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The map label for this gene is hisG [H]

Identifier: 117920299

GI number: 117920299

Start: 2196125

End: 2197024

Strand: Reverse

Name: hisG [H]

Synonym: Shewana3_1854

Alternate gene names: 117920299

Gene position: 2197024-2196125 (Counterclockwise)

Preceding gene: 117920300

Following gene: 117920298

Centisome position: 44.19

GC content: 49.33

Gene sequence:

>900_bases
ATGACTGAATCAAACCGTTTACGCATCGCCATCCAAAAATCTGGCCGTTTATCCACCGACTCTCAGCAATTACTCAAGAG
CTGCGGCATTAAGTTTTCCATTAATGAACAACGCCTTATCGCACACGCAGACAACATGCCTATCGATTTACTCAGAGTGC
GTGACGATGATATTCCAGGACTGGTGATGGATGGCGTGGTCGATTTAGGCATTATTGGTGAGAACGTGCTTGAAGAAGAG
CAGATTGAGCGTCAAACCTTAAATAAACCCGCCGAGTTTGTGAAGTTACGCCAGTTGGATTTTGGTGCCTGCCGCCTGTC
ATTAGCCGTACCAAGCGAATTTAGCTATGCCGATGCCTCATCCTTGGAAGGCTTGAGAATTGCCACCTCCTACCCCAATC
TACTCCGCCGTTTTATGCAACAAAAAGGCATAAGTTATCGCGACTGTATGTTAAAAGGCTCGGTTGAAGTCGCGCCCCGT
GCAGGGCTTGCCGATGGCATTTGTGACTTAGTCTCCACCGGTGCCACCCTTGAGGCCAACGGTTTATACGAGACAGAAGT
CATCTACCGTTCTATGGCCTGTGTTATTCAATCGACTCAAACCCAAACGCCGAGCAAACAAGCGCTAATCGACAGAATTT
TATCCCGCGTAAACGGCGTGATCCGCGCCCGTGAAAGTAAATATATTTTGCTGCACGCGCCTACAGAAACCTTAGATCAA
ATTGTCGCCCTGCTGCCCGGCGCCGAAAACCCAACGGTGCTGCCATTAAACGACGATACTAATCGAGTGGCCATCCACGC
CGTCAGTACCGAAGATTTATTCTGGGACACCATGGAAGAGCTCACCGCACTCGGCGCCAGCTCTATCCTCGTAATGCCAA
TTGAAAAAATGATGGGGTGA

Upstream 100 bases:

>100_bases
TATGTTAGCTAGATAAACACCGGCAAAACATAGAAACCAGTTAAACCATGCGACAAAAGAATATCATTTTGAATTTGTTA
ACTTTGAGCGAGACAAGACT

Downstream 100 bases:

>100_bases
TCTATGGATATTTTGACTTGGGCAGCGTTATCCGTCGATGAACAAAAAGCCGCGCTCCAACGCTCGCCTTTAATCGGTGA
CAGCGGCTTAGAACAAAGTG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MTESNRLRIAIQKSGRLSTDSQQLLKSCGIKFSINEQRLIAHADNMPIDLLRVRDDDIPGLVMDGVVDLGIIGENVLEEE
QIERQTLNKPAEFVKLRQLDFGACRLSLAVPSEFSYADASSLEGLRIATSYPNLLRRFMQQKGISYRDCMLKGSVEVAPR
AGLADGICDLVSTGATLEANGLYETEVIYRSMACVIQSTQTQTPSKQALIDRILSRVNGVIRARESKYILLHAPTETLDQ
IVALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEELTALGASSILVMPIEKMMG

Sequences:

>Translated_299_residues
MTESNRLRIAIQKSGRLSTDSQQLLKSCGIKFSINEQRLIAHADNMPIDLLRVRDDDIPGLVMDGVVDLGIIGENVLEEE
QIERQTLNKPAEFVKLRQLDFGACRLSLAVPSEFSYADASSLEGLRIATSYPNLLRRFMQQKGISYRDCMLKGSVEVAPR
AGLADGICDLVSTGATLEANGLYETEVIYRSMACVIQSTQTQTPSKQALIDRILSRVNGVIRARESKYILLHAPTETLDQ
IVALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEELTALGASSILVMPIEKMMG
>Mature_298_residues
TESNRLRIAIQKSGRLSTDSQQLLKSCGIKFSINEQRLIAHADNMPIDLLRVRDDDIPGLVMDGVVDLGIIGENVLEEEQ
IERQTLNKPAEFVKLRQLDFGACRLSLAVPSEFSYADASSLEGLRIATSYPNLLRRFMQQKGISYRDCMLKGSVEVAPRA
GLADGICDLVSTGATLEANGLYETEVIYRSMACVIQSTQTQTPSKQALIDRILSRVNGVIRARESKYILLHAPTETLDQI
VALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEELTALGASSILVMPIEKMMG

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=298, Percent_Identity=68.4563758389262, Blast_Score=424, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6320896, Length=298, Percent_Identity=30.5369127516779, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 32951; Mature: 32820

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESNRLRIAIQKSGRLSTDSQQLLKSCGIKFSINEQRLIAHADNMPIDLLRVRDDDIPG
CCCCCEEEEEEECCCCCCCCHHHHHHHCCCEEEECCCEEEEECCCCCEEEEEECCCCCCC
LVMDGVVDLGIIGENVLEEEQIERQTLNKPAEFVKLRQLDFGACRLSLAVPSEFSYADAS
HHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
SLEGLRIATSYPNLLRRFMQQKGISYRDCMLKGSVEVAPRAGLADGICDLVSTGATLEAN
CCCCEEEECCCHHHHHHHHHHCCCCHHHHEEECCEEECCCCCCHHHHHHHHHCCCEEECC
GLYETEVIYRSMACVIQSTQTQTPSKQALIDRILSRVNGVIRARESKYILLHAPTETLDQ
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEECCCCEEEEECCHHHHHH
IVALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEELTALGASSILVMPIEKMMG
HHHHCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure 
TESNRLRIAIQKSGRLSTDSQQLLKSCGIKFSINEQRLIAHADNMPIDLLRVRDDDIPG
CCCCEEEEEEECCCCCCCCHHHHHHHCCCEEEECCCEEEEECCCCCEEEEEECCCCCCC
LVMDGVVDLGIIGENVLEEEQIERQTLNKPAEFVKLRQLDFGACRLSLAVPSEFSYADAS
HHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
SLEGLRIATSYPNLLRRFMQQKGISYRDCMLKGSVEVAPRAGLADGICDLVSTGATLEAN
CCCCEEEECCCHHHHHHHHHHCCCCHHHHEEECCEEECCCCCCHHHHHHHHHCCCEEECC
GLYETEVIYRSMACVIQSTQTQTPSKQALIDRILSRVNGVIRARESKYILLHAPTETLDQ
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEECCCCEEEEECCHHHHHH
IVALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEELTALGASSILVMPIEKMMG
HHHHCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA