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The map label for this gene is melA [H]

Identifier: 117920925

GI number: 117920925

Start: 2968200

End: 2969240

Strand: Direct

Name: melA [H]

Synonym: Shewana3_2482

Alternate gene names: 117920925

Gene position: 2968200-2969240 (Clockwise)

Preceding gene: 117920924

Following gene: 117920928

Centisome position: 59.7

GC content: 45.24

Gene sequence:

>1041_bases
ATGGCAAGCGAACTCAATCCACTGGGCTTACTCGGTATCGAATTTACCGAATTTGCCAGCCCCGACAGCGATTTTATGCA
CAAAGTGTTTATCGACTTTGGTTTTTCACTGCTGAAAAAAGCCAAAAATAAAGACATTTTATACTACAAACAAAATGACA
TTAACTTCCTGCTTAACAACGAGCGCGAAGGGTTTTCGGCAGAATTTGCCAAATCCCACGGCCCTGCCATTAGCTCTATG
GGCTGGCGCGTAGAAGATGCCAGCTTTGCTCACCGTGTGGCGGTAGAGCGCGGCGCCAAAGCTGTGGCCGATTCGGCCAA
GGATCTGCCTTATCCAGCCATTTATGGTATTGGTGACAGCTTAATTTATTTTATCGACACCTTCGGTGCCGACAACAATA
TCTATGCAACTGACTTTGAAGACTTAAGTGAGCCAGTGATCACCCAAGAGAAAGGCTTTGTCGAAGTAGACCATTTAACC
AATAACGTCTACAAAGGCACCATGGAACATTGGGCGAACTTCTACAAAAACATCTTTGGTTTTACCGAAGTGCGCTACTT
CGACATCAGCGGCGTACAAACCGCACTGGTGTCTTACGCCCTGCGCTCACCTGATGGCAGCTTCTGTATCCCAATTAACG
AAGGTAAAGGCAACGATAAGAACCAAATCGATGAATACCTGAAGGAATACAATGGTCCAGGTGTACAACACTTAGCCTTT
AGAAGCCGTGATATCGTTAAATCCTTAGATGCGATGGAAGGTAGCTCGATTCAATGCTTGGATATTATTCCTGAATATTA
CGACACCATTTTCGATAAAGTCCCACAAGTGACCGAAAACCGTGAGCGTATCAAGCATCACCAAATTTTGGTGGATGGCG
ACGAGTCAGGCTATTTATTGCAGATCTTCACTAAAAACCTGTTTGGCCCGATTTTTATCGAAATCATTCAACGTAAGAAC
AACTTAGGTTTTGGCGAAGGTAACTTCACCGCCCTGTTCCAATCGATTGAACGTGACCAAATGCGCCGCGGCGTGCTGTA
A

Upstream 100 bases:

>100_bases
CATGAGTGAATGGCTTAACTAAGCCTACTAGCCGTAAGTCACCACAGCGAACAAGGCCAAAAGAGTGACTGCGTGTTGAA
TTAATCAAGAGGAACAGATC

Downstream 100 bases:

>100_bases
TCGCAGCCATTAATGCATAAGAAACAAAAACGGTACGCACTGCGTACCGTTTTTTTATGTCCTATAGTGACTCGCTGTTT
GTCACGCTTCGCTTATGGCC

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MASELNPLGLLGIEFTEFASPDSDFMHKVFIDFGFSLLKKAKNKDILYYKQNDINFLLNNEREGFSAEFAKSHGPAISSM
GWRVEDASFAHRVAVERGAKAVADSAKDLPYPAIYGIGDSLIYFIDTFGADNNIYATDFEDLSEPVITQEKGFVEVDHLT
NNVYKGTMEHWANFYKNIFGFTEVRYFDISGVQTALVSYALRSPDGSFCIPINEGKGNDKNQIDEYLKEYNGPGVQHLAF
RSRDIVKSLDAMEGSSIQCLDIIPEYYDTIFDKVPQVTENRERIKHHQILVDGDESGYLLQIFTKNLFGPIFIEIIQRKN
NLGFGEGNFTALFQSIERDQMRRGVL

Sequences:

>Translated_346_residues
MASELNPLGLLGIEFTEFASPDSDFMHKVFIDFGFSLLKKAKNKDILYYKQNDINFLLNNEREGFSAEFAKSHGPAISSM
GWRVEDASFAHRVAVERGAKAVADSAKDLPYPAIYGIGDSLIYFIDTFGADNNIYATDFEDLSEPVITQEKGFVEVDHLT
NNVYKGTMEHWANFYKNIFGFTEVRYFDISGVQTALVSYALRSPDGSFCIPINEGKGNDKNQIDEYLKEYNGPGVQHLAF
RSRDIVKSLDAMEGSSIQCLDIIPEYYDTIFDKVPQVTENRERIKHHQILVDGDESGYLLQIFTKNLFGPIFIEIIQRKN
NLGFGEGNFTALFQSIERDQMRRGVL
>Mature_345_residues
ASELNPLGLLGIEFTEFASPDSDFMHKVFIDFGFSLLKKAKNKDILYYKQNDINFLLNNEREGFSAEFAKSHGPAISSMG
WRVEDASFAHRVAVERGAKAVADSAKDLPYPAIYGIGDSLIYFIDTFGADNNIYATDFEDLSEPVITQEKGFVEVDHLTN
NVYKGTMEHWANFYKNIFGFTEVRYFDISGVQTALVSYALRSPDGSFCIPINEGKGNDKNQIDEYLKEYNGPGVQHLAFR
SRDIVKSLDAMEGSSIQCLDIIPEYYDTIFDKVPQVTENRERIKHHQILVDGDESGYLLQIFTKNLFGPIFIEIIQRKNN
LGFGEGNFTALFQSIERDQMRRGVL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI285002264, Length=320, Percent_Identity=29.6875, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4504477, Length=320, Percent_Identity=29.6875, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI14249394, Length=344, Percent_Identity=24.4186046511628, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17555220, Length=203, Percent_Identity=37.9310344827586, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17550752, Length=204, Percent_Identity=36.7647058823529, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI21356105, Length=299, Percent_Identity=33.1103678929766, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24667510, Length=299, Percent_Identity=33.1103678929766, Blast_Score=138, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 39214; Mature: 39082

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASELNPLGLLGIEFTEFASPDSDFMHKVFIDFGFSLLKKAKNKDILYYKQNDINFLLNN
CCCCCCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECC
EREGFSAEFAKSHGPAISSMGWRVEDASFAHRVAVERGAKAVADSAKDLPYPAIYGIGDS
CCCCCCHHHHHHCCCCHHHCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCC
LIYFIDTFGADNNIYATDFEDLSEPVITQEKGFVEVDHLTNNVYKGTMEHWANFYKNIFG
EEEEEECCCCCCCEEECCHHHHCCCCEECCCCCEEHHHHHCHHHHHHHHHHHHHHHHHHC
FTEVRYFDISGVQTALVSYALRSPDGSFCIPINEGKGNDKNQIDEYLKEYNGPGVQHLAF
HHHEEEEECCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHH
RSRDIVKSLDAMEGSSIQCLDIIPEYYDTIFDKVPQVTENRERIKHHQILVDGDESGYLL
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHCEEEEECCCCCCEE
QIFTKNLFGPIFIEIIQRKNNLGFGEGNFTALFQSIERDQMRRGVL
EEHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ASELNPLGLLGIEFTEFASPDSDFMHKVFIDFGFSLLKKAKNKDILYYKQNDINFLLNN
CCCCCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECC
EREGFSAEFAKSHGPAISSMGWRVEDASFAHRVAVERGAKAVADSAKDLPYPAIYGIGDS
CCCCCCHHHHHHCCCCHHHCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCC
LIYFIDTFGADNNIYATDFEDLSEPVITQEKGFVEVDHLTNNVYKGTMEHWANFYKNIFG
EEEEEECCCCCCCEEECCHHHHCCCCEECCCCCEEHHHHHCHHHHHHHHHHHHHHHHHHC
FTEVRYFDISGVQTALVSYALRSPDGSFCIPINEGKGNDKNQIDEYLKEYNGPGVQHLAF
HHHEEEEECCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHH
RSRDIVKSLDAMEGSSIQCLDIIPEYYDTIFDKVPQVTENRERIKHHQILVDGDESGYLL
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHCEEEEECCCCCCEE
QIFTKNLFGPIFIEIIQRKNNLGFGEGNFTALFQSIERDQMRRGVL
EEHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1756973 [H]