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The map label for this gene is etfA [H]

Identifier: 116624775

GI number: 116624775

Start: 7138895

End: 7139872

Strand: Direct

Name: etfA [H]

Synonym: Acid_5699

Alternate gene names: 116624775

Gene position: 7138895-7139872 (Clockwise)

Preceding gene: 116624774

Following gene: 116624776

Centisome position: 71.64

GC content: 63.8

Gene sequence:

>978_bases
ATGAAAGGCGTGCTCGTCATTCTGGAATATCGCGGCGCCTGGAACCGGATGTCGTGGGAAGCCCTCGCCGCAGGGCGCGG
AATCGCCGCCCAGCTCCACCAACCACTGTTCGCTGCCGTCGCCGGAGCGCAGCTCGAAACCGCCTCCGCCGATCTCGCCG
CCCTTCCGCTGGCCCGTGCCTATGCGGTCCGGCATCCCCTACTGCAGGAATACACGGCCGACGGATTTATCCCCGCCTTC
GAACAGCTCATTCACTCGCTCAACCCTTTGCTGGTCCTCTTCCCCCACACCTATCAGGTGCGCGACTTCGCCCCGGGCCT
CGCCGCCCGGTTCGGCCAGACCCTGATCGCCGATGTCGTGGCCATCGCGACCGGTACCGGCCATCCCGTCTTCGTTCGCC
AACTCCTCCAAGGCAAACTGAATGCCGACTATGTCCAAACCGGCACGGGTGTCTGCTTCGCCTCGCTTCAGGCCGGCGCC
TTCCGCGCGGACTTGCCCGAAGGCGCCTGCACGGTCGAGGAGTTCGTGCCGCAGCTTGTGTCTTCCCAGATCCGCAGCCA
GCCTGGCGAACGCTTCCGCGAATCCGCGCAGACCGTGGATCTCTCCGCCGCGAGCCTGATCGTCTCCGTCGGCCGCGGCA
TCAAAGAACAGGACAACATCCCCATTGTTCAGGAACTCGCGGATACGCTGGGCGCCGAGCTTGCCGCCTCCCGCCCCATT
TGCGATAGCGGCTGGCTCCCCATGGAGCGCCAGGTTGGAAGCTCCGGGCAAACCGTCTCGCCCAAGGTCTACATCGCCGT
AGGTATCTCCGGCGCCATCCAGCACCTGGTCGGGATGAAAGGCTCCAAGTCGATCATCGCGATCAACAAAGATGAGAACG
CGCCAATTTTCGAAGTCGCCGACTACGGTATTGTCGGTGACCTCTTCGAAGTAGTTCCGGCCCTCACGGCCGCCGTCAGA
AAGGTAAAGAACGCCTGA

Upstream 100 bases:

>100_bases
ACCTCCCCCAACGTAAGAAGGAAACACAGATCCTCGCCGGCACTCCGGCGGAATCCGCAGCCAAGCTGGCCGACGTCCTG
AAATTCGAAGTGAGGGTCAT

Downstream 100 bases:

>100_bases
TGGAGCAACTATGCCAGCCAATCTCTCGCCCGAAGATTTACCGCTTCAACGAATCTACAGATGGGAGCTCGAGCGCGCCA
ACGTGCCCTTCCTCACTCAA

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MKGVLVILEYRGAWNRMSWEALAAGRGIAAQLHQPLFAAVAGAQLETASADLAALPLARAYAVRHPLLQEYTADGFIPAF
EQLIHSLNPLLVLFPHTYQVRDFAPGLAARFGQTLIADVVAIATGTGHPVFVRQLLQGKLNADYVQTGTGVCFASLQAGA
FRADLPEGACTVEEFVPQLVSSQIRSQPGERFRESAQTVDLSAASLIVSVGRGIKEQDNIPIVQELADTLGAELAASRPI
CDSGWLPMERQVGSSGQTVSPKVYIAVGISGAIQHLVGMKGSKSIIAINKDENAPIFEVADYGIVGDLFEVVPALTAAVR
KVKNA

Sequences:

>Translated_325_residues
MKGVLVILEYRGAWNRMSWEALAAGRGIAAQLHQPLFAAVAGAQLETASADLAALPLARAYAVRHPLLQEYTADGFIPAF
EQLIHSLNPLLVLFPHTYQVRDFAPGLAARFGQTLIADVVAIATGTGHPVFVRQLLQGKLNADYVQTGTGVCFASLQAGA
FRADLPEGACTVEEFVPQLVSSQIRSQPGERFRESAQTVDLSAASLIVSVGRGIKEQDNIPIVQELADTLGAELAASRPI
CDSGWLPMERQVGSSGQTVSPKVYIAVGISGAIQHLVGMKGSKSIIAINKDENAPIFEVADYGIVGDLFEVVPALTAAVR
KVKNA
>Mature_325_residues
MKGVLVILEYRGAWNRMSWEALAAGRGIAAQLHQPLFAAVAGAQLETASADLAALPLARAYAVRHPLLQEYTADGFIPAF
EQLIHSLNPLLVLFPHTYQVRDFAPGLAARFGQTLIADVVAIATGTGHPVFVRQLLQGKLNADYVQTGTGVCFASLQAGA
FRADLPEGACTVEEFVPQLVSSQIRSQPGERFRESAQTVDLSAASLIVSVGRGIKEQDNIPIVQELADTLGAELAASRPI
CDSGWLPMERQVGSSGQTVSPKVYIAVGISGAIQHLVGMKGSKSIIAINKDENAPIFEVADYGIVGDLFEVVPALTAAVR
KVKNA

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=294, Percent_Identity=35.0340136054422, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI189181759, Length=299, Percent_Identity=35.7859531772575, Blast_Score=154, Evalue=8e-38,
Organism=Escherichia coli, GI1786226, Length=237, Percent_Identity=39.2405063291139, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1787990, Length=256, Percent_Identity=34.375, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI87082157, Length=276, Percent_Identity=30.4347826086957, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17506929, Length=219, Percent_Identity=39.7260273972603, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6325261, Length=125, Percent_Identity=46.4, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17136898, Length=340, Percent_Identity=33.5294117647059, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24652801, Length=340, Percent_Identity=33.5294117647059, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 34524; Mature: 34524

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGVLVILEYRGAWNRMSWEALAAGRGIAAQLHQPLFAAVAGAQLETASADLAALPLARA
CCCEEEEEEECCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHH
YAVRHPLLQEYTADGFIPAFEQLIHSLNPLLVLFPHTYQVRDFAPGLAARFGQTLIADVV
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCEEHHHCCCHHHHHHHHHHHHHHH
AIATGTGHPVFVRQLLQGKLNADYVQTGTGVCFASLQAGAFRADLPEGACTVEEFVPQLV
HHHCCCCCHHHHHHHHHCCCCCCCEECCCCCEEEHHHCCCCCCCCCCCCCCHHHHHHHHH
SSQIRSQPGERFRESAQTVDLSAASLIVSVGRGIKEQDNIPIVQELADTLGAELAASRPI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
CDSGWLPMERQVGSSGQTVSPKVYIAVGISGAIQHLVGMKGSKSIIAINKDENAPIFEVA
CCCCCCCHHHHCCCCCCEECCEEEEEECCHHHHHHHHCCCCCCCEEEEECCCCCCEEEEC
DYGIVGDLFEVVPALTAAVRKVKNA
CCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKGVLVILEYRGAWNRMSWEALAAGRGIAAQLHQPLFAAVAGAQLETASADLAALPLARA
CCCEEEEEEECCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHH
YAVRHPLLQEYTADGFIPAFEQLIHSLNPLLVLFPHTYQVRDFAPGLAARFGQTLIADVV
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCEEHHHCCCHHHHHHHHHHHHHHH
AIATGTGHPVFVRQLLQGKLNADYVQTGTGVCFASLQAGAFRADLPEGACTVEEFVPQLV
HHHCCCCCHHHHHHHHHCCCCCCCEECCCCCEEEHHHCCCCCCCCCCCCCCHHHHHHHHH
SSQIRSQPGERFRESAQTVDLSAASLIVSVGRGIKEQDNIPIVQELADTLGAELAASRPI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
CDSGWLPMERQVGSSGQTVSPKVYIAVGISGAIQHLVGMKGSKSIIAINKDENAPIFEVA
CCCCCCCHHHHCCCCCCEECCEEEEEECCHHHHHHHHCCCCCCCEEEEECCCCCCEEEEC
DYGIVGDLFEVVPALTAAVRKVKNA
CCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]