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The map label for this gene is clpA [H]

Identifier: 117920200

GI number: 117920200

Start: 2067010

End: 2069277

Strand: Direct

Name: clpA [H]

Synonym: Shewana3_1753

Alternate gene names: 117920200

Gene position: 2067010-2069277 (Clockwise)

Preceding gene: 117920199

Following gene: 117920204

Centisome position: 41.57

GC content: 49.6

Gene sequence:

>2268_bases
ATGCTGAACAAAGATCTGGAAGTCACCTTAAATCTGGCGTTTCAGCAAGCCAGAGAGGCACGTCACGAGTATATGACAGT
TGAACATCTGTTATTGGCTCTGATCGACAACCCTGCGGCTCAAGAAGCGCTAATCGCCTGTGGAGCGAATTTAGATAAAC
TCAGAGATGAAGTAGCAAGCTTTATCCAACAAACCACCCCAATCATTGCAGATATGGATGATGATAAAGAGACCCAGCCA
ACGCTTGGGTTTCAGCGGGTGCTGCAACGCGCCGTTTTCCATGTGCAGTCTTCGGGCCGCAATGAAGTCACTGGTGCCAA
TGTGCTGGTGGCCATTTTTAGTGAGCAAGAATCCCAAGCCGTGTATCTGCTGCGTCGCAGCGACATCAGCCGTTTAGATG
TGGTGAACTATATTTCCCATGGTTTTTCAAAAAATGAGGACAGCGACGCCCATCAAGATCACGAACGCATCGAAGATCAA
GCCGAAGCGGGTGAAGAGCGCAGCATGTTGTCGCAGTTTGCGAGCAATTTAAACCAGCTTGCAAAACAAGGGATTATCGA
CCCACTCATCGGCCGCGATCAAGAAATTGAACGGGCAATTCAGACCCTATGCCGTCGCCGTAAAAATAATCCGCTATTGG
TGGGTGAGGCCGGTGTGGGTAAAACTGCGATTGCTGAAGGCTTAGCCTATCGAATCGTTAATAATCAAGTGCCAGAGGTG
ATGTCGCAGGCGACGGTTTATTCCCTCGACTTAGGCTCCTTGCTTGCTGGCACTAAATACCGTGGCGATTTCGAAAAACG
TTTCAAGAGTCTGCTTAAGGAGCTTAGCGCCGATAAGCACGCTATTTTATTTATCGATGAAATTCACACCATCATTGGTG
CGGGCGCCGCATCGGGTGGGGTGATGGATGCGTCGAACCTGCTTAAGCCGTTATTATCGAGCGGTAACTTGCGCTGCATG
GGCTCGACCACCTTCCAAGAATATCAAAGTATTTTTGAGAAGGACCGGGCATTGGCGCGTCGTTTCCAAAAGGTTGATAT
CAATGAGCCTTCAGTGGCCGAAACCACGAAAATTCTGATGGGGCTCAAGGCCAAGTACGAAGAGTACCACGGGGTGCGTT
ATACCCAAGCGGCGATTAACAGCGCGGCTGAGCTGTCGGCAAAACACATCAATGACCGGCATTTACCCGATAAAGCCATC
GATGTGATCGATGAGGCGGGTGCGCGCATGGCCATGTTGCCACAGAGCAAACGTAAGAAAACCATAGGTCAGGCCGAGAT
TGAAACCATAGTGGCTAAGATTGCTCGGATCCCAGAAAAGTCTGTGTCTGCTACGGACAAAGACTTACTGCGTAATCTTG
AGCGCAATCTCAAGATGGTAGTCTTTGGTCAAGATAAGGCGATTGAGTCATTAAGTTCGGCGATTCGCTTATCTCGCAGT
GGATTAGGTACCGATAAAAAGCCTGTGGGCAGCTTCTTATTTGCAGGCCCAACAGGGGTTGGTAAGACAGAAGTCACCAA
TCAGTTAGCCAGTTGCCTTGGCATGAAACTGGTTCGCTTCGATATGTCTGAGTACATGGAAAGCCATACGGTTTCTCGCT
TAATTGGTGCGCCTCCAGGTTATGTGGGCTACGACCAAGGTGGCTTACTTACAGATGCTGTGATTAAGAATCCCCATTGC
GTGGTGCTGCTCGATGAAATTGAGAAGGCTCACCCCGATGTCTATAACCTGTTGCTGCAAGTCATGGATCACGGCACCTT
GACCGATAACAACGGTCGCAAGGCGGATTTTAGGCATGTCACCTTAGTGATGACGACAAACGCAGGGGTTCAGGAAACGA
TCCGTAAGTCCATTGGCTTTACTCAGCAGGATCATACCCAAGATGCCCTGTCGGAAATCAATCGGGTCTTTTCGCCTGAG
TTCCGCAACCGCTTAGATTCCATCATTTGGTTCAACCATCTAGACATGACCATCATTGCCAAAGTGGTGGATAAATTCTT
GGTGGAATTGCAGGCGCAACTGGATGCAAAGCATGTGGTGCTTGAAGTCAGCGATGAAGCCAGAACCTTACTCGCCGAGA
AAGGCTATGATAAGAGCATGGGCGCGCGGCCAATGGCCCGTGTGGTGACTGAGCTTATCAAACGTCCGTTAGCGGATGAA
ATCCTCTTCGGTGAGCTTGAGCATGGCGGTATTGCCCATGTTGATGCGAAGGAAGGGGAAATCGTTATCCACACCGAACG
GCATGAGAAGAGTACCAGCAAAGCGTAA

Upstream 100 bases:

>100_bases
AAATCAATTTGCAAGACAAAACCAACATCCGTTACTGTGTTCGTTAGAGAAGGCTTAACCGCGCTTACTCTGTTGTCAGT
TGTTAATTTTGGGGGTGCTT

Downstream 100 bases:

>100_bases
ATGCTTTGAAAACCAATAAAATGGCTGCAATTGCAGCCATTTTTCTGATCTTTCGCCAACAAAAAAACCCGGCCTCGCCG
GGTTTTTCAACTAAGGGGTA

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 755; Mature: 755

Protein sequence:

>755_residues
MLNKDLEVTLNLAFQQAREARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVASFIQQTTPIIADMDDDKETQP
TLGFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQAVYLLRRSDISRLDVVNYISHGFSKNEDSDAHQDHERIEDQ
AEAGEERSMLSQFASNLNQLAKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNNQVPEV
MSQATVYSLDLGSLLAGTKYRGDFEKRFKSLLKELSADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGNLRCM
GSTTFQEYQSIFEKDRALARRFQKVDINEPSVAETTKILMGLKAKYEEYHGVRYTQAAINSAAELSAKHINDRHLPDKAI
DVIDEAGARMAMLPQSKRKKTIGQAEIETIVAKIARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
GLGTDKKPVGSFLFAGPTGVGKTEVTNQLASCLGMKLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHC
VVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPE
FRNRLDSIIWFNHLDMTIIAKVVDKFLVELQAQLDAKHVVLEVSDEARTLLAEKGYDKSMGARPMARVVTELIKRPLADE
ILFGELEHGGIAHVDAKEGEIVIHTERHEKSTSKA

Sequences:

>Translated_755_residues
MLNKDLEVTLNLAFQQAREARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVASFIQQTTPIIADMDDDKETQP
TLGFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQAVYLLRRSDISRLDVVNYISHGFSKNEDSDAHQDHERIEDQ
AEAGEERSMLSQFASNLNQLAKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNNQVPEV
MSQATVYSLDLGSLLAGTKYRGDFEKRFKSLLKELSADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGNLRCM
GSTTFQEYQSIFEKDRALARRFQKVDINEPSVAETTKILMGLKAKYEEYHGVRYTQAAINSAAELSAKHINDRHLPDKAI
DVIDEAGARMAMLPQSKRKKTIGQAEIETIVAKIARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
GLGTDKKPVGSFLFAGPTGVGKTEVTNQLASCLGMKLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHC
VVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPE
FRNRLDSIIWFNHLDMTIIAKVVDKFLVELQAQLDAKHVVLEVSDEARTLLAEKGYDKSMGARPMARVVTELIKRPLADE
ILFGELEHGGIAHVDAKEGEIVIHTERHEKSTSKA
>Mature_755_residues
MLNKDLEVTLNLAFQQAREARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVASFIQQTTPIIADMDDDKETQP
TLGFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQAVYLLRRSDISRLDVVNYISHGFSKNEDSDAHQDHERIEDQ
AEAGEERSMLSQFASNLNQLAKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNNQVPEV
MSQATVYSLDLGSLLAGTKYRGDFEKRFKSLLKELSADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGNLRCM
GSTTFQEYQSIFEKDRALARRFQKVDINEPSVAETTKILMGLKAKYEEYHGVRYTQAAINSAAELSAKHINDRHLPDKAI
DVIDEAGARMAMLPQSKRKKTIGQAEIETIVAKIARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
GLGTDKKPVGSFLFAGPTGVGKTEVTNQLASCLGMKLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHC
VVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPE
FRNRLDSIIWFNHLDMTIIAKVVDKFLVELQAQLDAKHVVLEVSDEARTLLAEKGYDKSMGARPMARVVTELIKRPLADE
ILFGELEHGGIAHVDAKEGEIVIHTERHEKSTSKA

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=297, Percent_Identity=30.976430976431, Blast_Score=148, Evalue=2e-35,
Organism=Escherichia coli, GI1787109, Length=757, Percent_Identity=68.560105680317, Blast_Score=1085, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=328, Percent_Identity=43.9024390243902, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6320464, Length=320, Percent_Identity=48.4375, Blast_Score=279, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6323002, Length=421, Percent_Identity=37.7672209026128, Blast_Score=256, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83668; Mature: 83668

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKDLEVTLNLAFQQAREARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVAS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
FIQQTTPIIADMDDDKETQPTLGFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQA
HHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCE
VYLLRRSDISRLDVVNYISHGFSKNEDSDAHQDHERIEDQAEAGEERSMLSQFASNLNQL
EEEEHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNNQVPEV
HHHCCCCHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHH
MSQATVYSLDLGSLLAGTKYRGDFEKRFKSLLKELSADKHAILFIDEIHTIIGAGAASGG
HHHHHHEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCC
VMDASNLLKPLLSSGNLRCMGSTTFQEYQSIFEKDRALARRFQKVDINEPSVAETTKILM
CCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKAKYEEYHGVRYTQAAINSAAELSAKHINDRHLPDKAIDVIDEAGARMAMLPQSKRKK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEECCCHHHHH
TIGQAEIETIVAKIARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
HHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHC
GLGTDKKPVGSFLFAGPTGVGKTEVTNQLASCLGMKLVRFDMSEYMESHTVSRLIGAPPG
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGYDQGGLLTDAVIKNPHCVVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHV
CCCCCCCCCCHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCEECCCCCCCCCEEE
TLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPEFRNRLDSIIWFNHLDMTIIA
EEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
KVVDKFLVELQAQLDAKHVVLEVSDEARTLLAEKGYDKSMGARPMARVVTELIKRPLADE
HHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHH
ILFGELEHGGIAHVDAKEGEIVIHTERHEKSTSKA
HHHCCCCCCCEEEEECCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MLNKDLEVTLNLAFQQAREARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVAS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
FIQQTTPIIADMDDDKETQPTLGFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQA
HHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCE
VYLLRRSDISRLDVVNYISHGFSKNEDSDAHQDHERIEDQAEAGEERSMLSQFASNLNQL
EEEEHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNNQVPEV
HHHCCCCHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHH
MSQATVYSLDLGSLLAGTKYRGDFEKRFKSLLKELSADKHAILFIDEIHTIIGAGAASGG
HHHHHHEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCC
VMDASNLLKPLLSSGNLRCMGSTTFQEYQSIFEKDRALARRFQKVDINEPSVAETTKILM
CCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKAKYEEYHGVRYTQAAINSAAELSAKHINDRHLPDKAIDVIDEAGARMAMLPQSKRKK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEECCCHHHHH
TIGQAEIETIVAKIARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
HHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHC
GLGTDKKPVGSFLFAGPTGVGKTEVTNQLASCLGMKLVRFDMSEYMESHTVSRLIGAPPG
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGYDQGGLLTDAVIKNPHCVVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHV
CCCCCCCCCCHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCEECCCCCCCCCEEE
TLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPEFRNRLDSIIWFNHLDMTIIA
EEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
KVVDKFLVELQAQLDAKHVVLEVSDEARTLLAEKGYDKSMGARPMARVVTELIKRPLADE
HHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHH
ILFGELEHGGIAHVDAKEGEIVIHTERHEKSTSKA
HHHCCCCCCCEEEEECCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]