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The map label for this gene is ppiB [H]

Identifier: 117921106

GI number: 117921106

Start: 3182318

End: 3182809

Strand: Direct

Name: ppiB [H]

Synonym: Shewana3_2665

Alternate gene names: 117921106

Gene position: 3182318-3182809 (Clockwise)

Preceding gene: 117921104

Following gene: 117921107

Centisome position: 64.0

GC content: 45.93

Gene sequence:

>492_bases
ATGATCACATTACACACTAATTTTGGCGACATTAAACTGCAACTGAACGCCGAAAAAGCACCGCTGACTGTGGCAAACTT
TATGAAATATGTTGACGAAGGTTTCTTCGACGGCACCATTTTCCACCGTGTAATTGACGGCTTTATGATCCAAGGCGGTG
GCTTTACCGCTGAAATGAGCCAAAAACGTTGCCATGAGCCAGTGAAAAACGAAGCCAACAACGGTTTATCAAACCGTACT
GGTACTATCGCGATGGCGCGTACTTCTGATCCACACTCAGCGACGGCTCAGTTCTTCATCAACGTCAACGATAACACCTT
CCTCGATTTCAAATCTGAAAGCATGCAAGGTTGGGGTTACTGCGTATTTGGTGAAGTGGTTGAAGGCATGGACATCGTTG
AAAAAATCAAAGCTGTCAGCACTGGTAACCGTGGCATGCACCAAGATGTGCCATTAGAAGCGGTTGTGATTGAAAAAGTC
AGTGCGGCCTAA

Upstream 100 bases:

>100_bases
GGGTCAGTCTACCACGCTGGCGAGGGTTTTGAATACTGCACTTTGCGTGCAATCCGAGATAAGTTAGAATCGCGCCACTA
TTTACTGAGAGTATGAAAAC

Downstream 100 bases:

>100_bases
TTCCCTAGGATGCGGACCTTATTTATTGGCGATCTGCACTTAAGTGCCGATCGCCTCGATATCACCCAAGCCTTTAATCG
TTTCCTCGATACAGAACTTG

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MITLHTNFGDIKLQLNAEKAPLTVANFMKYVDEGFFDGTIFHRVIDGFMIQGGGFTAEMSQKRCHEPVKNEANNGLSNRT
GTIAMARTSDPHSATAQFFINVNDNTFLDFKSESMQGWGYCVFGEVVEGMDIVEKIKAVSTGNRGMHQDVPLEAVVIEKV
SAA

Sequences:

>Translated_163_residues
MITLHTNFGDIKLQLNAEKAPLTVANFMKYVDEGFFDGTIFHRVIDGFMIQGGGFTAEMSQKRCHEPVKNEANNGLSNRT
GTIAMARTSDPHSATAQFFINVNDNTFLDFKSESMQGWGYCVFGEVVEGMDIVEKIKAVSTGNRGMHQDVPLEAVVIEKV
SAA
>Mature_163_residues
MITLHTNFGDIKLQLNAEKAPLTVANFMKYVDEGFFDGTIFHRVIDGFMIQGGGFTAEMSQKRCHEPVKNEANNGLSNRT
GTIAMARTSDPHSATAQFFINVNDNTFLDFKSESMQGWGYCVFGEVVEGMDIVEKIKAVSTGNRGMHQDVPLEAVVIEKV
SAA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547212, Length=160, Percent_Identity=34.375, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI7657473, Length=160, Percent_Identity=34.375, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI22547215, Length=163, Percent_Identity=33.7423312883436, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI19557636, Length=163, Percent_Identity=30.0613496932515, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI7706339, Length=165, Percent_Identity=32.1212121212121, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI24308049, Length=157, Percent_Identity=33.1210191082803, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI64276486, Length=129, Percent_Identity=34.1085271317829, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI310110104, Length=140, Percent_Identity=34.2857142857143, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI310129267, Length=141, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI310120620, Length=141, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=66.2576687116564, Blast_Score=230, Evalue=3e-62,
Organism=Escherichia coli, GI1789763, Length=156, Percent_Identity=56.4102564102564, Blast_Score=185, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=32.8767123287671, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=32.8767123287671, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=161, Percent_Identity=32.9192546583851, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532641, Length=159, Percent_Identity=32.0754716981132, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17539496, Length=144, Percent_Identity=30.5555555555556, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=156, Percent_Identity=34.6153846153846, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71997782, Length=131, Percent_Identity=32.824427480916, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321848, Length=161, Percent_Identity=36.6459627329193, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922376, Length=160, Percent_Identity=29.375, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922912, Length=138, Percent_Identity=36.231884057971, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17986117, Length=160, Percent_Identity=30, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136360, Length=159, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24652460, Length=161, Percent_Identity=27.9503105590062, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17942; Mature: 17942

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLHTNFGDIKLQLNAEKAPLTVANFMKYVDEGFFDGTIFHRVIDGFMIQGGGFTAEMS
CEEEECCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCEEECCCCCCHHHH
QKRCHEPVKNEANNGLSNRTGTIAMARTSDPHSATAQFFINVNDNTFLDFKSESMQGWGY
HHHCCCHHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCCCEE
CVFGEVVEGMDIVEKIKAVSTGNRGMHQDVPLEAVVIEKVSAA
EEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHEEEEHHCCC
>Mature Secondary Structure
MITLHTNFGDIKLQLNAEKAPLTVANFMKYVDEGFFDGTIFHRVIDGFMIQGGGFTAEMS
CEEEECCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCEEECCCCCCHHHH
QKRCHEPVKNEANNGLSNRTGTIAMARTSDPHSATAQFFINVNDNTFLDFKSESMQGWGY
HHHCCCHHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCCCEE
CVFGEVVEGMDIVEKIKAVSTGNRGMHQDVPLEAVVIEKVSAA
EEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHEEEEHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]