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The map label for this gene is phoR [H]

Identifier: 118578947

GI number: 118578947

Start: 530883

End: 531833

Strand: Reverse

Name: phoR [H]

Synonym: Ppro_0508

Alternate gene names: 118578947

Gene position: 531833-530883 (Counterclockwise)

Preceding gene: 118578948

Following gene: 118578946

Centisome position: 13.27

GC content: 62.36

Gene sequence:

>951_bases
ATGAAGCTGCTGAGAAAAATTTTCAGCCCGGTCAAGACGCTGATCGCCATCCAGCTGGTCTGGATCACCCTGGTGGTCTC
CTGGATCTACTGGTTCGTGGGCAAGAACCGCCAGTTCCGCGAACTGGCCGAGAAGTACCGCCCGGAACTGCTGGGCGAGG
GCTTCAACTGGGTGGTCATGACCGAGGGACTGGTCATGCTGGCCGTCATCCTGGCCGGCGTGTACGTCATCTTCCACTAC
TGGAACCGCCAGTCCCGACTGTACGAAAACCAGCGCACCTTCATCTCCCAGGTCACCCACGAGCTGAAATCCCCCCTGGC
CTCCATCCAGCTGCACCTGGAGACCATCAGGCTGCGCACCCTCCCCCAAGAACGTCTGGACGCCTTTGTGAACACCATGC
TGGCTGACACGGAGCGTCTGCACTACCTGATCAACAACCTGCTCATGGCCGCCCGCCTGGAACAGCGCCGCAAGCCGGCG
GAGCGCAGGATGGCCAACATATCCGAGCTTGTACGGGAGTATGTGGAGCGGGAACGGGACAAGCTGCCCCAGGGGGGGCA
GATCACCCTGGAGACGGAGGAGGATGTCAAGCTGCTGGTGGACCCGGAGGAGCTGGAGATCGTCCTGCGCAACCTGTTCG
AAAACGCGGTACTCTACTCGCCCGGAACCCCGGACATCACCGTTCGCCTGGCGCGCGGCGGGAACACGGTCAGTCTGGCC
ATACAGGACCGGGGACGCGGCCTGGACGGCGCCGAGCTGAAGAAAGTCTTCGACAGGTTCTACCGCGTGCAGCAGGACGG
GGAGAATGTGCGCGGGACCGGCCTGGGGCTGTACATCGTGGATACCATCGTACGGGGATACGGCGGCACGGTAACGGCGG
AGAGCACAGGCATTGGCCAGGGCTGCACCTTTACCATCACCCTGCCCAAACCACAGACAAAGGGTAGCTGA

Upstream 100 bases:

>100_bases
CGGACACCGAGCTGGTGCGGGGCGCTTCCGACACACTGTTCGCCAGGATGGAGGCGTTCTTCTCCGGTACTACCGAGACA
GGTCAGGGAGATCCGTTGCC

Downstream 100 bases:

>100_bases
AGATGAACAGGGATACGGAAAAACCGCACATCATGCTGGTCGAGGACGAGATTCACCTGGCGCGGGGGATCTGTTTCAAC
CTGGAGGAAGATGGATGCCG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MKLLRKIFSPVKTLIAIQLVWITLVVSWIYWFVGKNRQFRELAEKYRPELLGEGFNWVVMTEGLVMLAVILAGVYVIFHY
WNRQSRLYENQRTFISQVTHELKSPLASIQLHLETIRLRTLPQERLDAFVNTMLADTERLHYLINNLLMAARLEQRRKPA
ERRMANISELVREYVERERDKLPQGGQITLETEEDVKLLVDPEELEIVLRNLFENAVLYSPGTPDITVRLARGGNTVSLA
IQDRGRGLDGAELKKVFDRFYRVQQDGENVRGTGLGLYIVDTIVRGYGGTVTAESTGIGQGCTFTITLPKPQTKGS

Sequences:

>Translated_316_residues
MKLLRKIFSPVKTLIAIQLVWITLVVSWIYWFVGKNRQFRELAEKYRPELLGEGFNWVVMTEGLVMLAVILAGVYVIFHY
WNRQSRLYENQRTFISQVTHELKSPLASIQLHLETIRLRTLPQERLDAFVNTMLADTERLHYLINNLLMAARLEQRRKPA
ERRMANISELVREYVERERDKLPQGGQITLETEEDVKLLVDPEELEIVLRNLFENAVLYSPGTPDITVRLARGGNTVSLA
IQDRGRGLDGAELKKVFDRFYRVQQDGENVRGTGLGLYIVDTIVRGYGGTVTAESTGIGQGCTFTITLPKPQTKGS
>Mature_316_residues
MKLLRKIFSPVKTLIAIQLVWITLVVSWIYWFVGKNRQFRELAEKYRPELLGEGFNWVVMTEGLVMLAVILAGVYVIFHY
WNRQSRLYENQRTFISQVTHELKSPLASIQLHLETIRLRTLPQERLDAFVNTMLADTERLHYLINNLLMAARLEQRRKPA
ERRMANISELVREYVERERDKLPQGGQITLETEEDVKLLVDPEELEIVLRNLFENAVLYSPGTPDITVRLARGGNTVSLA
IQDRGRGLDGAELKKVFDRFYRVQQDGENVRGTGLGLYIVDTIVRGYGGTVTAESTGIGQGCTFTITLPKPQTKGS

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG5002

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=222, Percent_Identity=29.7297297297297, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790861, Length=200, Percent_Identity=32, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786783, Length=236, Percent_Identity=27.5423728813559, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=27.7310924369748, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1786912, Length=223, Percent_Identity=30.4932735426009, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790346, Length=228, Percent_Identity=28.9473684210526, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI48994928, Length=238, Percent_Identity=26.4705882352941, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790551, Length=315, Percent_Identity=25.7142857142857, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788393, Length=232, Percent_Identity=25.4310344827586, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788713, Length=224, Percent_Identity=26.7857142857143, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790436, Length=274, Percent_Identity=24.4525547445255, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787894, Length=236, Percent_Identity=27.5423728813559, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI87082128, Length=235, Percent_Identity=28.936170212766, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 36194; Mature: 36194

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLRKIFSPVKTLIAIQLVWITLVVSWIYWFVGKNRQFRELAEKYRPELLGEGFNWVVM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHCCCCCEEEE
TEGLVMLAVILAGVYVIFHYWNRQSRLYENQRTFISQVTHELKSPLASIQLHLETIRLRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHC
LPQERLDAFVNTMLADTERLHYLINNLLMAARLEQRRKPAERRMANISELVREYVERERD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
KLPQGGQITLETEEDVKLLVDPEELEIVLRNLFENAVLYSPGTPDITVRLARGGNTVSLA
CCCCCCEEEEECCCCCEEEECHHHHHHHHHHHHHCCEEECCCCCCEEEEEECCCCEEEEE
IQDRGRGLDGAELKKVFDRFYRVQQDGENVRGTGLGLYIVDTIVRGYGGTVTAESTGIGQ
EECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCC
GCTFTITLPKPQTKGS
CCEEEEECCCCCCCCC
>Mature Secondary Structure
MKLLRKIFSPVKTLIAIQLVWITLVVSWIYWFVGKNRQFRELAEKYRPELLGEGFNWVVM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHCCCCCEEEE
TEGLVMLAVILAGVYVIFHYWNRQSRLYENQRTFISQVTHELKSPLASIQLHLETIRLRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHC
LPQERLDAFVNTMLADTERLHYLINNLLMAARLEQRRKPAERRMANISELVREYVERERD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
KLPQGGQITLETEEDVKLLVDPEELEIVLRNLFENAVLYSPGTPDITVRLARGGNTVSLA
CCCCCCEEEEECCCCCEEEECHHHHHHHHHHHHHCCEEECCCCCCEEEEEECCCCEEEEE
IQDRGRGLDGAELKKVFDRFYRVQQDGENVRGTGLGLYIVDTIVRGYGGTVTAESTGIGQ
EECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCC
GCTFTITLPKPQTKGS
CCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]