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The map label for this gene is menE [H]

Identifier: 116626397

GI number: 116626397

Start: 9233922

End: 9235445

Strand: Direct

Name: menE [H]

Synonym: Acid_7357

Alternate gene names: 116626397

Gene position: 9233922-9235445 (Clockwise)

Preceding gene: 116626390

Following gene: 116626398

Centisome position: 92.66

GC content: 65.88

Gene sequence:

>1524_bases
ATGATCGCGCCCCTCACTCCGCTCGATTTTCTCGCCCGGAGCGCATCCACCTGGCGCGACCGCATCGCGGTGGTGGATGG
TGACCGGCGCTTCACTTATAGCGGGTTCGCCGCCCGCGTGCAAGGTCAGGCCGCCGCGCTGCTCGCGCTCGGCGTCCAAC
CCGGAGACCGCGTCGCGGTGCTCGCTCCCAACGGCGCGATGGCCCTCGAATCCCACTTCGCCCCCATGTCGATCGGCGCT
GTGCTGGTTATGCTGAACACCCGCCTCGCGGCCGGCGAACTGGCCTGGATCCTCAATCACTGCGGCGCCAAAGTACTCCT
GGTGGATCCGCAGCTCGCACCCCTCGTCGCTGACGCCGCGGTCCCACACATCATCCAGGATTACGAGGCTTTCCTGAGCG
CCGCACCGCCGCACTACACTCCGGTTCCGGTCACCGACGAGAATGCCTGCATCGCCATCAACTACACTTCCGGCACCACC
GGTTTTCCCAAAGGCGTGATGTACACCCACCGCGGCGCCTGGGTCAACGCTCTCGGCGAGATTACGGAGCATGGCCTCAC
GCAGCGCAGCGTCTACCTGTGGACGCTGCCCATGTTCCACTGCAACGGCTGGTGCTTCCCCTGGGCCGTCACCGCCGCCG
GCGGACGCCACATCTGCATTCGCCAGCCCGACCCATGCGAAATGGTCGCGCTCATCCAGGCCCAAGGCGTGACCCACTTA
TGCGGCGCTCCCGTAGTGGTCAGTTCGCTCGCCCAATACTGCGCCGCCAATCAGGTAAAGTTCGAGCGCCCACTGCGGAT
CGTCACCGCCGGCGCGCCCCCGCCTCCCGCCGTCATCCGCGCCGCCGAAGAGACCGGCGCCGAGATCTGCCACGCCTACG
GCCTCACCGAAACCTACGGCCCGCACACCATCTGCAGCTGGAATCCCGAGTGGGACGAGCGCCCCGCTCCGGAGCGCGCC
CTCCTCAAAGCCCGCCAGGGCGTCGCCTACACGGTGGCCGGCACGGACCTGCGTGTGGTCGATTTCCAGATGCACGACGT
CCCCCCCGATGGCGAAACCATGGGCGAAGTCCTCATGCGCGGGAACAACGTCATGCTCGGCTACTACGCCAACCCCAAAG
CCACCGAGGACGCGTTTCAAGGCGGGTGGTTCCACTCAGGCGATCTCGCCGTGGTCCATCCCGATGGCTACATCGAACTG
CGCGACCGGATGAAAGACATCGTCATTTCCGGCGGCGAGAATATCTCTTCCATCGAGGTCGAAAAAACTCTCGCCGATCA
TCCCGCGGTCGCCGAAGTGGCGATCGTCGCCGTACCCGATGAAAAGTGGGGCGAGGTCCCCAAGGCTTACGTCGGCCTCA
AGCCCGGCTGCAGCGCCACCGCCGAAGAACTGATCGCCTGGTGCCGCGATCGCATGGCGCACTTCAAGGCCCCCAAACTG
GTGGAGTTCGGTCCGCTGCCGCGCACCGCCACCGGTAAGATCCGCAAGAACCAGCTGCGCGCCCAGGCAAAGGCAAACTC
ATGA

Upstream 100 bases:

>100_bases
GGGTGAACAGAGCCTTCGGTACTGGTACACGAGTTTGTCATCTAAGGTTGCGATACGATTGCGGCATGGACCGGCGCGTC
TTCTCTCTGCGGGGGCTGCC

Downstream 100 bases:

>100_bases
ACATCGAAATCGCCCACGAAGGTCCCATCGCGATCGTCACCTTGAACCGCCCCGAGCGCCGCAACGCGCTCTCGCTCGAG
CTGATGCTCGACCTGATCGC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MIAPLTPLDFLARSASTWRDRIAVVDGDRRFTYSGFAARVQGQAAALLALGVQPGDRVAVLAPNGAMALESHFAPMSIGA
VLVMLNTRLAAGELAWILNHCGAKVLLVDPQLAPLVADAAVPHIIQDYEAFLSAAPPHYTPVPVTDENACIAINYTSGTT
GFPKGVMYTHRGAWVNALGEITEHGLTQRSVYLWTLPMFHCNGWCFPWAVTAAGGRHICIRQPDPCEMVALIQAQGVTHL
CGAPVVVSSLAQYCAANQVKFERPLRIVTAGAPPPPAVIRAAEETGAEICHAYGLTETYGPHTICSWNPEWDERPAPERA
LLKARQGVAYTVAGTDLRVVDFQMHDVPPDGETMGEVLMRGNNVMLGYYANPKATEDAFQGGWFHSGDLAVVHPDGYIEL
RDRMKDIVISGGENISSIEVEKTLADHPAVAEVAIVAVPDEKWGEVPKAYVGLKPGCSATAEELIAWCRDRMAHFKAPKL
VEFGPLPRTATGKIRKNQLRAQAKANS

Sequences:

>Translated_507_residues
MIAPLTPLDFLARSASTWRDRIAVVDGDRRFTYSGFAARVQGQAAALLALGVQPGDRVAVLAPNGAMALESHFAPMSIGA
VLVMLNTRLAAGELAWILNHCGAKVLLVDPQLAPLVADAAVPHIIQDYEAFLSAAPPHYTPVPVTDENACIAINYTSGTT
GFPKGVMYTHRGAWVNALGEITEHGLTQRSVYLWTLPMFHCNGWCFPWAVTAAGGRHICIRQPDPCEMVALIQAQGVTHL
CGAPVVVSSLAQYCAANQVKFERPLRIVTAGAPPPPAVIRAAEETGAEICHAYGLTETYGPHTICSWNPEWDERPAPERA
LLKARQGVAYTVAGTDLRVVDFQMHDVPPDGETMGEVLMRGNNVMLGYYANPKATEDAFQGGWFHSGDLAVVHPDGYIEL
RDRMKDIVISGGENISSIEVEKTLADHPAVAEVAIVAVPDEKWGEVPKAYVGLKPGCSATAEELIAWCRDRMAHFKAPKL
VEFGPLPRTATGKIRKNQLRAQAKANS
>Mature_507_residues
MIAPLTPLDFLARSASTWRDRIAVVDGDRRFTYSGFAARVQGQAAALLALGVQPGDRVAVLAPNGAMALESHFAPMSIGA
VLVMLNTRLAAGELAWILNHCGAKVLLVDPQLAPLVADAAVPHIIQDYEAFLSAAPPHYTPVPVTDENACIAINYTSGTT
GFPKGVMYTHRGAWVNALGEITEHGLTQRSVYLWTLPMFHCNGWCFPWAVTAAGGRHICIRQPDPCEMVALIQAQGVTHL
CGAPVVVSSLAQYCAANQVKFERPLRIVTAGAPPPPAVIRAAEETGAEICHAYGLTETYGPHTICSWNPEWDERPAPERA
LLKARQGVAYTVAGTDLRVVDFQMHDVPPDGETMGEVLMRGNNVMLGYYANPKATEDAFQGGWFHSGDLAVVHPDGYIEL
RDRMKDIVISGGENISSIEVEKTLADHPAVAEVAIVAVPDEKWGEVPKAYVGLKPGCSATAEELIAWCRDRMAHFKAPKL
VEFGPLPRTATGKIRKNQLRAQAKANS

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=534, Percent_Identity=29.0262172284644, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI187761345, Length=527, Percent_Identity=29.4117647058824, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI187761343, Length=527, Percent_Identity=29.4117647058824, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI42544132, Length=495, Percent_Identity=28.8888888888889, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI38505220, Length=491, Percent_Identity=28.3095723014257, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI122937307, Length=490, Percent_Identity=27.3469387755102, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI58082049, Length=497, Percent_Identity=27.364185110664, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI157311624, Length=497, Percent_Identity=26.7605633802817, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI157311622, Length=497, Percent_Identity=26.7605633802817, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI115511026, Length=494, Percent_Identity=25.3036437246964, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI13375727, Length=551, Percent_Identity=22.5045372050817, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI28416953, Length=123, Percent_Identity=29.2682926829268, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI145693145, Length=530, Percent_Identity=33.0188679245283, Blast_Score=222, Evalue=6e-59,
Organism=Escherichia coli, GI1788107, Length=550, Percent_Identity=28.7272727272727, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI221142682, Length=502, Percent_Identity=27.0916334661355, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1786810, Length=524, Percent_Identity=27.6717557251908, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1788595, Length=492, Percent_Identity=23.9837398373984, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786801, Length=443, Percent_Identity=27.765237020316, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1790505, Length=554, Percent_Identity=24.0072202166065, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1789201, Length=292, Percent_Identity=25.3424657534247, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71994690, Length=531, Percent_Identity=29.1902071563089, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71994694, Length=531, Percent_Identity=29.1902071563089, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71994703, Length=531, Percent_Identity=29.1902071563089, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17558820, Length=503, Percent_Identity=27.4353876739563, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI32563687, Length=493, Percent_Identity=27.1805273833671, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17559526, Length=543, Percent_Identity=24.4935543278085, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17538037, Length=534, Percent_Identity=23.9700374531835, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17560308, Length=366, Percent_Identity=28.4153005464481, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17557194, Length=548, Percent_Identity=22.6277372262774, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71996755, Length=525, Percent_Identity=22.8571428571429, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17560140, Length=521, Percent_Identity=22.6487523992322, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17531443, Length=530, Percent_Identity=21.6981132075472, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71985884, Length=385, Percent_Identity=25.974025974026, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71983001, Length=391, Percent_Identity=25.0639386189258, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982997, Length=391, Percent_Identity=25.0639386189258, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193204819, Length=160, Percent_Identity=30, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319699, Length=352, Percent_Identity=30.1136363636364, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323182, Length=546, Percent_Identity=25.8241758241758, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319264, Length=159, Percent_Identity=31.4465408805031, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24581924, Length=546, Percent_Identity=27.8388278388278, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI18859661, Length=550, Percent_Identity=26.9090909090909, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21355181, Length=536, Percent_Identity=23.5074626865672, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI19921316, Length=576, Percent_Identity=22.9166666666667, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24648260, Length=361, Percent_Identity=27.4238227146814, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281365686, Length=349, Percent_Identity=24.3553008595989, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17933690, Length=181, Percent_Identity=30.3867403314917, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21356441, Length=347, Percent_Identity=26.5129682997118, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI19922652, Length=350, Percent_Identity=25.1428571428571, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24648257, Length=215, Percent_Identity=29.3023255813954, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21356947, Length=384, Percent_Identity=24.7395833333333, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24653035, Length=486, Percent_Identity=22.8395061728395, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21358303, Length=190, Percent_Identity=27.8947368421053, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24648253, Length=209, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI20130357, Length=352, Percent_Identity=25, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648255, Length=209, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 54704; Mature: 54704

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAPLTPLDFLARSASTWRDRIAVVDGDRRFTYSGFAARVQGQAAALLALGVQPGDRVAV
CCCCCCHHHHHHHCCCCHHCEEEEEECCCEEEECCHHEEECCCEEEEEEEECCCCCEEEE
LAPNGAMALESHFAPMSIGAVLVMLNTRLAAGELAWILNHCGAKVLLVDPQLAPLVADAA
ECCCCCEEHHHCCCCHHHHHEEEEHHCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
VPHIIQDYEAFLSAAPPHYTPVPVTDENACIAINYTSGTTGFPKGVMYTHRGAWVNALGE
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCHHHHHHHH
ITEHGLTQRSVYLWTLPMFHCNGWCFPWAVTAAGGRHICIRQPDPCEMVALIQAQGVTHL
HHHCCCCCCEEEEEEEEHHHCCCEEECEEEECCCCCEEEECCCCCHHEEEEEHHCCCHHH
CGAPVVVSSLAQYCAANQVKFERPLRIVTAGAPPPPAVIRAAEETGAEICHAYGLTETYG
CCCHHHHHHHHHHHHCCCCEECCCEEEEECCCCCCHHHEEECHHHHHHHHHHHCCCCCCC
PHTICSWNPEWDERPAPERALLKARQGVAYTVAGTDLRVVDFQMHDVPPDGETMGEVLMR
CCEEECCCCCCCCCCCCHHHHHHHHCCCEEEEECCCEEEEEEEECCCCCCHHHHHHHHHC
GNNVMLGYYANPKATEDAFQGGWFHSGDLAVVHPDGYIELRDRMKDIVISGGENISSIEV
CCCEEEEEECCCCCCHHHHCCCCEECCCEEEECCCCCEEHHHHHHHEEEECCCCCCEEEE
EKTLADHPAVAEVAIVAVPDEKWGEVPKAYVGLKPGCSATAEELIAWCRDRMAHFKAPKL
HHHHCCCCCEEEEEEEECCCHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCE
VEFGPLPRTATGKIRKNQLRAQAKANS
EECCCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MIAPLTPLDFLARSASTWRDRIAVVDGDRRFTYSGFAARVQGQAAALLALGVQPGDRVAV
CCCCCCHHHHHHHCCCCHHCEEEEEECCCEEEECCHHEEECCCEEEEEEEECCCCCEEEE
LAPNGAMALESHFAPMSIGAVLVMLNTRLAAGELAWILNHCGAKVLLVDPQLAPLVADAA
ECCCCCEEHHHCCCCHHHHHEEEEHHCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
VPHIIQDYEAFLSAAPPHYTPVPVTDENACIAINYTSGTTGFPKGVMYTHRGAWVNALGE
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCHHHHHHHH
ITEHGLTQRSVYLWTLPMFHCNGWCFPWAVTAAGGRHICIRQPDPCEMVALIQAQGVTHL
HHHCCCCCCEEEEEEEEHHHCCCEEECEEEECCCCCEEEECCCCCHHEEEEEHHCCCHHH
CGAPVVVSSLAQYCAANQVKFERPLRIVTAGAPPPPAVIRAAEETGAEICHAYGLTETYG
CCCHHHHHHHHHHHHCCCCEECCCEEEEECCCCCCHHHEEECHHHHHHHHHHHCCCCCCC
PHTICSWNPEWDERPAPERALLKARQGVAYTVAGTDLRVVDFQMHDVPPDGETMGEVLMR
CCEEECCCCCCCCCCCCHHHHHHHHCCCEEEEECCCEEEEEEEECCCCCCHHHHHHHHHC
GNNVMLGYYANPKATEDAFQGGWFHSGDLAVVHPDGYIELRDRMKDIVISGGENISSIEV
CCCEEEEEECCCCCCHHHHCCCCEECCCEEEECCCCCEEHHHHHHHEEEECCCCCCEEEE
EKTLADHPAVAEVAIVAVPDEKWGEVPKAYVGLKPGCSATAEELIAWCRDRMAHFKAPKL
HHHHCCCCCEEEEEEEECCCHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCE
VEFGPLPRTATGKIRKNQLRAQAKANS
EECCCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA