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The map label for this gene is cysG [H]

Identifier: 116690490

GI number: 116690490

Start: 2741043

End: 2741792

Strand: Reverse

Name: cysG [H]

Synonym: Bcen2424_2470

Alternate gene names: 116690490

Gene position: 2741792-2741043 (Counterclockwise)

Preceding gene: 116690491

Following gene: 116690486

Centisome position: 78.7

GC content: 71.6

Gene sequence:

>750_bases
ATGGGCAAGGTGTATCTGATCGGAGCAGGACCGGGCGCGGCGGACCTCATCACGGTGCGCGGCATGCGGCTGCTCGAGCA
GGCCGACGTCGTGCTGCACGACGCGCTCGTCGAGCCCGCGATGCTCGACTATGCGCCGAACGCGCGCAGGATCGCGGTCG
GCAAGCGCTGCGGGCAGCGCTCGACCGCGCAGCATTTCATCAACAAGCAGATCGTCGATGCGGCGCGCGAGCATGCGTGC
GTCGTGCGGCTGAAGGGCGGCGATCCGATGCTGTTCGGCCGCGCGGAAGAGGAAATGCGCGCGCTGGAAGCGGCCGGCAT
CGACTACGAGGTCGTGCCGGGCATCACCGCGGCGCTGGCCGGTGCGGCGACGCTCAAGCGTTCGCTGACGTTGCGCGGCG
TGTCGCGCAGCGTCGCGTTCGCGACGCACAGCCGCGCGCCGGGCAGCGACGAGATCCGCGAAGCGGCGCGCGCCGATTCG
ATCGTCTATTACATGGGCCGCGACAGCGCGCCCGGCATCGCGCAGGAACTGATCGACGCCGGCCGTGCGCCGGCGACGCC
GGTGGCGATCGTCGAGGCCTGCAGCACCGCACGCGAACGCACGCTGACGCTGACGCTCGCGCAGATGGCGGCCGGCGACG
CGCAGGCGTGGCTCGATCCCGCGGAACCGAGCCTGCTGATGATCGGCGATGCGTTCGCCGAACGCGCACGGCAGGCGCAG
GCGGGTGCGTCGGTGCGCCATGCCGCCTGA

Upstream 100 bases:

>100_bases
CACGGTCGCCGCGGGCATGATCCGCGCGTTCTCGGCGTAATCGTCAATCTGCGCGGCGGCGAACCGGCCGCCGCGGCAGG
ACCTTAGCGAAGCGACAAAC

Downstream 100 bases:

>100_bases
GCGCGGCTCGAACGCGGTCCGAAACGAAAAAAGCGCCGGCAGATGCCGGCGCTTTTTCTTTGGGTGCGGCGAAGGCGCGG
GCTGCTACGCGTCGCCGCCG

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MGKVYLIGAGPGAADLITVRGMRLLEQADVVLHDALVEPAMLDYAPNARRIAVGKRCGQRSTAQHFINKQIVDAAREHAC
VVRLKGGDPMLFGRAEEEMRALEAAGIDYEVVPGITAALAGAATLKRSLTLRGVSRSVAFATHSRAPGSDEIREAARADS
IVYYMGRDSAPGIAQELIDAGRAPATPVAIVEACSTARERTLTLTLAQMAAGDAQAWLDPAEPSLLMIGDAFAERARQAQ
AGASVRHAA

Sequences:

>Translated_249_residues
MGKVYLIGAGPGAADLITVRGMRLLEQADVVLHDALVEPAMLDYAPNARRIAVGKRCGQRSTAQHFINKQIVDAAREHAC
VVRLKGGDPMLFGRAEEEMRALEAAGIDYEVVPGITAALAGAATLKRSLTLRGVSRSVAFATHSRAPGSDEIREAARADS
IVYYMGRDSAPGIAQELIDAGRAPATPVAIVEACSTARERTLTLTLAQMAAGDAQAWLDPAEPSLLMIGDAFAERARQAQ
AGASVRHAA
>Mature_248_residues
GKVYLIGAGPGAADLITVRGMRLLEQADVVLHDALVEPAMLDYAPNARRIAVGKRCGQRSTAQHFINKQIVDAAREHACV
VRLKGGDPMLFGRAEEEMRALEAAGIDYEVVPGITAALAGAATLKRSLTLRGVSRSVAFATHSRAPGSDEIREAARADSI
VYYMGRDSAPGIAQELIDAGRAPATPVAIVEACSTARERTLTLTLAQMAAGDAQAWLDPAEPSLLMIGDAFAERARQAQA
GASVRHAA

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=231, Percent_Identity=41.1255411255411, Blast_Score=150, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322922, Length=233, Percent_Identity=29.1845493562232, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 26239; Mature: 26108

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVYLIGAGPGAADLITVRGMRLLEQADVVLHDALVEPAMLDYAPNARRIAVGKRCGQR
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEHHHHCCCH
STAQHFINKQIVDAAREHACVVRLKGGDPMLFGRAEEEMRALEAAGIDYEVVPGITAALA
HHHHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCHHHHHHHHHCCCCEEECCCHHHHHH
GAATLKRSLTLRGVSRSVAFATHSRAPGSDEIREAARADSIVYYMGRDSAPGIAQELIDA
HHHHHHHHHHHHCCCHHHEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHC
GRAPATPVAIVEACSTARERTLTLTLAQMAAGDAQAWLDPAEPSLLMIGDAFAERARQAQ
CCCCCCHHHHHHHHHHHHHHEEEEEHHHHHCCCHHHCCCCCCCCEEEEEHHHHHHHHHHH
AGASVRHAA
CCCCCCCCC
>Mature Secondary Structure 
GKVYLIGAGPGAADLITVRGMRLLEQADVVLHDALVEPAMLDYAPNARRIAVGKRCGQR
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEHHHHCCCH
STAQHFINKQIVDAAREHACVVRLKGGDPMLFGRAEEEMRALEAAGIDYEVVPGITAALA
HHHHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCHHHHHHHHHCCCCEEECCCHHHHHH
GAATLKRSLTLRGVSRSVAFATHSRAPGSDEIREAARADSIVYYMGRDSAPGIAQELIDA
HHHHHHHHHHHHCCCHHHEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHC
GRAPATPVAIVEACSTARERTLTLTLAQMAAGDAQAWLDPAEPSLLMIGDAFAERARQAQ
CCCCCCHHHHHHHHHHHHHHEEEEEHHHHHCCCHHHCCCCCCCCEEEEEHHHHHHHHHHH
AGASVRHAA
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA