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The map label for this gene is kefC [H]

Identifier: 117922013

GI number: 117922013

Start: 4291309

End: 4292952

Strand: Direct

Name: kefC [H]

Synonym: Shewana3_3577

Alternate gene names: 117922013

Gene position: 4291309-4292952 (Clockwise)

Preceding gene: 117922012

Following gene: 117922014

Centisome position: 86.31

GC content: 50.18

Gene sequence:

>1644_bases
ATGGAACCGGCTATTCTTATCATTACACTTATCTGCGGCATGCTGGTTAGCCGCATAGGGCTGCCTCCCCTGATCGGCTA
CTTAGTGGCAGGCTTTGTACTCTTTGTTTTTGGTATTGAGAAAGAAAGCCTGCCCCTGCTGCAAGAACTCGCTAACCTTG
GGGTCACCTTATTACTCTTTGCCATTGGTCTTAAACTGGATATTCGCAGCCTCTTTAAGGCCGAAGTCTGGGCCGGGTCG
AGCATACATTTAGTGCTCTCTATGGTGCTGTTTATTCCTATCCTCAAAATCTTCGGCTTTATTGGCCTTAGCCAACTCGA
TGGTTTGGGCATTGCACAACTGTCTTTAATCGCCTTTGCGCTCAGCTTCTCCAGTACGGTATTCGCGATTAAGGTATTGG
AAGATAAAGGCGACGTGCAGTCCCTCTATGGCCGTGTCGCCATTGGTATCCTGATTATGCAGGATATTTTTGCCGTCATC
TTCTTAACCATTTCTAAGGGCGCTGTTCCATCGGTTTGGGCACTGGCGTTATTGCTGTTACCTCTAGCAAAACCACTGAT
TTACAAAGCCTTCGACCGTGTTGGTCACGGCGAGCTCTTAGTGTTATTCGGATTAGTGATGGCGCTGGTTGTCGGCGCTT
GGTTGTTTGAGTCCGTCGGCCTCAAACCGGATCTTGGCGCGCTTATCATAGGCATTTTACTCGCTGGGCATAAAAAGGCC
TCCGAGCTGGCTAAATCCTTGTTCTACTTTAAAGAACTCTTCCTTGTTGCCTTCTTCCTAACCATTGGCCTCAATGGTTT
ACCTACGGTATCCGATGTGGTGCTCGCGGCCTTATTAGTGCTGTTAGTGCCGTTAAAAATCCTGTTATTCGTCTACCTTC
TGACGCGATTTAAACTGCGTTCGCGCACCTCTATGCTGGCCTCATTTAACTTAGGTAACTTCTCTGAGTTCGGCCTTATC
GTCGCAGCGGTCGCCACCAGCAAAGGTTGGCTACCACCACAATGGCTGGTGATTATCGCCGTTGCCTTAAGTTTCAGCTT
CCTATTTGCCGCGCCACTCAATACGGCAGTGGGGAATATTTACCAACGATTCCAACAACGTCTGGTACGACTCGAGAAGC
CACCACTGCACCCAGAAGACAGACCGATTGCCATTGGCAATCCGCGCTTTTTAATCTTAGGTATGGGTCGTATTGGTAGC
GGTGCCTACGATGAACTGCGCGCTCGTTTCGACGGTGAAATCCTCGGGATTGAACACAAGCAGGAATTGGTCGATTTACA
CCGCGCCAATGGCCGCAACGTGGTGCAAGGGGATGCTTCGGACACCGACTTTTGGGAGAAGCTAGATAGAGCACCAAACC
TTGAGTTAGTGCTGCTAGCGATGCCACACCATGCGGGGAATCTGTTCGCCGTTGAGCAGCTCAAGAAGCTGAATTATCAA
GGCAAACTCAGCGCCATAGTGCAATACGGCGATGATGCCGCGTCACTGAGAAGCTCAGGCGTGCACAGTGTGTATAACTT
GTACGAAGCGGCGGGTGCGGGTTTCGTCGACCATGTGGTTCATGAGCTATTGCCAGACTCTGAAACTAAGGCCGATGCCG
AAGCTCAGGAAGAGACTCAAAAACAAGGCTCTGCCCTCGCCTAA

Upstream 100 bases:

>100_bases
AAAAGCGGACTTTTTTCATTAAAAGTCCGCTTTTTTATCACGCTGTCATCGATTTCTTATACAATCCCTGTTTAACGTGG
ACTTTTTAGATTGGAGCATT

Downstream 100 bases:

>100_bases
AAATGGCGTTGCTGAATAGGCTTTAGTTCAGCAGTCACTCATTTTAGTGATGAATAAAACTCATCTTATTTAAGCTAATG
TTGGCTCAGGAAAGCAAACC

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MEPAILIITLICGMLVSRIGLPPLIGYLVAGFVLFVFGIEKESLPLLQELANLGVTLLLFAIGLKLDIRSLFKAEVWAGS
SIHLVLSMVLFIPILKIFGFIGLSQLDGLGIAQLSLIAFALSFSSTVFAIKVLEDKGDVQSLYGRVAIGILIMQDIFAVI
FLTISKGAVPSVWALALLLLPLAKPLIYKAFDRVGHGELLVLFGLVMALVVGAWLFESVGLKPDLGALIIGILLAGHKKA
SELAKSLFYFKELFLVAFFLTIGLNGLPTVSDVVLAALLVLLVPLKILLFVYLLTRFKLRSRTSMLASFNLGNFSEFGLI
VAAVATSKGWLPPQWLVIIAVALSFSFLFAAPLNTAVGNIYQRFQQRLVRLEKPPLHPEDRPIAIGNPRFLILGMGRIGS
GAYDELRARFDGEILGIEHKQELVDLHRANGRNVVQGDASDTDFWEKLDRAPNLELVLLAMPHHAGNLFAVEQLKKLNYQ
GKLSAIVQYGDDAASLRSSGVHSVYNLYEAAGAGFVDHVVHELLPDSETKADAEAQEETQKQGSALA

Sequences:

>Translated_547_residues
MEPAILIITLICGMLVSRIGLPPLIGYLVAGFVLFVFGIEKESLPLLQELANLGVTLLLFAIGLKLDIRSLFKAEVWAGS
SIHLVLSMVLFIPILKIFGFIGLSQLDGLGIAQLSLIAFALSFSSTVFAIKVLEDKGDVQSLYGRVAIGILIMQDIFAVI
FLTISKGAVPSVWALALLLLPLAKPLIYKAFDRVGHGELLVLFGLVMALVVGAWLFESVGLKPDLGALIIGILLAGHKKA
SELAKSLFYFKELFLVAFFLTIGLNGLPTVSDVVLAALLVLLVPLKILLFVYLLTRFKLRSRTSMLASFNLGNFSEFGLI
VAAVATSKGWLPPQWLVIIAVALSFSFLFAAPLNTAVGNIYQRFQQRLVRLEKPPLHPEDRPIAIGNPRFLILGMGRIGS
GAYDELRARFDGEILGIEHKQELVDLHRANGRNVVQGDASDTDFWEKLDRAPNLELVLLAMPHHAGNLFAVEQLKKLNYQ
GKLSAIVQYGDDAASLRSSGVHSVYNLYEAAGAGFVDHVVHELLPDSETKADAEAQEETQKQGSALA
>Mature_547_residues
MEPAILIITLICGMLVSRIGLPPLIGYLVAGFVLFVFGIEKESLPLLQELANLGVTLLLFAIGLKLDIRSLFKAEVWAGS
SIHLVLSMVLFIPILKIFGFIGLSQLDGLGIAQLSLIAFALSFSSTVFAIKVLEDKGDVQSLYGRVAIGILIMQDIFAVI
FLTISKGAVPSVWALALLLLPLAKPLIYKAFDRVGHGELLVLFGLVMALVVGAWLFESVGLKPDLGALIIGILLAGHKKA
SELAKSLFYFKELFLVAFFLTIGLNGLPTVSDVVLAALLVLLVPLKILLFVYLLTRFKLRSRTSMLASFNLGNFSEFGLI
VAAVATSKGWLPPQWLVIIAVALSFSFLFAAPLNTAVGNIYQRFQQRLVRLEKPPLHPEDRPIAIGNPRFLILGMGRIGS
GAYDELRARFDGEILGIEHKQELVDLHRANGRNVVQGDASDTDFWEKLDRAPNLELVLLAMPHHAGNLFAVEQLKKLNYQ
GKLSAIVQYGDDAASLRSSGVHSVYNLYEAAGAGFVDHVVHELLPDSETKADAEAQEETQKQGSALA

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG4651

COG function: function code P; Kef-type K+ transport system, predicted NAD-binding component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=368, Percent_Identity=26.9021739130435, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786232, Length=517, Percent_Identity=27.4661508704062, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1786685, Length=542, Percent_Identity=25.6457564575646, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1789749, Length=466, Percent_Identity=25.1072961373391, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 59486; Mature: 59486

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPAILIITLICGMLVSRIGLPPLIGYLVAGFVLFVFGIEKESLPLLQELANLGVTLLLF
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AIGLKLDIRSLFKAEVWAGSSIHLVLSMVLFIPILKIFGFIGLSQLDGLGIAQLSLIAFA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHH
LSFSSTVFAIKVLEDKGDVQSLYGRVAIGILIMQDIFAVIFLTISKGAVPSVWALALLLL
HHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
PLAKPLIYKAFDRVGHGELLVLFGLVMALVVGAWLFESVGLKPDLGALIIGILLAGHKKA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHH
SELAKSLFYFKELFLVAFFLTIGLNGLPTVSDVVLAALLVLLVPLKILLFVYLLTRFKLR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRTSMLASFNLGNFSEFGLIVAAVATSKGWLPPQWLVIIAVALSFSFLFAAPLNTAVGNI
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YQRFQQRLVRLEKPPLHPEDRPIAIGNPRFLILGMGRIGSGAYDELRARFDGEILGIEHK
HHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEECCCCCCCHHHHHHHHHCCCEECCHHH
QELVDLHRANGRNVVQGDASDTDFWEKLDRAPNLELVLLAMPHHAGNLFAVEQLKKLNYQ
HHHHHHHHCCCCCEEECCCCCCHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCC
GKLSAIVQYGDDAASLRSSGVHSVYNLYEAAGAGFVDHVVHELLPDSETKADAEAQEETQ
CHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
KQGSALA
HCCCCCC
>Mature Secondary Structure
MEPAILIITLICGMLVSRIGLPPLIGYLVAGFVLFVFGIEKESLPLLQELANLGVTLLLF
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AIGLKLDIRSLFKAEVWAGSSIHLVLSMVLFIPILKIFGFIGLSQLDGLGIAQLSLIAFA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHH
LSFSSTVFAIKVLEDKGDVQSLYGRVAIGILIMQDIFAVIFLTISKGAVPSVWALALLLL
HHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
PLAKPLIYKAFDRVGHGELLVLFGLVMALVVGAWLFESVGLKPDLGALIIGILLAGHKKA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHH
SELAKSLFYFKELFLVAFFLTIGLNGLPTVSDVVLAALLVLLVPLKILLFVYLLTRFKLR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRTSMLASFNLGNFSEFGLIVAAVATSKGWLPPQWLVIIAVALSFSFLFAAPLNTAVGNI
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YQRFQQRLVRLEKPPLHPEDRPIAIGNPRFLILGMGRIGSGAYDELRARFDGEILGIEHK
HHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEECCCCCCCHHHHHHHHHCCCEECCHHH
QELVDLHRANGRNVVQGDASDTDFWEKLDRAPNLELVLLAMPHHAGNLFAVEQLKKLNYQ
HHHHHHHHCCCCCEEECCCCCCHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCC
GKLSAIVQYGDDAASLRSSGVHSVYNLYEAAGAGFVDHVVHELLPDSETKADAEAQEETQ
CHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
KQGSALA
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA