Click here to switch to the map view.

The map label for this gene is pucD [H]

Identifier: 118579870

GI number: 118579870

Start: 1545909

End: 1548053

Strand: Reverse

Name: pucD [H]

Synonym: Ppro_1446

Alternate gene names: 118579870

Gene position: 1548053-1545909 (Counterclockwise)

Preceding gene: 118579874

Following gene: 118579869

Centisome position: 38.62

GC content: 63.4

Gene sequence:

>2145_bases
ATGCCATTGGAACCGATAAGCCGCCCCATCAGGCGTTTTGATTTCAACGAGAAGATCTCCGGCAGGGCGGACTTCTGCGC
TGACAGGAGATACGACGGCCTGCTGTACGCCAAAACCCTCCGTTCAACCAGGGCCAGAGCCAGGATACTCTCCATCCACG
TCCCCCCCCTTCCCGAGGGGTACTATACCGTGGATGCCGGCGACATACCCGGCAGGAACCTGGTCCCCATCGTGTACGAC
GACCAGCCATTCTTCGCCCGGGATCTGGTCAACTACATCGGCGAGCCGATCCTGCTGGTGGTGGGTCCCGACAAGGGAAC
CATCCTGGAACTGCTCAGCCGCATCAGCGTCAGCTACGAGGATCTGCCGCCCATCCTGAGCATCGCCGAGGCGGAACAGG
CCACGGACAACTTCATCTGCGGCGACAAACCCTTCTTCGTCTCCTACGAATGCGGCAAGGGAGACATCTCCCAGACCATA
ACCCGGGCCGCACGGGTCTTCGAGGACGAATTCCGCACCGGCTACCAGGAGCACGTGTATCTGGAAACCCAGGGCTTTAT
CGGCGTCTACGAGGAGGGACGCATCACGGTCTCCGGTTCCATGCAGTGCCCCTACTATGTTAAGGAGGCGCTCATGCAGG
CCCTGGGGTGGCCGGATGAGCGGGTGCGGGTCATCCAGCTCCCCACCGGTGGCGGCTTCGGCGGCAAGGAGGAGTACCCA
TCCCTACCCGGCGTCCATGCCGGCCTGGCCGCCATCAAGTCGCGACGCCCGGTGCAGCTGGTCTTCGATCGCCATGAGGA
CATGCTCTGCACCACCAAGCGGCACCCGGCCATCATCAGGATCAAAAGCTACCTTGATGCACGCAACCGCATCATCGGCC
GGGAAATCGATGTCAAGACCGATGGCGGCGCCTATGCCGGGCTCTCCAGCGTGGTGCTGCAGCGGATGATGTTCTCCAGC
AACGGCGTCTACGATGTTCCCCACCTGAAGATCAGCGGAACGGCATATGCCACCAACAACATCGTCAGCGGCGCCTTCCG
CGGCTTCGGCGGGCCACAGGCCTTCTTCGCCGTGGAGATGCACATGGAGAACATCGCCCGCAACCTGAAGCTTGATTCCA
TAGCCTTCAGGCGCAGCCACTTCCTGCACCGGGGGGACAGCTCCTCCACCGCTGGAGAGTTCCACTACGACATACGGCTG
GATGAGATCGCCGAAACCCTGGAGCGCATCTCCTCATATGGCGAGAAACGGAGCCACCGGGCAGAGGGGAGGCCAGGCAT
GCTGCGGGGCATCGGCTGCTCCTTCTTCTACCACGGCTGCGGATTCACCGGCAGTGGCGAGGATCTGCTGATCAGGGCCA
GGGTACGGCTGAAGAAATACGCCGACGACAGCGTGCAGATCTTCGTTTCCAGCGCCGAGATCGGCCAGGGAGTGCTGACT
ACCCTGCGCAAGATCGTGGCCCACACCCTGGAGATCCCCATTGAGCGGATCCGGCACGACTATCCCGACAGCGACCACTG
CCCCAACTCCGGCCCCACGGTGGCTTCACGCACGGTCGTGATCGTGGGCAAACTGCTCCAGGATGCGGCCAGGGAGATGA
AGGAGAGGTGGCATGAGGAGACCTGCGATATCCAGCGGGTCTTCCACTTCCCCGACCACCTGAGCTGGGACAACGACACG
TTCAGGGGCAACGCCTATCCGGAGTATTCCTGGGGGGGCAACCTGGTGGAGGTGGAGGTGGACCCGGTCACCGGCCAGGT
CGAGGTGCTGGGGGCCTGGGCGACGTACGACATCGGAACGCCCATCGACGACACCATCGTGCGAGGCCAGATCCAGGGGG
GCCTCGTGCAGGGGCTGGCCTACGGCGGCATGGAGCGGCTTACCACGAGAGACGGCGCGCTGCAGCAGACCAGTCTGGCC
GACTATCTCATCCCCACAGCCCTTGACGTCCCCAGGATCGAGAGCAGGCTGATCGACAACCCCTTTGACGACGGCCCCTT
CGGCGCCCGCGGCCTGGGTGAACTGACCCTGATCGGGGCAGCGCCGGCCCTGGCCTTGGCGGTGCAAAACGCCATCGGCC
GCGACCTACGCCAGCTGCCGGTCACGCCGGAACTGATACGGGAGGCAATGCAACGTGCTGATTGA

Upstream 100 bases:

>100_bases
TATGGTGCCTGAATCAGGCAATCACGCACCCTTCTCCAAAAAAAGCCCCATGCACAGCGATCCACCACATCCAGTGCCCT
TCGGCACAGATCAGGAGGTG

Downstream 100 bases:

>100_bases
TGTTACCTTTGAGCTGAATGGCAAAACCGTCACCATCACCACCCATCCCCTGCGGCGTCTGCTGGACATCTTGCGGGATG
ACCTGCGGCTCACCGGAACC

Product: molybdopterin binding aldehyde oxidase and xanthine dehydrogenase

Products: NA

Alternate protein names: XDHase subunit D [H]

Number of amino acids: Translated: 714; Mature: 713

Protein sequence:

>714_residues
MPLEPISRPIRRFDFNEKISGRADFCADRRYDGLLYAKTLRSTRARARILSIHVPPLPEGYYTVDAGDIPGRNLVPIVYD
DQPFFARDLVNYIGEPILLVVGPDKGTILELLSRISVSYEDLPPILSIAEAEQATDNFICGDKPFFVSYECGKGDISQTI
TRAARVFEDEFRTGYQEHVYLETQGFIGVYEEGRITVSGSMQCPYYVKEALMQALGWPDERVRVIQLPTGGGFGGKEEYP
SLPGVHAGLAAIKSRRPVQLVFDRHEDMLCTTKRHPAIIRIKSYLDARNRIIGREIDVKTDGGAYAGLSSVVLQRMMFSS
NGVYDVPHLKISGTAYATNNIVSGAFRGFGGPQAFFAVEMHMENIARNLKLDSIAFRRSHFLHRGDSSSTAGEFHYDIRL
DEIAETLERISSYGEKRSHRAEGRPGMLRGIGCSFFYHGCGFTGSGEDLLIRARVRLKKYADDSVQIFVSSAEIGQGVLT
TLRKIVAHTLEIPIERIRHDYPDSDHCPNSGPTVASRTVVIVGKLLQDAAREMKERWHEETCDIQRVFHFPDHLSWDNDT
FRGNAYPEYSWGGNLVEVEVDPVTGQVEVLGAWATYDIGTPIDDTIVRGQIQGGLVQGLAYGGMERLTTRDGALQQTSLA
DYLIPTALDVPRIESRLIDNPFDDGPFGARGLGELTLIGAAPALALAVQNAIGRDLRQLPVTPELIREAMQRAD

Sequences:

>Translated_714_residues
MPLEPISRPIRRFDFNEKISGRADFCADRRYDGLLYAKTLRSTRARARILSIHVPPLPEGYYTVDAGDIPGRNLVPIVYD
DQPFFARDLVNYIGEPILLVVGPDKGTILELLSRISVSYEDLPPILSIAEAEQATDNFICGDKPFFVSYECGKGDISQTI
TRAARVFEDEFRTGYQEHVYLETQGFIGVYEEGRITVSGSMQCPYYVKEALMQALGWPDERVRVIQLPTGGGFGGKEEYP
SLPGVHAGLAAIKSRRPVQLVFDRHEDMLCTTKRHPAIIRIKSYLDARNRIIGREIDVKTDGGAYAGLSSVVLQRMMFSS
NGVYDVPHLKISGTAYATNNIVSGAFRGFGGPQAFFAVEMHMENIARNLKLDSIAFRRSHFLHRGDSSSTAGEFHYDIRL
DEIAETLERISSYGEKRSHRAEGRPGMLRGIGCSFFYHGCGFTGSGEDLLIRARVRLKKYADDSVQIFVSSAEIGQGVLT
TLRKIVAHTLEIPIERIRHDYPDSDHCPNSGPTVASRTVVIVGKLLQDAAREMKERWHEETCDIQRVFHFPDHLSWDNDT
FRGNAYPEYSWGGNLVEVEVDPVTGQVEVLGAWATYDIGTPIDDTIVRGQIQGGLVQGLAYGGMERLTTRDGALQQTSLA
DYLIPTALDVPRIESRLIDNPFDDGPFGARGLGELTLIGAAPALALAVQNAIGRDLRQLPVTPELIREAMQRAD
>Mature_713_residues
PLEPISRPIRRFDFNEKISGRADFCADRRYDGLLYAKTLRSTRARARILSIHVPPLPEGYYTVDAGDIPGRNLVPIVYDD
QPFFARDLVNYIGEPILLVVGPDKGTILELLSRISVSYEDLPPILSIAEAEQATDNFICGDKPFFVSYECGKGDISQTIT
RAARVFEDEFRTGYQEHVYLETQGFIGVYEEGRITVSGSMQCPYYVKEALMQALGWPDERVRVIQLPTGGGFGGKEEYPS
LPGVHAGLAAIKSRRPVQLVFDRHEDMLCTTKRHPAIIRIKSYLDARNRIIGREIDVKTDGGAYAGLSSVVLQRMMFSSN
GVYDVPHLKISGTAYATNNIVSGAFRGFGGPQAFFAVEMHMENIARNLKLDSIAFRRSHFLHRGDSSSTAGEFHYDIRLD
EIAETLERISSYGEKRSHRAEGRPGMLRGIGCSFFYHGCGFTGSGEDLLIRARVRLKKYADDSVQIFVSSAEIGQGVLTT
LRKIVAHTLEIPIERIRHDYPDSDHCPNSGPTVASRTVVIVGKLLQDAAREMKERWHEETCDIQRVFHFPDHLSWDNDTF
RGNAYPEYSWGGNLVEVEVDPVTGQVEVLGAWATYDIGTPIDDTIVRGQIQGGLVQGLAYGGMERLTTRDGALQQTSLAD
YLIPTALDVPRIESRLIDNPFDDGPFGARGLGELTLIGAAPALALAVQNAIGRDLRQLPVTPELIREAMQRAD

Specific function: Oxidizes hypoxanthine and xanthine to uric acid [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=757, Percent_Identity=28.665785997358, Blast_Score=259, Evalue=8e-69,
Organism=Homo sapiens, GI71773480, Length=757, Percent_Identity=25.3632760898283, Blast_Score=195, Evalue=1e-49,
Organism=Escherichia coli, GI1789230, Length=756, Percent_Identity=25.5291005291005, Blast_Score=209, Evalue=6e-55,
Organism=Escherichia coli, GI1789246, Length=802, Percent_Identity=23.8154613466334, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1786478, Length=640, Percent_Identity=22.96875, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17540638, Length=764, Percent_Identity=27.6178010471204, Blast_Score=240, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI32566215, Length=727, Percent_Identity=24.7592847317744, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17539860, Length=728, Percent_Identity=23.7637362637363, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17737937, Length=762, Percent_Identity=28.4776902887139, Blast_Score=218, Evalue=8e-57,
Organism=Drosophila melanogaster, GI24647193, Length=732, Percent_Identity=23.6338797814208, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24647201, Length=758, Percent_Identity=23.2189973614776, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24647199, Length=715, Percent_Identity=22.7972027972028, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR017609 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 79353; Mature: 79222

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLEPISRPIRRFDFNEKISGRADFCADRRYDGLLYAKTLRSTRARARILSIHVPPLPEG
CCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCCC
YYTVDAGDIPGRNLVPIVYDDQPFFARDLVNYIGEPILLVVGPDKGTILELLSRISVSYE
CEEEECCCCCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCHH
DLPPILSIAEAEQATDNFICGDKPFFVSYECGKGDISQTITRAARVFEDEFRTGYQEHVY
CCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEE
LETQGFIGVYEEGRITVSGSMQCPYYVKEALMQALGWPDERVRVIQLPTGGGFGGKEEYP
EEECCCEEEEECCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
SLPGVHAGLAAIKSRRPVQLVFDRHEDMLCTTKRHPAIIRIKSYLDARNRIIGREIDVKT
CCCCHHHHHHHHHCCCCEEEEECCCCCCEEECCCCCEEEEEHHHHHHHHHHCCCEEEEEC
DGGAYAGLSSVVLQRMMFSSNGVYDVPHLKISGTAYATNNIVSGAFRGFGGPQAFFAVEM
CCCCHHHHHHHHHHHHHHCCCCCEECCCEEECCCEEECCCHHHHHHHCCCCCCCEEEHHH
HMENIARNLKLDSIAFRRSHFLHRGDSSSTAGEFHYDIRLDEIAETLERISSYGEKRSHR
HHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHC
AEGRPGMLRGIGCSFFYHGCGFTGSGEDLLIRARVRLKKYADDSVQIFVSSAEIGQGVLT
CCCCCCCEECCCHHHHEECCCCCCCCCCEEEEEEHHHHHCCCCCEEEEEECCHHCHHHHH
TLRKIVAHTLEIPIERIRHDYPDSDHCPNSGPTVASRTVVIVGKLLQDAAREMKERWHEE
HHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TCDIQRVFHFPDHLSWDNDTFRGNAYPEYSWGGNLVEVEVDPVTGQVEVLGAWATYDIGT
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEEEECCCC
PIDDTIVRGQIQGGLVQGLAYGGMERLTTRDGALQQTSLADYLIPTALDVPRIESRLIDN
CCCHHHHHHHHCCHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHCCC
PFDDGPFGARGLGELTLIGAAPALALAVQNAIGRDLRQLPVTPELIREAMQRAD
CCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PLEPISRPIRRFDFNEKISGRADFCADRRYDGLLYAKTLRSTRARARILSIHVPPLPEG
CCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCCC
YYTVDAGDIPGRNLVPIVYDDQPFFARDLVNYIGEPILLVVGPDKGTILELLSRISVSYE
CEEEECCCCCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCHH
DLPPILSIAEAEQATDNFICGDKPFFVSYECGKGDISQTITRAARVFEDEFRTGYQEHVY
CCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEE
LETQGFIGVYEEGRITVSGSMQCPYYVKEALMQALGWPDERVRVIQLPTGGGFGGKEEYP
EEECCCEEEEECCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
SLPGVHAGLAAIKSRRPVQLVFDRHEDMLCTTKRHPAIIRIKSYLDARNRIIGREIDVKT
CCCCHHHHHHHHHCCCCEEEEECCCCCCEEECCCCCEEEEEHHHHHHHHHHCCCEEEEEC
DGGAYAGLSSVVLQRMMFSSNGVYDVPHLKISGTAYATNNIVSGAFRGFGGPQAFFAVEM
CCCCHHHHHHHHHHHHHHCCCCCEECCCEEECCCEEECCCHHHHHHHCCCCCCCEEEHHH
HMENIARNLKLDSIAFRRSHFLHRGDSSSTAGEFHYDIRLDEIAETLERISSYGEKRSHR
HHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHC
AEGRPGMLRGIGCSFFYHGCGFTGSGEDLLIRARVRLKKYADDSVQIFVSSAEIGQGVLT
CCCCCCCEECCCHHHHEECCCCCCCCCCEEEEEEHHHHHCCCCCEEEEEECCHHCHHHHH
TLRKIVAHTLEIPIERIRHDYPDSDHCPNSGPTVASRTVVIVGKLLQDAAREMKERWHEE
HHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TCDIQRVFHFPDHLSWDNDTFRGNAYPEYSWGGNLVEVEVDPVTGQVEVLGAWATYDIGT
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEEEECCCC
PIDDTIVRGQIQGGLVQGLAYGGMERLTTRDGALQQTSLADYLIPTALDVPRIESRLIDN
CCCHHHHHHHHCCHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHCCC
PFDDGPFGARGLGELTLIGAAPALALAVQNAIGRDLRQLPVTPELIREAMQRAD
CCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 11344136 [H]