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The map label for this gene is pyrE [H]

Identifier: 118579585

GI number: 118579585

Start: 1203020

End: 1203568

Strand: Direct

Name: pyrE [H]

Synonym: Ppro_1154

Alternate gene names: 118579585

Gene position: 1203020-1203568 (Clockwise)

Preceding gene: 118579584

Following gene: 118579586

Centisome position: 30.02

GC content: 63.21

Gene sequence:

>549_bases
ATGAATGACCGTGAACGACTGAAACAGATTATCCAGGAGCTTTCCTATGAAAACCGGAAGGTGACCCTGGCCTCGGGGCG
GGAGAGCGATTTCTACTTCGACGGCAAACAGACCACCCTGCACGCCGAGGGGGGCTATCTGGTGGGCAAGCTGTTCTACG
AGGCCATCAAGGACATGGAGGGCGTACAGGCTGTGGGCGGCATCACCCTGGGGGCCGACCCCATCGCCACGGCAACCTCC
ATCGCCGCCCACCTGGACGGTAGGAGCATGCACGCCTTCATCATCCGCAAGGAGCCTAAGGGGCATGGAACCGGCCAGTG
GCTGGAGGGGCGCAAGAACCTCCCCCCCGGCACGGGGGTCGTGATCGTGGAGGACGTGGTCACCACCGGCGGTTCATCCA
TGAAGGCGGTGCGCCGCGCCGAGGAGGAGGGACTCAAGGTGCTGGGCATCGTCACCCTAGTGGACCGTGAAGAGGGAGGC
CGGGAAAATATCGAGGCCGAGGGGTACCAGCTGCGGACGATCTTCACCAGATCCCAGATCGTGGGCTGA

Upstream 100 bases:

>100_bases
GAGGTCTGCAAGGCCTGTTTCTCCGGGGCGTACCCGATCGCCTTTCCGAAACCGATGGACAATAACCAGAGAGAGCTGTT
CGAAGAGGGAGACGCCCATA

Downstream 100 bases:

>100_bases
TGGCCGCCAGGCAGCGCCTCGACAAACTGGTGCTGGAGCGGGGACTGGCCCCCTCGCGGGAGAAAGCCCAGGCCCTGATC
ATGGCCGGCCAGGTGATCGT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MNDRERLKQIIQELSYENRKVTLASGRESDFYFDGKQTTLHAEGGYLVGKLFYEAIKDMEGVQAVGGITLGADPIATATS
IAAHLDGRSMHAFIIRKEPKGHGTGQWLEGRKNLPPGTGVVIVEDVVTTGGSSMKAVRRAEEEGLKVLGIVTLVDREEGG
RENIEAEGYQLRTIFTRSQIVG

Sequences:

>Translated_182_residues
MNDRERLKQIIQELSYENRKVTLASGRESDFYFDGKQTTLHAEGGYLVGKLFYEAIKDMEGVQAVGGITLGADPIATATS
IAAHLDGRSMHAFIIRKEPKGHGTGQWLEGRKNLPPGTGVVIVEDVVTTGGSSMKAVRRAEEEGLKVLGIVTLVDREEGG
RENIEAEGYQLRTIFTRSQIVG
>Mature_182_residues
MNDRERLKQIIQELSYENRKVTLASGRESDFYFDGKQTTLHAEGGYLVGKLFYEAIKDMEGVQAVGGITLGADPIATATS
IAAHLDGRSMHAFIIRKEPKGHGTGQWLEGRKNLPPGTGVVIVEDVVTTGGSSMKAVRRAEEEGLKVLGIVTLVDREEGG
RENIEAEGYQLRTIFTRSQIVG

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=161, Percent_Identity=31.055900621118, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17554964, Length=179, Percent_Identity=32.4022346368715, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17933654, Length=154, Percent_Identity=37.012987012987, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 19876; Mature: 19876

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDRERLKQIIQELSYENRKVTLASGRESDFYFDGKQTTLHAEGGYLVGKLFYEAIKDME
CCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEECCCCEEEEECCCCHHHHHHHHHHHHHH
GVQAVGGITLGADPIATATSIAAHLDGRSMHAFIIRKEPKGHGTGQWLEGRKNLPPGTGV
HHHHHCCEEECCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCE
VIVEDVVTTGGSSMKAVRRAEEEGLKVLGIVTLVDREEGGRENIEAEGYQLRTIFTRSQI
EEEEEEHHCCCHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCCCEEEEEEEECHHC
VG
CC
>Mature Secondary Structure
MNDRERLKQIIQELSYENRKVTLASGRESDFYFDGKQTTLHAEGGYLVGKLFYEAIKDME
CCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEECCCCEEEEECCCCHHHHHHHHHHHHHH
GVQAVGGITLGADPIATATSIAAHLDGRSMHAFIIRKEPKGHGTGQWLEGRKNLPPGTGV
HHHHHCCEEECCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCE
VIVEDVVTTGGSSMKAVRRAEEEGLKVLGIVTLVDREEGGRENIEAEGYQLRTIFTRSQI
EEEEEEHHCCCHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCCCEEEEEEEECHHC
VG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA