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The map label for this gene is dxs [H]

Identifier: 117921342

GI number: 117921342

Start: 3469970

End: 3471838

Strand: Direct

Name: dxs [H]

Synonym: Shewana3_2901

Alternate gene names: 117921342

Gene position: 3469970-3471838 (Clockwise)

Preceding gene: 117921341

Following gene: 117921344

Centisome position: 69.79

GC content: 52.11

Gene sequence:

>1869_bases
ATGAGTTTGGACATTTCACAGTTTCCCGTGTTGGCTCAGGCCAACACTCCTAATGAACTCCGCCAGCTTCCTCAGGCCCT
GTTACCTCAATTGGCCGATGAGTTGCGGGAGTTTCTTCTTAAGTCCGTTGGCATGTCCAGCGGACATTTTGCCTCTGGAC
TTGGCACGGTCGAACTGACTGTCGCCCTGCATTATGTCTATAACACCCCGTTTGATCGTTTGATTTGGGACGTTGGCCAC
CAAGCCTATCCCCATAAAATTCTCACCGGTCGCCGCGACAGAATGCACACCATTAGGCAAAAGAACGGCTTACACCCTTT
CCCTTGGCGGGAAGAAAGTGAATACGACACCTTTAGCGTCGGACACTCCGGTACATCCATCAGTGCCGCATTAGCCATGG
CCGTTGCCGCCGAAAAAGAACAGGCTGGCCGCAAAGTGGTTGCCGTGATTGGCGATGGCGCCATGACGGGCGGTATGGTG
TTCGAGGCCATGAATCACGCGGGTGATTTGCACAACGATATGCTGATGGTGCTGAACGATAACGAAATGTCGATTTCAGA
AAACGTCGGCGCGCTCAACAATCACCTAGCGCAACTGATGTCGGGCCGCCTCTACACCACCATTCGTGAAAGCAGCAAGA
AAGTCCTCAAGGGCATGCCGGTCATCAAAGAGATGGCCAAGCGCACCGAAGAGCACCTCAAGGGCATGGTTGTACCTGGC
ACTCTGTTTGAAGAGCTAGGCTTTAACTATATCGGCCCCATCGATGGCCACGATGTCGATGCCTTAGTGGAAACCCTGCG
CAATATGCGCTCTCTAAAGGGCCCACAAGTGCTGCACATCATGACCAAAAAAGGTCGTGGCTATGAACCGGCCGAGAAAG
ATCCTATCGGTTGGCACGCAGTACCTAAATTTGACCCATCACAGTTTAAGAAGCCAGCGACTAAGCCGGGACTGCCAACC
TTCTCCCAAGTGTTTGGCAAATGGTTATGTGATATTGCCGAGCAGGATGAAAAAGTCTTAGGCATTACCCCAGCCATGCG
TGAAGGTTCGGGCATGGTGGAGTTCTCACAACGCTTCCCGAAACAATATTTCGATGCCGCCATTGCCGAGCAACATGCGG
TGACCTTAGGGGCCGGATTTGCCTGTGAAGGCTTTAAGCCTGTGGTCGCCATTTACTCGACCTTCCTGCAACGGGGCTAT
GACCAGCTAATCCACGATGTGGCACTACAACGTTTACCGGTATTGTTCGCCATTGACCGTGGCGGTATCGTCGGTGCCGA
CGGCCCAACCCACCAAGGAGCATTCGATTTAAGCTTTATGCGCTGCATTCCGAATATGGTGATCATGGCGCCATCGGATG
AAAATGAATGTCGCCAAATGCTCTATACAGGTTATTGCTATGATGCAGGCCCGAGCGCGGTGCGTTATCCAAGGGGAAGC
GCCACAGGCGCGACTCAGGTAGAAGCCATGACGGCGCTGCCAATTGGTAAAGGCGTGATTAAGCGTTTAGGCAAAGGTAT
CGCCATGCTGAACTTTGGCACCACCTTAGCCGCCGCCTTAACCGCCGCAGAAAGCTTAGACGCCACCGTCGTCGATATGC
GCTTTGTGAAGCCGTTAGATGTGGATTTAGTCAAAGAGATGGCGCAAACCCACGATGTGCTCGTCACAGTGGAAGAAAAC
GCCATTATGGGCGGCGCTGGCTCTGGTGTATTAGAACTGCTGCAAAAGCTTAAAATGCCGAAACCTGTGCTGCAAATAGG
CCTACCCGATGAGTTTATTAAACATGGCTCTCCAGAAGAAGTGACCCATGATTTACAACTCGATGCCGAAGGTATGTTAG
CGCAAATTAATGCCTTTCTTGCCGATTAA

Upstream 100 bases:

>100_bases
ATCAGCGCTGGCTAAATTGCCATACAATAGCCAGTTAATCGCAGACTTCGCCCGCTATATCATTGAGCGAAGAATATAAT
AAGAGACGAAGTATCTCGCT

Downstream 100 bases:

>100_bases
GTGTTATGGGAGCTAAGCTCCCAGCAACAGTGCAAAGCGTGATGAATCGCGATTAGCAGGCAAAAAACAGACAAATAAAA
AGGACTGCATCTGCAGTCCT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 622; Mature: 621

Protein sequence:

>622_residues
MSLDISQFPVLAQANTPNELRQLPQALLPQLADELREFLLKSVGMSSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGH
QAYPHKILTGRRDRMHTIRQKNGLHPFPWREESEYDTFSVGHSGTSISAALAMAVAAEKEQAGRKVVAVIGDGAMTGGMV
FEAMNHAGDLHNDMLMVLNDNEMSISENVGALNNHLAQLMSGRLYTTIRESSKKVLKGMPVIKEMAKRTEEHLKGMVVPG
TLFEELGFNYIGPIDGHDVDALVETLRNMRSLKGPQVLHIMTKKGRGYEPAEKDPIGWHAVPKFDPSQFKKPATKPGLPT
FSQVFGKWLCDIAEQDEKVLGITPAMREGSGMVEFSQRFPKQYFDAAIAEQHAVTLGAGFACEGFKPVVAIYSTFLQRGY
DQLIHDVALQRLPVLFAIDRGGIVGADGPTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYCYDAGPSAVRYPRGS
ATGATQVEAMTALPIGKGVIKRLGKGIAMLNFGTTLAAALTAAESLDATVVDMRFVKPLDVDLVKEMAQTHDVLVTVEEN
AIMGGAGSGVLELLQKLKMPKPVLQIGLPDEFIKHGSPEEVTHDLQLDAEGMLAQINAFLAD

Sequences:

>Translated_622_residues
MSLDISQFPVLAQANTPNELRQLPQALLPQLADELREFLLKSVGMSSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGH
QAYPHKILTGRRDRMHTIRQKNGLHPFPWREESEYDTFSVGHSGTSISAALAMAVAAEKEQAGRKVVAVIGDGAMTGGMV
FEAMNHAGDLHNDMLMVLNDNEMSISENVGALNNHLAQLMSGRLYTTIRESSKKVLKGMPVIKEMAKRTEEHLKGMVVPG
TLFEELGFNYIGPIDGHDVDALVETLRNMRSLKGPQVLHIMTKKGRGYEPAEKDPIGWHAVPKFDPSQFKKPATKPGLPT
FSQVFGKWLCDIAEQDEKVLGITPAMREGSGMVEFSQRFPKQYFDAAIAEQHAVTLGAGFACEGFKPVVAIYSTFLQRGY
DQLIHDVALQRLPVLFAIDRGGIVGADGPTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYCYDAGPSAVRYPRGS
ATGATQVEAMTALPIGKGVIKRLGKGIAMLNFGTTLAAALTAAESLDATVVDMRFVKPLDVDLVKEMAQTHDVLVTVEEN
AIMGGAGSGVLELLQKLKMPKPVLQIGLPDEFIKHGSPEEVTHDLQLDAEGMLAQINAFLAD
>Mature_621_residues
SLDISQFPVLAQANTPNELRQLPQALLPQLADELREFLLKSVGMSSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGHQ
AYPHKILTGRRDRMHTIRQKNGLHPFPWREESEYDTFSVGHSGTSISAALAMAVAAEKEQAGRKVVAVIGDGAMTGGMVF
EAMNHAGDLHNDMLMVLNDNEMSISENVGALNNHLAQLMSGRLYTTIRESSKKVLKGMPVIKEMAKRTEEHLKGMVVPGT
LFEELGFNYIGPIDGHDVDALVETLRNMRSLKGPQVLHIMTKKGRGYEPAEKDPIGWHAVPKFDPSQFKKPATKPGLPTF
SQVFGKWLCDIAEQDEKVLGITPAMREGSGMVEFSQRFPKQYFDAAIAEQHAVTLGAGFACEGFKPVVAIYSTFLQRGYD
QLIHDVALQRLPVLFAIDRGGIVGADGPTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYCYDAGPSAVRYPRGSA
TGATQVEAMTALPIGKGVIKRLGKGIAMLNFGTTLAAALTAAESLDATVVDMRFVKPLDVDLVKEMAQTHDVLVTVEENA
IMGGAGSGVLELLQKLKMPKPVLQIGLPDEFIKHGSPEEVTHDLQLDAEGMLAQINAFLAD

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=517, Percent_Identity=22.0502901353965, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI4507521, Length=517, Percent_Identity=22.0502901353965, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI133778974, Length=618, Percent_Identity=23.7864077669903, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786622, Length=621, Percent_Identity=71.1755233494364, Blast_Score=931, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=562, Percent_Identity=23.4875444839858, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24666278, Length=526, Percent_Identity=24.7148288973384, Blast_Score=113, Evalue=5e-25,
Organism=Drosophila melanogaster, GI45551847, Length=620, Percent_Identity=24.3548387096774, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI45550715, Length=620, Percent_Identity=24.3548387096774, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24645119, Length=524, Percent_Identity=24.4274809160305, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67928; Mature: 67797

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDISQFPVLAQANTPNELRQLPQALLPQLADELREFLLKSVGMSSGHFASGLGTVELT
CCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDRMHTIRQKNGLHPFPWREESEYDTFSV
EEEEHHHCCCHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEC
GHSGTSISAALAMAVAAEKEQAGRKVVAVIGDGAMTGGMVFEAMNHAGDLHNDMLMVLND
CCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLMSGRLYTTIRESSKKVLKGMPVIKEMAKRTEEHLKGMVVPG
CCCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPIDGHDVDALVETLRNMRSLKGPQVLHIMTKKGRGYEPAEKDPIGWHA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPSQFKKPATKPGLPTFSQVFGKWLCDIAEQDEKVLGITPAMREGSGMVEFSQRFP
CCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCHHCCCCCHHHHHHCC
KQYFDAAIAEQHAVTLGAGFACEGFKPVVAIYSTFLQRGYDQLIHDVALQRLPVLFAIDR
HHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
GGIVGADGPTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYCYDAGPSAVRYPRGS
CCEECCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCEECCCCCCEECCCCC
ATGATQVEAMTALPIGKGVIKRLGKGIAMLNFGTTLAAALTAAESLDATVVDMRFVKPLD
CCCCHHHHHHHHCCCCHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCEEHHHHCCCCC
VDLVKEMAQTHDVLVTVEENAIMGGAGSGVLELLQKLKMPKPVLQIGLPDEFIKHGSPEE
HHHHHHHHHCCCEEEEEECCEEECCCCHHHHHHHHHHCCCCCCEECCCCHHHHHCCCHHH
VTHDLQLDAEGMLAQINAFLAD
HHHHHEECCCHHHHHHHHHHCC
>Mature Secondary Structure 
SLDISQFPVLAQANTPNELRQLPQALLPQLADELREFLLKSVGMSSGHFASGLGTVELT
CCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDRMHTIRQKNGLHPFPWREESEYDTFSV
EEEEHHHCCCHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEC
GHSGTSISAALAMAVAAEKEQAGRKVVAVIGDGAMTGGMVFEAMNHAGDLHNDMLMVLND
CCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLMSGRLYTTIRESSKKVLKGMPVIKEMAKRTEEHLKGMVVPG
CCCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPIDGHDVDALVETLRNMRSLKGPQVLHIMTKKGRGYEPAEKDPIGWHA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPSQFKKPATKPGLPTFSQVFGKWLCDIAEQDEKVLGITPAMREGSGMVEFSQRFP
CCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCHHCCCCCHHHHHHCC
KQYFDAAIAEQHAVTLGAGFACEGFKPVVAIYSTFLQRGYDQLIHDVALQRLPVLFAIDR
HHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
GGIVGADGPTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYCYDAGPSAVRYPRGS
CCEECCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCEECCCCCCEECCCCC
ATGATQVEAMTALPIGKGVIKRLGKGIAMLNFGTTLAAALTAAESLDATVVDMRFVKPLD
CCCCHHHHHHHHCCCCHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCEEHHHHCCCCC
VDLVKEMAQTHDVLVTVEENAIMGGAGSGVLELLQKLKMPKPVLQIGLPDEFIKHGSPEE
HHHHHHHHHCCCEEEEEECCEEECCCCHHHHHHHHHHCCCCCCEECCCCHHHHHCCCHHH
VTHDLQLDAEGMLAQINAFLAD
HHHHHEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA