Click here to switch to the map view.

The map label for this gene is fadA [H]

Identifier: 116624621

GI number: 116624621

Start: 6948344

End: 6949504

Strand: Reverse

Name: fadA [H]

Synonym: Acid_5545

Alternate gene names: 116624621

Gene position: 6949504-6948344 (Counterclockwise)

Preceding gene: 116624622

Following gene: 116624620

Centisome position: 69.73

GC content: 67.44

Gene sequence:

>1161_bases
ATGCGAGACGCTGTTATTGTCGATTGCCTCCGAACCCCCGTCGGTAAAGCCCCCCGCGGCGCCCTGCGCAATACCCGCCC
GGACGACCTCGCCGCCATCGCCATCCGGGCCGTGCTCGATCGCTATCCGGCGGCGCTCGACCTGGTGGACGACGTCATCC
TCGGCTGCGCCATGCCCGAAGGCGAGGCCGGCGCCAACATGGCGCGCCAGGCCGCGCTCCGTGCCGGTCTGGCCGATTCC
GTTCCGGCGATGACCATCAATCGCTTCTGCAGTTCCGGTCTCCAGGCCATCGCCCTCGCCGCCGAACGCATCCGCTCGGG
CGGCGCCGATGTCATCATTGCCGGCGGCGCCGAATCCATGTCGATGATTCCCTCCGGCGGACGCAAGCCCGCGCCCAACC
CCTGGTTCGTCGATCACTGGCCCGAGGTCTACATGACCATGGGACTCACCGCCGAGCGCGTGCAGCGCAAATACAACGTC
TCCCGCGAAGATGCCGACGCCTTCGCGCTGCGCAGCCACCAGAACGCCCTCCGCGCCCAGCAGGACGGGAAGTTCGACGA
TGAACTCGTCCCCGTCGAAACCCAGAACATCATGCCGGGAATTGTGGAGCGCGCCGTCTTCAGCCGCGACGAAGGTCCGC
GCGCCGATACCTCGTTCGAAGCTCTCGCCAAACTGAAACCCGTCTTCCACGCCAATGGCTCCGTCACTGCCGGCAACTCC
TCGCAGACCAGCGACGGCGCCGCCGCCGCGCTCGTGATGTCGGCCGCCAAGGCCCGCCAGTTCGGTTTCGCTCCCAAGGC
GCGCTTCGTAAGCTACGCGACCGCCGGAGTGCCGCCCGAGATCATGGGCATCGGCCCCGTGGTCGCGATCCCCAAAGCGC
TCGCCATGGCCGGCCTCAAGCTGAACGATATCGGCGTCATCGAGCTCAACGAAGCCTTCGCCGTGCAAGCCCTCGCCGTC
ATCCGCAAGGCCGGCATCGACCCCGACCGCGTCAATGTCAATGGCGGCGCCATCGCGCTCGGCCACCCCCTTGGTTGCAC
CGGGGCGAAACTCACCGCCACCATCCTTCGCGAGATGCAGCGCGGCCAAATCCGCTACGGCATGGTCACTATGTGCGTCG
GGGGCGGCCAGGGTGCCGCCGGTATCTTCGAGCTCATGTAG

Upstream 100 bases:

>100_bases
AAGCCTTCCTCAGCCTCTGCGGCAATGTCAAAACCCGGGAGCGCATGCAGTACATGCTGAAGAGCGGCAAGCCCCTCAGA
AACTAATAAGGACTCAACCC

Downstream 100 bases:

>100_bases
CACAGGCTCCACTGGCAGCCTGATTGCTGTCCTTTACGCGTGCGCTACCGCCTCACGGTATTCCTCCTGTTCGCGTTTTC
ACTTCCGGCACAGCAGGCTC

Product: 3-ketoacyl-CoA thiolase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MRDAVIVDCLRTPVGKAPRGALRNTRPDDLAAIAIRAVLDRYPAALDLVDDVILGCAMPEGEAGANMARQAALRAGLADS
VPAMTINRFCSSGLQAIALAAERIRSGGADVIIAGGAESMSMIPSGGRKPAPNPWFVDHWPEVYMTMGLTAERVQRKYNV
SREDADAFALRSHQNALRAQQDGKFDDELVPVETQNIMPGIVERAVFSRDEGPRADTSFEALAKLKPVFHANGSVTAGNS
SQTSDGAAAALVMSAAKARQFGFAPKARFVSYATAGVPPEIMGIGPVVAIPKALAMAGLKLNDIGVIELNEAFAVQALAV
IRKAGIDPDRVNVNGGAIALGHPLGCTGAKLTATILREMQRGQIRYGMVTMCVGGGQGAAGIFELM

Sequences:

>Translated_386_residues
MRDAVIVDCLRTPVGKAPRGALRNTRPDDLAAIAIRAVLDRYPAALDLVDDVILGCAMPEGEAGANMARQAALRAGLADS
VPAMTINRFCSSGLQAIALAAERIRSGGADVIIAGGAESMSMIPSGGRKPAPNPWFVDHWPEVYMTMGLTAERVQRKYNV
SREDADAFALRSHQNALRAQQDGKFDDELVPVETQNIMPGIVERAVFSRDEGPRADTSFEALAKLKPVFHANGSVTAGNS
SQTSDGAAAALVMSAAKARQFGFAPKARFVSYATAGVPPEIMGIGPVVAIPKALAMAGLKLNDIGVIELNEAFAVQALAV
IRKAGIDPDRVNVNGGAIALGHPLGCTGAKLTATILREMQRGQIRYGMVTMCVGGGQGAAGIFELM
>Mature_386_residues
MRDAVIVDCLRTPVGKAPRGALRNTRPDDLAAIAIRAVLDRYPAALDLVDDVILGCAMPEGEAGANMARQAALRAGLADS
VPAMTINRFCSSGLQAIALAAERIRSGGADVIIAGGAESMSMIPSGGRKPAPNPWFVDHWPEVYMTMGLTAERVQRKYNV
SREDADAFALRSHQNALRAQQDGKFDDELVPVETQNIMPGIVERAVFSRDEGPRADTSFEALAKLKPVFHANGSVTAGNS
SQTSDGAAAALVMSAAKARQFGFAPKARFVSYATAGVPPEIMGIGPVVAIPKALAMAGLKLNDIGVIELNEAFAVQALAV
IRKAGIDPDRVNVNGGAIALGHPLGCTGAKLTATILREMQRGQIRYGMVTMCVGGGQGAAGIFELM

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=44.7570332480818, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=39.3939393939394, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=40.1028277634961, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI4557237, Length=397, Percent_Identity=37.5314861460957, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI4504327, Length=431, Percent_Identity=35.0348027842227, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI194353979, Length=385, Percent_Identity=33.5064935064935, Blast_Score=169, Evalue=4e-42,
Organism=Escherichia coli, GI48994986, Length=389, Percent_Identity=45.5012853470437, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1787663, Length=410, Percent_Identity=46.3414634146341, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI87082165, Length=396, Percent_Identity=44.6969696969697, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI1788554, Length=401, Percent_Identity=43.8902743142145, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI1788683, Length=415, Percent_Identity=31.3253012048193, Blast_Score=176, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=41.4322250639386, Blast_Score=280, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI25147385, Length=393, Percent_Identity=35.8778625954198, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17535921, Length=391, Percent_Identity=35.0383631713555, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17551802, Length=431, Percent_Identity=32.2505800464037, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17535917, Length=398, Percent_Identity=31.6582914572864, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=41.1616161616162, Blast_Score=283, Evalue=4e-77,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=35.5, Blast_Score=224, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=42.3469387755102, Blast_Score=290, Evalue=9e-79,
Organism=Drosophila melanogaster, GI17648125, Length=351, Percent_Identity=39.8860398860399, Blast_Score=248, Evalue=5e-66,
Organism=Drosophila melanogaster, GI24640423, Length=394, Percent_Identity=37.8172588832487, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI17137578, Length=430, Percent_Identity=32.5581395348837, Blast_Score=184, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40475; Mature: 40475

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAVIVDCLRTPVGKAPRGALRNTRPDDLAAIAIRAVLDRYPAALDLVDDVILGCAMPE
CCCCEEHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
GEAGANMARQAALRAGLADSVPAMTINRFCSSGLQAIALAAERIRSGGADVIIAGGAESM
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCH
SMIPSGGRKPAPNPWFVDHWPEVYMTMGLTAERVQRKYNVSREDADAFALRSHQNALRAQ
HCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
QDGKFDDELVPVETQNIMPGIVERAVFSRDEGPRADTSFEALAKLKPVFHANGSVTAGNS
CCCCCCCCCCCCCHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCHHEECCCCEECCCC
SQTSDGAAAALVMSAAKARQFGFAPKARFVSYATAGVPPEIMGIGPVVAIPKALAMAGLK
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCE
LNDIGVIELNEAFAVQALAVIRKAGIDPDRVNVNGGAIALGHPLGCTGAKLTATILREMQ
ECCCEEEEECHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCCHHHHHHHHHHHH
RGQIRYGMVTMCVGGGQGAAGIFELM
HCCEEEEEEEEEECCCCCCCHHHHCC
>Mature Secondary Structure
MRDAVIVDCLRTPVGKAPRGALRNTRPDDLAAIAIRAVLDRYPAALDLVDDVILGCAMPE
CCCCEEHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
GEAGANMARQAALRAGLADSVPAMTINRFCSSGLQAIALAAERIRSGGADVIIAGGAESM
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCH
SMIPSGGRKPAPNPWFVDHWPEVYMTMGLTAERVQRKYNVSREDADAFALRSHQNALRAQ
HCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
QDGKFDDELVPVETQNIMPGIVERAVFSRDEGPRADTSFEALAKLKPVFHANGSVTAGNS
CCCCCCCCCCCCCHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCHHEECCCCEECCCC
SQTSDGAAAALVMSAAKARQFGFAPKARFVSYATAGVPPEIMGIGPVVAIPKALAMAGLK
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCE
LNDIGVIELNEAFAVQALAVIRKAGIDPDRVNVNGGAIALGHPLGCTGAKLTATILREMQ
ECCCEEEEECHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCCHHHHHHHHHHHH
RGQIRYGMVTMCVGGGQGAAGIFELM
HCCEEEEEEEEEECCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]