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The map label for this gene is nuoE [H]

Identifier: 116624104

GI number: 116624104

Start: 6335239

End: 6335751

Strand: Reverse

Name: nuoE [H]

Synonym: Acid_5019

Alternate gene names: 116624104

Gene position: 6335751-6335239 (Counterclockwise)

Preceding gene: 116624107

Following gene: 116624103

Centisome position: 63.58

GC content: 62.77

Gene sequence:

>513_bases
ATGCAGACGTATCTGGGAGCACCCCAACTACCGTCAGACGACAAGCGGTGGAAACTGGTGGAGGCCACGGCGCGCCGGCA
CGGGCGCGAACCGCATGCTCTCATTGAAACCCTGCACACGGTCCAGGAATGCTTCGGGTATCTCGACGAGGCCGGGCTTC
GCTTCGTCGCCTCGGTACTACGGGTACCGCTCAGCCGCGTTTATGGCGCGGCGACGTTCTATCACTTCTTCACGCTGAAA
CCGAAGGGGCGCCACACATGTGTGGTCTGCACCGGCACGGCCTGCTACATCAAAGGAGCGCCGGCGCTGCTGGGCGCGAT
TGAGAAACAGTACGGGATAAAACCCGGCGAGACCACGGCGGACGGCGAATTGAGCGTATTGACCGCGCGCTGCCTGGGAT
CGTGCGGATTGGCGCCGGCGGCCGTGATGGATCAGGCCGTCCTGGGCAAAATCGGACCCGCCGAGATGCTGGCGCGGATC
GAGAAAGATATCCGCCTAGAGGTCCAGAAATGA

Upstream 100 bases:

>100_bases
TTGGGTGATTCGCCGCTATAGCACCCCAGACTGCGGCCTCCCAAGTCTTCTGATATCAGACAAAGCTATCTGGAATGGCG
CGTGCACCGATAAGTAGGCT

Downstream 100 bases:

>100_bases
CAATTGAAGAACTTCGCAAGATCGGTGAGGCGGAACGTGAAGCGCAGAATAAGGTGCAGCACCACGTTTGCGTGTGTATC
GCGGCGGGCTGCCTTTCGAG

Product: NADH dehydrogenase (ubiquinone), 24 kDa subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MQTYLGAPQLPSDDKRWKLVEATARRHGREPHALIETLHTVQECFGYLDEAGLRFVASVLRVPLSRVYGAATFYHFFTLK
PKGRHTCVVCTGTACYIKGAPALLGAIEKQYGIKPGETTADGELSVLTARCLGSCGLAPAAVMDQAVLGKIGPAEMLARI
EKDIRLEVQK

Sequences:

>Translated_170_residues
MQTYLGAPQLPSDDKRWKLVEATARRHGREPHALIETLHTVQECFGYLDEAGLRFVASVLRVPLSRVYGAATFYHFFTLK
PKGRHTCVVCTGTACYIKGAPALLGAIEKQYGIKPGETTADGELSVLTARCLGSCGLAPAAVMDQAVLGKIGPAEMLARI
EKDIRLEVQK
>Mature_170_residues
MQTYLGAPQLPSDDKRWKLVEATARRHGREPHALIETLHTVQECFGYLDEAGLRFVASVLRVPLSRVYGAATFYHFFTLK
PKGRHTCVVCTGTACYIKGAPALLGAIEKQYGIKPGETTADGELSVLTARCLGSCGLAPAAVMDQAVLGKIGPAEMLARI
EKDIRLEVQK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=144, Percent_Identity=35.4166666666667, Blast_Score=93, Evalue=1e-19,
Organism=Escherichia coli, GI1788621, Length=138, Percent_Identity=34.7826086956522, Blast_Score=93, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17561328, Length=130, Percent_Identity=35.3846153846154, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI18859877, Length=130, Percent_Identity=33.8461538461538, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355353, Length=133, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 18486; Mature: 18486

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTYLGAPQLPSDDKRWKLVEATARRHGREPHALIETLHTVQECFGYLDEAGLRFVASVL
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVPLSRVYGAATFYHFFTLKPKGRHTCVVCTGTACYIKGAPALLGAIEKQYGIKPGETTA
HHHHHHHHHHHHHHHEEEECCCCCEEEEEEECCEEEECCCHHHHHHHHHHHCCCCCCCCC
DGELSVLTARCLGSCGLAPAAVMDQAVLGKIGPAEMLARIEKDIRLEVQK
CCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHEEEECC
>Mature Secondary Structure
MQTYLGAPQLPSDDKRWKLVEATARRHGREPHALIETLHTVQECFGYLDEAGLRFVASVL
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVPLSRVYGAATFYHFFTLKPKGRHTCVVCTGTACYIKGAPALLGAIEKQYGIKPGETTA
HHHHHHHHHHHHHHHEEEECCCCCEEEEEEECCEEEECCCHHHHHHHHHHHCCCCCCCCC
DGELSVLTARCLGSCGLAPAAVMDQAVLGKIGPAEMLARIEKDIRLEVQK
CCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]