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The map label for this gene is ampH [H]

Identifier: 116626129

GI number: 116626129

Start: 8902917

End: 8904641

Strand: Direct

Name: ampH [H]

Synonym: Acid_7087

Alternate gene names: 116626129

Gene position: 8902917-8904641 (Clockwise)

Preceding gene: 116626128

Following gene: 116626141

Centisome position: 89.34

GC content: 61.68

Gene sequence:

>1725_bases
ATGAACCGAGCGCTGATTTTGTCGATGTTGGCGTGTAGTAGCGCATTGGCGCAAATGCCCCCGGACGTCGAAATTCGAAA
GATTCTGGCGGAACGGGTCGGGCCTGAGAACCTCGGCTCGACGATCGTAGTCGGGGTGATCGACGCGCAGGGGCGCAGGG
TAGTGGCCTATGGGAGCCTTGCGAAGAACGACGCGCGCAAGCCGGGAGGCGATACCGTCTTCGAGATCGGCTCGATGAGC
AAGGTGTTCACGTCCCTCCTGCTGATGGACATGTCGCGGAAGGGCGAGCTGGTCGTGAGCGATCCGGTGGCGAAGTTCCT
GCCGGAGACGGTAAAGGTGCCGGAGCGCGGCGGACGAAAGATTACGCTGGCTGATCTTTCAACGCAAAGCTCGGGGCTGC
CGCGGATGCCCACGAACTTTACTCCCAAAGATGCGGGGAATCCGTACGCCGATTATTCGGTACAGCAAATGTACGACTTC
ATTTCGGGGTATCAGCTGACGCGCGACATCGGGTCGCAATACGAGTACTCGAACCTGGGGGTCGGGCTGCTGGGCCATGC
GCTGGCGCGGCGCGCGGGGATGAGTTGGGAGGAACTGGTCCGTAAGCGCATCTGCGATCCGCTGGGGATGTCGAATACTC
GGGTGACGCTGACGCCGGAGATGAAGGCGCGGCTGGCAGTAGGGCACAGCGCCGGGCTGGCGGCGGTGCCCAATTGGGAC
ATCCCTACGCTGGCCGGCGCGGGCGCGCTGCGGTCAACCGCGAACGACATGCTGATCTTTCTGGCGGCGAATCTGGGGTA
TGCCAAGACTCCGCTGGCGCAGGCGATGGCCGACGAGATCGCGATCCGGCGTCCGGTAGGCGGAGATATGGAGATCGCCT
ACGGCTGGCACGTGCAGAACAAGGACGGCAACTCGATCATCTGGCACAACGGCGGGACGGGCGGGTATCGGACCTACATG
GGCTTCGATCCGAAGGCGCGGACGGGCGTGGTGGTGCTCTCCAATGTCTCCACGCCGGCGGGGCCGGACGATATCGGGCG
GCACCTGTTGAATGCGAGCTATCCGCTGACGAAGGTGGATGCGCCGGTGGAACACAAGGAAATCACGCTGGATGCGAAGG
CTCTGGACCGCTACGTGGGGACCTATCAGATGGACCGGTACGTCCTGATGAGCATGTCGCGCGATGGTCAGCGGATGTAT
ACGGAACTGACGGGACAACCGAAGTTCGAGGTCTTCCCGGAGAGCGAGCGTAAGTTCTTCCTGAAGGTGGTGGATGCGCA
GCTCATATTCGATGAAGATGCACAGCGGGTCACTCTTCACCAGAATGGCAACGATATCGCTGCCAGGCGATTGACTGAGG
TCGAGGCAAAGAGAGCGGCGGACGCTATAGAGGCGCACAAAGCCGACATCGCCAGCCGGTTTAAGGAGCAGAAGCAATCG
CCGGGTACGGAGGCGGCGGTGAGGCGGTCGGTGACGGAGCTACAGACGGGCGCGGCGAAATACGAACTGATGACGGATGC
GTTCGCGGCGGCGGCGCGGAAATCGTGGCCTCCCTTGAAGGCTGTGATGGCGCAGTTCGGCGGGCTGCAATCGGTCAAGT
TCACCGGTGTGGGGCCGGGCGGCGCGGATATTTACGAAGTGCAGTTCGAAAAGGCGAAGACGGAGTGGAGAATCATGTTG
GATGAGGACGGAAAGACAGCTCTATTGAATTTCCGGCCGCTGTAA

Upstream 100 bases:

>100_bases
CCGTTATGGTTTGGAACGCCGTACACTAGACTCCAACTGGCCGCGAGGTGTAAGAAAGATCCAGCAACCGAGACTATCTA
GTCGTTGGAAGGAGAGTGCG

Downstream 100 bases:

>100_bases
GCGCTAGAGCTTGCGGGCAGTGAGCACGGCGCCGGGGTCGTAGACGGTGAGAGTGTTCCCGCTGAAGGTGATGCGGACGG
CGCGGGAGCCGGCGGGGTGG

Product: beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MNRALILSMLACSSALAQMPPDVEIRKILAERVGPENLGSTIVVGVIDAQGRRVVAYGSLAKNDARKPGGDTVFEIGSMS
KVFTSLLLMDMSRKGELVVSDPVAKFLPETVKVPERGGRKITLADLSTQSSGLPRMPTNFTPKDAGNPYADYSVQQMYDF
ISGYQLTRDIGSQYEYSNLGVGLLGHALARRAGMSWEELVRKRICDPLGMSNTRVTLTPEMKARLAVGHSAGLAAVPNWD
IPTLAGAGALRSTANDMLIFLAANLGYAKTPLAQAMADEIAIRRPVGGDMEIAYGWHVQNKDGNSIIWHNGGTGGYRTYM
GFDPKARTGVVVLSNVSTPAGPDDIGRHLLNASYPLTKVDAPVEHKEITLDAKALDRYVGTYQMDRYVLMSMSRDGQRMY
TELTGQPKFEVFPESERKFFLKVVDAQLIFDEDAQRVTLHQNGNDIAARRLTEVEAKRAADAIEAHKADIASRFKEQKQS
PGTEAAVRRSVTELQTGAAKYELMTDAFAAAARKSWPPLKAVMAQFGGLQSVKFTGVGPGGADIYEVQFEKAKTEWRIML
DEDGKTALLNFRPL

Sequences:

>Translated_574_residues
MNRALILSMLACSSALAQMPPDVEIRKILAERVGPENLGSTIVVGVIDAQGRRVVAYGSLAKNDARKPGGDTVFEIGSMS
KVFTSLLLMDMSRKGELVVSDPVAKFLPETVKVPERGGRKITLADLSTQSSGLPRMPTNFTPKDAGNPYADYSVQQMYDF
ISGYQLTRDIGSQYEYSNLGVGLLGHALARRAGMSWEELVRKRICDPLGMSNTRVTLTPEMKARLAVGHSAGLAAVPNWD
IPTLAGAGALRSTANDMLIFLAANLGYAKTPLAQAMADEIAIRRPVGGDMEIAYGWHVQNKDGNSIIWHNGGTGGYRTYM
GFDPKARTGVVVLSNVSTPAGPDDIGRHLLNASYPLTKVDAPVEHKEITLDAKALDRYVGTYQMDRYVLMSMSRDGQRMY
TELTGQPKFEVFPESERKFFLKVVDAQLIFDEDAQRVTLHQNGNDIAARRLTEVEAKRAADAIEAHKADIASRFKEQKQS
PGTEAAVRRSVTELQTGAAKYELMTDAFAAAARKSWPPLKAVMAQFGGLQSVKFTGVGPGGADIYEVQFEKAKTEWRIML
DEDGKTALLNFRPL
>Mature_574_residues
MNRALILSMLACSSALAQMPPDVEIRKILAERVGPENLGSTIVVGVIDAQGRRVVAYGSLAKNDARKPGGDTVFEIGSMS
KVFTSLLLMDMSRKGELVVSDPVAKFLPETVKVPERGGRKITLADLSTQSSGLPRMPTNFTPKDAGNPYADYSVQQMYDF
ISGYQLTRDIGSQYEYSNLGVGLLGHALARRAGMSWEELVRKRICDPLGMSNTRVTLTPEMKARLAVGHSAGLAAVPNWD
IPTLAGAGALRSTANDMLIFLAANLGYAKTPLAQAMADEIAIRRPVGGDMEIAYGWHVQNKDGNSIIWHNGGTGGYRTYM
GFDPKARTGVVVLSNVSTPAGPDDIGRHLLNASYPLTKVDAPVEHKEITLDAKALDRYVGTYQMDRYVLMSMSRDGQRMY
TELTGQPKFEVFPESERKFFLKVVDAQLIFDEDAQRVTLHQNGNDIAARRLTEVEAKRAADAIEAHKADIASRFKEQKQS
PGTEAAVRRSVTELQTGAAKYELMTDAFAAAARKSWPPLKAVMAQFGGLQSVKFTGVGPGGADIYEVQFEKAKTEWRIML
DEDGKTALLNFRPL

Specific function: Binds penicillin and contributes to the normal morphology [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI239747261, Length=332, Percent_Identity=26.5060240963855, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI239752721, Length=332, Percent_Identity=26.5060240963855, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI239741085, Length=332, Percent_Identity=26.5060240963855, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1786574, Length=358, Percent_Identity=29.8882681564246, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1790593, Length=324, Percent_Identity=27.7777777777778, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: NA

Molecular weight: Translated: 62688; Mature: 62688

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS00336 BETA_LACTAMASE_C

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRALILSMLACSSALAQMPPDVEIRKILAERVGPENLGSTIVVGVIDAQGRRVVAYGSL
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEEECCH
AKNDARKPGGDTVFEIGSMSKVFTSLLLMDMSRKGELVVSDPVAKFLPETVKVPERGGRK
HCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCEEEECCHHHHCCHHHCCCCCCCCE
ITLADLSTQSSGLPRMPTNFTPKDAGNPYADYSVQQMYDFISGYQLTRDIGSQYEYSNLG
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VGLLGHALARRAGMSWEELVRKRICDPLGMSNTRVTLTPEMKARLAVGHSAGLAAVPNWD
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCC
IPTLAGAGALRSTANDMLIFLAANLGYAKTPLAQAMADEIAIRRPVGGDMEIAYGWHVQN
CCCCCCCCHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHEECCCCCCEEEEEEEEEEC
KDGNSIIWHNGGTGGYRTYMGFDPKARTGVVVLSNVSTPAGPDDIGRHLLNASYPLTKVD
CCCCEEEEECCCCCCEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEECC
APVEHKEITLDAKALDRYVGTYQMDRYVLMSMSRDGQRMYTELTGQPKFEVFPESERKFF
CCCCCCEEEEEHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHCCCCCEEECCCCHHEEE
LKVVDAQLIFDEDAQRVTLHQNGNDIAARRLTEVEAKRAADAIEAHKADIASRFKEQKQS
EEEECHHEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGTEAAVRRSVTELQTGAAKYELMTDAFAAAARKSWPPLKAVMAQFGGLQSVKFTGVGPG
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCC
GADIYEVQFEKAKTEWRIMLDEDGKTALLNFRPL
CCCEEEEEEECCCCEEEEEEECCCCEEEEEECCC
>Mature Secondary Structure
MNRALILSMLACSSALAQMPPDVEIRKILAERVGPENLGSTIVVGVIDAQGRRVVAYGSL
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEEECCH
AKNDARKPGGDTVFEIGSMSKVFTSLLLMDMSRKGELVVSDPVAKFLPETVKVPERGGRK
HCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCEEEECCHHHHCCHHHCCCCCCCCE
ITLADLSTQSSGLPRMPTNFTPKDAGNPYADYSVQQMYDFISGYQLTRDIGSQYEYSNLG
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VGLLGHALARRAGMSWEELVRKRICDPLGMSNTRVTLTPEMKARLAVGHSAGLAAVPNWD
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCC
IPTLAGAGALRSTANDMLIFLAANLGYAKTPLAQAMADEIAIRRPVGGDMEIAYGWHVQN
CCCCCCCCHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHEECCCCCCEEEEEEEEEEC
KDGNSIIWHNGGTGGYRTYMGFDPKARTGVVVLSNVSTPAGPDDIGRHLLNASYPLTKVD
CCCCEEEEECCCCCCEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEECC
APVEHKEITLDAKALDRYVGTYQMDRYVLMSMSRDGQRMYTELTGQPKFEVFPESERKFF
CCCCCCEEEEEHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHCCCCCEEECCCCHHEEE
LKVVDAQLIFDEDAQRVTLHQNGNDIAARRLTEVEAKRAADAIEAHKADIASRFKEQKQS
EEEECHHEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGTEAAVRRSVTELQTGAAKYELMTDAFAAAARKSWPPLKAVMAQFGGLQSVKFTGVGPG
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCC
GADIYEVQFEKAKTEWRIMLDEDGKTALLNFRPL
CCCEEEEEEECCCCEEEEEEECCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]