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The map label for this gene is hisD [H]

Identifier: 117920298

GI number: 117920298

Start: 2194820

End: 2196121

Strand: Reverse

Name: hisD [H]

Synonym: Shewana3_1853

Alternate gene names: 117920298

Gene position: 2196121-2194820 (Counterclockwise)

Preceding gene: 117920299

Following gene: 117920297

Centisome position: 44.17

GC content: 53.38

Gene sequence:

>1302_bases
ATGGATATTTTGACTTGGGCAGCGTTATCCGTCGATGAACAAAAAGCCGCGCTCCAACGCTCGCCTTTAATCGGTGACAG
CGGCTTAGAACAAAGTGTTCGGGCGATTGTCGATGCCGTGGCTAGCCGTGGCGATGCGGCGCTGAAAGAGTTTAATCAAA
AGTTTGATGGCTTTAATAGCGCCAATATCGACAGTCTGCGCTTAAGTGAAAGCGAGATTAGCGCCGCCAGCGCACGAGTC
TCGGCAGAACTTAAAGCCGCCATTGCCCAAGCGATGGCCAATATTGATGTGTTCCACAGCGCGCAGCAATTTCGCCCCAT
AGACATTGAAACCCAAGCGGGTGTTCGCTGCGAGCTTCGTAGCGAACCGATTGAAAAAGTCGGTTTATATATTCCCGGCG
GCAGCGCGCCTCTCATTTCGACCGTGATGATGTTGGCCCTGCCCGCCAAAATTGCCGGTTGCGAAAAACGCGTATTGGTG
AGTCCGCCGCCGATTAACGATGCCATTGTGTATGCGGCAAACGCCTGTGGGATCACCGAAATTTACCAAGTGGGTGGCGC
GCAGGCCATTGCCGCATTGGCCTTTGGCACTGAATCTATTCCTAGCGTCGATAAGATTTTTGGTCCGGGTAATCGTTATG
TCACCGAAGCCAAACGCTTAGTCTCCCAAGATGGGCGCTGCACTGTGTCTATCGATATGCCTGCGGGGCCTTCCGAGGTG
TTGGTGATTGCCGATAGCGATGCCAATGCGCAGTTTATTGCCGCGGATTTACTCTCCCAAGCGGAGCATGGCCCAGATTC
GCAGGTCATTTTAGTCACGGATTCTGAGCCATTAGCACAGGCAGTCAATCAAGCGCTCGCGTCACAACTGGCCGCCCTAC
CGCGCCAAGAGATTGCCACGACCGCCCTAAAAGGCAGCCGCACCATTTTGGTAAAAGATATGCAAGAAGCGGCGCTCGTT
TCAAATCGCTATGGGCCCGAACACTTAATTATTCAAACCCGCTTCCCAGGGGACGTGCTAAAACATATTCGGGCCGCAGG
CTCAGTGTTTTTAGGCGCTTATACACCTGAATCGGTTGGGGATTATGCCAGTGGGACTAACCATGTATTGCCAACTTACG
GTTATAGCCGCGCGGTATCTAGCCTCTCCTTGGCAGACTTTAGCCGCCGCTTTACGGTGCAAGAGCTCAGCGCCAAGGGC
CTGCTCGGACTCGGACAAGCGGTGATGACCCTGGCCAGTAATGAGTTACTCGATGCCCATAAAAATGCGGTCGCGATACG
CTTAGCCAGTCTTAAGGACTGA

Upstream 100 bases:

>100_bases
CAGTACCGAAGATTTATTCTGGGACACCATGGAAGAGCTCACCGCACTCGGCGCCAGCTCTATCCTCGTAATGCCAATTG
AAAAAATGATGGGGTGATCT

Downstream 100 bases:

>100_bases
TGAAAATAAGTAACGCAATCAACAGTACGCTTAATTAACGCCATAGCGAGACTTAGGATGAATAGGATGAGCCAAGTGCC
AACTAGCCAAGCCCCAACGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MDILTWAALSVDEQKAALQRSPLIGDSGLEQSVRAIVDAVASRGDAALKEFNQKFDGFNSANIDSLRLSESEISAASARV
SAELKAAIAQAMANIDVFHSAQQFRPIDIETQAGVRCELRSEPIEKVGLYIPGGSAPLISTVMMLALPAKIAGCEKRVLV
SPPPINDAIVYAANACGITEIYQVGGAQAIAALAFGTESIPSVDKIFGPGNRYVTEAKRLVSQDGRCTVSIDMPAGPSEV
LVIADSDANAQFIAADLLSQAEHGPDSQVILVTDSEPLAQAVNQALASQLAALPRQEIATTALKGSRTILVKDMQEAALV
SNRYGPEHLIIQTRFPGDVLKHIRAAGSVFLGAYTPESVGDYASGTNHVLPTYGYSRAVSSLSLADFSRRFTVQELSAKG
LLGLGQAVMTLASNELLDAHKNAVAIRLASLKD

Sequences:

>Translated_433_residues
MDILTWAALSVDEQKAALQRSPLIGDSGLEQSVRAIVDAVASRGDAALKEFNQKFDGFNSANIDSLRLSESEISAASARV
SAELKAAIAQAMANIDVFHSAQQFRPIDIETQAGVRCELRSEPIEKVGLYIPGGSAPLISTVMMLALPAKIAGCEKRVLV
SPPPINDAIVYAANACGITEIYQVGGAQAIAALAFGTESIPSVDKIFGPGNRYVTEAKRLVSQDGRCTVSIDMPAGPSEV
LVIADSDANAQFIAADLLSQAEHGPDSQVILVTDSEPLAQAVNQALASQLAALPRQEIATTALKGSRTILVKDMQEAALV
SNRYGPEHLIIQTRFPGDVLKHIRAAGSVFLGAYTPESVGDYASGTNHVLPTYGYSRAVSSLSLADFSRRFTVQELSAKG
LLGLGQAVMTLASNELLDAHKNAVAIRLASLKD
>Mature_433_residues
MDILTWAALSVDEQKAALQRSPLIGDSGLEQSVRAIVDAVASRGDAALKEFNQKFDGFNSANIDSLRLSESEISAASARV
SAELKAAIAQAMANIDVFHSAQQFRPIDIETQAGVRCELRSEPIEKVGLYIPGGSAPLISTVMMLALPAKIAGCEKRVLV
SPPPINDAIVYAANACGITEIYQVGGAQAIAALAFGTESIPSVDKIFGPGNRYVTEAKRLVSQDGRCTVSIDMPAGPSEV
LVIADSDANAQFIAADLLSQAEHGPDSQVILVTDSEPLAQAVNQALASQLAALPRQEIATTALKGSRTILVKDMQEAALV
SNRYGPEHLIIQTRFPGDVLKHIRAAGSVFLGAYTPESVGDYASGTNHVLPTYGYSRAVSSLSLADFSRRFTVQELSAKG
LLGLGQAVMTLASNELLDAHKNAVAIRLASLKD

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=433, Percent_Identity=57.5057736720554, Blast_Score=500, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6319819, Length=421, Percent_Identity=47.0308788598575, Blast_Score=369, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45681; Mature: 45681

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILTWAALSVDEQKAALQRSPLIGDSGLEQSVRAIVDAVASRGDAALKEFNQKFDGFNS
CCCEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
ANIDSLRLSESEISAASARVSAELKAAIAQAMANIDVFHSAQQFRPIDIETQAGVRCELR
CCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCEECCCCCEEEEC
SEPIEKVGLYIPGGSAPLISTVMMLALPAKIAGCEKRVLVSPPPINDAIVYAANACGITE
CCCHHHCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEECCCCHHH
IYQVGGAQAIAALAFGTESIPSVDKIFGPGNRYVTEAKRLVSQDGRCTVSIDMPAGPSEV
HHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCE
LVIADSDANAQFIAADLLSQAEHGPDSQVILVTDSEPLAQAVNQALASQLAALPRQEIAT
EEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHH
TALKGSRTILVKDMQEAALVSNRYGPEHLIIQTRFPGDVLKHIRAAGSVFLGAYTPESVG
HHHCCCCEEEEECHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCEEEECCCCHHHC
DYASGTNHVLPTYGYSRAVSSLSLADFSRRFTVQELSAKGLLGLGQAVMTLASNELLDAH
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
KNAVAIRLASLKD
CCEEEEEEECCCC
>Mature Secondary Structure
MDILTWAALSVDEQKAALQRSPLIGDSGLEQSVRAIVDAVASRGDAALKEFNQKFDGFNS
CCCEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
ANIDSLRLSESEISAASARVSAELKAAIAQAMANIDVFHSAQQFRPIDIETQAGVRCELR
CCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCEECCCCCEEEEC
SEPIEKVGLYIPGGSAPLISTVMMLALPAKIAGCEKRVLVSPPPINDAIVYAANACGITE
CCCHHHCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEECCCCHHH
IYQVGGAQAIAALAFGTESIPSVDKIFGPGNRYVTEAKRLVSQDGRCTVSIDMPAGPSEV
HHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCE
LVIADSDANAQFIAADLLSQAEHGPDSQVILVTDSEPLAQAVNQALASQLAALPRQEIAT
EEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHH
TALKGSRTILVKDMQEAALVSNRYGPEHLIIQTRFPGDVLKHIRAAGSVFLGAYTPESVG
HHHCCCCEEEEECHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCEEEECCCCHHHC
DYASGTNHVLPTYGYSRAVSSLSLADFSRRFTVQELSAKGLLGLGQAVMTLASNELLDAH
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
KNAVAIRLASLKD
CCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]