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The map label for this gene is mntH [H]

Identifier: 116626128

GI number: 116626128

Start: 8901631

End: 8902845

Strand: Direct

Name: mntH [H]

Synonym: Acid_7086

Alternate gene names: 116626128

Gene position: 8901631-8902845 (Clockwise)

Preceding gene: 116626127

Following gene: 116626129

Centisome position: 89.32

GC content: 60.74

Gene sequence:

>1215_bases
TTGCGGCTCTCCGCGGTCTTTGCGGTCCTCGGTCCCGGCTTCATCACTGCCAACGTTGATAACGATCCGGGCGGCATCCT
CACCTATTCCCAGGCCGGCGCCAAGTTCGGCTACACGCTCCTGTGGACCCTCATCCCCACCACCATCGCCCTCATCGTGG
TTCAGGAAATGGCCGCCCGCATGGGCGCCGTCACTGGCAAAGGCCTATCGGATCTCATCCGCGAAGAGTTCGGCTTGCGC
ATCACCTTCTTCACCATGGTCGTCCTCGGCCTCGCAGACCTCGGCAATATCGCCGCCGAGTTCGCGGGCATCGCCAGCGG
CATGGGAATTTTCGGCCTCTCCAAATATCTCACCGTCCCGATCGGTGCCGCTGTCGTCTGGTTCGTTATTGTACGCGGAT
CCTATAAGCCCGTCGAGCGCATCTTCATCATCCTGTCGCTGATCTACTTCACCTATCCGATCTCCGCCATCCTCGCCCAT
CCCGACTGGACCACCGCCATCCGCCAGACGTTCATCCCCGAATGGAATTCCAGCCCGGATTACATCGTGATGATCGTCGG
CCTCATCGGTACCACCGTCACCCCGTGGATGCAGTTCTACCTGCAGGCCTCCATCGTGGAAAAGGGCATCACGGAAAAGC
ACTATTCCATCACGCGGTGGGATGTCATCATCGGCTGCATTGTCACCGACGTCATTGCCTTCTTCATCGTGGTCGCCTGC
GCCGCGACGCTTTTTAAGGCCGGCCACCACGAACTCAACGATGCCTCGGAAGCCGCCCAGGCGCTCGTGCCCTTCGCCGG
CCGCTTCGCGGGGCTACTCTTCGCCGTCGGCCTGGTCAACGCCTCCATGCTCTCCGCCGCCATCCTCCCCCTCGCCACCG
CCTACAACGTCTGCGAAGGGCTCGGCTTCGAATCCGGCATCGATCGCCGCTTCGGGGAAGCGCCCATCTTTTACGGCCTC
TATACCTTTCTGATCGTGGTCGGCGCCGGCTGCGTTCTCATCCCCGGTCTCCCCCTGCTGAAGCTGATTCTCTTCTCCCA
GGTGGCCAATGGCGTCCTGATCCCGTTCGTCCTGATCTTTATGCTGATCCTGATCAACAAACGCGGACTCATGGGCGATT
GGCGCAACGGAATGTGGGCCAATCTCATTGCCGGCGCCACCAGCGTGATCATGATCTGTCTCACCGCCGTTATGGTTTGG
AACGCCGTACACTAG

Upstream 100 bases:

>100_bases
CCAGCACTCCCAGCCAATCGGGAGCAATTCGCTGCCAACCGGACACGAGATCGCCAAAAGACCGCACCGCCCCCGCAAAC
TCGGTTTCGGCCTCATCTTT

Downstream 100 bases:

>100_bases
ACTCCAACTGGCCGCGAGGTGTAAGAAAGATCCAGCAACCGAGACTATCTAGTCGTTGGAAGGAGAGTGCGATGAACCGA
GCGCTGATTTTGTCGATGTT

Product: natural resistance-associated macrophage protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MRLSAVFAVLGPGFITANVDNDPGGILTYSQAGAKFGYTLLWTLIPTTIALIVVQEMAARMGAVTGKGLSDLIREEFGLR
ITFFTMVVLGLADLGNIAAEFAGIASGMGIFGLSKYLTVPIGAAVVWFVIVRGSYKPVERIFIILSLIYFTYPISAILAH
PDWTTAIRQTFIPEWNSSPDYIVMIVGLIGTTVTPWMQFYLQASIVEKGITEKHYSITRWDVIIGCIVTDVIAFFIVVAC
AATLFKAGHHELNDASEAAQALVPFAGRFAGLLFAVGLVNASMLSAAILPLATAYNVCEGLGFESGIDRRFGEAPIFYGL
YTFLIVVGAGCVLIPGLPLLKLILFSQVANGVLIPFVLIFMLILINKRGLMGDWRNGMWANLIAGATSVIMICLTAVMVW
NAVH

Sequences:

>Translated_404_residues
MRLSAVFAVLGPGFITANVDNDPGGILTYSQAGAKFGYTLLWTLIPTTIALIVVQEMAARMGAVTGKGLSDLIREEFGLR
ITFFTMVVLGLADLGNIAAEFAGIASGMGIFGLSKYLTVPIGAAVVWFVIVRGSYKPVERIFIILSLIYFTYPISAILAH
PDWTTAIRQTFIPEWNSSPDYIVMIVGLIGTTVTPWMQFYLQASIVEKGITEKHYSITRWDVIIGCIVTDVIAFFIVVAC
AATLFKAGHHELNDASEAAQALVPFAGRFAGLLFAVGLVNASMLSAAILPLATAYNVCEGLGFESGIDRRFGEAPIFYGL
YTFLIVVGAGCVLIPGLPLLKLILFSQVANGVLIPFVLIFMLILINKRGLMGDWRNGMWANLIAGATSVIMICLTAVMVW
NAVH
>Mature_404_residues
MRLSAVFAVLGPGFITANVDNDPGGILTYSQAGAKFGYTLLWTLIPTTIALIVVQEMAARMGAVTGKGLSDLIREEFGLR
ITFFTMVVLGLADLGNIAAEFAGIASGMGIFGLSKYLTVPIGAAVVWFVIVRGSYKPVERIFIILSLIYFTYPISAILAH
PDWTTAIRQTFIPEWNSSPDYIVMIVGLIGTTVTPWMQFYLQASIVEKGITEKHYSITRWDVIIGCIVTDVIAFFIVVAC
AATLFKAGHHELNDASEAAQALVPFAGRFAGLLFAVGLVNASMLSAAILPLATAYNVCEGLGFESGIDRRFGEAPIFYGL
YTFLIVVGAGCVLIPGLPLLKLILFSQVANGVLIPFVLIFMLILINKRGLMGDWRNGMWANLIAGATSVIMICLTAVMVW
NAVH

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=272, Percent_Identity=23.8970588235294, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788736, Length=410, Percent_Identity=27.3170731707317, Blast_Score=115, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24648607, Length=290, Percent_Identity=22.0689655172414, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281362176, Length=290, Percent_Identity=22.0689655172414, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24648609, Length=290, Percent_Identity=22.0689655172414, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45553443, Length=290, Percent_Identity=22.0689655172414, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 43592; Mature: 43592

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]