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The map label for this gene is ispA [H]

Identifier: 117921341

GI number: 117921341

Start: 3469067

End: 3469948

Strand: Direct

Name: ispA [H]

Synonym: Shewana3_2900

Alternate gene names: 117921341

Gene position: 3469067-3469948 (Clockwise)

Preceding gene: 117921340

Following gene: 117921342

Centisome position: 69.77

GC content: 51.36

Gene sequence:

>882_bases
GTGTTAGTCAATGCAATAAAAGAATATCAACTACGGGTTGATGACCAATTAAAACAACGTTTCAGCACACTCGAAGACAC
TGCGCCGCAGTTAAAGGCCGCCATGACCCACGGCGCGCTATTAGGCGGTAAGCGTATTCGTCCCTTCTTGGTTTACAGCG
TGGGGCAAATGTTTGGCGTGCCGCTTGAAAAGCTCGACGCCAGCGCCGCCGCCATTGAGTGTATTCATGCTTATTCGTTA
ATCCATGACGATTTACCCGCCATGGACGATGACGACCTTCGTCGTGGTCAGCCCACAGTGCATATCGCCTTCGATGAGGC
GACCGCCATCCTTGCTGGGGATGCACTGCAAACCTTAGCCTTTGAAATTGTGACCGAAGCCGTACCTGGGATCAGCAGCG
AGCAACATATCGCTATGGTGAGGGCGCTGGCGAAAGCCTCGGGTTACCGTGGTATGTGTGGCGGCCAAGCGATTGACTTA
GCCTCAACCGATAAGCTCATCGACCTTAAAGCCTTAACTCAACTGCATAATATGAAAACGGGCGCCCTTATCAGCTGCGC
CGTTGAGTTAGCCCTGATCGCCGCTAATGCGCCAAAAGATGAATATCAGACTATGATGGAATTTGCCCATGCGGTAGGAC
TTGCCTTCCAAGTGCAAGACGATATTCTGGACATCATTGCCACCACGGAAGAACTCGGCAAACCCCAAGGCTCTGACGCC
GAGTCCAATAAGAGTACTTTTCCGCAACTACTTGGACTGCAAGGCGCCAAAGATACCGCCGCGCAACTGATCCAAGAGGC
ACTATCAGCGCTGGCTAAATTGCCATACAATAGCCAGTTAATCGCAGACTTCGCCCGCTATATCATTGAGCGAAGAATAT
AA

Upstream 100 bases:

>100_bases
GCCAAGCAAAACTCGAGCAAGCTCAGCAAAAAGTGGCCATTTTACTCAAGCAGGATGAAAATGCGCCCCTCTCTCCCTAT
GCCGTTGAGGGCGAATAAGC

Downstream 100 bases:

>100_bases
TAAGAGACGAAGTATCTCGCTATGAGTTTGGACATTTCACAGTTTCCCGTGTTGGCTCAGGCCAACACTCCTAATGAACT
CCGCCAGCTTCCTCAGGCCC

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MLVNAIKEYQLRVDDQLKQRFSTLEDTAPQLKAAMTHGALLGGKRIRPFLVYSVGQMFGVPLEKLDASAAAIECIHAYSL
IHDDLPAMDDDDLRRGQPTVHIAFDEATAILAGDALQTLAFEIVTEAVPGISSEQHIAMVRALAKASGYRGMCGGQAIDL
ASTDKLIDLKALTQLHNMKTGALISCAVELALIAANAPKDEYQTMMEFAHAVGLAFQVQDDILDIIATTEELGKPQGSDA
ESNKSTFPQLLGLQGAKDTAAQLIQEALSALAKLPYNSQLIADFARYIIERRI

Sequences:

>Translated_293_residues
MLVNAIKEYQLRVDDQLKQRFSTLEDTAPQLKAAMTHGALLGGKRIRPFLVYSVGQMFGVPLEKLDASAAAIECIHAYSL
IHDDLPAMDDDDLRRGQPTVHIAFDEATAILAGDALQTLAFEIVTEAVPGISSEQHIAMVRALAKASGYRGMCGGQAIDL
ASTDKLIDLKALTQLHNMKTGALISCAVELALIAANAPKDEYQTMMEFAHAVGLAFQVQDDILDIIATTEELGKPQGSDA
ESNKSTFPQLLGLQGAKDTAAQLIQEALSALAKLPYNSQLIADFARYIIERRI
>Mature_293_residues
MLVNAIKEYQLRVDDQLKQRFSTLEDTAPQLKAAMTHGALLGGKRIRPFLVYSVGQMFGVPLEKLDASAAAIECIHAYSL
IHDDLPAMDDDDLRRGQPTVHIAFDEATAILAGDALQTLAFEIVTEAVPGISSEQHIAMVRALAKASGYRGMCGGQAIDL
ASTDKLIDLKALTQLHNMKTGALISCAVELALIAANAPKDEYQTMMEFAHAVGLAFQVQDDILDIIATTEELGKPQGSDA
ESNKSTFPQLLGLQGAKDTAAQLIQEALSALAKLPYNSQLIADFARYIIERRI

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=232, Percent_Identity=25.8620689655172, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786623, Length=262, Percent_Identity=56.1068702290076, Blast_Score=250, Evalue=6e-68,
Organism=Escherichia coli, GI1789578, Length=228, Percent_Identity=30.7017543859649, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17505681, Length=188, Percent_Identity=28.1914893617021, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24651612, Length=184, Percent_Identity=28.2608695652174, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31665; Mature: 31665

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVNAIKEYQLRVDDQLKQRFSTLEDTAPQLKAAMTHGALLGGKRIRPFLVYSVGQMFGV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
PLEKLDASAAAIECIHAYSLIHDDLPAMDDDDLRRGQPTVHIAFDEATAILAGDALQTLA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEEEEECCCHHHHHHHHHHHHH
FEIVTEAVPGISSEQHIAMVRALAKASGYRGMCGGQAIDLASTDKLIDLKALTQLHNMKT
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHHCCCC
GALISCAVELALIAANAPKDEYQTMMEFAHAVGLAFQVQDDILDIIATTEELGKPQGSDA
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHCCCCCCCC
ESNKSTFPQLLGLQGAKDTAAQLIQEALSALAKLPYNSQLIADFARYIIERRI
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLVNAIKEYQLRVDDQLKQRFSTLEDTAPQLKAAMTHGALLGGKRIRPFLVYSVGQMFGV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
PLEKLDASAAAIECIHAYSLIHDDLPAMDDDDLRRGQPTVHIAFDEATAILAGDALQTLA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEEEEECCCHHHHHHHHHHHHH
FEIVTEAVPGISSEQHIAMVRALAKASGYRGMCGGQAIDLASTDKLIDLKALTQLHNMKT
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHHCCCC
GALISCAVELALIAANAPKDEYQTMMEFAHAVGLAFQVQDDILDIIATTEELGKPQGSDA
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHCCCCCCCC
ESNKSTFPQLLGLQGAKDTAAQLIQEALSALAKLPYNSQLIADFARYIIERRI
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]