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The map label for this gene is 117920924

Identifier: 117920924

GI number: 117920924

Start: 2966926

End: 2968086

Strand: Direct

Name: 117920924

Synonym: Shewana3_2481

Alternate gene names: NA

Gene position: 2966926-2968086 (Clockwise)

Preceding gene: 117920921

Following gene: 117920925

Centisome position: 59.67

GC content: 47.03

Gene sequence:

>1161_bases
ATGCCATTTTATGTGAAACAAGGCCAAGTCCCCCATAAGCGCCATATCGCATTTGAGAAAGAAAACGGCGAGCTATATCG
TGAGGAGCTGTTTTCAACCCATGGTTTTTCCAATATTTACTCGAATAAATATCACCACAATATGCCGACTAAGGCATTGG
AAGTGGCGCCCTACCGCCTCGGTCACGGTGCCCAATGGGAAGATTCATTAGTTCAAAACTATAAACTGGACTCTCGTACG
GCCGATCGTGAAGGCAACTTCTTTAGCGCCCGCAACAAAATCTTTTATAACAATGATGTGGCCATTTATACCGCAAAAGT
GACTCAAGACACGCCGGAGTTTTACCGCAATGCCTATGCCGATGAAGTGGTGTTTGTGCATGAAGGTGAAGGTACGCTCT
ACAGTGAATATGGCACTCTAGAGATCAAGAAATGGGACTACTTAGTGATCCCACGCGGCACCACACATCAGCTCAAATTT
AACGATTACAGTAATGTGCGCTTATTTGTGATTGAAGCCTTTTCAATGGTGGAAGTGCCAAAACATTTCCGTAATGAATA
CGGTCAGTTACTCGAGTCTGCCCCCTATTGTGAACGCGATCTGCGCACGCCCGTATTGCAAGATGCCGTGGTTGAACGTG
GCGCCTTCCCGCTGGTATGTAAATTTGGTGATAAGTACCAACTGACCACCTTAGAGTGGCATCCCTTTGACCTTGCGGGT
TGGGACGGCTGTGTTTACCCCTGGGCATTTAACATTACCGAATACGCCCCTAAAGTCGGCAAAATTCACTTACCGCCTTC
AGACCACTTAGTGTTTACCGCCCACAACTTTGTGGTGTGTAACTTTGTGCCGCGTCCTTATGACTTCCACGAGCGTGCCA
TTCCTGCGCCTTACTATCACAACAATATTGATAGTGATGAAGTGCTGTACTACGTCGACGGTGACTTTATGAGTCGTACA
GAGATTGAAGCCGGTTACATCACCCTACATCAAAAAGGCGTGGCACATGGCCCACAGCCAGGCCGCACCGAAGCCTCGAT
TGGCAAAAAAGAAACCTATGAATATGCAGTGATGGTGGACACCTTCGCCCCACTGAAATTAACCGAACATGTGCAAAATT
GCATGAGTAAAGACTACAACCGCTCTTGGCTAGAAAACTAA

Upstream 100 bases:

>100_bases
TTCAAGCAACTAAATTGATAAGAAGATCACACTAATGCAACTTGCAGCATAACGACTCGCGGTGTAGGTAAGCCTGCAGC
GCAACTTTGAAGGAATCACC

Downstream 100 bases:

>100_bases
CGCTGCACCGCAGCATGAGTGAATGGCTTAACTAAGCCTACTAGCCGTAAGTCACCACAGCGAACAAGGCCAAAAGAGTG
ACTGCGTGTTGAATTAATCA

Product: homogentisate 1,2-dioxygenase

Products: 4-maleylacetoacetate

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MPFYVKQGQVPHKRHIAFEKENGELYREELFSTHGFSNIYSNKYHHNMPTKALEVAPYRLGHGAQWEDSLVQNYKLDSRT
ADREGNFFSARNKIFYNNDVAIYTAKVTQDTPEFYRNAYADEVVFVHEGEGTLYSEYGTLEIKKWDYLVIPRGTTHQLKF
NDYSNVRLFVIEAFSMVEVPKHFRNEYGQLLESAPYCERDLRTPVLQDAVVERGAFPLVCKFGDKYQLTTLEWHPFDLAG
WDGCVYPWAFNITEYAPKVGKIHLPPSDHLVFTAHNFVVCNFVPRPYDFHERAIPAPYYHNNIDSDEVLYYVDGDFMSRT
EIEAGYITLHQKGVAHGPQPGRTEASIGKKETYEYAVMVDTFAPLKLTEHVQNCMSKDYNRSWLEN

Sequences:

>Translated_386_residues
MPFYVKQGQVPHKRHIAFEKENGELYREELFSTHGFSNIYSNKYHHNMPTKALEVAPYRLGHGAQWEDSLVQNYKLDSRT
ADREGNFFSARNKIFYNNDVAIYTAKVTQDTPEFYRNAYADEVVFVHEGEGTLYSEYGTLEIKKWDYLVIPRGTTHQLKF
NDYSNVRLFVIEAFSMVEVPKHFRNEYGQLLESAPYCERDLRTPVLQDAVVERGAFPLVCKFGDKYQLTTLEWHPFDLAG
WDGCVYPWAFNITEYAPKVGKIHLPPSDHLVFTAHNFVVCNFVPRPYDFHERAIPAPYYHNNIDSDEVLYYVDGDFMSRT
EIEAGYITLHQKGVAHGPQPGRTEASIGKKETYEYAVMVDTFAPLKLTEHVQNCMSKDYNRSWLEN
>Mature_385_residues
PFYVKQGQVPHKRHIAFEKENGELYREELFSTHGFSNIYSNKYHHNMPTKALEVAPYRLGHGAQWEDSLVQNYKLDSRTA
DREGNFFSARNKIFYNNDVAIYTAKVTQDTPEFYRNAYADEVVFVHEGEGTLYSEYGTLEIKKWDYLVIPRGTTHQLKFN
DYSNVRLFVIEAFSMVEVPKHFRNEYGQLLESAPYCERDLRTPVLQDAVVERGAFPLVCKFGDKYQLTTLEWHPFDLAGW
DGCVYPWAFNITEYAPKVGKIHLPPSDHLVFTAHNFVVCNFVPRPYDFHERAIPAPYYHNNIDSDEVLYYVDGDFMSRTE
IEAGYITLHQKGVAHGPQPGRTEASIGKKETYEYAVMVDTFAPLKLTEHVQNCMSKDYNRSWLEN

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR014710 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: 1.13.11.5

Molecular weight: Translated: 44903; Mature: 44772

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFYVKQGQVPHKRHIAFEKENGELYREELFSTHGFSNIYSNKYHHNMPTKALEVAPYRL
CCEEECCCCCCHHHCEEEECCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHEECCEEC
GHGAQWEDSLVQNYKLDSRTADREGNFFSARNKIFYNNDVAIYTAKVTQDTPEFYRNAYA
CCCCCCHHHHHHHCCCCCCCCCCCCCEEECCCEEEECCCEEEEEEEECCCCHHHHHCCCC
DEVVFVHEGEGTLYSEYGTLEIKKWDYLVIPRGTTHQLKFNDYSNVRLFVIEAFSMVEVP
CCEEEEECCCCEEEECCCEEEEEECEEEEECCCCCEEEEECCCCCEEEEEEEHHHHHHHH
KHFRNEYGQLLESAPYCERDLRTPVLQDAVVERGAFPLVCKFGDKYQLTTLEWHPFDLAG
HHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHCCCCEEEEECCCCEEEEEEEECCCCCCC
WDGCVYPWAFNITEYAPKVGKIHLPPSDHLVFTAHNFVVCNFVPRPYDFHERAIPAPYYH
CCCEECCEEECHHHHCCCCCEEECCCCCCEEEEECCEEEEEECCCCCCCHHCCCCCCCCC
NNIDSDEVLYYVDGDFMSRTEIEAGYITLHQKGVAHGPQPGRTEASIGKKETYEYAVMVD
CCCCCCCEEEEECCCCCCCEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEE
TFAPLKLTEHVQNCMSKDYNRSWLEN
CCCCHHHHHHHHHHHHCCCCHHHCCC
>Mature Secondary Structure 
PFYVKQGQVPHKRHIAFEKENGELYREELFSTHGFSNIYSNKYHHNMPTKALEVAPYRL
CEEECCCCCCHHHCEEEECCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHEECCEEC
GHGAQWEDSLVQNYKLDSRTADREGNFFSARNKIFYNNDVAIYTAKVTQDTPEFYRNAYA
CCCCCCHHHHHHHCCCCCCCCCCCCCEEECCCEEEECCCEEEEEEEECCCCHHHHHCCCC
DEVVFVHEGEGTLYSEYGTLEIKKWDYLVIPRGTTHQLKFNDYSNVRLFVIEAFSMVEVP
CCEEEEECCCCEEEECCCEEEEEECEEEEECCCCCEEEEECCCCCEEEEEEEHHHHHHHH
KHFRNEYGQLLESAPYCERDLRTPVLQDAVVERGAFPLVCKFGDKYQLTTLEWHPFDLAG
HHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHCCCCEEEEECCCCEEEEEEEECCCCCCC
WDGCVYPWAFNITEYAPKVGKIHLPPSDHLVFTAHNFVVCNFVPRPYDFHERAIPAPYYH
CCCEECCEEECHHHHCCCCCEEECCCCCCEEEEECCEEEEEECCCCCCCHHCCCCCCCCC
NNIDSDEVLYYVDGDFMSRTEIEAGYITLHQKGVAHGPQPGRTEASIGKKETYEYAVMVD
CCCCCCCEEEEECCCCCCCEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEE
TFAPLKLTEHVQNCMSKDYNRSWLEN
CCCCHHHHHHHHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: homogentisate; O2

Specific reaction: homogentisate + O2 = 4-maleylacetoacetate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]