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The map label for this gene is pip [H]

Identifier: 117919940

GI number: 117919940

Start: 1739069

End: 1740358

Strand: Reverse

Name: pip [H]

Synonym: Shewana3_1492

Alternate gene names: 117919940

Gene position: 1740358-1739069 (Counterclockwise)

Preceding gene: 117919951

Following gene: 117919936

Centisome position: 35.0

GC content: 50.78

Gene sequence:

>1290_bases
ATGAAACCCGATATGATGCTCGCCGGTGTCCTCGCCAAAAAACACACATTCAACCTGCCACTTGATTATCAACAACCGAT
TGGTGAACAGATCAGTGTGTTCGCGCGGGAGCTCTGCGCCATTGAAAATAAAGATAAAAAACTACCTTATATCGTCTTTT
TTCAGGGTGGCCCCGGCTTTGCTGCCATGCGCCCAGCGAATAACAGCGGTTGGATCCGCCGCGCACTCAAAGAGTTTAGA
GTATTATTGCTCGACCAACGGGGAACTGGGCTTTCTAGCCCCATTAATTACCAAAGCCTCGGGCACTTAACGCCTGAACA
GCAGGCCGATTATTTAAGCCATTTTAGGGCCGACAATATCGTCCGCGATGCCGAATCAATTCGCGCCCAGCTCTGCCCCG
CCGACAAGTGGGCGATTCTAGGTCAAAGCTTTGGTGGTTTCTGCGTGCTTCATTATTTAAGCGCCGCGCCTCAGGGCGTG
AGTGAAGCCTATATCACCGGCGGCATTCCTTCCCTTACGCGCAGCAGTGATGAAGTCTATCAGGCTACCTATCAGCGCGT
ACTCGCCAAGAATAAAGACTTCTTCCAGCGCTTCCACGATGCGCAGCATCTCGTGACACGCCTCACCAAACATTTACTCG
AGCACCCAGTGCAGTTAGCCACGGGCGAGCGCCTCACGGTTGAAATGTTGCAGCTGCTCGGCATTAACTTGGGCATGGAG
CAAGGCCCAGAGTCGGTTTACTATTTGCTTGAACAAGCACTAGTGCACTCGCCCCAAGGTGATTATGTCAACCCACTGTT
TTTAAATCATTTCGGCCAATTGCTCGACTATAACACCAACCCAATTTTTGCCCTGTTACACGAGGCCATCTACTGCCAAC
ACAGTGCGTCACAGTGGTCTGCCCATAGGGTGCGTGAACAGTATCCGGCCTTTAACTATCAAGTCGGTAAGCCTTTCCTG
TTTACTGGCGAGATGATTTACCCTTGGATGTTTGAGCAATTTAGCCATTTAGCCCCACTCCAAGCCGCGGCCAATCTCCT
TGCCCATAAAACGGACTGGCCGGCGTTATACAATCTTGAGCAGCTCAGCCAGAACCGCGTCCCAGTTGCGGCCGCGATTT
ACAGCGAAGATATGTATGTCGAGATGGACTACAGCCTAGAAACCGCCAAACAAGTAGCTCATCTAAGATATTGGTTAACC
TCGGAATATGAGCACAATGGCATTCGAATGGATGGCGAGCGGATCTTAGATAAGCTCATCAGTCTCAACCGCGGTGACAG
CTTAAGATAA

Upstream 100 bases:

>100_bases
GATCTTGACCAAAGGCGAATCAAATAATCCTAACTTGCGACAACAGGGCTTTTGTATACAATCTGCCATAAACAACAGAC
CCTACCCTTAAGGTTAATTG

Downstream 100 bases:

>100_bases
ATGTTAATTTTAAGGGTTAATTAAGTAAAAGCTGTCATTGTGTGCTGGCTCCTCATCCATATGAGTGATTTTGGCTACAA
CATTCAACGACCAATTTTCC

Product: prolyl aminopeptidase 2

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MKPDMMLAGVLAKKHTFNLPLDYQQPIGEQISVFARELCAIENKDKKLPYIVFFQGGPGFAAMRPANNSGWIRRALKEFR
VLLLDQRGTGLSSPINYQSLGHLTPEQQADYLSHFRADNIVRDAESIRAQLCPADKWAILGQSFGGFCVLHYLSAAPQGV
SEAYITGGIPSLTRSSDEVYQATYQRVLAKNKDFFQRFHDAQHLVTRLTKHLLEHPVQLATGERLTVEMLQLLGINLGME
QGPESVYYLLEQALVHSPQGDYVNPLFLNHFGQLLDYNTNPIFALLHEAIYCQHSASQWSAHRVREQYPAFNYQVGKPFL
FTGEMIYPWMFEQFSHLAPLQAAANLLAHKTDWPALYNLEQLSQNRVPVAAAIYSEDMYVEMDYSLETAKQVAHLRYWLT
SEYEHNGIRMDGERILDKLISLNRGDSLR

Sequences:

>Translated_429_residues
MKPDMMLAGVLAKKHTFNLPLDYQQPIGEQISVFARELCAIENKDKKLPYIVFFQGGPGFAAMRPANNSGWIRRALKEFR
VLLLDQRGTGLSSPINYQSLGHLTPEQQADYLSHFRADNIVRDAESIRAQLCPADKWAILGQSFGGFCVLHYLSAAPQGV
SEAYITGGIPSLTRSSDEVYQATYQRVLAKNKDFFQRFHDAQHLVTRLTKHLLEHPVQLATGERLTVEMLQLLGINLGME
QGPESVYYLLEQALVHSPQGDYVNPLFLNHFGQLLDYNTNPIFALLHEAIYCQHSASQWSAHRVREQYPAFNYQVGKPFL
FTGEMIYPWMFEQFSHLAPLQAAANLLAHKTDWPALYNLEQLSQNRVPVAAAIYSEDMYVEMDYSLETAKQVAHLRYWLT
SEYEHNGIRMDGERILDKLISLNRGDSLR
>Mature_429_residues
MKPDMMLAGVLAKKHTFNLPLDYQQPIGEQISVFARELCAIENKDKKLPYIVFFQGGPGFAAMRPANNSGWIRRALKEFR
VLLLDQRGTGLSSPINYQSLGHLTPEQQADYLSHFRADNIVRDAESIRAQLCPADKWAILGQSFGGFCVLHYLSAAPQGV
SEAYITGGIPSLTRSSDEVYQATYQRVLAKNKDFFQRFHDAQHLVTRLTKHLLEHPVQLATGERLTVEMLQLLGINLGME
QGPESVYYLLEQALVHSPQGDYVNPLFLNHFGQLLDYNTNPIFALLHEAIYCQHSASQWSAHRVREQYPAFNYQVGKPFL
FTGEMIYPWMFEQFSHLAPLQAAANLLAHKTDWPALYNLEQLSQNRVPVAAAIYSEDMYVEMDYSLETAKQVAHLRYWLT
SEYEHNGIRMDGERILDKLISLNRGDSLR

Specific function: Higher activity toward long peptides. Acts on hydroxyproline beta-naphthylamide with almost as high an activity as on proline beta-naphthylamide [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 48884; Mature: 48884

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDMMLAGVLAKKHTFNLPLDYQQPIGEQISVFARELCAIENKDKKLPYIVFFQGGPGF
CCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
AAMRPANNSGWIRRALKEFRVLLLDQRGTGLSSPINYQSLGHLTPEQQADYLSHFRADNI
EEECCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHH
VRDAESIRAQLCPADKWAILGQSFGGFCVLHYLSAAPQGVSEAYITGGIPSLTRSSDEVY
HHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCHHHHH
QATYQRVLAKNKDFFQRFHDAQHLVTRLTKHLLEHPVQLATGERLTVEMLQLLGINLGME
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCCCCCC
QGPESVYYLLEQALVHSPQGDYVNPLFLNHFGQLLDYNTNPIFALLHEAIYCQHSASQWS
CCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHH
AHRVREQYPAFNYQVGKPFLFTGEMIYPWMFEQFSHLAPLQAAANLLAHKTDWPALYNLE
HHHHHHHCCCCCEECCCCEEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHH
QLSQNRVPVAAAIYSEDMYVEMDYSLETAKQVAHLRYWLTSEYEHNGIRMDGERILDKLI
HHHCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHH
SLNRGDSLR
CCCCCCCCC
>Mature Secondary Structure
MKPDMMLAGVLAKKHTFNLPLDYQQPIGEQISVFARELCAIENKDKKLPYIVFFQGGPGF
CCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
AAMRPANNSGWIRRALKEFRVLLLDQRGTGLSSPINYQSLGHLTPEQQADYLSHFRADNI
EEECCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHH
VRDAESIRAQLCPADKWAILGQSFGGFCVLHYLSAAPQGVSEAYITGGIPSLTRSSDEVY
HHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCHHHHH
QATYQRVLAKNKDFFQRFHDAQHLVTRLTKHLLEHPVQLATGERLTVEMLQLLGINLGME
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCCCCCC
QGPESVYYLLEQALVHSPQGDYVNPLFLNHFGQLLDYNTNPIFALLHEAIYCQHSASQWS
CCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHH
AHRVREQYPAFNYQVGKPFLFTGEMIYPWMFEQFSHLAPLQAAANLLAHKTDWPALYNLE
HHHHHHHCCCCCEECCCCEEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHH
QLSQNRVPVAAAIYSEDMYVEMDYSLETAKQVAHLRYWLTSEYEHNGIRMDGERILDKLI
HHHCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHH
SLNRGDSLR
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7883756 [H]