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The map label for this gene is ilvD [H]

Identifier: 117920514

GI number: 117920514

Start: 2477453

End: 2479213

Strand: Direct

Name: ilvD [H]

Synonym: Shewana3_2070

Alternate gene names: 117920514

Gene position: 2477453-2479213 (Clockwise)

Preceding gene: 117920512

Following gene: 117920515

Centisome position: 49.83

GC content: 49.74

Gene sequence:

>1761_bases
ATGTGCCTTGGAAGACGAAGGTGTCATATGAATAATAAAAAACCGAAAACACTTCGTTCGGCTAGTTGGTTTGGTAGTGA
TGACAAAAATGGCTTTATGTATCGCAGTTGGATGAAAAACCAAGGCATACCCGAGCATCACTTTCAAAATAAGCCTGTGA
TTGGTATTTGCAATACTTGGTCAGAATTGACGCCCTGTAATGGTCATCTACGGGAATTGGCGCAAAGAGTAAAGAATGGC
ATTCGGGAAGCGGGTGGCATTCCGGTGGAGTTTCCGGTGTTTTCGAATGGTGAGTCCAACTTGCGTCCAAGTGCCATGCT
GACCCGTAACCTTGCGGCCATGGACACGGAAGAAGCCATTCGTGGCAACCCCATCGACGGTGTTGTGCTGTTAGTAGGCT
GCGATAAAACGACTCCGGCTTTATTAATGGGCGCGGCCAGTTGTGATTTACCGACAATCGTTGTTACTGGTGGTCCCATG
CTCAATGGTAAGCATAAGGGTAAGGATGTTGGTTCGGGCACACTCGTGTGGGAACTGCATCAAGAATATAAAGCGGGCAA
TATCAGCCTTGCCGCATTTATGAATGCCGAAGCGGATATGTCACGCTCAACGGGCACCTGTAACACTATGGGGACGGCAT
CGACCATGGCTTGTATGGTGGAAACCCTTGGGGTGAGTTTGCCACACAATGCAACCATTCCTGCGGTGGATTCTCGCCGC
CAAGTGCTGGCCCATATGTCGGGAATGCGAATTGTGGACATGGTCAAAGAGGATTTGACCTTAAGTAAAATTTTAAGCCG
TGATGCTTTTATCAATGCCATCAAAGTGAATGCTGCCATTGGGGGGTCAACCAACGCCGTAATCCATTTAAAGGCGATCG
CCGGCAGGATAGGGGTTGAGCTGTCACTCGATGACTGGCGCCATGGTTACACAGTACCGACCATAGTGAATCTTAAACCT
TCGGGTCAGTACTTAATGGAAGACTTTTACTACGCAGGTGGCCTGCCAGCAGTACTAAGGCAACTGTTTGAGCATGATTT
ACTGAGCAAAAATACGCTTACAGTCAATGCCGCTAGCCTCTGGGACAATGTCAAAGAGGCGCCGTGTTATAACCAAGAGG
TGATCATGTCACTTGAAAATCCCTTGGTTGAAAATGGCGGCATTCGCGTACTGCGCGGCAATCTCGCGCCTAGAGGCGCT
GTGATCAAGCCTTCAGCCGCCAGCGCACACCTGATGCAACACCGCGGTAAAGCCGTGGTGTTTGAAAGCTTCGACGATTA
CAACGCTCGCATCGGCGATCCTGAATTGGATATCGATGAAAACAGCATTATGGTGCTTAAAAACTGTGGCCCAAAGGGAT
ATCCGGGCATGGCAGAGGTCGGCAATATGGGACTGCCACCGAAGTTGTTGAAAAAAGGAATTAAGGACATGGTGAGGATT
TCCGATGCACGCATGAGTGGCACCGCCTTTGGCACAGTTGTGCTGCATGTTGCCCCAGAAGCACAAGCCCTTGGGCCACT
GGCCGCCGTCCAAAATGGTGACATGATAGCGCTAGATACCTATGCCGGAACGTTACAGCTGGAGATCAGTGACCAAGAGT
TACAAGCCCGTCTTGCCAAACTGGCGACAGTGAAATCCATTCCTGTGAATGGTGGCTATCTCTCGCTCTTTAAGGAGCAT
GTTCTCCAGGCGGATGAGGGCTGTGATTTTGATTTTCTCGTGGGATGTCGAGGTGCAGAGATACCAGCACATTCCCATTA
A

Upstream 100 bases:

>100_bases
TTTTACGTGCTAGCAATATTAAAGTACAAATTGTTAACTCAGGGCATCAGCTTCATCCGTTCGTTTTATGTTGAGTGTTA
CTCAATCGTGCGGGTAGGGC

Downstream 100 bases:

>100_bases
ATATGAACTCGTTTTCTTTTATAATAAAACCAGATAATTATTTTAATAAAAGGTTGAGTTATGAAGTTGACTAATCAATA
CCCGAGTTTACAAGGGAAAA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 586; Mature: 586

Protein sequence:

>586_residues
MCLGRRRCHMNNKKPKTLRSASWFGSDDKNGFMYRSWMKNQGIPEHHFQNKPVIGICNTWSELTPCNGHLRELAQRVKNG
IREAGGIPVEFPVFSNGESNLRPSAMLTRNLAAMDTEEAIRGNPIDGVVLLVGCDKTTPALLMGAASCDLPTIVVTGGPM
LNGKHKGKDVGSGTLVWELHQEYKAGNISLAAFMNAEADMSRSTGTCNTMGTASTMACMVETLGVSLPHNATIPAVDSRR
QVLAHMSGMRIVDMVKEDLTLSKILSRDAFINAIKVNAAIGGSTNAVIHLKAIAGRIGVELSLDDWRHGYTVPTIVNLKP
SGQYLMEDFYYAGGLPAVLRQLFEHDLLSKNTLTVNAASLWDNVKEAPCYNQEVIMSLENPLVENGGIRVLRGNLAPRGA
VIKPSAASAHLMQHRGKAVVFESFDDYNARIGDPELDIDENSIMVLKNCGPKGYPGMAEVGNMGLPPKLLKKGIKDMVRI
SDARMSGTAFGTVVLHVAPEAQALGPLAAVQNGDMIALDTYAGTLQLEISDQELQARLAKLATVKSIPVNGGYLSLFKEH
VLQADEGCDFDFLVGCRGAEIPAHSH

Sequences:

>Translated_586_residues
MCLGRRRCHMNNKKPKTLRSASWFGSDDKNGFMYRSWMKNQGIPEHHFQNKPVIGICNTWSELTPCNGHLRELAQRVKNG
IREAGGIPVEFPVFSNGESNLRPSAMLTRNLAAMDTEEAIRGNPIDGVVLLVGCDKTTPALLMGAASCDLPTIVVTGGPM
LNGKHKGKDVGSGTLVWELHQEYKAGNISLAAFMNAEADMSRSTGTCNTMGTASTMACMVETLGVSLPHNATIPAVDSRR
QVLAHMSGMRIVDMVKEDLTLSKILSRDAFINAIKVNAAIGGSTNAVIHLKAIAGRIGVELSLDDWRHGYTVPTIVNLKP
SGQYLMEDFYYAGGLPAVLRQLFEHDLLSKNTLTVNAASLWDNVKEAPCYNQEVIMSLENPLVENGGIRVLRGNLAPRGA
VIKPSAASAHLMQHRGKAVVFESFDDYNARIGDPELDIDENSIMVLKNCGPKGYPGMAEVGNMGLPPKLLKKGIKDMVRI
SDARMSGTAFGTVVLHVAPEAQALGPLAAVQNGDMIALDTYAGTLQLEISDQELQARLAKLATVKSIPVNGGYLSLFKEH
VLQADEGCDFDFLVGCRGAEIPAHSH
>Mature_586_residues
MCLGRRRCHMNNKKPKTLRSASWFGSDDKNGFMYRSWMKNQGIPEHHFQNKPVIGICNTWSELTPCNGHLRELAQRVKNG
IREAGGIPVEFPVFSNGESNLRPSAMLTRNLAAMDTEEAIRGNPIDGVVLLVGCDKTTPALLMGAASCDLPTIVVTGGPM
LNGKHKGKDVGSGTLVWELHQEYKAGNISLAAFMNAEADMSRSTGTCNTMGTASTMACMVETLGVSLPHNATIPAVDSRR
QVLAHMSGMRIVDMVKEDLTLSKILSRDAFINAIKVNAAIGGSTNAVIHLKAIAGRIGVELSLDDWRHGYTVPTIVNLKP
SGQYLMEDFYYAGGLPAVLRQLFEHDLLSKNTLTVNAASLWDNVKEAPCYNQEVIMSLENPLVENGGIRVLRGNLAPRGA
VIKPSAASAHLMQHRGKAVVFESFDDYNARIGDPELDIDENSIMVLKNCGPKGYPGMAEVGNMGLPPKLLKKGIKDMVRI
SDARMSGTAFGTVVLHVAPEAQALGPLAAVQNGDMIALDTYAGTLQLEISDQELQARLAKLATVKSIPVNGGYLSLFKEH
VLQADEGCDFDFLVGCRGAEIPAHSH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=557, Percent_Identity=30.5206463195691, Blast_Score=222, Evalue=5e-59,
Organism=Escherichia coli, GI1788157, Length=548, Percent_Identity=28.8321167883212, Blast_Score=185, Evalue=7e-48,
Organism=Escherichia coli, GI2367371, Length=479, Percent_Identity=30.8977035490605, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1786464, Length=484, Percent_Identity=30.3719008264463, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322476, Length=577, Percent_Identity=31.5424610051993, Blast_Score=254, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 63311; Mature: 63311

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCLGRRRCHMNNKKPKTLRSASWFGSDDKNGFMYRSWMKNQGIPEHHFQNKPVIGICNTW
CCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCEEEHHHHCCCCCHHHCCCCCEEEEECCC
SELTPCNGHLRELAQRVKNGIREAGGIPVEFPVFSNGESNLRPSAMLTRNLAAMDTEEAI
CCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECEECCCCCCCCCHHHHHHHHHHCCHHHHH
RGNPIDGVVLLVGCDKTTPALLMGAASCDLPTIVVTGGPMLNGKHKGKDVGSGTLVWELH
CCCCCCCEEEEEECCCCCHHHEEECCCCCCCEEEEECCCEECCCCCCCCCCCCCEEEEEH
QEYKAGNISLAAFMNAEADMSRSTGTCNTMGTASTMACMVETLGVSLPHNATIPAVDSRR
HHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHH
QVLAHMSGMRIVDMVKEDLTLSKILSRDAFINAIKVNAAIGGSTNAVIHLKAIAGRIGVE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCEEEEEEEECCCCCEE
LSLDDWRHGYTVPTIVNLKPSGQYLMEDFYYAGGLPAVLRQLFEHDLLSKNTLTVNAASL
EEECCCCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEHHHH
WDNVKEAPCYNQEVIMSLENPLVENGGIRVLRGNLAPRGAVIKPSAASAHLMQHRGKAVV
HCCHHHCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCCEECCCCHHHHHHHHCCCEEE
FESFDDYNARIGDPELDIDENSIMVLKNCGPKGYPGMAEVGNMGLPPKLLKKGIKDMVRI
EECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHH
SDARMSGTAFGTVVLHVAPEAQALGPLAAVQNGDMIALDTYAGTLQLEISDQELQARLAK
HHCCCCCCEEEEEEEEECCCHHHHCCHHEECCCCEEEEEECCEEEEEEECHHHHHHHHHH
LATVKSIPVNGGYLSLFKEHVLQADEGCDFDFLVGCRGAEIPAHSH
HHHHEECCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MCLGRRRCHMNNKKPKTLRSASWFGSDDKNGFMYRSWMKNQGIPEHHFQNKPVIGICNTW
CCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCEEEHHHHCCCCCHHHCCCCCEEEEECCC
SELTPCNGHLRELAQRVKNGIREAGGIPVEFPVFSNGESNLRPSAMLTRNLAAMDTEEAI
CCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECEECCCCCCCCCHHHHHHHHHHCCHHHHH
RGNPIDGVVLLVGCDKTTPALLMGAASCDLPTIVVTGGPMLNGKHKGKDVGSGTLVWELH
CCCCCCCEEEEEECCCCCHHHEEECCCCCCCEEEEECCCEECCCCCCCCCCCCCEEEEEH
QEYKAGNISLAAFMNAEADMSRSTGTCNTMGTASTMACMVETLGVSLPHNATIPAVDSRR
HHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHH
QVLAHMSGMRIVDMVKEDLTLSKILSRDAFINAIKVNAAIGGSTNAVIHLKAIAGRIGVE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCEEEEEEEECCCCCEE
LSLDDWRHGYTVPTIVNLKPSGQYLMEDFYYAGGLPAVLRQLFEHDLLSKNTLTVNAASL
EEECCCCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEHHHH
WDNVKEAPCYNQEVIMSLENPLVENGGIRVLRGNLAPRGAVIKPSAASAHLMQHRGKAVV
HCCHHHCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCCEECCCCHHHHHHHHCCCEEE
FESFDDYNARIGDPELDIDENSIMVLKNCGPKGYPGMAEVGNMGLPPKLLKKGIKDMVRI
EECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHH
SDARMSGTAFGTVVLHVAPEAQALGPLAAVQNGDMIALDTYAGTLQLEISDQELQARLAK
HHCCCCCCEEEEEEEEECCCHHHHCCHHEECCCCEEEEEECCEEEEEEECHHHHHHHHHH
LATVKSIPVNGGYLSLFKEHVLQADEGCDFDFLVGCRGAEIPAHSH
HHHHEECCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA