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The map label for this gene is hisC [H]

Identifier: 117920297

GI number: 117920297

Start: 2193548

End: 2194753

Strand: Reverse

Name: hisC [H]

Synonym: Shewana3_1852

Alternate gene names: 117920297

Gene position: 2194753-2193548 (Counterclockwise)

Preceding gene: 117920298

Following gene: 117920296

Centisome position: 44.14

GC content: 53.65

Gene sequence:

>1206_bases
ATGAGCCAAGTGCCAACTAGCCAAGCCCCAACGAGCCCAGCACCGGCGAGCAATGTGCCTGTGACAAAGATTCCGAGCGC
CAATTGCGCCAGTAATACTCTCGACAACAATACTCTCGATAACGTAAACATCGAGCCAACAACTCTGGCCGCACGTCTTG
CGCGGCCAGAACTGCTCGAGTTAACGCCCTACCAAAGTGCTCGCAGACTGGGTGGTCGAGGGGATATTTGGATCAACGCT
AACGAATCGCCCTTCAATAATGTGGCGGTTGCCGAACTCGATTTATCTAAGTTAAATCGTTACCCCGAGTGCCAACCGCC
CGCGTTGATCAATGCCTACAGCCAATATAGTGGTGTAGTGGAGAGTAAAATTGTCGCCAGTCGCGGTGCCGATGAGGCCA
TCGAACTGCTGATCCGTGCCTTTTGTGTCCCTGGCATCGATTCCATTGCGACCTTTGGGCCCACTTACGGCATGTACGCC
ATTAGCGCGCAAACCTTTAATGTGGGCGTTAAGGCATTAAGCTTAACGGCTGAGTACGGTCTCCCTGCCGACTTTGCGAC
GGCTGCACGCGGCGCTAAATTAGTTTTTATCTGCAATCCTAATAACCCAACCGGCACTGTGATTGACAAGGCGCGCATAG
AGCAAGCCATCCAAGCCCTGCCCGACGCCATTGTTGTCGTCGATGAGGCTTATATCGAGTTTTGCCCAGAATATAGCGTC
GCCGATTTACTCGAGTCTTACCCAAACCTTGTGGTGCTGCGCACCCTTTCAAAGGCCTTTGCCTTAGCAGGCGCCCGCTG
CGGCTTTTTGCTCGCCAATGAAGAGATTATCGAAATCATCATGCGGGTCATTGCGCCCTATCCCGTGCCATTGCCCGTGA
GTGAAGTGGCCGTGCAAGCGCTATCAGCAGCAGGAATTGCGCGGATGAAAACCCAAGTCAAAGAGCTCAATGCGCAGGGC
GAGCGACTCGCGGCGGCGCTGAATTTGTACTGCGAGCAATGGGGCGGCGCCGTGCTAACACCCAATGGCAACTATGTGCT
CGCCGAATTTGACGACGTGGCCAAAGTGGCACAGCTGCTTATCGATAATGGCATTGTCGCGCGGGCCTATAAGGACCCAA
GGCTGGCTAAAGCCATTCGTTTTAGCTTTAGCTCTCAGGCTGATACCGACCGCTTAGTGTCGCTATTTGAATCGCAAAAG
CTATGA

Upstream 100 bases:

>100_bases
GGTCGCGATACGCTTAGCCAGTCTTAAGGACTGATGAAAATAAGTAACGCAATCAACAGTACGCTTAATTAACGCCATAG
CGAGACTTAGGATGAATAGG

Downstream 100 bases:

>100_bases
GCATTTAGCGCAAGTCTTGTCGCAGCATTGGCCTAATAAACTGATTTTATAAAGATAACAAACTGAATTGAAAGGTAGCA
GCATGAACCCAGTATTTACC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSQVPTSQAPTSPAPASNVPVTKIPSANCASNTLDNNTLDNVNIEPTTLAARLARPELLELTPYQSARRLGGRGDIWINA
NESPFNNVAVAELDLSKLNRYPECQPPALINAYSQYSGVVESKIVASRGADEAIELLIRAFCVPGIDSIATFGPTYGMYA
ISAQTFNVGVKALSLTAEYGLPADFATAARGAKLVFICNPNNPTGTVIDKARIEQAIQALPDAIVVVDEAYIEFCPEYSV
ADLLESYPNLVVLRTLSKAFALAGARCGFLLANEEIIEIIMRVIAPYPVPLPVSEVAVQALSAAGIARMKTQVKELNAQG
ERLAAALNLYCEQWGGAVLTPNGNYVLAEFDDVAKVAQLLIDNGIVARAYKDPRLAKAIRFSFSSQADTDRLVSLFESQK
L

Sequences:

>Translated_401_residues
MSQVPTSQAPTSPAPASNVPVTKIPSANCASNTLDNNTLDNVNIEPTTLAARLARPELLELTPYQSARRLGGRGDIWINA
NESPFNNVAVAELDLSKLNRYPECQPPALINAYSQYSGVVESKIVASRGADEAIELLIRAFCVPGIDSIATFGPTYGMYA
ISAQTFNVGVKALSLTAEYGLPADFATAARGAKLVFICNPNNPTGTVIDKARIEQAIQALPDAIVVVDEAYIEFCPEYSV
ADLLESYPNLVVLRTLSKAFALAGARCGFLLANEEIIEIIMRVIAPYPVPLPVSEVAVQALSAAGIARMKTQVKELNAQG
ERLAAALNLYCEQWGGAVLTPNGNYVLAEFDDVAKVAQLLIDNGIVARAYKDPRLAKAIRFSFSSQADTDRLVSLFESQK
L
>Mature_400_residues
SQVPTSQAPTSPAPASNVPVTKIPSANCASNTLDNNTLDNVNIEPTTLAARLARPELLELTPYQSARRLGGRGDIWINAN
ESPFNNVAVAELDLSKLNRYPECQPPALINAYSQYSGVVESKIVASRGADEAIELLIRAFCVPGIDSIATFGPTYGMYAI
SAQTFNVGVKALSLTAEYGLPADFATAARGAKLVFICNPNNPTGTVIDKARIEQAIQALPDAIVVVDEAYIEFCPEYSVA
DLLESYPNLVVLRTLSKAFALAGARCGFLLANEEIIEIIMRVIAPYPVPLPVSEVAVQALSAAGIARMKTQVKELNAQGE
RLAAALNLYCEQWGGAVLTPNGNYVLAEFDDVAKVAQLLIDNGIVARAYKDPRLAKAIRFSFSSQADTDRLVSLFESQKL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=355, Percent_Identity=46.4788732394366, Blast_Score=308, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6322075, Length=380, Percent_Identity=30.7894736842105, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 43010; Mature: 42878

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVPTSQAPTSPAPASNVPVTKIPSANCASNTLDNNTLDNVNIEPTTLAARLARPELLE
CCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEE
LTPYQSARRLGGRGDIWINANESPFNNVAVAELDLSKLNRYPECQPPALINAYSQYSGVV
ECCCHHHHHCCCCCCEEEECCCCCCCCEEEEEEEHHHHCCCCCCCCCHHHHHHHHHCCHH
ESKIVASRGADEAIELLIRAFCVPGIDSIATFGPTYGMYAISAQTFNVGVKALSLTAEYG
HHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEEEEEHCCCEEEEEEECCCC
LPADFATAARGAKLVFICNPNNPTGTVIDKARIEQAIQALPDAIVVVDEAYIEFCPEYSV
CCCHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHCCCCCH
ADLLESYPNLVVLRTLSKAFALAGARCGFLLANEEIIEIIMRVIAPYPVPLPVSEVAVQA
HHHHHHCCCEEEHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHH
LSAAGIARMKTQVKELNAQGERLAAALNLYCEQWGGAVLTPNGNYVLAEFDDVAKVAQLL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEHHHHHHHHHHH
IDNGIVARAYKDPRLAKAIRFSFSSQADTDRLVSLFESQKL
HCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SQVPTSQAPTSPAPASNVPVTKIPSANCASNTLDNNTLDNVNIEPTTLAARLARPELLE
CCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEE
LTPYQSARRLGGRGDIWINANESPFNNVAVAELDLSKLNRYPECQPPALINAYSQYSGVV
ECCCHHHHHCCCCCCEEEECCCCCCCCEEEEEEEHHHHCCCCCCCCCHHHHHHHHHCCHH
ESKIVASRGADEAIELLIRAFCVPGIDSIATFGPTYGMYAISAQTFNVGVKALSLTAEYG
HHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEEEEEHCCCEEEEEEECCCC
LPADFATAARGAKLVFICNPNNPTGTVIDKARIEQAIQALPDAIVVVDEAYIEFCPEYSV
CCCHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHCCCCCH
ADLLESYPNLVVLRTLSKAFALAGARCGFLLANEEIIEIIMRVIAPYPVPLPVSEVAVQA
HHHHHHCCCEEEHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHH
LSAAGIARMKTQVKELNAQGERLAAALNLYCEQWGGAVLTPNGNYVLAEFDDVAKVAQLL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEHHHHHHHHHHH
IDNGIVARAYKDPRLAKAIRFSFSSQADTDRLVSLFESQKL
HCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]