACAGACCCTGCAGCAGGCGCTGGACATTCGGGGCAGCCGCATGACGACCCTCTTTGCCGGCGGCAGC
GACCTGATGGTCAGGCACCG

Product: 2Fe-2S iron-sulfur cluster binding domain-containing protein

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase small FeS subunit; NAH [H]

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MLIDVTFELNGKTVTITTHPLRRLLDILRDDLRLTGTKEGCGEGECGACAVLLDRHLVNACLIAAASLEGKSVLTIEGYR
ETERFAVLSKAFARAGSVQCGFCTPGMVMAAEALLRRTPHPTEEQVREGLTGNLCRCTGYNMIVDGIMLAAQEGDGLW

Sequences:

>Translated_158_residues
MLIDVTFELNGKTVTITTHPLRRLLDILRDDLRLTGTKEGCGEGECGACAVLLDRHLVNACLIAAASLEGKSVLTIEGYR
ETERFAVLSKAFARAGSVQCGFCTPGMVMAAEALLRRTPHPTEEQVREGLTGNLCRCTGYNMIVDGIMLAAQEGDGLW
>Mature_158_residues
MLIDVTFELNGKTVTITTHPLRRLLDILRDDLRLTGTKEGCGEGECGACAVLLDRHLVNACLIAAASLEGKSVLTIEGYR
ETERFAVLSKAFARAGSVQCGFCTPGMVMAAEALLRRTPHPTEEQVREGLTGNLCRCTGYNMIVDGIMLAAQEGDGLW

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=155, Percent_Identity=46.4516129032258, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI91823271, Length=160, Percent_Identity=42.5, Blast_Score=93, Evalue=1e-19,
Organism=Escherichia coli, GI1789232, Length=149, Percent_Identity=42.9530201342282, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI1786480, Length=167, Percent_Identity=35.3293413173653, Blast_Score=110, Evalue=4e-26,
Organism=Escherichia coli, GI1789246, Length=146, Percent_Identity=27.3972602739726, Blast_Score=61, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17540638, Length=164, Percent_Identity=42.0731707317073, Blast_Score=125, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17539860, Length=154, Percent_Identity=41.5584415584416, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI32566215, Length=166, Percent_Identity=37.3493975903614, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17737937, Length=161, Percent_Identity=44.0993788819876, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24647197, Length=160, Percent_Identity=33.75, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24647201, Length=154, Percent_Identity=33.7662337662338, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24647195, Length=160, Percent_Identity=33.75, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24647199, Length=150, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24647193, Length=132, Percent_Identity=34.8484848484849, Blast_Score=77, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 17072; Mature: 17072

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
5.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIDVTFELNGKTVTITTHPLRRLLDILRDDLRLTGTKEGCGEGECGACAVLLDRHLVNA
CEEEEEEEECCCEEEEEHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHH
CLIAAASLEGKSVLTIEGYRETERFAVLSKAFARAGSVQCGFCTPGMVMAAEALLRRTPH
HHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCC
PTEEQVREGLTGNLCRCTGYNMIVDGIMLAAQEGDGLW
CCHHHHHCCCCCCEEEECCCHHHHHHHHEEECCCCCCC
>Mature Secondary Structure
MLIDVTFELNGKTVTITTHPLRRLLDILRDDLRLTGTKEGCGEGECGACAVLLDRHLVNA
CEEEEEEEECCCEEEEEHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHH
CLIAAASLEGKSVLTIEGYRETERFAVLSKAFARAGSVQCGFCTPGMVMAAEALLRRTPH
HHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCC
PTEEQVREGLTGNLCRCTGYNMIVDGIMLAAQEGDGLW
CCHHHHHCCCCCCEEEECCCHHHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA