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The map label for this gene is serS [H]

Identifier: 116689002

GI number: 116689002

Start: 1088333

End: 1089634

Strand: Direct

Name: serS [H]

Synonym: Bcen2424_0979

Alternate gene names: 116689002

Gene position: 1088333-1089634 (Clockwise)

Preceding gene: 116689000

Following gene: 116689004

Centisome position: 31.24

GC content: 67.05

Gene sequence:

>1302_bases
ATGCTCGACATCCAGTTGCTGCGCAAAGACCTCGACGGCGTCGCCAAGCGCCTCGCCGATCGCGGCTACACCCTCGACGT
CGCCGCGTTCTCCGCACTCGAAGCGGAACGCCGCGCGATCCAGACCCACACCGAAGAGCTCCAGGCGCGCCGCAACAGCC
TGTCGAAGCAGATCGGCGCGATGAAGGGCAAGGGCGAGGACACGTCGGCCGTGATGGCCGAGGTCGGCGGGATCGGCGAC
GACATGAAGGCGTCGGAAGCCAAGCTCGGCGAGATCCAGGCGCGCCTGTCCGACCTGATGCTGGGCATGCCGAACGTCGC
GCACGAGAGCGTGCCGGTCGGCAAGGACGAAGCCGACAACGTCGAGGCGCGCCGCTGGGGCACGCCGCGCCAGTTCGACT
TCGAGGTGAAGGATCACGTCGACGTCGGCACGCCGCTCGGCCTCGATTTCGAGACGGGCGCGAAGCTCGCCGGCGCGCGC
TTCACGATGCTGCGCGGCCCGATCGCGCGCCTGCACCGCGCCCTCGCGCAGTTCATGATCGACACGCACACGCAGCAGCA
CGGCTATACCGAAACGTACACGCCGTACATCGTGAACCCGGAGATCCTGTACGGCACGGGCCAGTTGCCGAAATTCGCGG
ACGACATGTTCCGCGTCGAGAAGGGCGGCGCGGAAAACACGGTCACGCAATACCTGATCTCCACGTCCGAGATTTCGCTG
ACGAACACCGTGCGCGAGTCGATCGTCGACGCGTCCGCGCTGCCGATCAAGCTCACCGCGCATTCCCCGTGCTTCCGTTC
GGAAGCCGGTTCGTACGGCCGCGACACGCGCGGGATGATCCGTCAGCACCAGTTCGACAAGGTCGAGATGGTGCAGGTCG
TCGCGCCGGAAACATCGTACGCGGCACTCGACGAGATGGTCGGCCACGCGGAAGCGATCCTGCAGAAGCTCGGCCTGCCG
TACCGCGTGATCACGCTGTGCACGGGCGACATGGGCTTCTCGGCCGCGAAGACGTTCGACCTCGAGGTGTGGCTGCCCGC
GCAGAACACCTATCGCGAGATCTCGAGCTGCTCGAACACCGAGGCGTTCCAGGCGCGCCGGATGCAGGCGCGGTTCCGCA
ACGCGCAGGGCAAGCCGGAGCTCGTGCATACGCTGAACGGTTCGGGTCTGGCGGTCGGCCGCACGCTCGTCGCGGTGCTG
GAGAACTACCAGAACGCGGACGGCTCGGTCACGGTGCCGGAAGTGCTGCGTCCGTACATGGGCGGCATGGAGCGGATCGA
CGCGCCGGCACAGGCGTCCTAA

Upstream 100 bases:

>100_bases
TGGCCGCCCGTTTGCGGCATTGTCCATCCGGCCGGTGCCGTGGCGGGCGCGCGGTGCGTTAGAATTCCCGTCTTACACAA
CGATTTTTCCAAGTCCTCCC

Downstream 100 bases:

>100_bases
CGCGAGCCTGCCGAAGCCCTCGCAAAAAAATTTGCAGAAAGGGCTTGTCAGCCGCGAAGCGATCGTCTTATAATCTTTTT
CTCGCGGAAACGACCAGCCG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTHTEELQARRNSLSKQIGAMKGKGEDTSAVMAEVGGIGD
DMKASEAKLGEIQARLSDLMLGMPNVAHESVPVGKDEADNVEARRWGTPRQFDFEVKDHVDVGTPLGLDFETGAKLAGAR
FTMLRGPIARLHRALAQFMIDTHTQQHGYTETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGAENTVTQYLISTSEISL
TNTVRESIVDASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQVVAPETSYAALDEMVGHAEAILQKLGLP
YRVITLCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPEVLRPYMGGMERIDAPAQAS

Sequences:

>Translated_433_residues
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTHTEELQARRNSLSKQIGAMKGKGEDTSAVMAEVGGIGD
DMKASEAKLGEIQARLSDLMLGMPNVAHESVPVGKDEADNVEARRWGTPRQFDFEVKDHVDVGTPLGLDFETGAKLAGAR
FTMLRGPIARLHRALAQFMIDTHTQQHGYTETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGAENTVTQYLISTSEISL
TNTVRESIVDASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQVVAPETSYAALDEMVGHAEAILQKLGLP
YRVITLCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPEVLRPYMGGMERIDAPAQAS
>Mature_433_residues
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTHTEELQARRNSLSKQIGAMKGKGEDTSAVMAEVGGIGD
DMKASEAKLGEIQARLSDLMLGMPNVAHESVPVGKDEADNVEARRWGTPRQFDFEVKDHVDVGTPLGLDFETGAKLAGAR
FTMLRGPIARLHRALAQFMIDTHTQQHGYTETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGAENTVTQYLISTSEISL
TNTVRESIVDASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQVVAPETSYAALDEMVGHAEAILQKLGLP
YRVITLCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPEVLRPYMGGMERIDAPAQAS

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=469, Percent_Identity=32.8358208955224, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI8923421, Length=417, Percent_Identity=28.7769784172662, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI225579074, Length=333, Percent_Identity=32.1321321321321, Blast_Score=172, Evalue=6e-43,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=62.9370629370629, Blast_Score=562, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI17539260, Length=335, Percent_Identity=36.4179104477612, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17542084, Length=334, Percent_Identity=31.7365269461078, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320226, Length=399, Percent_Identity=32.5814536340852, Blast_Score=209, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6321799, Length=390, Percent_Identity=31.025641025641, Blast_Score=192, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24581334, Length=470, Percent_Identity=32.3404255319149, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI17737985, Length=346, Percent_Identity=30.635838150289, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47501; Mature: 47501

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTHTEELQARRNSLSKQIGA
CCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGKGEDTSAVMAEVGGIGDDMKASEAKLGEIQARLSDLMLGMPNVAHESVPVGKDEADN
CCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEARRWGTPRQFDFEVKDHVDVGTPLGLDFETGAKLAGARFTMLRGPIARLHRALAQFMI
CHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHH
DTHTQQHGYTETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGAENTVTQYLISTSEISL
HHHHHHCCCCCCCCCEEECCEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCHH
TNTVRESIVDASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQVVAPETSY
HHHHHHHHHCCCCCEEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCHHHEEEEECCCCHH
AALDEMVGHAEAILQKLGLPYRVITLCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHCCCCH
EAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPEVLRPYM
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHH
GGMERIDAPAQAS
CCHHHCCCCCCCC
>Mature Secondary Structure
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTHTEELQARRNSLSKQIGA
CCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGKGEDTSAVMAEVGGIGDDMKASEAKLGEIQARLSDLMLGMPNVAHESVPVGKDEADN
CCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEARRWGTPRQFDFEVKDHVDVGTPLGLDFETGAKLAGARFTMLRGPIARLHRALAQFMI
CHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHH
DTHTQQHGYTETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGAENTVTQYLISTSEISL
HHHHHHCCCCCCCCCEEECCEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCHH
TNTVRESIVDASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQVVAPETSY
HHHHHHHHHCCCCCEEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCHHHEEEEECCCCHH
AALDEMVGHAEAILQKLGLPYRVITLCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHCCCCH
EAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPEVLRPYM
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHH
GGMERIDAPAQAS
CCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA