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The map label for this gene is galK [H]

Identifier: 117922014

GI number: 117922014

Start: 4293280

End: 4294425

Strand: Direct

Name: galK [H]

Synonym: Shewana3_3578

Alternate gene names: 117922014

Gene position: 4293280-4294425 (Clockwise)

Preceding gene: 117922013

Following gene: 117922015

Centisome position: 86.35

GC content: 52.62

Gene sequence:

>1146_bases
ATGTCGAACCCTGCGCAGCGCGCCACTAAGTTATTTGTCCAAACCTTTGGCACTAAAGCCGATGATTTATACCAAGCCCC
AGGTCGGGTGAATTTGATCGGTGAATATACGGATTACAACGACGGCTTCGTGCTGCCCGCCGCCATTAATTTTCATACGG
TTATTGCAGTAAAACGCCGAGAGGACAATAAGTTTCGCGCCGTTGCCGACGCCTTTCCGGGGCAAATCAAGGAATGGAGC
TTCGGTAAAGACACTGAAATCAATCCCGAAGATGGTTGGGTCAATTATCTCAAGGGCCTGACGGTAGCCATGGCCAATAC
TGGCCTTATCGCCAAAGGGTTAGACTTAGCGGTCGTCGGCGATGTGCCATTAGCTGCGGGTCTGTCTTCCTCCGGCGCCT
TAGTCGTCGCTTTTGGCACTGCTATCAGCGACAGCAGCCAACTGCATCTGTCTCCTATGGCGGTGGCACAACTCGCTCAG
CGTGGTGAATATCGCTATGTCTCATCGGCTTGCAGCATTATGGACCATATGGTCTGCGCCATGGGCGAACCGGATCATGC
CTTGCTCATCGATTGTCTGGATCTGGATAGCGAACCTATTGCGATCCCTGAAAACCTTAGCCTGATCATTATCGATGCCC
ATATCGAGAAACAACGCTTAGCGGCGATAAATCAACAACGCCGCGAAGAATGCGCACAGGCCGCCGACTTTTTTGGCCTC
GATGCCCTGCGTCACCTCGACCAGCGTCAGCTCGAAAGTGCTAAAGATCAATTGGATGACACCCTGTATCGCCGTGCCAA
ACACGTTGTCACCGAAAACAAGCGCACCCAGAGTGCCGCTCGAGCGCTAGAGCAAAATAATCTATCTAAATTCAGTTTGT
TAATGGCACAGTCCCATCAATCTCTACGGGATGATTTTGAGGTGACGTTGCCCGAATTTGATACCTTGGTAGACATAGTC
AGCCAAGTGATTGGAGAGCGTGGCGGCATTCGCATGACCGACGGTTGTGTTGTCGCCTTAGTGGATCACGAACTCACCGA
TGCCGTGGTCTCGGCGGTCGAGCATGCATTTTATGAGCAGACCGGAATCGATGCCACTGTGTATCTCTGCTCGGCGAGTG
CTGGCGCGGGGCGCATCGACAGCTAG

Upstream 100 bases:

>100_bases
CTATGCCCTACAAAATCTCAGTTACAACACTGAGTTAGTCGTGATATAAATCGAAGACAAGAACGCAATTTAGCCCAGCT
TTTTTGGAAGTCTTCCCAGC

Downstream 100 bases:

>100_bases
TCCGTCAATCACGCTCTATCCATTCTTCCAGACAAATACCATACGAATTCAACCTTGAATCCTATGGTATTTGTTGTTTT
TAAGAGGCAAAATCAAGCGG

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MSNPAQRATKLFVQTFGTKADDLYQAPGRVNLIGEYTDYNDGFVLPAAINFHTVIAVKRREDNKFRAVADAFPGQIKEWS
FGKDTEINPEDGWVNYLKGLTVAMANTGLIAKGLDLAVVGDVPLAAGLSSSGALVVAFGTAISDSSQLHLSPMAVAQLAQ
RGEYRYVSSACSIMDHMVCAMGEPDHALLIDCLDLDSEPIAIPENLSLIIIDAHIEKQRLAAINQQRREECAQAADFFGL
DALRHLDQRQLESAKDQLDDTLYRRAKHVVTENKRTQSAARALEQNNLSKFSLLMAQSHQSLRDDFEVTLPEFDTLVDIV
SQVIGERGGIRMTDGCVVALVDHELTDAVVSAVEHAFYEQTGIDATVYLCSASAGAGRIDS

Sequences:

>Translated_381_residues
MSNPAQRATKLFVQTFGTKADDLYQAPGRVNLIGEYTDYNDGFVLPAAINFHTVIAVKRREDNKFRAVADAFPGQIKEWS
FGKDTEINPEDGWVNYLKGLTVAMANTGLIAKGLDLAVVGDVPLAAGLSSSGALVVAFGTAISDSSQLHLSPMAVAQLAQ
RGEYRYVSSACSIMDHMVCAMGEPDHALLIDCLDLDSEPIAIPENLSLIIIDAHIEKQRLAAINQQRREECAQAADFFGL
DALRHLDQRQLESAKDQLDDTLYRRAKHVVTENKRTQSAARALEQNNLSKFSLLMAQSHQSLRDDFEVTLPEFDTLVDIV
SQVIGERGGIRMTDGCVVALVDHELTDAVVSAVEHAFYEQTGIDATVYLCSASAGAGRIDS
>Mature_380_residues
SNPAQRATKLFVQTFGTKADDLYQAPGRVNLIGEYTDYNDGFVLPAAINFHTVIAVKRREDNKFRAVADAFPGQIKEWSF
GKDTEINPEDGWVNYLKGLTVAMANTGLIAKGLDLAVVGDVPLAAGLSSSGALVVAFGTAISDSSQLHLSPMAVAQLAQR
GEYRYVSSACSIMDHMVCAMGEPDHALLIDCLDLDSEPIAIPENLSLIIIDAHIEKQRLAAINQQRREECAQAADFFGLD
ALRHLDQRQLESAKDQLDDTLYRRAKHVVTENKRTQSAARALEQNNLSKFSLLMAQSHQSLRDDFEVTLPEFDTLVDIVS
QVIGERGGIRMTDGCVVALVDHELTDAVVSAVEHAFYEQTGIDATVYLCSASAGAGRIDS

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=385, Percent_Identity=35.8441558441558, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI4503897, Length=416, Percent_Identity=26.4423076923077, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI48527957, Length=416, Percent_Identity=26.4423076923077, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786972, Length=377, Percent_Identity=41.6445623342175, Blast_Score=314, Evalue=5e-87,
Organism=Caenorhabditis elegans, GI71989053, Length=405, Percent_Identity=24.9382716049383, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319494, Length=216, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320212, Length=234, Percent_Identity=29.9145299145299, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24661292, Length=437, Percent_Identity=25.629290617849, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355577, Length=437, Percent_Identity=25.629290617849, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24661285, Length=437, Percent_Identity=25.629290617849, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 41516; Mature: 41385

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPAQRATKLFVQTFGTKADDLYQAPGRVNLIGEYTDYNDGFVLPAAINFHTVIAVKRR
CCCHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEEECCCCCCEEEEEEECEEEEEEEEEC
EDNKFRAVADAFPGQIKEWSFGKDTEINPEDGWVNYLKGLTVAMANTGLIAKGLDLAVVG
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCEEEEC
DVPLAAGLSSSGALVVAFGTAISDSSQLHLSPMAVAQLAQRGEYRYVSSACSIMDHMVCA
CCCHHCCCCCCCCEEEEEECEECCCCCEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MGEPDHALLIDCLDLDSEPIAIPENLSLIIIDAHIEKQRLAAINQQRREECAQAADFFGL
CCCCCCEEEEEEECCCCCCEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
DALRHLDQRQLESAKDQLDDTLYRRAKHVVTENKRTQSAARALEQNNLSKFSLLMAQSHQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
SLRDDFEVTLPEFDTLVDIVSQVIGERGGIRMTDGCVVALVDHELTDAVVSAVEHAFYEQ
HHHCCCEEECCCHHHHHHHHHHHHCCCCCEEEECCEEEEEECCHHHHHHHHHHHHHHHHH
TGIDATVYLCSASAGAGRIDS
CCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
SNPAQRATKLFVQTFGTKADDLYQAPGRVNLIGEYTDYNDGFVLPAAINFHTVIAVKRR
CCHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEEECCCCCCEEEEEEECEEEEEEEEEC
EDNKFRAVADAFPGQIKEWSFGKDTEINPEDGWVNYLKGLTVAMANTGLIAKGLDLAVVG
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCEEEEC
DVPLAAGLSSSGALVVAFGTAISDSSQLHLSPMAVAQLAQRGEYRYVSSACSIMDHMVCA
CCCHHCCCCCCCCEEEEEECEECCCCCEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MGEPDHALLIDCLDLDSEPIAIPENLSLIIIDAHIEKQRLAAINQQRREECAQAADFFGL
CCCCCCEEEEEEECCCCCCEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
DALRHLDQRQLESAKDQLDDTLYRRAKHVVTENKRTQSAARALEQNNLSKFSLLMAQSHQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
SLRDDFEVTLPEFDTLVDIVSQVIGERGGIRMTDGCVVALVDHELTDAVVSAVEHAFYEQ
HHHCCCEEECCCHHHHHHHHHHHHCCCCCEEEECCEEEEEECCHHHHHHHHHHHHHHHHH
TGIDATVYLCSASAGAGRIDS
CCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA