Click here to switch to the map view.

The map label for this gene is lpxH

Identifier: 117921107

GI number: 117921107

Start: 3182819

End: 3183538

Strand: Direct

Name: lpxH

Synonym: Shewana3_2666

Alternate gene names: 117921107

Gene position: 3182819-3183538 (Clockwise)

Preceding gene: 117921106

Following gene: 117921109

Centisome position: 64.01

GC content: 47.92

Gene sequence:

>720_bases
ATGCGGACCTTATTTATTGGCGATCTGCACTTAAGTGCCGATCGCCTCGATATCACCCAAGCCTTTAATCGTTTCCTCGA
TACAGAACTTGATGATGCCGATGCCCTCTATATTCTGGGGGATTTATTTGAGGTATGGGTCGGCGACGATTTAGCCGCGC
CTTTTGCCCTCGAATTAGCGCGCAAGCTCAATCAAGTCTCCCAAAGATTGCCCATCTACTTTATTCACGGTAATCGTGAC
TTTATGTTAGGCAAACAATTTGCCGATGTTGCGGGCATGCAAATGTTGCCCGAAGTCACTTGTTTAGATCTCTATGGTGT
GAATACGGTTATCTTGCACGGCGATAGCCTGTGCACCTTAGATAAAGCCTACCAACGCTTTCGCAAATTACGCAGTTTTG
CCTTCGCCCGTTGGCTGTATAGCTGTTTGCCGAAGAAAAAACGTCAAGCCATTGCCAATAAAATCCGCAGTAATAGCCAA
AGCAGCAATCAACAAAAAAGCTATGTCATCATGGATGTGGAACCTAGTGCGGTGGATGCGTTATTTGCCCAGAGCCACTG
TAAACAGATGATCCACGGTCATACCCACAGACCCGCCATCCACGAGTTCACTAACGGCTGTAAACGTATTGTGGTCGGTG
ATTGGTACGAGCAAGGCAGTGTGTTGGTGGTCAGCTCCGACGGCGTAGATTTAAAAAGCCTGCCCTTCGACGCCAGCTAA

Upstream 100 bases:

>100_bases
AAAAATCAAAGCTGTCAGCACTGGTAACCGTGGCATGCACCAAGATGTGCCATTAGAAGCGGTTGTGATTGAAAAAGTCA
GTGCGGCCTAATTCCCTAGG

Downstream 100 bases:

>100_bases
GCACCTATAGCGCCCTCACCATTAACACATTGAACCGCTTAGGCCTCATACCTGAATATGGTGAGGCCGCTATTTGTATT
GCCACTAGGCAACTGAGGGT

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MRTLFIGDLHLSADRLDITQAFNRFLDTELDDADALYILGDLFEVWVGDDLAAPFALELARKLNQVSQRLPIYFIHGNRD
FMLGKQFADVAGMQMLPEVTCLDLYGVNTVILHGDSLCTLDKAYQRFRKLRSFAFARWLYSCLPKKKRQAIANKIRSNSQ
SSNQQKSYVIMDVEPSAVDALFAQSHCKQMIHGHTHRPAIHEFTNGCKRIVVGDWYEQGSVLVVSSDGVDLKSLPFDAS

Sequences:

>Translated_239_residues
MRTLFIGDLHLSADRLDITQAFNRFLDTELDDADALYILGDLFEVWVGDDLAAPFALELARKLNQVSQRLPIYFIHGNRD
FMLGKQFADVAGMQMLPEVTCLDLYGVNTVILHGDSLCTLDKAYQRFRKLRSFAFARWLYSCLPKKKRQAIANKIRSNSQ
SSNQQKSYVIMDVEPSAVDALFAQSHCKQMIHGHTHRPAIHEFTNGCKRIVVGDWYEQGSVLVVSSDGVDLKSLPFDAS
>Mature_239_residues
MRTLFIGDLHLSADRLDITQAFNRFLDTELDDADALYILGDLFEVWVGDDLAAPFALELARKLNQVSQRLPIYFIHGNRD
FMLGKQFADVAGMQMLPEVTCLDLYGVNTVILHGDSLCTLDKAYQRFRKLRSFAFARWLYSCLPKKKRQAIANKIRSNSQ
SSNQQKSYVIMDVEPSAVDALFAQSHCKQMIHGHTHRPAIHEFTNGCKRIVVGDWYEQGSVLVVSSDGVDLKSLPFDAS

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family

Homologues:

Organism=Escherichia coli, GI1786735, Length=240, Percent_Identity=47.0833333333333, Blast_Score=222, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXH_SHESA (A0KYM4)

Other databases:

- EMBL:   CP000469
- RefSeq:   YP_870299.1
- ProteinModelPortal:   A0KYM4
- STRING:   A0KYM4
- GeneID:   4478433
- GenomeReviews:   CP000469_GR
- KEGG:   shn:Shewana3_2666
- NMPDR:   fig|94122.5.peg.2707
- eggNOG:   COG2908
- HOGENOM:   HBG288883
- OMA:   CHGDTLC
- PhylomeDB:   A0KYM4
- ProtClustDB:   PRK05340
- BioCyc:   SSP94122:SHEWANA3_2666-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00575
- InterPro:   IPR004843
- InterPro:   IPR010138
- TIGRFAMs:   TIGR01854

Pfam domain/function: PF00149 Metallophos

EC number: 3.6.1.-

Molecular weight: Translated: 27048; Mature: 27048

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLFIGDLHLSADRLDITQAFNRFLDTELDDADALYILGDLFEVWVGDDLAAPFALELA
CCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
RKLNQVSQRLPIYFIHGNRDFMLGKQFADVAGMQMLPEVTCLDLYGVNTVILHGDSLCTL
HHHHHHHHHCCEEEEECCCCEECHHHHHHHHHHHHCCCHHEEEEECCCEEEEECCCCHHH
DKAYQRFRKLRSFAFARWLYSCLPKKKRQAIANKIRSNSQSSNQQKSYVIMDVEPSAVDA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHH
LFAQSHCKQMIHGHTHRPAIHEFTNGCKRIVVGDWYEQGSVLVVSSDGVDLKSLPFDAS
HHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MRTLFIGDLHLSADRLDITQAFNRFLDTELDDADALYILGDLFEVWVGDDLAAPFALELA
CCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
RKLNQVSQRLPIYFIHGNRDFMLGKQFADVAGMQMLPEVTCLDLYGVNTVILHGDSLCTL
HHHHHHHHHCCEEEEECCCCEECHHHHHHHHHHHHCCCHHEEEEECCCEEEEECCCCHHH
DKAYQRFRKLRSFAFARWLYSCLPKKKRQAIANKIRSNSQSSNQQKSYVIMDVEPSAVDA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHH
LFAQSHCKQMIHGHTHRPAIHEFTNGCKRIVVGDWYEQGSVLVVSSDGVDLKSLPFDAS
HHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA