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The map label for this gene is fadN [H]

Identifier: 116624622

GI number: 116624622

Start: 6949519

End: 6951855

Strand: Reverse

Name: fadN [H]

Synonym: Acid_5546

Alternate gene names: 116624622

Gene position: 6951855-6949519 (Counterclockwise)

Preceding gene: 116624625

Following gene: 116624621

Centisome position: 69.76

GC content: 64.01

Gene sequence:

>2337_bases
GTGATGAAGCCACTACGCCGTGTTGCCGTCTTGGGTGCGGGGACCATGGGCGCGCGCATTGCCGCCCACTTTGCCAACGC
CGGGTTTCCGGTCGATCTCCTCGATCTCGTCCTCCCCGACAAGCCGCAGCGCAACGCCCTCGCCCTCGCCGGCATCGAGA
GCGCAGCCAAACAGCGACCAGTCGGCTTCTTCACTGACGCCGCCAAAACGCTCATCACTCCCGGCAACTTCGAAGACGAT
CTAGGCCGCGTCGGCCGCTGCGAATGGATCGTCGAGGCCGTCGCCGAAAACCTCGAGATCAAGCGCGCCCTCTGGCAGCG
CGTCGCCGCTCTCCGCGCTCCAGGCGCCATCCTTTCCACCAACACCAGCGGCATCCCGCTCGCCCAAATCTCCGCCGGCT
TCGATTCCGAATTCCGCCGGCACTTTCTCGGCACTCACTTCTTCAATCCGCCGCGCTACCTCCATCTCGCCGAAGTCATC
CCTGGCGCCGAAACCAATCCCGAAGTCCTCGACTGGGTCTCCAGCTTCTGCGACCTCCACCTCGGCAAAGGCGTGGTCCG
CTGCAAGGACACGCCGAATTTCATCGCCAACCGCATCGGCTGTTTCTTCGGCGCGAAAATCGCCCAGCTCACCGAAGAGG
GCGATTACACCGTCGAAGAAGTCGATGCCCTCACCGGCCCTCTCATCGGACTTCCCAAAAGCGCCAGCTTCCGCCTAATC
GATATCATCGGCCTGGATGTATGGGTCCACGTCCTGCGCAATCTCGCCGAAGCCGTGCCCAACGATCCCGCGCGCGAGCT
CTACACCATCCCCGATGTCATGCAGAAAATGATCGATCGCGGCTGGCTCGGCGAGAAGCGCGGCCAGGGCTTCTACAAAC
GAGTCGGCAAGGGAGCCGAAAAAGAGATCTGGGCCATCGATCGCAAGACCCTTGAATACCACCTCGCGCACAAACCAACC
TTGCCCGCCGTCGAAGCCGTCCGCGGCATTGAGGATCTCGGCGCGCGCCTCCGCGCCCTCGTCGCCGGACACGATCGCGC
CGGCGAGTTTCTGTGGAAGCTCTTCCGCGATTTCTTCCTCTACTCCGCCCGTATGGTCCCCGAGATCTCAGACCGCATCG
TCGAAATCGATCGCGCCATGCGCTGGGGCTTTGCCTTCAAACTCGGCCCCTTCGAACTCTGGGATTCCCTCGGCGTGCCC
GGGACCGTAGCCCGCATGCGCGCCGAAGGCTGCGCCATCCCCGAAAACGTGGAGCGCATGCTGGCCAGCGGCGCCACCAG
CTTCTACGAATTCGCCGATCGCGATGGCGAACCCGGCGTCCGCTACTACGATCTCAACGCCACCGCCTACCGCAATCTGC
CGAAGCGTCCCGGCGTCCTCGTCCTCAACGACATCAAGCGCGCCCGCGGCGTCGTCAAATCCAATCCCGGCGCCTCCCTG
GTCGATCTCGGCGATGGCGTCCTCTGCCTCGAATTCCACAGCAAGATGAATGCCCTCGGCGAGGACATGGTGCGCATGGT
CTCAAGCGCCCTCGATGAAGTCGATCGCGCTTTCCAGGCGCTTGTGATCGCCAACGACGGCGAAAACTTCAGCGTCGGCG
CCAACCTCATGCAGGTCCTCCTCGCCGCCCACGAAGGCGAATGGGACGAGCTCGATCTCGCCGTCCGCCGCTTCCAGTCC
GCCGGCATGGCGATGAAGTATGCGTCGCGCCCCGTCGTCGCCGCCGTATTCGGCATGACCCTCGGCGGCGGCTGCGAAGT
AGCCCTCCACGCCGGACGCGTGCAGGCGGCCGCGGAAAGTTATATGGGTCTCGTCGAAACCGGTGTCGGCTTGATCCCGG
CTGGTGGGGGCTGCAAGGAGATGCTCCTCCGGCTCGGCAGCGCCAAACGAGCCTTCGACCTCATCGGCTTCGGCAAAGTC
AGCGAAAGCGCCCCGCATGCCCGCGAACTCGGATTCCTGCGCGATTCCGACAGCGTCTCCATGAATCGCGAACGTCTCAC
TGCCGACGCCAAGGCCGCCGCCCTCTCCATGGTTGCCGGCTGGGCCCCCGGCATTCCGCGCCAGGATATCCCGGTGGAAG
GCGCCGCCGGCTATGCCCTCCTCCAGATGGGTGTGAAGATCGCCGCCGAGGGCGGCTACATCACGGAATACGATACTGTG
GTCGGCGAGAAACTGGCCCACATCCTGAGCGGCGGTAGACTCACCGGCCCTCAGAAAGTCAGCGAGCAATACCTGTTGGA
CCTCGAGCGCGAAGCCTTCCTCAGCCTCTGCGGCAATGTCAAAACCCGGGAGCGCATGCAGTACATGCTGAAGAGCGGCA
AGCCCCTCAGAAACTAA

Upstream 100 bases:

>100_bases
TTGTCCCGCCTCTGATAAGTAACTCTCCGGGATTCAACAAAGCCCCGGCGAAAGGGGGACGAAATGTCCCGCCTGCGCCC
TGCCTTGGGATACTCTAGCT

Downstream 100 bases:

>100_bases
TAAGGACTCAACCCATGCGAGACGCTGTTATTGTCGATTGCCTCCGAACCCCCGTCGGTAAAGCCCCCCGCGGCGCCCTG
CGCAATACCCGCCCGGACGA

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 778; Mature: 778

Protein sequence:

>778_residues
MMKPLRRVAVLGAGTMGARIAAHFANAGFPVDLLDLVLPDKPQRNALALAGIESAAKQRPVGFFTDAAKTLITPGNFEDD
LGRVGRCEWIVEAVAENLEIKRALWQRVAALRAPGAILSTNTSGIPLAQISAGFDSEFRRHFLGTHFFNPPRYLHLAEVI
PGAETNPEVLDWVSSFCDLHLGKGVVRCKDTPNFIANRIGCFFGAKIAQLTEEGDYTVEEVDALTGPLIGLPKSASFRLI
DIIGLDVWVHVLRNLAEAVPNDPARELYTIPDVMQKMIDRGWLGEKRGQGFYKRVGKGAEKEIWAIDRKTLEYHLAHKPT
LPAVEAVRGIEDLGARLRALVAGHDRAGEFLWKLFRDFFLYSARMVPEISDRIVEIDRAMRWGFAFKLGPFELWDSLGVP
GTVARMRAEGCAIPENVERMLASGATSFYEFADRDGEPGVRYYDLNATAYRNLPKRPGVLVLNDIKRARGVVKSNPGASL
VDLGDGVLCLEFHSKMNALGEDMVRMVSSALDEVDRAFQALVIANDGENFSVGANLMQVLLAAHEGEWDELDLAVRRFQS
AGMAMKYASRPVVAAVFGMTLGGGCEVALHAGRVQAAAESYMGLVETGVGLIPAGGGCKEMLLRLGSAKRAFDLIGFGKV
SESAPHARELGFLRDSDSVSMNRERLTADAKAAALSMVAGWAPGIPRQDIPVEGAAGYALLQMGVKIAAEGGYITEYDTV
VGEKLAHILSGGRLTGPQKVSEQYLLDLEREAFLSLCGNVKTRERMQYMLKSGKPLRN

Sequences:

>Translated_778_residues
MMKPLRRVAVLGAGTMGARIAAHFANAGFPVDLLDLVLPDKPQRNALALAGIESAAKQRPVGFFTDAAKTLITPGNFEDD
LGRVGRCEWIVEAVAENLEIKRALWQRVAALRAPGAILSTNTSGIPLAQISAGFDSEFRRHFLGTHFFNPPRYLHLAEVI
PGAETNPEVLDWVSSFCDLHLGKGVVRCKDTPNFIANRIGCFFGAKIAQLTEEGDYTVEEVDALTGPLIGLPKSASFRLI
DIIGLDVWVHVLRNLAEAVPNDPARELYTIPDVMQKMIDRGWLGEKRGQGFYKRVGKGAEKEIWAIDRKTLEYHLAHKPT
LPAVEAVRGIEDLGARLRALVAGHDRAGEFLWKLFRDFFLYSARMVPEISDRIVEIDRAMRWGFAFKLGPFELWDSLGVP
GTVARMRAEGCAIPENVERMLASGATSFYEFADRDGEPGVRYYDLNATAYRNLPKRPGVLVLNDIKRARGVVKSNPGASL
VDLGDGVLCLEFHSKMNALGEDMVRMVSSALDEVDRAFQALVIANDGENFSVGANLMQVLLAAHEGEWDELDLAVRRFQS
AGMAMKYASRPVVAAVFGMTLGGGCEVALHAGRVQAAAESYMGLVETGVGLIPAGGGCKEMLLRLGSAKRAFDLIGFGKV
SESAPHARELGFLRDSDSVSMNRERLTADAKAAALSMVAGWAPGIPRQDIPVEGAAGYALLQMGVKIAAEGGYITEYDTV
VGEKLAHILSGGRLTGPQKVSEQYLLDLEREAFLSLCGNVKTRERMQYMLKSGKPLRN
>Mature_778_residues
MMKPLRRVAVLGAGTMGARIAAHFANAGFPVDLLDLVLPDKPQRNALALAGIESAAKQRPVGFFTDAAKTLITPGNFEDD
LGRVGRCEWIVEAVAENLEIKRALWQRVAALRAPGAILSTNTSGIPLAQISAGFDSEFRRHFLGTHFFNPPRYLHLAEVI
PGAETNPEVLDWVSSFCDLHLGKGVVRCKDTPNFIANRIGCFFGAKIAQLTEEGDYTVEEVDALTGPLIGLPKSASFRLI
DIIGLDVWVHVLRNLAEAVPNDPARELYTIPDVMQKMIDRGWLGEKRGQGFYKRVGKGAEKEIWAIDRKTLEYHLAHKPT
LPAVEAVRGIEDLGARLRALVAGHDRAGEFLWKLFRDFFLYSARMVPEISDRIVEIDRAMRWGFAFKLGPFELWDSLGVP
GTVARMRAEGCAIPENVERMLASGATSFYEFADRDGEPGVRYYDLNATAYRNLPKRPGVLVLNDIKRARGVVKSNPGASL
VDLGDGVLCLEFHSKMNALGEDMVRMVSSALDEVDRAFQALVIANDGENFSVGANLMQVLLAAHEGEWDELDLAVRRFQS
AGMAMKYASRPVVAAVFGMTLGGGCEVALHAGRVQAAAESYMGLVETGVGLIPAGGGCKEMLLRLGSAKRAFDLIGFGKV
SESAPHARELGFLRDSDSVSMNRERLTADAKAAALSMVAGWAPGIPRQDIPVEGAAGYALLQMGVKIAAEGGYITEYDTV
VGEKLAHILSGGRLTGPQKVSEQYLLDLEREAFLSLCGNVKTRERMQYMLKSGKPLRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=299, Percent_Identity=31.1036789297659, Blast_Score=123, Evalue=8e-28,
Organism=Homo sapiens, GI296179427, Length=316, Percent_Identity=29.4303797468354, Blast_Score=113, Evalue=9e-25,
Organism=Homo sapiens, GI20127408, Length=290, Percent_Identity=26.8965517241379, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI261878539, Length=319, Percent_Identity=30.0940438871473, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI68989263, Length=319, Percent_Identity=30.0940438871473, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI115430219, Length=235, Percent_Identity=25.9574468085106, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1787661, Length=300, Percent_Identity=34, Blast_Score=114, Evalue=3e-26,
Organism=Escherichia coli, GI1790281, Length=226, Percent_Identity=28.3185840707965, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1788682, Length=219, Percent_Identity=27.3972602739726, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17549919, Length=305, Percent_Identity=30.8196721311475, Blast_Score=126, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17553560, Length=297, Percent_Identity=30.6397306397306, Blast_Score=124, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17563036, Length=297, Percent_Identity=31.986531986532, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17508951, Length=296, Percent_Identity=29.0540540540541, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17508953, Length=296, Percent_Identity=29.0540540540541, Blast_Score=95, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25144276, Length=296, Percent_Identity=29.0540540540541, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17558304, Length=337, Percent_Identity=28.486646884273, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71985923, Length=250, Percent_Identity=27.6, Blast_Score=87, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71985930, Length=302, Percent_Identity=24.8344370860927, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24583077, Length=412, Percent_Identity=25.7281553398058, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24583079, Length=412, Percent_Identity=25.7281553398058, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921000, Length=412, Percent_Identity=25.7281553398058, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45549573, Length=224, Percent_Identity=26.7857142857143, Blast_Score=76, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 84812; Mature: 84812

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKPLRRVAVLGAGTMGARIAAHFANAGFPVDLLDLVLPDKPQRNALALAGIESAAKQRP
CCCHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEHHHHHHHHCCC
VGFFTDAAKTLITPGNFEDDLGRVGRCEWIVEAVAENLEIKRALWQRVAALRAPGAILST
CCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
NTSGIPLAQISAGFDSEFRRHFLGTHFFNPPRYLHLAEVIPGAETNPEVLDWVSSFCDLH
CCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCEEHHHHCCCCCCCHHHHHHHHHHHHHH
LGKGVVRCKDTPNFIANRIGCFFGAKIAQLTEEGDYTVEEVDALTGPLIGLPKSASFRLI
HCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEE
DIIGLDVWVHVLRNLAEAVPNDPARELYTIPDVMQKMIDRGWLGEKRGQGFYKRVGKGAE
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCC
KEIWAIDRKTLEYHLAHKPTLPAVEAVRGIEDLGARLRALVAGHDRAGEFLWKLFRDFFL
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
YSARMVPEISDRIVEIDRAMRWGFAFKLGPFELWDSLGVPGTVARMRAEGCAIPENVERM
HHHHHCHHHHHHHHHHHHHHHHCCEEECCHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHH
LASGATSFYEFADRDGEPGVRYYDLNATAYRNLPKRPGVLVLNDIKRARGVVKSNPGASL
HHHCCHHHHHHHCCCCCCCCEEEECCHHHHHCCCCCCCEEEEHHHHHHCCCCCCCCCCCE
VDLGDGVLCLEFHSKMNALGEDMVRMVSSALDEVDRAFQALVIANDGENFSVGANLMQVL
EECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHH
LAAHEGEWDELDLAVRRFQSAGMAMKYASRPVVAAVFGMTLGGGCEVALHAGRVQAAAES
HHHCCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHH
YMGLVETGVGLIPAGGGCKEMLLRLGSAKRAFDLIGFGKVSESAPHARELGFLRDSDSVS
HHHHHHCCCCEEECCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCC
MNRERLTADAKAAALSMVAGWAPGIPRQDIPVEGAAGYALLQMGVKIAAEGGYITEYDTV
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCHHEEECCCEEEHHHHH
VGEKLAHILSGGRLTGPQKVSEQYLLDLEREAFLSLCGNVKTRERMQYMLKSGKPLRN
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MMKPLRRVAVLGAGTMGARIAAHFANAGFPVDLLDLVLPDKPQRNALALAGIESAAKQRP
CCCHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEHHHHHHHHCCC
VGFFTDAAKTLITPGNFEDDLGRVGRCEWIVEAVAENLEIKRALWQRVAALRAPGAILST
CCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
NTSGIPLAQISAGFDSEFRRHFLGTHFFNPPRYLHLAEVIPGAETNPEVLDWVSSFCDLH
CCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCEEHHHHCCCCCCCHHHHHHHHHHHHHH
LGKGVVRCKDTPNFIANRIGCFFGAKIAQLTEEGDYTVEEVDALTGPLIGLPKSASFRLI
HCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEE
DIIGLDVWVHVLRNLAEAVPNDPARELYTIPDVMQKMIDRGWLGEKRGQGFYKRVGKGAE
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCC
KEIWAIDRKTLEYHLAHKPTLPAVEAVRGIEDLGARLRALVAGHDRAGEFLWKLFRDFFL
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
YSARMVPEISDRIVEIDRAMRWGFAFKLGPFELWDSLGVPGTVARMRAEGCAIPENVERM
HHHHHCHHHHHHHHHHHHHHHHCCEEECCHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHH
LASGATSFYEFADRDGEPGVRYYDLNATAYRNLPKRPGVLVLNDIKRARGVVKSNPGASL
HHHCCHHHHHHHCCCCCCCCEEEECCHHHHHCCCCCCCEEEEHHHHHHCCCCCCCCCCCE
VDLGDGVLCLEFHSKMNALGEDMVRMVSSALDEVDRAFQALVIANDGENFSVGANLMQVL
EECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHH
LAAHEGEWDELDLAVRRFQSAGMAMKYASRPVVAAVFGMTLGGGCEVALHAGRVQAAAES
HHHCCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHH
YMGLVETGVGLIPAGGGCKEMLLRLGSAKRAFDLIGFGKVSESAPHARELGFLRDSDSVS
HHHHHHCCCCEEECCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCC
MNRERLTADAKAAALSMVAGWAPGIPRQDIPVEGAAGYALLQMGVKIAAEGGYITEYDTV
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCHHEEECCCEEEHHHHH
VGEKLAHILSGGRLTGPQKVSEQYLLDLEREAFLSLCGNVKTRERMQYMLKSGKPLRN
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]