Click here to switch to the map view.

The map label for this gene is icd [H]

Identifier: 116626390

GI number: 116626390

Start: 9226716

End: 9227720

Strand: Direct

Name: icd [H]

Synonym: Acid_7350

Alternate gene names: 116626390

Gene position: 9226716-9227720 (Clockwise)

Preceding gene: 116626387

Following gene: 116626397

Centisome position: 92.59

GC content: 63.88

Gene sequence:

>1005_bases
ATGGCCCACCAAATCACACTCATCCCAGGCGACGGAATCGGACCCGAAGTCGCCGACGCTACCGTTCGCGCTGTAGACGC
CACCGGCGCCAAAATCGAATGGGAGCGCGTCGATGCCGGCGCCCGCGCTCTCGCCGAACAGGGCCAACTGATCCCCGACG
ACGTCTTCGCCTCCCTCGAATGCACGCGCGTCGGACTCAAAGGTCCCACCGCAACTCCGATTGGCGGCGGGCACCAGAGC
ATCAACGTCGCACTCCGCAAGAAACTCGGGCTGTACACAAATTTCCGCCCGGTGCGCATGCTGCCTGGGCTCAAGACGCG
CTACCACGATCTCGCGCTCGATCTCGCCATTTTCCGCGAAAACACGGAGGACCTCTACTCCGGGCTGGAGCACGAGGTCG
TGCCCGGCGTGGTCGAGAGCCTGAAGATTATCACGCAGAATGCCTCGATGCGGATCGCGCGCGCCGCCTTCGAGTGGTCG
CGCCGCGAGAGCCGCAAGAAAGTGGTCGCCATCCACAAGGCCAACATCATGAAGTTGAGCGACGGCCTGTTCTTGAAGTG
CTGCCGCGAGGTCGCCTCGCATTTCCCCGACGTCGCCTATAGCGAAATGATCGTGGACAACGCCTGCATGCAGCTGGTGA
TGCGCCCGGAGACCTTCGACGTGCTGGTGCTGCCCAACCTCTATGGCGACATCATCAGCGACCTGACCGCGGGCCTGGTC
GGCGGTCTCGGCATTGTCCCCGGCGCCAATATCGGCGACAATCACGCCATCTTCGAAGCCGTCCACGGCACTGCTCCCGA
CATCGCCGGCAAGTGCATGGCGAACCCCACCGCGCTGATGCAGTCCGCCGTGCTCATGCTGGCCCACCTCGGCGAGCGCG
ATGCCTCCGCACGCCTCCACGCAGCTATCTATCAGACCTACGCAGAGCGCGATCACCTCACTGGGGATGTCGGCGGCAAA
TCCTCCACCACGGAATTCACCGAGGCCGTGATCCGCCGCTTGTGA

Upstream 100 bases:

>100_bases
GTCGCGGATGCCGCGCCGGCGAAGTTGCGTTTCCACCATCCGGCGGCGTTCTTCTGCCCAATCCGGTACCAACTCCACCC
CCAACTTTATAATAGCTATG

Downstream 100 bases:

>100_bases
GAGCGACGGCGAACACGGCGCCGCTCACCGCCGACTTCAATGAGAACCTCGTTCCTCAATCAGCTTAGCGTCCCCGCGTC
AGCCCGAGGGCGCGAATACG

Product: isocitrate dehydrogenase (NAD(+))

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MAHQITLIPGDGIGPEVADATVRAVDATGAKIEWERVDAGARALAEQGQLIPDDVFASLECTRVGLKGPTATPIGGGHQS
INVALRKKLGLYTNFRPVRMLPGLKTRYHDLALDLAIFRENTEDLYSGLEHEVVPGVVESLKIITQNASMRIARAAFEWS
RRESRKKVVAIHKANIMKLSDGLFLKCCREVASHFPDVAYSEMIVDNACMQLVMRPETFDVLVLPNLYGDIISDLTAGLV
GGLGIVPGANIGDNHAIFEAVHGTAPDIAGKCMANPTALMQSAVLMLAHLGERDASARLHAAIYQTYAERDHLTGDVGGK
SSTTEFTEAVIRRL

Sequences:

>Translated_334_residues
MAHQITLIPGDGIGPEVADATVRAVDATGAKIEWERVDAGARALAEQGQLIPDDVFASLECTRVGLKGPTATPIGGGHQS
INVALRKKLGLYTNFRPVRMLPGLKTRYHDLALDLAIFRENTEDLYSGLEHEVVPGVVESLKIITQNASMRIARAAFEWS
RRESRKKVVAIHKANIMKLSDGLFLKCCREVASHFPDVAYSEMIVDNACMQLVMRPETFDVLVLPNLYGDIISDLTAGLV
GGLGIVPGANIGDNHAIFEAVHGTAPDIAGKCMANPTALMQSAVLMLAHLGERDASARLHAAIYQTYAERDHLTGDVGGK
SSTTEFTEAVIRRL
>Mature_333_residues
AHQITLIPGDGIGPEVADATVRAVDATGAKIEWERVDAGARALAEQGQLIPDDVFASLECTRVGLKGPTATPIGGGHQSI
NVALRKKLGLYTNFRPVRMLPGLKTRYHDLALDLAIFRENTEDLYSGLEHEVVPGVVESLKIITQNASMRIARAAFEWSR
RESRKKVVAIHKANIMKLSDGLFLKCCREVASHFPDVAYSEMIVDNACMQLVMRPETFDVLVLPNLYGDIISDLTAGLVG
GLGIVPGANIGDNHAIFEAVHGTAPDIAGKCMANPTALMQSAVLMLAHLGERDASARLHAAIYQTYAERDHLTGDVGGKS
STTEFTEAVIRRL

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=333, Percent_Identity=51.9519519519519, Blast_Score=351, Evalue=4e-97,
Organism=Homo sapiens, GI4758582, Length=335, Percent_Identity=45.0746268656716, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI28178821, Length=335, Percent_Identity=44.1791044776119, Blast_Score=266, Evalue=1e-71,
Organism=Homo sapiens, GI28178816, Length=335, Percent_Identity=44.1791044776119, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI28178838, Length=304, Percent_Identity=46.7105263157895, Blast_Score=263, Evalue=1e-70,
Organism=Homo sapiens, GI28178819, Length=201, Percent_Identity=49.7512437810945, Blast_Score=194, Evalue=1e-49,
Organism=Escherichia coli, GI1787381, Length=345, Percent_Identity=35.3623188405797, Blast_Score=194, Evalue=5e-51,
Organism=Escherichia coli, GI1788101, Length=357, Percent_Identity=32.7731092436975, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI87081683, Length=356, Percent_Identity=33.7078651685393, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71986051, Length=332, Percent_Identity=49.6987951807229, Blast_Score=338, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI17550882, Length=336, Percent_Identity=42.8571428571429, Blast_Score=262, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI25144293, Length=336, Percent_Identity=41.3690476190476, Blast_Score=260, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI17505779, Length=334, Percent_Identity=41.9161676646707, Blast_Score=257, Evalue=6e-69,
Organism=Saccharomyces cerevisiae, GI6324709, Length=336, Percent_Identity=45.5357142857143, Blast_Score=308, Evalue=7e-85,
Organism=Saccharomyces cerevisiae, GI6324291, Length=333, Percent_Identity=46.2462462462462, Blast_Score=291, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6322097, Length=350, Percent_Identity=39.1428571428571, Blast_Score=219, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6319830, Length=356, Percent_Identity=28.3707865168539, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24643270, Length=331, Percent_Identity=50.1510574018127, Blast_Score=356, Evalue=1e-98,
Organism=Drosophila melanogaster, GI24643268, Length=331, Percent_Identity=50.1510574018127, Blast_Score=355, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24661184, Length=337, Percent_Identity=46.8842729970326, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI161078635, Length=334, Percent_Identity=41.3173652694611, Blast_Score=263, Evalue=9e-71,
Organism=Drosophila melanogaster, GI161078637, Length=334, Percent_Identity=41.3173652694611, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI161078633, Length=334, Percent_Identity=41.3173652694611, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24650122, Length=334, Percent_Identity=41.3173652694611, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI161078639, Length=330, Percent_Identity=41.2121212121212, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI281362242, Length=333, Percent_Identity=43.8438438438438, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24648872, Length=333, Percent_Identity=43.8438438438438, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI20130355, Length=328, Percent_Identity=33.5365853658537, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI45550436, Length=247, Percent_Identity=26.3157894736842, Blast_Score=95, Evalue=7e-20,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 36076; Mature: 35945

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHQITLIPGDGIGPEVADATVRAVDATGAKIEWERVDAGARALAEQGQLIPDDVFASLE
CCCEEEEECCCCCCCHHHHHHHEEEECCCCEEEHHHHCHHHHHHHHCCCCCCHHHHHHHH
CTRVGLKGPTATPIGGGHQSINVALRKKLGLYTNFRPVRMLPGLKTRYHDLALDLAIFRE
HEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHC
NTEDLYSGLEHEVVPGVVESLKIITQNASMRIARAAFEWSRRESRKKVVAIHKANIMKLS
CHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEC
DGLFLKCCREVASHFPDVAYSEMIVDNACMQLVMRPETFDVLVLPNLYGDIISDLTAGLV
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHH
GGLGIVPGANIGDNHAIFEAVHGTAPDIAGKCMANPTALMQSAVLMLAHLGERDASARLH
CCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHHHHHHCCCCCHHHHHH
AAIYQTYAERDHLTGDVGGKSSTTEFTEAVIRRL
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
AHQITLIPGDGIGPEVADATVRAVDATGAKIEWERVDAGARALAEQGQLIPDDVFASLE
CCEEEEECCCCCCCHHHHHHHEEEECCCCEEEHHHHCHHHHHHHHCCCCCCHHHHHHHH
CTRVGLKGPTATPIGGGHQSINVALRKKLGLYTNFRPVRMLPGLKTRYHDLALDLAIFRE
HEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHC
NTEDLYSGLEHEVVPGVVESLKIITQNASMRIARAAFEWSRRESRKKVVAIHKANIMKLS
CHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEC
DGLFLKCCREVASHFPDVAYSEMIVDNACMQLVMRPETFDVLVLPNLYGDIISDLTAGLV
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHH
GGLGIVPGANIGDNHAIFEAVHGTAPDIAGKCMANPTALMQSAVLMLAHLGERDASARLH
CCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHHHHHHCCCCCHHHHHH
AAIYQTYAERDHLTGDVGGKSSTTEFTEAVIRRL
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1539996 [H]