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The map label for this gene is adk [H]

Identifier: 116624181

GI number: 116624181

Start: 6430584

End: 6431237

Strand: Reverse

Name: adk [H]

Synonym: Acid_5097

Alternate gene names: 116624181

Gene position: 6431237-6430584 (Counterclockwise)

Preceding gene: 116624182

Following gene: 116624180

Centisome position: 64.53

GC content: 59.17

Gene sequence:

>654_bases
GTGAAAGCCATCGTACTGTTCGGCTCACCAGGCTCCGGAAAAGGTACCCAGGCTAAGATGTTGACGCAATGCCTGGCGAT
CCCCCATATCTCGACGGGGGACATGCTCAGGGACCGGATTCGATCCGGTACCGAGTGTGGGACCGCGATGGAAGCCACGA
TGCAATCTGGCGCGCTGGTATCCGATGCGCTGGTGAACGAGATGGTGAAAGAGCGGCTCAGCGAGCCGGACGCCTCGGCT
GGCTTTATTTTGGATGGATATCCGCGGACCCTGGATCAGGCGAGGCACTTGGCAGCCTGGTTGCTAGGGCGGGGAATCCA
CGAGTTGGTGATCCACCTCGCAGTAGATTACAATATTATTATTGCCCGTTTGACAGGACGCCGTCAGTGCCCCCTCTGCG
GCACGCTGTACAACGTAGCTTCCCAACCACCCAAAGTGGATGAACTGTGCGACCTGGACGGGGAGAAGTTGGTCATCCGG
GATGATGACAGCGAGACGGTGATTCGCGGGCGGTTGGACGCGTATGATCGCCAGACAAAGCCGGTGTTGGAGTTTTTCCA
GACGTCCGGCCACCGGGTGATCCGGGTGGATGCCGATAGCGATCCGCCGGAGAAGGTGTTCGAGAGGATCTGCCGGGCCA
TGGAGTCAGCTTGA

Upstream 100 bases:

>100_bases
GGATACGATCAACCAGATCGAAGCCCAGCTCATTATGCGGCATTACGAAGGATTCACGCCGCGCTCGGGCCGTATTCGTG
GCCGGCGCTAGCTTGAATTT

Downstream 100 bases:

>100_bases
TTGTCAGGAAAACCGCCGCGGAATTGGAAAAGATGCGGCGCAGCGGACTCCTTGTATGGAACGTCCTGCACGCGTTAAAG
GATATGGCCGTAGAGGGCGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MKAIVLFGSPGSGKGTQAKMLTQCLAIPHISTGDMLRDRIRSGTECGTAMEATMQSGALVSDALVNEMVKERLSEPDASA
GFILDGYPRTLDQARHLAAWLLGRGIHELVIHLAVDYNIIIARLTGRRQCPLCGTLYNVASQPPKVDELCDLDGEKLVIR
DDDSETVIRGRLDAYDRQTKPVLEFFQTSGHRVIRVDADSDPPEKVFERICRAMESA

Sequences:

>Translated_217_residues
MKAIVLFGSPGSGKGTQAKMLTQCLAIPHISTGDMLRDRIRSGTECGTAMEATMQSGALVSDALVNEMVKERLSEPDASA
GFILDGYPRTLDQARHLAAWLLGRGIHELVIHLAVDYNIIIARLTGRRQCPLCGTLYNVASQPPKVDELCDLDGEKLVIR
DDDSETVIRGRLDAYDRQTKPVLEFFQTSGHRVIRVDADSDPPEKVFERICRAMESA
>Mature_217_residues
MKAIVLFGSPGSGKGTQAKMLTQCLAIPHISTGDMLRDRIRSGTECGTAMEATMQSGALVSDALVNEMVKERLSEPDASA
GFILDGYPRTLDQARHLAAWLLGRGIHELVIHLAVDYNIIIARLTGRRQCPLCGTLYNVASQPPKVDELCDLDGEKLVIR
DDDSETVIRGRLDAYDRQTKPVLEFFQTSGHRVIRVDADSDPPEKVFERICRAMESA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=215, Percent_Identity=40.9302325581395, Blast_Score=151, Evalue=5e-37,
Organism=Homo sapiens, GI4502013, Length=215, Percent_Identity=40.9302325581395, Blast_Score=150, Evalue=6e-37,
Organism=Homo sapiens, GI19923437, Length=188, Percent_Identity=41.4893617021277, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI310110345, Length=188, Percent_Identity=34.5744680851064, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI53832003, Length=188, Percent_Identity=34.5744680851064, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI8051579, Length=188, Percent_Identity=34.5744680851064, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI53832001, Length=188, Percent_Identity=34.5744680851064, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4502011, Length=216, Percent_Identity=27.3148148148148, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI28144897, Length=216, Percent_Identity=29.1666666666667, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI28144899, Length=216, Percent_Identity=29.1666666666667, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI22749187, Length=208, Percent_Identity=28.8461538461538, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1786680, Length=184, Percent_Identity=41.8478260869565, Blast_Score=149, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17552384, Length=195, Percent_Identity=39.4871794871795, Blast_Score=141, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17537943, Length=222, Percent_Identity=31.5315315315315, Blast_Score=106, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17567503, Length=196, Percent_Identity=30.1020408163265, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17533833, Length=217, Percent_Identity=25.3456221198157, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17550688, Length=217, Percent_Identity=23.963133640553, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=41.7840375586854, Blast_Score=152, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321018, Length=188, Percent_Identity=36.1702127659575, Blast_Score=111, Evalue=1e-25,
Organism=Drosophila melanogaster, GI22026816, Length=195, Percent_Identity=41.025641025641, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI17737899, Length=186, Percent_Identity=37.6344086021505, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24645822, Length=186, Percent_Identity=37.6344086021505, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24663208, Length=213, Percent_Identity=27.6995305164319, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI17647141, Length=213, Percent_Identity=27.6995305164319, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI221459597, Length=210, Percent_Identity=27.1428571428571, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21356893, Length=210, Percent_Identity=27.1428571428571, Blast_Score=77, Evalue=9e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23869; Mature: 23869

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIVLFGSPGSGKGTQAKMLTQCLAIPHISTGDMLRDRIRSGTECGTAMEATMQSGALV
CCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCHH
SDALVNEMVKERLSEPDASAGFILDGYPRTLDQARHLAAWLLGRGIHELVIHLAVDYNII
HHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEE
IARLTGRRQCPLCGTLYNVASQPPKVDELCDLDGEKLVIRDDDSETVIRGRLDAYDRQTK
EEEECCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCHH
PVLEFFQTSGHRVIRVDADSDPPEKVFERICRAMESA
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAIVLFGSPGSGKGTQAKMLTQCLAIPHISTGDMLRDRIRSGTECGTAMEATMQSGALV
CCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCHH
SDALVNEMVKERLSEPDASAGFILDGYPRTLDQARHLAAWLLGRGIHELVIHLAVDYNII
HHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEE
IARLTGRRQCPLCGTLYNVASQPPKVDELCDLDGEKLVIRDDDSETVIRGRLDAYDRQTK
EEEECCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCHH
PVLEFFQTSGHRVIRVDADSDPPEKVFERICRAMESA
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA