Click here to switch to the map view.

The map label for this gene is pepA [H]

Identifier: 116690486

GI number: 116690486

Start: 2736669

End: 2738180

Strand: Reverse

Name: pepA [H]

Synonym: Bcen2424_2466

Alternate gene names: 116690486

Gene position: 2738180-2736669 (Counterclockwise)

Preceding gene: 116690490

Following gene: 116690485

Centisome position: 78.6

GC content: 67.26

Gene sequence:

>1512_bases
ATGGACTTTAGCATAAAAGGCTGTGATTGGAGCAAAGGCGAGGCCAAGGGGTTCCTGACCGGGAAGTCCGACTGCATCGT
GCTCGGCATCTTCGAGGCGCAGACCCTGTCGGGCGCGGCGCTCGACATCGACACGGCCACCAAGGGACTGATCTCGCGCG
TGGTGAAGGCCGGCGACATGGACGGCAAGCGCGGCAAGACGCTGTTCCTGCACGAAGTGTCGGGCATCGGCGCGTCGCGC
GTGCTGCTCGTCGGGCTCGGCAAGCAGGATGCTTTCAATCAGAAAGCCTATAACGATGCGGCGACGACCGCCTGGCGCGC
GCTGCTGGCGACCAAGGTCGTCCAGGTCACGTTCTCGCTCGCGCAACTGCCGGTCGACGAGCGCAGCTCCGACTGGGGCG
TGCGCGCCGCGATCCTCGCGCTGCGCAACGAGACCTACCGCTTCACGCAGATGAAGAGCAAGCCGGAACCGGCGTCGCAC
ACGCTCAAGCGCGTCGTGTTCAGCGTCGACCCGGCGGACGAAAAGGCCGCGAAGGTCGCGATCAAGCAGGCCGTCGCGCT
CGCGAACGGGATGGATCTCACCCGCGACCTCGGTAACCTGCCCGGCAACGTCTGCACGCCGATCTATCTCGGCAACACCG
CGAAGAAGATCGCGAAGGATTGGGGCCTGAAGGCCGAAGTCCTCGGGCTCAAGCAGATCCAGGCGCTGAAGATGGGGTCG
TTCCTGTCGGTCGCGCGCGCATCGGTCGAGCCGCCGCAGTTCATCGTGCTGCACTACCAGGGCGCCGCCGCGAAGGCCGC
GCCGGTCGTGCTGGTCGGCAAGGGCATCACGTTCGACACGGGCGGCATCTCGCTGAAGCCTGGCGAGGGCATGGACGAGA
TGAAGTACGACATGTGCGGCGCGGGCTCGGTGCTCGGCACGATGCGTGCGGTCGCCGAGATGGGCCTGAAGATCAACGTC
GTCGCGATCGTGCCGACCTGCGAGAACATGCCGGGCGGCAATGCGACGAAGCCGGGCGACATCGTCACCAGCATGAAGGG
GCTGACGATCGAGGTGCTGAACACCGACGCCGAAGGCCGCCTGATCCTGTGCGACGCACTCACGTACGCCGAGCGCTTCA
AGCCGGCCGCCGTGATCGACGTCGCGACGCTGACGGGCGCGTGCGTGATCGCGCTGGGCGGCCACAACAGCGGGCTGTTC
TCGACGAACGACGCGCTCGCGGGCGAACTGCTCGACGCGTCGCGCGAGGCGAACGACCCGGCATGGCGCATGCCGCTCGA
CGACGAGTACCAGGATCAGCTGAAGTCGAATTTCGCGGATCTCGCGAACATCGGCGGGCGCCCGGCCGGCGCCGTGACGG
CCGCGTGCTTCCTGTCGCGCTTCACCGAGAGCTATCCGTGGGCCCACCTCGACATCGCGGGCACCGCATGGAAGGGCGGT
GCCGCGAAGGGTGCGACGGGCCGTCCGGTGCCGTTGCTCGCGCAGTTCCTGATCGACCGCGCCGGCCAGTGA

Upstream 100 bases:

>100_bases
GGCTGCGCACGCGTGGTGGAGCGCTCGCGCCGCCACGGGAAAAATAGCGGATAATTGCGGCTTTCATCCTTAGCCCAGAT
TTTATCCGAGGACAAGCGCG

Downstream 100 bases:

>100_bases
TGGCGGGGCTGACGACGCTGCGGGTGCGCGGGCAATGACGCGGATCGATTTCCACTCGAACGTCGGCGATTCGCTCGCGT
ACGCGTGCCGGCTGCTGCGC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVVKAGDMDGKRGKTLFLHEVSGIGASR
VLLVGLGKQDAFNQKAYNDAATTAWRALLATKVVQVTFSLAQLPVDERSSDWGVRAAILALRNETYRFTQMKSKPEPASH
TLKRVVFSVDPADEKAAKVAIKQAVALANGMDLTRDLGNLPGNVCTPIYLGNTAKKIAKDWGLKAEVLGLKQIQALKMGS
FLSVARASVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAGSVLGTMRAVAEMGLKINV
VAIVPTCENMPGGNATKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACVIALGGHNSGLF
STNDALAGELLDASREANDPAWRMPLDDEYQDQLKSNFADLANIGGRPAGAVTAACFLSRFTESYPWAHLDIAGTAWKGG
AAKGATGRPVPLLAQFLIDRAGQ

Sequences:

>Translated_503_residues
MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVVKAGDMDGKRGKTLFLHEVSGIGASR
VLLVGLGKQDAFNQKAYNDAATTAWRALLATKVVQVTFSLAQLPVDERSSDWGVRAAILALRNETYRFTQMKSKPEPASH
TLKRVVFSVDPADEKAAKVAIKQAVALANGMDLTRDLGNLPGNVCTPIYLGNTAKKIAKDWGLKAEVLGLKQIQALKMGS
FLSVARASVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAGSVLGTMRAVAEMGLKINV
VAIVPTCENMPGGNATKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACVIALGGHNSGLF
STNDALAGELLDASREANDPAWRMPLDDEYQDQLKSNFADLANIGGRPAGAVTAACFLSRFTESYPWAHLDIAGTAWKGG
AAKGATGRPVPLLAQFLIDRAGQ
>Mature_503_residues
MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVVKAGDMDGKRGKTLFLHEVSGIGASR
VLLVGLGKQDAFNQKAYNDAATTAWRALLATKVVQVTFSLAQLPVDERSSDWGVRAAILALRNETYRFTQMKSKPEPASH
TLKRVVFSVDPADEKAAKVAIKQAVALANGMDLTRDLGNLPGNVCTPIYLGNTAKKIAKDWGLKAEVLGLKQIQALKMGS
FLSVARASVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAGSVLGTMRAVAEMGLKINV
VAIVPTCENMPGGNATKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACVIALGGHNSGLF
STNDALAGELLDASREANDPAWRMPLDDEYQDQLKSNFADLANIGGRPAGAVTAACFLSRFTESYPWAHLDIAGTAWKGG
AAKGATGRPVPLLAQFLIDRAGQ

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=491, Percent_Identity=37.8818737270876, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI47155554, Length=320, Percent_Identity=32.1875, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI1790710, Length=506, Percent_Identity=49.802371541502, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=41.3793103448276, Blast_Score=206, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17556903, Length=322, Percent_Identity=32.9192546583851, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17565172, Length=250, Percent_Identity=30.8, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20129969, Length=523, Percent_Identity=30.4015296367113, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI21355725, Length=333, Percent_Identity=35.7357357357357, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24661038, Length=333, Percent_Identity=35.4354354354354, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24662227, Length=374, Percent_Identity=34.7593582887701, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI161077148, Length=499, Percent_Identity=30.8617234468938, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI20130057, Length=499, Percent_Identity=30.8617234468938, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI21355645, Length=490, Percent_Identity=30.2040816326531, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24662223, Length=490, Percent_Identity=30.2040816326531, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI19922386, Length=508, Percent_Identity=28.740157480315, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI20129963, Length=501, Percent_Identity=28.1437125748503, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21357381, Length=312, Percent_Identity=32.0512820512821, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI221379063, Length=310, Percent_Identity=32.258064516129, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI221379062, Length=310, Percent_Identity=32.258064516129, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24646701, Length=232, Percent_Identity=31.4655172413793, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646703, Length=232, Percent_Identity=31.4655172413793, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21358201, Length=232, Percent_Identity=31.4655172413793, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53021; Mature: 53021

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVVKAGDM
CCCCCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCCEEECHHHHHHHHHHHHHHCCC
DGKRGKTLFLHEVSGIGASRVLLVGLGKQDAFNQKAYNDAATTAWRALLATKVVQVTFSL
CCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLPVDERSSDWGVRAAILALRNETYRFTQMKSKPEPASHTLKRVVFSVDPADEKAAKVA
HHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHEECCCCHHHHHHHH
IKQAVALANGMDLTRDLGNLPGNVCTPIYLGNTAKKIAKDWGLKAEVLGLKQIQALKMGS
HHHHHHHHCCCHHHHHHHCCCCCCCCCEEECCHHHHHHHHCCCEEEEHHHHHHHHHHHCH
FLSVARASVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCG
HHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHCC
AGSVLGTMRAVAEMGLKINVVAIVPTCENMPGGNATKPGDIVTSMKGLTIEVLNTDAEGR
CCHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
LILCDALTYAERFKPAAVIDVATLTGACVIALGGHNSGLFSTNDALAGELLDASREANDP
EEEEEHHHHHHHCCCCCEEEHHHHCCEEEEEECCCCCCCEECCCHHHHHHHHHHCCCCCC
AWRMPLDDEYQDQLKSNFADLANIGGRPAGAVTAACFLSRFTESYPWAHLDIAGTAWKGG
EEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
AAKGATGRPVPLLAQFLIDRAGQ
CCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVVKAGDM
CCCCCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCCEEECHHHHHHHHHHHHHHCCC
DGKRGKTLFLHEVSGIGASRVLLVGLGKQDAFNQKAYNDAATTAWRALLATKVVQVTFSL
CCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLPVDERSSDWGVRAAILALRNETYRFTQMKSKPEPASHTLKRVVFSVDPADEKAAKVA
HHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHEECCCCHHHHHHHH
IKQAVALANGMDLTRDLGNLPGNVCTPIYLGNTAKKIAKDWGLKAEVLGLKQIQALKMGS
HHHHHHHHCCCHHHHHHHCCCCCCCCCEEECCHHHHHHHHCCCEEEEHHHHHHHHHHHCH
FLSVARASVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCG
HHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHCC
AGSVLGTMRAVAEMGLKINVVAIVPTCENMPGGNATKPGDIVTSMKGLTIEVLNTDAEGR
CCHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
LILCDALTYAERFKPAAVIDVATLTGACVIALGGHNSGLFSTNDALAGELLDASREANDP
EEEEEHHHHHHHCCCCCEEEHHHHCCEEEEEECCCCCCCEECCCHHHHHHHHHHCCCCCC
AWRMPLDDEYQDQLKSNFADLANIGGRPAGAVTAACFLSRFTESYPWAHLDIAGTAWKGG
EEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
AAKGATGRPVPLLAQFLIDRAGQ
CCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA