Click here to switch to the map view.

The map label for this gene is map [H]

Identifier: 116624180

GI number: 116624180

Start: 6429817

End: 6430587

Strand: Reverse

Name: map [H]

Synonym: Acid_5096

Alternate gene names: 116624180

Gene position: 6430587-6429817 (Counterclockwise)

Preceding gene: 116624181

Following gene: 116624179

Centisome position: 64.53

GC content: 58.24

Gene sequence:

>771_bases
TTGATTGTCAGGAAAACCGCCGCGGAATTGGAAAAGATGCGGCGCAGCGGACTCCTTGTATGGAACGTCCTGCACGCGTT
AAAGGATATGGCCGTAGAGGGCGCCTCGACCATGGATCTAGAGGTGGCCGCCGAGAAGATGATCGCCGATGCGGGGGCGA
AACCGGCTTTTAAAGGTTATTACGTGCCGGCGGCGGGCGAGGCCTTCAAGTTTGTTTTGTGTACGTCGGTGAACGACGAG
ATCGTCCACGGGATGCCGAATGTGAAACGGGTCCTGAAGAAGGGCGACATTGTTTCGATCGACACCGGGGTGAAGTTGGA
CGGCTATTATGGCGATTCGGCCATCACCGTCCCGATCGGCGAAGTCAGCGAGCAGACGAAGAAGCTGCTCCAGGTGACGC
AGGATTCCCTGGAACTCGCCATCGAAAAGGTTCGGTCGGGCAACCGGCTGTTTGACGTGTGTGCCACGGTGGAAAACCAC
GTCAAGGGTAACGGGTTTTCGATTGTCCGGGAGTATGTGGGCCATGGTATCGGCACCCAGCTCCACGAGGAACCGCAGGT
CCCGAATTACGTGGATCGCAAGAACGAGAACCCGAAGTTGAAGCCTGGGATGGTTTTGGCGGTGGAGCCGATGGTGAATG
CCGGGAAGCCGGAAGCCATGGTGTTGAAGGACAAGTGGACGGCGGTGACGAGGGATGGCTCCTACTCGGCGCATTTTGAA
CACTGCATCGCGGTTACGGAGAACGGGCCGTGGGTGCTGACGAGGCCGTAG

Upstream 100 bases:

>100_bases
AGTTTTTCCAGACGTCCGGCCACCGGGTGATCCGGGTGGATGCCGATAGCGATCCGCCGGAGAAGGTGTTCGAGAGGATC
TGCCGGGCCATGGAGTCAGC

Downstream 100 bases:

>100_bases
GTTCGGTAAAGGTAGCGGCCACGGTGGTGGAAGAGCGGCCGAGTGCGATCTACCTGGTCGTGCTGGAAGGCCAGCAGAAG
GTATTAGCCCACTTGGTGGG

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP 1; Peptidase M [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MIVRKTAAELEKMRRSGLLVWNVLHALKDMAVEGASTMDLEVAAEKMIADAGAKPAFKGYYVPAAGEAFKFVLCTSVNDE
IVHGMPNVKRVLKKGDIVSIDTGVKLDGYYGDSAITVPIGEVSEQTKKLLQVTQDSLELAIEKVRSGNRLFDVCATVENH
VKGNGFSIVREYVGHGIGTQLHEEPQVPNYVDRKNENPKLKPGMVLAVEPMVNAGKPEAMVLKDKWTAVTRDGSYSAHFE
HCIAVTENGPWVLTRP

Sequences:

>Translated_256_residues
MIVRKTAAELEKMRRSGLLVWNVLHALKDMAVEGASTMDLEVAAEKMIADAGAKPAFKGYYVPAAGEAFKFVLCTSVNDE
IVHGMPNVKRVLKKGDIVSIDTGVKLDGYYGDSAITVPIGEVSEQTKKLLQVTQDSLELAIEKVRSGNRLFDVCATVENH
VKGNGFSIVREYVGHGIGTQLHEEPQVPNYVDRKNENPKLKPGMVLAVEPMVNAGKPEAMVLKDKWTAVTRDGSYSAHFE
HCIAVTENGPWVLTRP
>Mature_256_residues
MIVRKTAAELEKMRRSGLLVWNVLHALKDMAVEGASTMDLEVAAEKMIADAGAKPAFKGYYVPAAGEAFKFVLCTSVNDE
IVHGMPNVKRVLKKGDIVSIDTGVKLDGYYGDSAITVPIGEVSEQTKKLLQVTQDSLELAIEKVRSGNRLFDVCATVENH
VKGNGFSIVREYVGHGIGTQLHEEPQVPNYVDRKNENPKLKPGMVLAVEPMVNAGKPEAMVLKDKWTAVTRDGSYSAHFE
HCIAVTENGPWVLTRP

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=250, Percent_Identity=37.2, Blast_Score=161, Evalue=6e-40,
Organism=Homo sapiens, GI40385867, Length=252, Percent_Identity=32.1428571428571, Blast_Score=141, Evalue=7e-34,
Organism=Escherichia coli, GI1786364, Length=251, Percent_Identity=41.0358565737052, Blast_Score=193, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71996291, Length=251, Percent_Identity=33.8645418326693, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323273, Length=248, Percent_Identity=36.6935483870968, Blast_Score=157, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21355531, Length=247, Percent_Identity=37.6518218623482, Blast_Score=157, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24583427, Length=252, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=2e-38,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28019; Mature: 28019

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVRKTAAELEKMRRSGLLVWNVLHALKDMAVEGASTMDLEVAAEKMIADAGAKPAFKGY
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCE
YVPAAGEAFKFVLCTSVNDEIVHGMPNVKRVLKKGDIVSIDTGVKLDGYYGDSAITVPIG
ECCCCCCEEEEEEEECCCHHHHHCCHHHHHHHHCCCEEEECCCEEEECEECCCEEEEECH
EVSEQTKKLLQVTQDSLELAIEKVRSGNRLFDVCATVENHVKGNGFSIVREYVGHGIGTQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
LHEEPQVPNYVDRKNENPKLKPGMVLAVEPMVNAGKPEAMVLKDKWTAVTRDGSYSAHFE
CCCCCCCCCHHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCEEEECCCCCCCCEE
HCIAVTENGPWVLTRP
EEEEEECCCCEEEECC
>Mature Secondary Structure
MIVRKTAAELEKMRRSGLLVWNVLHALKDMAVEGASTMDLEVAAEKMIADAGAKPAFKGY
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCE
YVPAAGEAFKFVLCTSVNDEIVHGMPNVKRVLKKGDIVSIDTGVKLDGYYGDSAITVPIG
ECCCCCCEEEEEEEECCCHHHHHCCHHHHHHHHCCCEEEECCCEEEECEECCCEEEEECH
EVSEQTKKLLQVTQDSLELAIEKVRSGNRLFDVCATVENHVKGNGFSIVREYVGHGIGTQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
LHEEPQVPNYVDRKNENPKLKPGMVLAVEPMVNAGKPEAMVLKDKWTAVTRDGSYSAHFE
CCCCCCCCCHHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCEEEECCCCCCCCEE
HCIAVTENGPWVLTRP
EEEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2113521; 8635744; 9384377 [H]