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The map label for this gene is hoxU [H]

Identifier: 116624102

GI number: 116624102

Start: 6332874

End: 6333599

Strand: Reverse

Name: hoxU [H]

Synonym: Acid_5017

Alternate gene names: 116624102

Gene position: 6333599-6332874 (Counterclockwise)

Preceding gene: 116624103

Following gene: 116624101

Centisome position: 63.55

GC content: 62.95

Gene sequence:

>726_bases
ATGAGTATCAAAGCGGCGGTACGGGTAAAGACGCTCACCATTGACGGCCGCGAAGTGGGCGCGCGCGAGGACCAGACGGT
ACTCGAGGTGGCGCGCGAGAACGGCATCTTCATTCCGACCTTGTGTGCGCTTCCCGGTTTGAGCACGGTGGGAGCGTGCA
GGCTGTGCATCGTTGAAGTCAAGGGTATTAACAAGCTGCTGCCGGCGTGCGTCACGCGGGTGACCGAGGGCATGGAGGTC
ACGGCGAATTCCCCGCGGCTCGCCCAACTTCGTCGCGGAATTCTGGAACTGGTCTTCGCCGAGCGCAACCACGTGTGCAG
CGTATGCGTGGCCAATGGCAACTGCGATCTGCAATCCCTGGCACTGAAACTCGGCATGACCCACGTGCACTTCCCCTACC
GGTATCCGCGGCTCCCGGTGGATGCCTCTCACGAGCGCTTCGTGATGGATCACAATCGCTGTGTCCTGTGCACGCGCTGC
GTCCGGGTCTGCGACGAAATTGAAGGCGCCCACACCTGGGACGTGATGGCGCGCGGGGTGGAATGCCGCGTGATCACCGA
TCTTGCCCAGCCCTGGGGGGAGAGCGAAAGCTGCACCGGCTGCGGTAAGTGCGTGCAGGTCTGCCCCACCGGGGCGCTGT
CTGAAAAGGGAAGGTCAGTGGCCGAGATGTCGAAACGCCGCCAGTTCCTGCCCTATCTGACGTTGATGAGGGAAGGGCGG
CGATGA

Upstream 100 bases:

>100_bases
CGGTAGTCACCACGTTGAAATACTTTCGGGGCGAGTACGATGCGCACCTCGCAGGCAGCTGTCCGGCGGGAACCTGCAAG
ATCAAGCACGAGGTGACGGC

Downstream 100 bases:

>100_bases
GTAGCCATAAGATTCGCCTGGCGACCGTGTGGCTGGATGGCTGCTCCGGATGCCACATGTCGATTCTCGACACCGATGAG
CGCCTGATCGCGATTGCACA

Product: bidirectional hydrogenase complex protein HoxU

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MSIKAAVRVKTLTIDGREVGAREDQTVLEVARENGIFIPTLCALPGLSTVGACRLCIVEVKGINKLLPACVTRVTEGMEV
TANSPRLAQLRRGILELVFAERNHVCSVCVANGNCDLQSLALKLGMTHVHFPYRYPRLPVDASHERFVMDHNRCVLCTRC
VRVCDEIEGAHTWDVMARGVECRVITDLAQPWGESESCTGCGKCVQVCPTGALSEKGRSVAEMSKRRQFLPYLTLMREGR
R

Sequences:

>Translated_241_residues
MSIKAAVRVKTLTIDGREVGAREDQTVLEVARENGIFIPTLCALPGLSTVGACRLCIVEVKGINKLLPACVTRVTEGMEV
TANSPRLAQLRRGILELVFAERNHVCSVCVANGNCDLQSLALKLGMTHVHFPYRYPRLPVDASHERFVMDHNRCVLCTRC
VRVCDEIEGAHTWDVMARGVECRVITDLAQPWGESESCTGCGKCVQVCPTGALSEKGRSVAEMSKRRQFLPYLTLMREGR
R
>Mature_240_residues
SIKAAVRVKTLTIDGREVGAREDQTVLEVARENGIFIPTLCALPGLSTVGACRLCIVEVKGINKLLPACVTRVTEGMEVT
ANSPRLAQLRRGILELVFAERNHVCSVCVANGNCDLQSLALKLGMTHVHFPYRYPRLPVDASHERFVMDHNRCVLCTRCV
RVCDEIEGAHTWDVMARGVECRVITDLAQPWGESESCTGCGKCVQVCPTGALSEKGRSVAEMSKRRQFLPYLTLMREGRR

Specific function: Subunits alpha and gamma of hoxS constitute an NADH-- oxidoreductase [H]

COG id: COG1034

COG function: function code C; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI33519475, Length=222, Percent_Identity=29.7297297297297, Blast_Score=104, Evalue=8e-23,
Organism=Escherichia coli, GI145693161, Length=240, Percent_Identity=29.1666666666667, Blast_Score=92, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193209088, Length=213, Percent_Identity=29.1079812206573, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI32566231, Length=213, Percent_Identity=29.1079812206573, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17565758, Length=213, Percent_Identity=29.1079812206573, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24640559, Length=204, Percent_Identity=30.3921568627451, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24640557, Length=204, Percent_Identity=30.3921568627451, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR016214
- InterPro:   IPR000283
- InterPro:   IPR019574 [H]

Pfam domain/function: PF00111 Fer2; PF10588 NADH-G_4Fe-4S_3 [H]

EC number: =1.12.1.2 [H]

Molecular weight: Translated: 26643; Mature: 26512

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
9.5 %Cys+Met (Translated Protein)
6.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
9.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKAAVRVKTLTIDGREVGAREDQTVLEVARENGIFIPTLCALPGLSTVGACRLCIVEV
CCCCEEEEEEEEEECCHHCCCCCHHHHHHHHHHCCCEEEHHHHCCCCCHHHHHHEEEEEH
KGINKLLPACVTRVTEGMEVTANSPRLAQLRRGILELVFAERNHVCSVCVANGNCDLQSL
HCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHH
ALKLGMTHVHFPYRYPRLPVDASHERFVMDHNRCVLCTRCVRVCDEIEGAHTWDVMARGV
HHHHCCCEEECCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHCCC
ECRVITDLAQPWGESESCTGCGKCVQVCPTGALSEKGRSVAEMSKRRQFLPYLTLMREGR
CEEEEHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCC
R
C
>Mature Secondary Structure 
SIKAAVRVKTLTIDGREVGAREDQTVLEVARENGIFIPTLCALPGLSTVGACRLCIVEV
CCCEEEEEEEEEECCHHCCCCCHHHHHHHHHHCCCEEEHHHHCCCCCHHHHHHEEEEEH
KGINKLLPACVTRVTEGMEVTANSPRLAQLRRGILELVFAERNHVCSVCVANGNCDLQSL
HCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHH
ALKLGMTHVHFPYRYPRLPVDASHERFVMDHNRCVLCTRCVRVCDEIEGAHTWDVMARGV
HHHHCCCEEECCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHCCC
ECRVITDLAQPWGESESCTGCGKCVQVCPTGALSEKGRSVAEMSKRRQFLPYLTLMREGR
CEEEEHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2188945; 12948488; 2496982 [H]