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The map label for this gene is nuoF2 [H]

Identifier: 116624103

GI number: 116624103

Start: 6333596

End: 6335242

Strand: Reverse

Name: nuoF2 [H]

Synonym: Acid_5018

Alternate gene names: 116624103

Gene position: 6335242-6333596 (Counterclockwise)

Preceding gene: 116624104

Following gene: 116624102

Centisome position: 63.57

GC content: 62.9

Gene sequence:

>1647_bases
ATGACAATTGAAGAACTTCGCAAGATCGGTGAGGCGGAACGTGAAGCGCAGAATAAGGTGCAGCACCACGTTTGCGTGTG
TATCGCGGCGGGCTGCCTTTCGAGCGGCGCCGAGCAGGTGCGCGACGCATTGAAAAAGGAAGTAGCCGAATCGGGGATGC
AGAACGAGGTGCTGGTGAAAGGTGTCGGCTGCATGGGGTTGTGCAGCGCCGGCCCCCTGGTGGGCGTGACCACGGACGGC
CAGATGTTTGCCGAAGTGACGCCAGCGGCGGCGCCTGAGATCATCCGCAGCCTGGACACGGGCAGCGAGCCGGGTGGAGT
GAAGCGCTGTCCCACCGATGTGCCATTCTTCGCGCGACAGAAGAAGATCGTTCTCGAAAACTCAGGGGTGATCGACCCTG
AGCGGATTGAGGACTACATCGCCCATCACGGCTATGCCGCACTAGTCACTGCGATTACGGAGATGTCGCCGCAGGAGGTG
ATCGAACAGGTGAAATCGAGTAGCCTGCGCGGCCGCGGCGGCGCCGGCTATCCGACGGGTTTGAAGTGGAGCACGGTCGC
CAAGACCGGCGAACAGCAGAAGTACGTAATCTGCAACGCCGACGAAGGCGACCCCGGCGCGTTCATGGATCGCGCGGTAC
TGGAGAGCGATCCGCACCGCGTGCTCGAAGGGATGGCGATCGCGGCCTTTGCGGTGGGGGCGCAGAAGGGCTTCATCTAC
GTGCGCGCCGAGTATCCTCTGGCGGTGAAGCATTTGAAGGGCGCCATCCGGCAAGCCGAGCGGCTCGGACTGCTCGGCAA
CAGCATCTGCGGCACGCGTTTCAGCTTTCACATCGATATCCGGCTTGGCGCCGGCGCCTTCGTCTGCGGCGAAGAGACCG
CGCTGATCGCGAGCATCGAGGGCAAGCGCGGGACCCCGCGTCCGCGACCGCCCTTCCCGGCGGAATCGGGCCTATGGGAG
TGCCCCACGCTGATCAACAACGTGGAGACGTTCGCCAACATCGCTCCTATCCTGCGAAACGGCGCCGCTTGGTTCGCCGC
CATCGGCACGGAGAGGAGCAAAGGGACCAAGGTATTCGCACTGGCAGGAAGGGTAGCGAATACGGGGCTCATTGAGGTGC
CGATGGGGATCACGCTGCGCGAAATCATTCACGAGATCGGCGGGGGCGTTCCCGATGGCAAGCGGTATAAGGCGGTGCAG
ACCGGAGGACCTTCAGGCGGGTGCATTCCGGAGCAGCATCTGGATTCCCCGGTGGACTACGAATCGCTCGCCAGGATCGG
TTCCATTATGGGCTCGGGCGGCATGATCGTGATGGACCAGACCTCCTGCATGGTGGATGTCGCCAAGTATTTCATGGAGT
TCTGCATGAGCGAATCCTGCGGCAAATGCATTCCCTGCCGCGCCGGAACGCAGCAGATGCACGCGATTCTGGAGAAGATC
ACGGCCGGCGAGGCGACCGCCCAGGATGTCGCGCTGCTGGAAGAACTGTGCGACCTGGTGCGCTCCACGAGCCTCTGCGG
GCTGGGGCAGAGCGCGCCCAATCCGGTAGTCACCACGTTGAAATACTTTCGGGGCGAGTACGATGCGCACCTCGCAGGCA
GCTGTCCGGCGGGAACCTGCAAGATCAAGCACGAGGTGACGGCATGA

Upstream 100 bases:

>100_bases
TGGCGCCGGCGGCCGTGATGGATCAGGCCGTCCTGGGCAAAATCGGACCCGCCGAGATGCTGGCGCGGATCGAGAAAGAT
ATCCGCCTAGAGGTCCAGAA

Downstream 100 bases:

>100_bases
GTATCAAAGCGGCGGTACGGGTAAAGACGCTCACCATTGACGGCCGCGAAGTGGGCGCGCGCGAGGACCAGACGGTACTC
GAGGTGGCGCGCGAGAACGG

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MTIEELRKIGEAEREAQNKVQHHVCVCIAAGCLSSGAEQVRDALKKEVAESGMQNEVLVKGVGCMGLCSAGPLVGVTTDG
QMFAEVTPAAAPEIIRSLDTGSEPGGVKRCPTDVPFFARQKKIVLENSGVIDPERIEDYIAHHGYAALVTAITEMSPQEV
IEQVKSSSLRGRGGAGYPTGLKWSTVAKTGEQQKYVICNADEGDPGAFMDRAVLESDPHRVLEGMAIAAFAVGAQKGFIY
VRAEYPLAVKHLKGAIRQAERLGLLGNSICGTRFSFHIDIRLGAGAFVCGEETALIASIEGKRGTPRPRPPFPAESGLWE
CPTLINNVETFANIAPILRNGAAWFAAIGTERSKGTKVFALAGRVANTGLIEVPMGITLREIIHEIGGGVPDGKRYKAVQ
TGGPSGGCIPEQHLDSPVDYESLARIGSIMGSGGMIVMDQTSCMVDVAKYFMEFCMSESCGKCIPCRAGTQQMHAILEKI
TAGEATAQDVALLEELCDLVRSTSLCGLGQSAPNPVVTTLKYFRGEYDAHLAGSCPAGTCKIKHEVTA

Sequences:

>Translated_548_residues
MTIEELRKIGEAEREAQNKVQHHVCVCIAAGCLSSGAEQVRDALKKEVAESGMQNEVLVKGVGCMGLCSAGPLVGVTTDG
QMFAEVTPAAAPEIIRSLDTGSEPGGVKRCPTDVPFFARQKKIVLENSGVIDPERIEDYIAHHGYAALVTAITEMSPQEV
IEQVKSSSLRGRGGAGYPTGLKWSTVAKTGEQQKYVICNADEGDPGAFMDRAVLESDPHRVLEGMAIAAFAVGAQKGFIY
VRAEYPLAVKHLKGAIRQAERLGLLGNSICGTRFSFHIDIRLGAGAFVCGEETALIASIEGKRGTPRPRPPFPAESGLWE
CPTLINNVETFANIAPILRNGAAWFAAIGTERSKGTKVFALAGRVANTGLIEVPMGITLREIIHEIGGGVPDGKRYKAVQ
TGGPSGGCIPEQHLDSPVDYESLARIGSIMGSGGMIVMDQTSCMVDVAKYFMEFCMSESCGKCIPCRAGTQQMHAILEKI
TAGEATAQDVALLEELCDLVRSTSLCGLGQSAPNPVVTTLKYFRGEYDAHLAGSCPAGTCKIKHEVTA
>Mature_547_residues
TIEELRKIGEAEREAQNKVQHHVCVCIAAGCLSSGAEQVRDALKKEVAESGMQNEVLVKGVGCMGLCSAGPLVGVTTDGQ
MFAEVTPAAAPEIIRSLDTGSEPGGVKRCPTDVPFFARQKKIVLENSGVIDPERIEDYIAHHGYAALVTAITEMSPQEVI
EQVKSSSLRGRGGAGYPTGLKWSTVAKTGEQQKYVICNADEGDPGAFMDRAVLESDPHRVLEGMAIAAFAVGAQKGFIYV
RAEYPLAVKHLKGAIRQAERLGLLGNSICGTRFSFHIDIRLGAGAFVCGEETALIASIEGKRGTPRPRPPFPAESGLWEC
PTLINNVETFANIAPILRNGAAWFAAIGTERSKGTKVFALAGRVANTGLIEVPMGITLREIIHEIGGGVPDGKRYKAVQT
GGPSGGCIPEQHLDSPVDYESLARIGSIMGSGGMIVMDQTSCMVDVAKYFMEFCMSESCGKCIPCRAGTQQMHAILEKIT
AGEATAQDVALLEELCDLVRSTSLCGLGQSAPNPVVTTLKYFRGEYDAHLAGSCPAGTCKIKHEVTA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI260656005, Length=378, Percent_Identity=40.4761904761905, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI20149568, Length=378, Percent_Identity=40.4761904761905, Blast_Score=303, Evalue=3e-82,
Organism=Escherichia coli, GI1788620, Length=399, Percent_Identity=43.1077694235589, Blast_Score=353, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI17531727, Length=376, Percent_Identity=38.563829787234, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI19920794, Length=375, Percent_Identity=39.7333333333333, Blast_Score=299, Evalue=4e-81,
Organism=Drosophila melanogaster, GI45550452, Length=368, Percent_Identity=40.4891304347826, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24653819, Length=385, Percent_Identity=33.5064935064935, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24653817, Length=355, Percent_Identity=31.830985915493, Blast_Score=191, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 58200; Mature: 58069

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIEELRKIGEAEREAQNKVQHHVCVCIAAGCLSSGAEQVRDALKKEVAESGMQNEVLVK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEE
GVGCMGLCSAGPLVGVTTDGQMFAEVTPAAAPEIIRSLDTGSEPGGVKRCPTDVPFFARQ
CCCHHHCCCCCCEEEEECCCCEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCC
KKIVLENSGVIDPERIEDYIAHHGYAALVTAITEMSPQEVIEQVKSSSLRGRGGAGYPTG
CEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
LKWSTVAKTGEQQKYVICNADEGDPGAFMDRAVLESDPHRVLEGMAIAAFAVGAQKGFIY
CCCHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEE
VRAEYPLAVKHLKGAIRQAERLGLLGNSICGTRFSFHIDIRLGAGAFVCGEETALIASIE
EEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCEEEECCCCEEEEEEC
GKRGTPRPRPPFPAESGLWECPTLINNVETFANIAPILRNGAAWFAAIGTERSKGTKVFA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEE
LAGRVANTGLIEVPMGITLREIIHEIGGGVPDGKRYKAVQTGGPSGGCIPEQHLDSPVDY
EECCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHCCCCCCH
ESLARIGSIMGSGGMIVMDQTSCMVDVAKYFMEFCMSESCGKCIPCRAGTQQMHAILEKI
HHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
TAGEATAQDVALLEELCDLVRSTSLCGLGQSAPNPVVTTLKYFRGEYDAHLAGSCPAGTC
HCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCCCCCCCE
KIKHEVTA
EEEEECCC
>Mature Secondary Structure 
TIEELRKIGEAEREAQNKVQHHVCVCIAAGCLSSGAEQVRDALKKEVAESGMQNEVLVK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEE
GVGCMGLCSAGPLVGVTTDGQMFAEVTPAAAPEIIRSLDTGSEPGGVKRCPTDVPFFARQ
CCCHHHCCCCCCEEEEECCCCEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCC
KKIVLENSGVIDPERIEDYIAHHGYAALVTAITEMSPQEVIEQVKSSSLRGRGGAGYPTG
CEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
LKWSTVAKTGEQQKYVICNADEGDPGAFMDRAVLESDPHRVLEGMAIAAFAVGAQKGFIY
CCCHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEE
VRAEYPLAVKHLKGAIRQAERLGLLGNSICGTRFSFHIDIRLGAGAFVCGEETALIASIE
EEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCEEEECCCCEEEEEEC
GKRGTPRPRPPFPAESGLWECPTLINNVETFANIAPILRNGAAWFAAIGTERSKGTKVFA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEE
LAGRVANTGLIEVPMGITLREIIHEIGGGVPDGKRYKAVQTGGPSGGCIPEQHLDSPVDY
EECCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHCCCCCCH
ESLARIGSIMGSGGMIVMDQTSCMVDVAKYFMEFCMSESCGKCIPCRAGTQQMHAILEKI
HHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
TAGEATAQDVALLEELCDLVRSTSLCGLGQSAPNPVVTTLKYFRGEYDAHLAGSCPAGTC
HCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCCCCCCCE
KIKHEVTA
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]