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The map label for this gene is fadD [C]

Identifier: 116624776

GI number: 116624776

Start: 7139883

End: 7141547

Strand: Direct

Name: fadD [C]

Synonym: Acid_5700

Alternate gene names: 116624776

Gene position: 7139883-7141547 (Clockwise)

Preceding gene: 116624775

Following gene: 116624778

Centisome position: 71.65

GC content: 63.6

Gene sequence:

>1665_bases
ATGCCAGCCAATCTCTCGCCCGAAGATTTACCGCTTCAACGAATCTACAGATGGGAGCTCGAGCGCGCCAACGTGCCCTT
CCTCACTCAACCCTGGGGCGGCGGCCAAGTGCGCGATTGGACCTGGGGTCAGGCGGTGGATGAAATTCGCCGCATTGCAA
CCTGGTTGAAATCCCAGGATTGGGAACCCGGCAGCCGCATCGCCATCCTCTCCCGAAATTGCGCCTGGTGGATCATGGCC
GACCTCGCCATCTGGATGGCCGGCCACGTCACCGTCCCCATCTACCCCTCGCTCAAAGCCCAGTCGATCCGCCAGATTCT
GGAACACTGCGGCGCCCGAGCCTGCTTCCTCGGCGCCACCGATGAGCGCGAGGCCACCGACGCCGGCATTCCCCCAGGCG
TCTGCTGCGTCCGTTTCCCCACCGCGGCGCCGAATGACTGGCCCTCCTGGGACGTCCTGGTCACCGCCAATCGTCCGCTT
TCCGGCCGCCCCACGCGTGCCCCCGAAGAGCTCTCCACCATCATCTACACTTCCGGCACCACCGGCACTCCGAAGGGCGT
CATGCACTCCTTCGCAAGCTTCGCCTTCGATGCCAAGGTGCTTGCCGAGTTGATCAAACTCACGCCTAACGAGCGCGTGC
TCTCCTATCTGCCGCTGGCTCACATCGTGGAGCGCGCCGGCATGGAAGGCACCGCGGTCTGGCTCGGCTACCGCGTCTTC
TTCACCGAAGGCATCGATACCTTCGTCGCCGACCTGGCCCGCGCCCGCCCCACGATTTTTCTCTCGGTGCCGCGCCTGCT
CCTTAAATTCCAGCAGGGCGTCTTCGCCAAAATCCCGGAGCACAAGCTGGAGCGCCTGCTCCGCATCCCTATCCTGAATC
GCACCGTCCGCAAGCGCGTCTTACAAAAGCTCGGCCTCGACACCGTGGTGAATGCGGCCTGCGGCGCTGCCCCGCTGCCC
ACCGATATCCTGCTCTGGTATCGGAAGCTCGGCCTCAACCTCGCCGAGGGTTATGGCATGACCGAGACGCTTATCACCCA
CCTGCCTGCCCCCGGCTCCATCCGTCCCGGCTACGTCGGCTGCGCGATCCCCGGCGTCGATGCCAAGGTCACTGAGACCG
ATGAGCTCCTGCTCCGCAGCCCCATGAACATGCTCGGCTACTACCGCGATCCTGAAGCCACCAAGGCATCTTTCACCGAT
GACGGTTTCTTCCGCACCGGCGATCTCGCCCGCATCGATCCCGATGGCCAGCTCAAAATTATCGGCCGCGTCAAAGAGCA
ATTCAAAACCAGCAAGGGTAAATACGTGATGCCCACACCCATCGAGAGCCAGTTGCTCGCCCACCCCGTGGTCGATGCCT
GTTGCCTGATGGGAGCCGGCATGCCGCGCCCCTTCGCCGTAGTGCTCCTGGCCAACGCCCCCGCCGAACGCGCCGTGGTC
GAACAAACCCTGCTCGACCTCATGAACACCGTCAACACTCAGCTGGACCCGCACGAGCAGCTCAGCTTCGTCGCCGTTGC
CAAGGGCCCGTGGACCGTGGGCAACGGCTTCGTCACGCCCACTCTCAAGATCAAGCGCAATGTCCTGGAAAGCCGCTACC
AACCCTGCGTAGACGAGTGGATGCGCCAGAATCGCCCCATAGTCTGGGAATCGCCGCCAGTCTGA

Upstream 100 bases:

>100_bases
TTCGAAGTCGCCGACTACGGTATTGTCGGTGACCTCTTCGAAGTAGTTCCGGCCCTCACGGCCGCCGTCAGAAAGGTAAA
GAACGCCTGATGGAGCAACT

Downstream 100 bases:

>100_bases
TACCTCCGCCGCCAACGAGCGCAACGAGCCCTCGCCCAAGTGCGTCGCCCTCAATCAGAGCCGCGACCGTGAGGGAGCGT
CCGTTGCTGCTACGGCGTCA

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MPANLSPEDLPLQRIYRWELERANVPFLTQPWGGGQVRDWTWGQAVDEIRRIATWLKSQDWEPGSRIAILSRNCAWWIMA
DLAIWMAGHVTVPIYPSLKAQSIRQILEHCGARACFLGATDEREATDAGIPPGVCCVRFPTAAPNDWPSWDVLVTANRPL
SGRPTRAPEELSTIIYTSGTTGTPKGVMHSFASFAFDAKVLAELIKLTPNERVLSYLPLAHIVERAGMEGTAVWLGYRVF
FTEGIDTFVADLARARPTIFLSVPRLLLKFQQGVFAKIPEHKLERLLRIPILNRTVRKRVLQKLGLDTVVNAACGAAPLP
TDILLWYRKLGLNLAEGYGMTETLITHLPAPGSIRPGYVGCAIPGVDAKVTETDELLLRSPMNMLGYYRDPEATKASFTD
DGFFRTGDLARIDPDGQLKIIGRVKEQFKTSKGKYVMPTPIESQLLAHPVVDACCLMGAGMPRPFAVVLLANAPAERAVV
EQTLLDLMNTVNTQLDPHEQLSFVAVAKGPWTVGNGFVTPTLKIKRNVLESRYQPCVDEWMRQNRPIVWESPPV

Sequences:

>Translated_554_residues
MPANLSPEDLPLQRIYRWELERANVPFLTQPWGGGQVRDWTWGQAVDEIRRIATWLKSQDWEPGSRIAILSRNCAWWIMA
DLAIWMAGHVTVPIYPSLKAQSIRQILEHCGARACFLGATDEREATDAGIPPGVCCVRFPTAAPNDWPSWDVLVTANRPL
SGRPTRAPEELSTIIYTSGTTGTPKGVMHSFASFAFDAKVLAELIKLTPNERVLSYLPLAHIVERAGMEGTAVWLGYRVF
FTEGIDTFVADLARARPTIFLSVPRLLLKFQQGVFAKIPEHKLERLLRIPILNRTVRKRVLQKLGLDTVVNAACGAAPLP
TDILLWYRKLGLNLAEGYGMTETLITHLPAPGSIRPGYVGCAIPGVDAKVTETDELLLRSPMNMLGYYRDPEATKASFTD
DGFFRTGDLARIDPDGQLKIIGRVKEQFKTSKGKYVMPTPIESQLLAHPVVDACCLMGAGMPRPFAVVLLANAPAERAVV
EQTLLDLMNTVNTQLDPHEQLSFVAVAKGPWTVGNGFVTPTLKIKRNVLESRYQPCVDEWMRQNRPIVWESPPV
>Mature_553_residues
PANLSPEDLPLQRIYRWELERANVPFLTQPWGGGQVRDWTWGQAVDEIRRIATWLKSQDWEPGSRIAILSRNCAWWIMAD
LAIWMAGHVTVPIYPSLKAQSIRQILEHCGARACFLGATDEREATDAGIPPGVCCVRFPTAAPNDWPSWDVLVTANRPLS
GRPTRAPEELSTIIYTSGTTGTPKGVMHSFASFAFDAKVLAELIKLTPNERVLSYLPLAHIVERAGMEGTAVWLGYRVFF
TEGIDTFVADLARARPTIFLSVPRLLLKFQQGVFAKIPEHKLERLLRIPILNRTVRKRVLQKLGLDTVVNAACGAAPLPT
DILLWYRKLGLNLAEGYGMTETLITHLPAPGSIRPGYVGCAIPGVDAKVTETDELLLRSPMNMLGYYRDPEATKASFTDD
GFFRTGDLARIDPDGQLKIIGRVKEQFKTSKGKYVMPTPIESQLLAHPVVDACCLMGAGMPRPFAVVLLANAPAERAVVE
QTLLDLMNTVNTQLDPHEQLSFVAVAKGPWTVGNGFVTPTLKIKRNVLESRYQPCVDEWMRQNRPIVWESPPV

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42794756, Length=571, Percent_Identity=26.0945709281961, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI42794760, Length=571, Percent_Identity=26.0945709281961, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI42794758, Length=571, Percent_Identity=26.0945709281961, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI40807491, Length=553, Percent_Identity=27.124773960217, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI57165412, Length=546, Percent_Identity=27.6556776556777, Blast_Score=159, Evalue=9e-39,
Organism=Homo sapiens, GI57165410, Length=546, Percent_Identity=27.8388278388278, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI83745141, Length=626, Percent_Identity=22.3642172523962, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI27477105, Length=583, Percent_Identity=23.156089193825, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI42794754, Length=566, Percent_Identity=23.6749116607774, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI42794752, Length=566, Percent_Identity=23.6749116607774, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI12669909, Length=583, Percent_Identity=22.8130360205832, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4758332, Length=583, Percent_Identity=22.8130360205832, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI187761345, Length=444, Percent_Identity=25.4504504504505, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI187761343, Length=444, Percent_Identity=25.4504504504505, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI157311624, Length=408, Percent_Identity=24.7549019607843, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI157311622, Length=408, Percent_Identity=24.7549019607843, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI58082049, Length=410, Percent_Identity=24.390243902439, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI42544132, Length=491, Percent_Identity=23.2179226069246, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI156151445, Length=470, Percent_Identity=22.1276595744681, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI38505220, Length=530, Percent_Identity=23.3962264150943, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI115511026, Length=454, Percent_Identity=23.1277533039648, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI42544134, Length=367, Percent_Identity=24.7956403269755, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788107, Length=489, Percent_Identity=23.3128834355828, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI145693145, Length=433, Percent_Identity=24.2494226327945, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1786810, Length=328, Percent_Identity=27.4390243902439, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1789201, Length=304, Percent_Identity=27.6315789473684, Blast_Score=83, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17541856, Length=581, Percent_Identity=27.1944922547332, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17510401, Length=557, Percent_Identity=28.1867145421903, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17556552, Length=555, Percent_Identity=26.8468468468468, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25147511, Length=611, Percent_Identity=24.2225859247136, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI193204819, Length=605, Percent_Identity=24.297520661157, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17553312, Length=608, Percent_Identity=24.3421052631579, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17564090, Length=597, Percent_Identity=24.4556113902848, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17531443, Length=529, Percent_Identity=25.5198487712665, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17558820, Length=325, Percent_Identity=30.1538461538462, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17559526, Length=398, Percent_Identity=29.3969849246231, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI32563687, Length=323, Percent_Identity=25.3869969040248, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17557194, Length=450, Percent_Identity=26.4444444444444, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320852, Length=570, Percent_Identity=24.9122807017544, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323903, Length=437, Percent_Identity=27.9176201372998, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6322182, Length=436, Percent_Identity=27.7522935779816, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324893, Length=438, Percent_Identity=26.9406392694064, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319699, Length=428, Percent_Identity=24.0654205607477, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24666501, Length=550, Percent_Identity=27.8181818181818, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24666497, Length=550, Percent_Identity=27.8181818181818, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI281366413, Length=550, Percent_Identity=27.8181818181818, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI17933690, Length=600, Percent_Identity=23, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI19921316, Length=497, Percent_Identity=26.9617706237425, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI62471689, Length=592, Percent_Identity=24.3243243243243, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI62471679, Length=592, Percent_Identity=24.3243243243243, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI62471683, Length=592, Percent_Identity=24.3243243243243, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI62471685, Length=592, Percent_Identity=24.3243243243243, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24586636, Length=592, Percent_Identity=24.3243243243243, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI62471681, Length=592, Percent_Identity=24.3243243243243, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI62471687, Length=592, Percent_Identity=24.3243243243243, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24586634, Length=592, Percent_Identity=24.3243243243243, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI22026970, Length=592, Percent_Identity=24.3243243243243, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI18859661, Length=495, Percent_Identity=25.2525252525253, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21356947, Length=441, Percent_Identity=24.4897959183673, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355181, Length=361, Percent_Identity=26.8698060941828, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24648260, Length=346, Percent_Identity=26.5895953757225, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 61580; Mature: 61449

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPANLSPEDLPLQRIYRWELERANVPFLTQPWGGGQVRDWTWGQAVDEIRRIATWLKSQD
CCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
WEPGSRIAILSRNCAWWIMADLAIWMAGHVTVPIYPSLKAQSIRQILEHCGARACFLGAT
CCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHCCCCEEEECCC
DEREATDAGIPPGVCCVRFPTAAPNDWPSWDVLVTANRPLSGRPTRAPEELSTIIYTSGT
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHCEEEEECCC
TGTPKGVMHSFASFAFDAKVLAELIKLTPNERVLSYLPLAHIVERAGMEGTAVWLGYRVF
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEE
FTEGIDTFVADLARARPTIFLSVPRLLLKFQQGVFAKIPEHKLERLLRIPILNRTVRKRV
ECCCHHHHHHHHHHCCCEEEEHHHHHHHHHHCCHHHCCCHHHHHHHHHCHHHHHHHHHHH
LQKLGLDTVVNAACGAAPLPTDILLWYRKLGLNLAEGYGMTETLITHLPAPGSIRPGYVG
HHHHCHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHCCCCHHHHHHHHCCCCCCCCCCEEE
CAIPGVDAKVTETDELLLRSPMNMLGYYRDPEATKASFTDDGFFRTGDLARIDPDGQLKI
EECCCCCCCCCCHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCEECCCEEEECCCCCEEE
IGRVKEQFKTSKGKYVMPTPIESQLLAHPVVDACCLMGAGMPRPFAVVLLANAPAERAVV
HHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHH
EQTLLDLMNTVNTQLDPHEQLSFVAVAKGPWTVGNGFVTPTLKIKRNVLESRYQPCVDEW
HHHHHHHHHHHCCCCCHHHCEEEEEEECCCEECCCCEECCHHHHHHHHHHHHCCHHHHHH
MRQNRPIVWESPPV
HHCCCCEEECCCCC
>Mature Secondary Structure 
PANLSPEDLPLQRIYRWELERANVPFLTQPWGGGQVRDWTWGQAVDEIRRIATWLKSQD
CCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
WEPGSRIAILSRNCAWWIMADLAIWMAGHVTVPIYPSLKAQSIRQILEHCGARACFLGAT
CCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHCCCCEEEECCC
DEREATDAGIPPGVCCVRFPTAAPNDWPSWDVLVTANRPLSGRPTRAPEELSTIIYTSGT
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHCEEEEECCC
TGTPKGVMHSFASFAFDAKVLAELIKLTPNERVLSYLPLAHIVERAGMEGTAVWLGYRVF
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEE
FTEGIDTFVADLARARPTIFLSVPRLLLKFQQGVFAKIPEHKLERLLRIPILNRTVRKRV
ECCCHHHHHHHHHHCCCEEEEHHHHHHHHHHCCHHHCCCHHHHHHHHHCHHHHHHHHHHH
LQKLGLDTVVNAACGAAPLPTDILLWYRKLGLNLAEGYGMTETLITHLPAPGSIRPGYVG
HHHHCHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHCCCCHHHHHHHHCCCCCCCCCCEEE
CAIPGVDAKVTETDELLLRSPMNMLGYYRDPEATKASFTDDGFFRTGDLARIDPDGQLKI
EECCCCCCCCCCHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCEECCCEEEECCCCCEEE
IGRVKEQFKTSKGKYVMPTPIESQLLAHPVVDACCLMGAGMPRPFAVVLLANAPAERAVV
HHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHH
EQTLLDLMNTVNTQLDPHEQLSFVAVAKGPWTVGNGFVTPTLKIKRNVLESRYQPCVDEW
HHHHHHHHHHHCCCCCHHHCEEEEEEECCCEECCCCEECCHHHHHHHHHHHHCCHHHHHH
MRQNRPIVWESPPV
HHCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]