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The map label for this gene is ahcY [H]

Identifier: 116688296

GI number: 116688296

Start: 313959

End: 315377

Strand: Direct

Name: ahcY [H]

Synonym: Bcen2424_0272

Alternate gene names: 116688296

Gene position: 313959-315377 (Clockwise)

Preceding gene: 116688295

Following gene: 116688297

Centisome position: 9.01

GC content: 63.92

Gene sequence:

>1419_bases
ATGAACGCCATTATCGATTCCAAGGCTTCCCACGATTACGTCGTCGCCGACATGGCGCTGGCCGGCTGGGGCCGCAAGGA
ACTCAACATCGCCGAGACCGAAATGCCGGGCCTCGTGCAGATCCGCGACGAATACAAGGCGCAGCAGCCGCTGAAGGGCG
CGCGCATCGCCGGTTCGCTGCACATGACGATCCAGACGGGCGTGCTGATCGAGACGCTGAAGGCGCTCGGCGCCGACGTG
CGCTGGGCGTCGTGCAACATCTTCTCGACCCAGGATCACGCGGCGGCCGCGATCGTCGAAGCCGGCACGCCGGTGTTCGC
GTTCAAGGGCGAATCGCTCGACGAATACTGGGAGTTCTCGCACCGCATCTTCGAATGGCCGAACGGCGAATTCGCGAACA
TGATCCTGGACGACGGCGGTGACGCAACGCTGCTGCTGATCCTCGGCTCGAAGGCCGAGAAGGACCGTTCGGTGATCGCG
AAGCCGACCAACGAGGAAGAAGTCGCGCTGTACAAGTCGATCGCGGCCCACCTCGACGTCGACGCGAACTGGTACTCGAA
GCGCCTCGCGCACATCAAGGGCGTGACCGAAGAGACCACGACCGGCGTGCACCGCCTGTACCAGATGGAAAAGGACGGCC
GCCTGCCGTTCCCGGCGTTCAACGTGAACGATTCGGTCACGAAGTCGAAGTTCGACAACCTGTACGGCTGCCGTGAATCG
CTCGTCGACGGCATCAAGCGCGCGACCGACGTGATGATCGCGGGCAAGGTCGCGGTCGTCGCGGGCTACGGCGACGTGGG
CAAGGGCTGCGCGCAGTCGCTGCGCGGCCTGGGCGCGACCGTGTGGGTCACCGAAATCGATCCGATCTGCGCGCTGCAGG
CGGCGATGGAAGGCTACCGCGTCGTGACGATGGAATACGCGGCCGACAGGGCCGACATCTTCGTGACGGCGACCGGCAAC
TACCACGTGATCAACCACGATCACATGAAGGCGATGCGCCACAACGCGATCGTCTGCAACATCGGTCACTTCGACTCGGA
AATCGACGTTGCGTCGACGCGCCAGTACCAGTGGGAAAACATCAAGCCGCAGGTCGACCACATCATCTTCCCGGACGGCA
AGCGCGTGATCCTGCTGGCCGAAGGCCGCCTCGTGAACCTCGGCTGCGCGACCGGCCACCCGTCGTTCGTGATGTCGAAC
TCGTTCGCGAACCAGACGCTCGCGCAGATCGAGCTGTTCACGCGCGGCGAGCAGTACGAGAACAAGGTGTACGTGCTGCC
GAAGCATCTCGATGAAAAGGTCGCGCGCCTGCACCTGGCGCGCATCGGCGCGAACCTGTCGGTGCTGTCGGACGAGCAGG
CTTCGTACATCGGCGTGCAGAAGGACGGCCCGTTCAAGCCGAACCACTACCGCTACTGA

Upstream 100 bases:

>100_bases
CTTCACCAAGCAGCCGTGCGGCGATTTTTTTCGCGCCGGCCCCGCTTCCTGAACGGCGCTCACGTCACCAATCTAGAAAC
TTTTTAGAAAGGAGGGCGTG

Downstream 100 bases:

>100_bases
TGTACTGATGCGCTGCCGCCGCGCCGCGCGCCCGTTGCGGGCGCGCGGCGCGGCGGCGCTCACCGATCGTACCGATCGAC
AACCGAACCGGAGCCCTCCA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MNAIIDSKASHDYVVADMALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSLHMTIQTGVLIETLKALGADV
RWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVIA
KPTNEEEVALYKSIAAHLDVDANWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRES
LVDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADRADIFVTATGN
YHVINHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSN
SFANQTLAQIELFTRGEQYENKVYVLPKHLDEKVARLHLARIGANLSVLSDEQASYIGVQKDGPFKPNHYRY

Sequences:

>Translated_472_residues
MNAIIDSKASHDYVVADMALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSLHMTIQTGVLIETLKALGADV
RWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVIA
KPTNEEEVALYKSIAAHLDVDANWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRES
LVDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADRADIFVTATGN
YHVINHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSN
SFANQTLAQIELFTRGEQYENKVYVLPKHLDEKVARLHLARIGANLSVLSDEQASYIGVQKDGPFKPNHYRY
>Mature_472_residues
MNAIIDSKASHDYVVADMALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSLHMTIQTGVLIETLKALGADV
RWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVIA
KPTNEEEVALYKSIAAHLDVDANWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRES
LVDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADRADIFVTATGN
YHVINHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSN
SFANQTLAQIELFTRGEQYENKVYVLPKHLDEKVARLHLARIGANLSVLSDEQASYIGVQKDGPFKPNHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=59.0909090909091, Blast_Score=523, Evalue=1e-148,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=58.6363636363636, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI298286489, Length=470, Percent_Identity=50.2127659574468, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI24308043, Length=470, Percent_Identity=50.2127659574468, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI195539349, Length=470, Percent_Identity=50.2127659574468, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI195539337, Length=470, Percent_Identity=50.2127659574468, Blast_Score=475, Evalue=1e-134,
Organism=Homo sapiens, GI21361647, Length=470, Percent_Identity=50, Blast_Score=458, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=59.3548387096774, Blast_Score=525, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6320882, Length=483, Percent_Identity=57.1428571428571, Blast_Score=511, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=59.3073593073593, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24656245, Length=471, Percent_Identity=50.3184713375796, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45553387, Length=469, Percent_Identity=49.2537313432836, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45553385, Length=468, Percent_Identity=49.1452991452991, Blast_Score=442, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52204; Mature: 52204

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAIIDSKASHDYVVADMALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSL
CCCCCCCCCCCCEEEEEHHHHCCCCCCCEEECCCCCCEEEEHHHHCCCCCCCCCEEECEE
HMTIQTGVLIETLKALGADVRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFS
EEEEECCHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCEEEEEECCCHHHHHHHH
HRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVIAKPTNEEEVALYKSIAAHLDV
HHEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHCCC
DANWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRES
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHHH
LVDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYR
HHHHHHHHHHEEEECCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCEE
VVTMEYAADRADIFVTATGNYHVINHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWEN
EEEEEECCCCCCEEEEECCCEEEEECHHHHHHHCCEEEEEECCCCCCCCCCCCCCEECCC
IKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSNSFANQTLAQIELFTRGEQYE
CCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHEEEEEECCCCCC
NKVYVLPKHLDEKVARLHLARIGANLSVLSDEQASYIGVQKDGPFKPNHYRY
CEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MNAIIDSKASHDYVVADMALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSL
CCCCCCCCCCCCEEEEEHHHHCCCCCCCEEECCCCCCEEEEHHHHCCCCCCCCCEEECEE
HMTIQTGVLIETLKALGADVRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFS
EEEEECCHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCEEEEEECCCHHHHHHHH
HRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVIAKPTNEEEVALYKSIAAHLDV
HHEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHCCC
DANWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRES
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHHH
LVDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYR
HHHHHHHHHHEEEECCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCEE
VVTMEYAADRADIFVTATGNYHVINHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWEN
EEEEEECCCCCCEEEEECCCEEEEECHHHHHHHCCEEEEEECCCCCCCCCCCCCCEECCC
IKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSNSFANQTLAQIELFTRGEQYE
CCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHEEEEEECCCCCC
NKVYVLPKHLDEKVARLHLARIGANLSVLSDEQASYIGVQKDGPFKPNHYRY
CEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA