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The map label for this gene is msrA [H]

Identifier: 117920577

GI number: 117920577

Start: 2559135

End: 2559614

Strand: Direct

Name: msrA [H]

Synonym: Shewana3_2133

Alternate gene names: 117920577

Gene position: 2559135-2559614 (Clockwise)

Preceding gene: 117920568

Following gene: 117920580

Centisome position: 51.47

GC content: 49.38

Gene sequence:

>480_bases
ATGGCGTTAGCAACTTTCGGTGCCGGCTGTTTTTGGGGCGTGGAGTATTTCTTTAGACAAGTCAACGGCGTGACCAACGC
GACCTGCGGCTATATGGGTGGTAATAACGAAGCGACCACCTATGAGGAAGTCAAAAAAGGCAAAACAGGCCATGCTGAAG
TCGTGCAAGTGGAATTTGACCCTGCGATTGTCAGCTACGACGAGTTACTGGATGTGTTTTGGAAGAACCACAACCCCACC
ACGCTCAATATGCAGGGCGGCGATATCGGCACTCAGTACCGCAGTACCATTTTCTTCCATGACCGTGAGCAAAAAGCGAC
GGCCGAAGCTTCTAAACTGGCCTTTGCCCGGTCGGGCCGCTGGGGATTACGCCACATTGTGACTGAAATTGTACCTTTGC
AGCAATTCCATGTTGCAGAGGAATATCATCAAAACTATATCGATAAGAACAACTTACCTAGTTGCCATCTCGAGTATTGA

Upstream 100 bases:

>100_bases
CGCATTTGGTCGACATAGGATTAATTTTGTCGACACACTTGCTTTTAGGGATGAGTTTTATCACAATCCTTAGCCATCTA
GACTTCTATCAGGATTTATC

Downstream 100 bases:

>100_bases
TCAAAACCATTTAGCATCTTCGTGAGAGGCTTGGCTTCTCATCGCTACAAATAAAAACGCACTCATAGGATTTCCATGAG
TGCGTTTTTTATCGGAAAAA

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MALATFGAGCFWGVEYFFRQVNGVTNATCGYMGGNNEATTYEEVKKGKTGHAEVVQVEFDPAIVSYDELLDVFWKNHNPT
TLNMQGGDIGTQYRSTIFFHDREQKATAEASKLAFARSGRWGLRHIVTEIVPLQQFHVAEEYHQNYIDKNNLPSCHLEY

Sequences:

>Translated_159_residues
MALATFGAGCFWGVEYFFRQVNGVTNATCGYMGGNNEATTYEEVKKGKTGHAEVVQVEFDPAIVSYDELLDVFWKNHNPT
TLNMQGGDIGTQYRSTIFFHDREQKATAEASKLAFARSGRWGLRHIVTEIVPLQQFHVAEEYHQNYIDKNNLPSCHLEY
>Mature_158_residues
ALATFGAGCFWGVEYFFRQVNGVTNATCGYMGGNNEATTYEEVKKGKTGHAEVVQVEFDPAIVSYDELLDVFWKNHNPTT
LNMQGGDIGTQYRSTIFFHDREQKATAEASKLAFARSGRWGLRHIVTEIVPLQQFHVAEEYHQNYIDKNNLPSCHLEY

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=44.8717948717949, Blast_Score=127, Evalue=5e-30,
Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=44.8717948717949, Blast_Score=127, Evalue=6e-30,
Organism=Homo sapiens, GI208609993, Length=111, Percent_Identity=45.945945945946, Blast_Score=92, Evalue=3e-19,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=48.0263157894737, Blast_Score=140, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=36.0544217687075, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320881, Length=156, Percent_Identity=39.1025641025641, Blast_Score=114, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24664627, Length=145, Percent_Identity=42.0689655172414, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24664631, Length=145, Percent_Identity=41.3793103448276, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45553131, Length=138, Percent_Identity=40.5797101449275, Blast_Score=106, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 18033; Mature: 17902

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALATFGAGCFWGVEYFFRQVNGVTNATCGYMGGNNEATTYEEVKKGKTGHAEVVQVEFD
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEECC
PAIVSYDELLDVFWKNHNPTTLNMQGGDIGTQYRSTIFFHDREQKATAEASKLAFARSGR
CCEECHHHHHHHHHCCCCCEEEEECCCCCCCCHHEEEEEECCCHHHHHHHHHHHHHCCCC
WGLRHIVTEIVPLQQFHVAEEYHQNYIDKNNLPSCHLEY
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
>Mature Secondary Structure 
ALATFGAGCFWGVEYFFRQVNGVTNATCGYMGGNNEATTYEEVKKGKTGHAEVVQVEFD
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEECC
PAIVSYDELLDVFWKNHNPTTLNMQGGDIGTQYRSTIFFHDREQKATAEASKLAFARSGR
CCEECHHHHHHHHHCCCCCEEEEECCCCCCCCHHEEEEEECCCHHHHHHHHHHHHHCCCC
WGLRHIVTEIVPLQQFHVAEEYHQNYIDKNNLPSCHLEY
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]