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The map label for this gene is comP [H]

Identifier: 118478474

GI number: 118478474

Start: 3015477

End: 3017066

Strand: Direct

Name: comP [H]

Synonym: BALH_2846

Alternate gene names: 118478474

Gene position: 3015477-3017066 (Clockwise)

Preceding gene: 118478473

Following gene: 118478475

Centisome position: 57.36

GC content: 27.23

Gene sequence:

>1590_bases
ATGAAAAACTACTATGAGCAAAAACAAATTTTAATTTTAATTAACCAACTTTGTATGATTATTTTTTTGTGCTATGAATT
TTCAATGAACAATATTATAGGAACAGCAAAATTACTCCCTTTACTACTTATAACAGTCATGTCCATTTATGGATCATACA
TTAGTTTTATCAATTTAAAAAACAATACTCTATTATCACAGTTTTCGAGTTTACTACTTTTTACTTCTTGGCAGTTTTTA
CTTACAGTGAATGATGAACAGATTTTTCGTACAGTCAGTACACTGCTTAGTATCTTGATTCTATATAAGATCGTGCAATT
TATACTCCTATTCTTTTTCCAAGATTCTATTTATAGTTATAAAAAAGAAAAGGATTGGATTTTACGAGTTACATGTTTAC
TAACATTAGGCGCATACTTAATAAACGATAGAATATTCTCCGTTCTATTTTCATTTCAATGGCTTATTAGTGTTAGTTGC
ATTATTTTTCTGTTCCTGCAACATTACAAACGAATACAATTTGTTTGTAAAAGTGAAAAAAAGCATTTACTTAAATCTAC
TACAATTCTTATCGTTCCTTTTATCGTATATGTTACGTTATTTGGAAAGAATCCCGAATACGTAAATAATTTAGGATGGT
ACATAATAATTTTGTTCCCCCTATTTAGTATTCATGCAATAGCTTTTAAAAATCATATGTCTATGAAACAATATTTCCCC
TTAAAAAAAGGCGCGATCGCTTTTATATTTTTATGCATTTTTATTTTTATGAGTGCACTTGGGGTACTCTTTCAATTTCA
TATGATGACTTATTTCATTTTTATACATACAATTATTTGGTTCGTTCAGCTTTATTTCACATTATTATTTCAAGACACAA
AAAACACTATCTCAAATTTGAATACAAAAGAATTAAAAACTTTGCCAGACAGTTCTTATGTTCATAACTTAGTACAAATA
GTGAAAGAAGAACAATTAAAAAGTGGATTTTCTAATTATTTACACGATGAAATACTACAAGACATATTAGCTGTAAAAAA
TATGATGAACAAATCTAACAAAAAAGAAATTCATGACATGATCGTAGCGACACTGGACAACTTAAGTCATACAATACGCA
TTGAAATGCAAGAGTATCATCCAACTCTATTAAAAACACTTACATTAAAAGAAAATTATCATAATTTACTTAAAATGATA
CAAAAAAAATATGAAACAAAACATGTTAATATATCCTTTACATGTAACGACGACTTATTTTTAGTAGAACCCTATCACCT
TGTCGTATATCGAATATTAAAAGAACTAGTAACGAATGCATTCAAACATTCAAATTGTTCGCAGATATATTTACATTTAA
CACAAGAAAATGATGAAATAAAACTTATTGTGAAAGATGATGGTAAAGGTTTAGCAACTACCGAAGCAGATATACTAAAT
GGTCATAAAGGATTGAATTCAATTAAAGAACAGCTACTTTTATTGAATGGTGAAATGACCATTTCAAATAGTAATCCTTC
TGGTTTATGCATTACTATTTTTATTCCGATGAAAGGAGATGATTCCTATAAACATTTTATTAATAGATGA

Upstream 100 bases:

>100_bases
ATATTTAATAAGAAAAATTAAAAAATCTACAGATAAAGCTGATGATAGGCAACAAACATCAGCTTTATCTGTATGTAATC
TAACAAAGGTAAGTGAATTT

Downstream 100 bases:

>100_bases
TCACGCTTTGTTTGCAAAAAGCTTGGAAATAGCCTTAGAAGATTATCCTGAAATAGATGCATTTCACTCATTACAAAATA
TCGAAAATGTCATTACAATG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MKNYYEQKQILILINQLCMIIFLCYEFSMNNIIGTAKLLPLLLITVMSIYGSYISFINLKNNTLLSQFSSLLLFTSWQFL
LTVNDEQIFRTVSTLLSILILYKIVQFILLFFFQDSIYSYKKEKDWILRVTCLLTLGAYLINDRIFSVLFSFQWLISVSC
IIFLFLQHYKRIQFVCKSEKKHLLKSTTILIVPFIVYVTLFGKNPEYVNNLGWYIIILFPLFSIHAIAFKNHMSMKQYFP
LKKGAIAFIFLCIFIFMSALGVLFQFHMMTYFIFIHTIIWFVQLYFTLLFQDTKNTISNLNTKELKTLPDSSYVHNLVQI
VKEEQLKSGFSNYLHDEILQDILAVKNMMNKSNKKEIHDMIVATLDNLSHTIRIEMQEYHPTLLKTLTLKENYHNLLKMI
QKKYETKHVNISFTCNDDLFLVEPYHLVVYRILKELVTNAFKHSNCSQIYLHLTQENDEIKLIVKDDGKGLATTEADILN
GHKGLNSIKEQLLLLNGEMTISNSNPSGLCITIFIPMKGDDSYKHFINR

Sequences:

>Translated_529_residues
MKNYYEQKQILILINQLCMIIFLCYEFSMNNIIGTAKLLPLLLITVMSIYGSYISFINLKNNTLLSQFSSLLLFTSWQFL
LTVNDEQIFRTVSTLLSILILYKIVQFILLFFFQDSIYSYKKEKDWILRVTCLLTLGAYLINDRIFSVLFSFQWLISVSC
IIFLFLQHYKRIQFVCKSEKKHLLKSTTILIVPFIVYVTLFGKNPEYVNNLGWYIIILFPLFSIHAIAFKNHMSMKQYFP
LKKGAIAFIFLCIFIFMSALGVLFQFHMMTYFIFIHTIIWFVQLYFTLLFQDTKNTISNLNTKELKTLPDSSYVHNLVQI
VKEEQLKSGFSNYLHDEILQDILAVKNMMNKSNKKEIHDMIVATLDNLSHTIRIEMQEYHPTLLKTLTLKENYHNLLKMI
QKKYETKHVNISFTCNDDLFLVEPYHLVVYRILKELVTNAFKHSNCSQIYLHLTQENDEIKLIVKDDGKGLATTEADILN
GHKGLNSIKEQLLLLNGEMTISNSNPSGLCITIFIPMKGDDSYKHFINR
>Mature_529_residues
MKNYYEQKQILILINQLCMIIFLCYEFSMNNIIGTAKLLPLLLITVMSIYGSYISFINLKNNTLLSQFSSLLLFTSWQFL
LTVNDEQIFRTVSTLLSILILYKIVQFILLFFFQDSIYSYKKEKDWILRVTCLLTLGAYLINDRIFSVLFSFQWLISVSC
IIFLFLQHYKRIQFVCKSEKKHLLKSTTILIVPFIVYVTLFGKNPEYVNNLGWYIIILFPLFSIHAIAFKNHMSMKQYFP
LKKGAIAFIFLCIFIFMSALGVLFQFHMMTYFIFIHTIIWFVQLYFTLLFQDTKNTISNLNTKELKTLPDSSYVHNLVQI
VKEEQLKSGFSNYLHDEILQDILAVKNMMNKSNKKEIHDMIVATLDNLSHTIRIEMQEYHPTLLKTLTLKENYHNLLKMI
QKKYETKHVNISFTCNDDLFLVEPYHLVVYRILKELVTNAFKHSNCSQIYLHLTQENDEIKLIVKDDGKGLATTEADILN
GHKGLNSIKEQLLLLNGEMTISNSNPSGLCITIFIPMKGDDSYKHFINR

Specific function: Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61999; Mature: 61999

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNYYEQKQILILINQLCMIIFLCYEFSMNNIIGTAKLLPLLLITVMSIYGSYISFINLK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
NNTLLSQFSSLLLFTSWQFLLTVNDEQIFRTVSTLLSILILYKIVQFILLFFFQDSIYSY
CCHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKEKDWILRVTCLLTLGAYLINDRIFSVLFSFQWLISVSCIIFLFLQHYKRIQFVCKSEK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KHLLKSTTILIVPFIVYVTLFGKNPEYVNNLGWYIIILFPLFSIHAIAFKNHMSMKQYFP
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCC
LKKGAIAFIFLCIFIFMSALGVLFQFHMMTYFIFIHTIIWFVQLYFTLLFQDTKNTISNL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NTKELKTLPDSSYVHNLVQIVKEEQLKSGFSNYLHDEILQDILAVKNMMNKSNKKEIHDM
CHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IVATLDNLSHTIRIEMQEYHPTLLKTLTLKENYHNLLKMIQKKYETKHVNISFTCNDDLF
HHHHHHCCCEEEEEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEE
LVEPYHLVVYRILKELVTNAFKHSNCSQIYLHLTQENDEIKLIVKDDGKGLATTEADILN
EECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCCHHHHHC
GHKGLNSIKEQLLLLNGEMTISNSNPSGLCITIFIPMKGDDSYKHFINR
CCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEEECCCCHHHHHCCC
>Mature Secondary Structure
MKNYYEQKQILILINQLCMIIFLCYEFSMNNIIGTAKLLPLLLITVMSIYGSYISFINLK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
NNTLLSQFSSLLLFTSWQFLLTVNDEQIFRTVSTLLSILILYKIVQFILLFFFQDSIYSY
CCHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKEKDWILRVTCLLTLGAYLINDRIFSVLFSFQWLISVSCIIFLFLQHYKRIQFVCKSEK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KHLLKSTTILIVPFIVYVTLFGKNPEYVNNLGWYIIILFPLFSIHAIAFKNHMSMKQYFP
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCC
LKKGAIAFIFLCIFIFMSALGVLFQFHMMTYFIFIHTIIWFVQLYFTLLFQDTKNTISNL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NTKELKTLPDSSYVHNLVQIVKEEQLKSGFSNYLHDEILQDILAVKNMMNKSNKKEIHDM
CHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IVATLDNLSHTIRIEMQEYHPTLLKTLTLKENYHNLLKMIQKKYETKHVNISFTCNDDLF
HHHHHHCCCEEEEEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEE
LVEPYHLVVYRILKELVTNAFKHSNCSQIYLHLTQENDEIKLIVKDDGKGLATTEADILN
EECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCCHHHHHC
GHKGLNSIKEQLLLLNGEMTISNSNPSGLCITIFIPMKGDDSYKHFINR
CCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEEECCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2116363; 9274030; 9384377; 1715859 [H]