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The map label for this gene is kinA [H]

Identifier: 116623299

GI number: 116623299

Start: 5330140

End: 5331735

Strand: Direct

Name: kinA [H]

Synonym: Acid_4206

Alternate gene names: 116623299

Gene position: 5330140-5331735 (Clockwise)

Preceding gene: 116623298

Following gene: 116623300

Centisome position: 53.49

GC content: 62.34

Gene sequence:

>1596_bases
ATGAAACTGCTGACTGAGTTGCGCGTTGGTCTGGCCGCCAAGCTCGCGATCTGCGTGATCGCGAGCACCGCGGCCTTCTT
TGCTTTATTCGGCTATATCAACCTGCGCCTGGAGCGCTCCAACTCCGAGGAGTTGATCAAACAGTCGGCCTACCGCGTCG
CCGACGTCATCCTGCGCAGCACGCATTATGAGATGCTGCACAACGACCGCGCGGGCCTCCACAACGTCATTCAGGAACTG
GGCAACGAAACCGGCATCCGGCGAATCCGGCTCTTCAACAAGGAAGGCCGCATCACATATTCCACCGATGCCGCCGAGCT
CAATACCGTCGTCGATAAGAAGGCCGAAGCCTGCTACGGCTGCCACCAGCAGTCCGCGCCCCTCGTCAGACTTCACCGCA
AGGATCGCGCCCGCCGCTTCACCGACAAGCAGGGACAAAGCGTGCTCGCCGTGATTCAACCCATCGCCAACGCCCCCGAG
TGCTCGAACGCCGCCTGCCACGAACACCCCGCCGACCGCCAGGTGCTGGGCGTCATTGACGCCAACCTGTCGCTCGCCAC
CGTAGATGAGCAGATCGCGCAGCACCAGGCCAGCCTGGCGTACTTCCTGATCGGCGCCATCGTATTCGGCTCCGCCCTGG
CGGTGGCCTTCATCTGGATCATGGTCTACCGTCCCGTGAAGGCGCTGATCGATGGCACCCACCGCGTGGCCGAGGGCGAT
CTCTCCTACCGCCTGCCCGTCACTTCCGAAGACGAGCTCGGCGACCTGGCGCGTTCCTTCAACAAGATGACCGTCGAGGT
CGAGGGTGTCCATGCCGAGATCGAAGAGCGCGTGCGCCGCAAGACCGCCGAATTGGAAAAGACGCACAAGGTTCTGCTCA
GTACGGAGAAAATGGCTTCGATCGGCAAACTCGCTGCCACTGTTGCCCACGAGATTAATAATCCGCTTTTCGGCATCCTG
ACCTACGCCCGCCTGGTATTGCGCAACCTCATGAAGGTGGAGGTGGAGGGCCGCGACGAAATGGCCGAGCAGCTCCAAAC
TATCGAGCGCGAGAGCAAACGCTGCGGCGATCTGGTGAAGAACCTGCTCAGCTTCTCCCGCCAGGCGCCCAGCAATCGCG
AGCCGCAGGATCTCAACACCATCGTGCATCGCGCCACCCTGCTGGTGAAGCACAAGCTCGACATGCAGAGCATCGAGTTG
CGCGAAACCCTGGCCGAAGGCCTGCCGCCGGTGGAATGCGATGCCAACCAGATTCAGCAGGTAATCCTCGTGCTGATGGT
GAACGCCTCGGAGGCGATGCCGAAGGGCGGCACGCTCGAGGTGTCCACCGAATTCGATAAGACCGCGGAACAGGGCGTGG
TCCGCGTGCGCGATACCGGCAGCGGCATCCCGGCGGACGTGCTGCCGCGCATTTTCGATCCATTCTTTACGACTAAAGAA
GACGTGAATCGTACCGGCCTGGGTTTGGCCGTGGCAGCCGGCATTGTGGAACAGCACACCGGCGAGATCACGGTACACTC
CACACCGGGCGAGGGTACCCAATTCAGAGTGGCGCTGCCGGCGACGGCGGCCGTGCCATCCGGGGCCGGACAGTGA

Upstream 100 bases:

>100_bases
TCCGCGTGATTGCCCATTATTTCCCTGTCTTTGAGGCGCACCAGTCGGAACATGCGCCTGACCTGCAGGAACAAACGGAG
GAAGACCCCGTTGCGGTCGG

Downstream 100 bases:

>100_bases
CAGGCAACCGTAACGGGAACAAACGGGAGGAACCAATGGCAAGCGTAGTGGAACCAGCAACTTCAACCCGAACCAAGGGC
AGAATACTCATCGTTGACGA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Stage II sporulation protein F; Stage II sporulation protein J [H]

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MKLLTELRVGLAAKLAICVIASTAAFFALFGYINLRLERSNSEELIKQSAYRVADVILRSTHYEMLHNDRAGLHNVIQEL
GNETGIRRIRLFNKEGRITYSTDAAELNTVVDKKAEACYGCHQQSAPLVRLHRKDRARRFTDKQGQSVLAVIQPIANAPE
CSNAACHEHPADRQVLGVIDANLSLATVDEQIAQHQASLAYFLIGAIVFGSALAVAFIWIMVYRPVKALIDGTHRVAEGD
LSYRLPVTSEDELGDLARSFNKMTVEVEGVHAEIEERVRRKTAELEKTHKVLLSTEKMASIGKLAATVAHEINNPLFGIL
TYARLVLRNLMKVEVEGRDEMAEQLQTIERESKRCGDLVKNLLSFSRQAPSNREPQDLNTIVHRATLLVKHKLDMQSIEL
RETLAEGLPPVECDANQIQQVILVLMVNASEAMPKGGTLEVSTEFDKTAEQGVVRVRDTGSGIPADVLPRIFDPFFTTKE
DVNRTGLGLAVAAGIVEQHTGEITVHSTPGEGTQFRVALPATAAVPSGAGQ

Sequences:

>Translated_531_residues
MKLLTELRVGLAAKLAICVIASTAAFFALFGYINLRLERSNSEELIKQSAYRVADVILRSTHYEMLHNDRAGLHNVIQEL
GNETGIRRIRLFNKEGRITYSTDAAELNTVVDKKAEACYGCHQQSAPLVRLHRKDRARRFTDKQGQSVLAVIQPIANAPE
CSNAACHEHPADRQVLGVIDANLSLATVDEQIAQHQASLAYFLIGAIVFGSALAVAFIWIMVYRPVKALIDGTHRVAEGD
LSYRLPVTSEDELGDLARSFNKMTVEVEGVHAEIEERVRRKTAELEKTHKVLLSTEKMASIGKLAATVAHEINNPLFGIL
TYARLVLRNLMKVEVEGRDEMAEQLQTIERESKRCGDLVKNLLSFSRQAPSNREPQDLNTIVHRATLLVKHKLDMQSIEL
RETLAEGLPPVECDANQIQQVILVLMVNASEAMPKGGTLEVSTEFDKTAEQGVVRVRDTGSGIPADVLPRIFDPFFTTKE
DVNRTGLGLAVAAGIVEQHTGEITVHSTPGEGTQFRVALPATAAVPSGAGQ
>Mature_531_residues
MKLLTELRVGLAAKLAICVIASTAAFFALFGYINLRLERSNSEELIKQSAYRVADVILRSTHYEMLHNDRAGLHNVIQEL
GNETGIRRIRLFNKEGRITYSTDAAELNTVVDKKAEACYGCHQQSAPLVRLHRKDRARRFTDKQGQSVLAVIQPIANAPE
CSNAACHEHPADRQVLGVIDANLSLATVDEQIAQHQASLAYFLIGAIVFGSALAVAFIWIMVYRPVKALIDGTHRVAEGD
LSYRLPVTSEDELGDLARSFNKMTVEVEGVHAEIEERVRRKTAELEKTHKVLLSTEKMASIGKLAATVAHEINNPLFGIL
TYARLVLRNLMKVEVEGRDEMAEQLQTIERESKRCGDLVKNLLSFSRQAPSNREPQDLNTIVHRATLLVKHKLDMQSIEL
RETLAEGLPPVECDANQIQQVILVLMVNASEAMPKGGTLEVSTEFDKTAEQGVVRVRDTGSGIPADVLPRIFDPFFTTKE
DVNRTGLGLAVAAGIVEQHTGEITVHSTPGEGTQFRVALPATAAVPSGAGQ

Specific function: Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. It also autophosphorylates in the presence of ATP [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=228, Percent_Identity=36.4035087719298, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788549, Length=235, Percent_Identity=31.9148936170213, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1789149, Length=370, Percent_Identity=24.5945945945946, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788393, Length=306, Percent_Identity=28.4313725490196, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI87081816, Length=370, Percent_Identity=26.4864864864865, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790300, Length=242, Percent_Identity=31.8181818181818, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI145693157, Length=235, Percent_Identity=31.063829787234, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI48994928, Length=267, Percent_Identity=27.3408239700375, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1786783, Length=439, Percent_Identity=24.6013667425968, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=25.6637168141593, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790346, Length=235, Percent_Identity=25.9574468085106, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR013655
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF08447 PAS_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 58387; Mature: 58387

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLTELRVGLAAKLAICVIASTAAFFALFGYINLRLERSNSEELIKQSAYRVADVILRS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHH
THYEMLHNDRAGLHNVIQELGNETGIRRIRLFNKEGRITYSTDAAELNTVVDKKAEACYG
HHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHC
CHQQSAPLVRLHRKDRARRFTDKQGQSVLAVIQPIANAPECSNAACHEHPADRQVLGVID
CCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEE
ANLSLATVDEQIAQHQASLAYFLIGAIVFGSALAVAFIWIMVYRPVKALIDGTHRVAEGD
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC
LSYRLPVTSEDELGDLARSFNKMTVEVEGVHAEIEERVRRKTAELEKTHKVLLSTEKMAS
CEEECCCCCCHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGKLAATVAHEINNPLFGILTYARLVLRNLMKVEVEGRDEMAEQLQTIERESKRCGDLVK
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHH
NLLSFSRQAPSNREPQDLNTIVHRATLLVKHKLDMQSIELRETLAEGLPPVECDANQIQQ
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHH
VILVLMVNASEAMPKGGTLEVSTEFDKTAEQGVVRVRDTGSGIPADVLPRIFDPFFTTKE
HHHHHHHCCHHCCCCCCEEEEECCHHHHHHCCEEEEEECCCCCCHHHHHHHHCHHHCCHH
DVNRTGLGLAVAAGIVEQHTGEITVHSTPGEGTQFRVALPATAAVPSGAGQ
HCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCHHCCCCCCCC
>Mature Secondary Structure
MKLLTELRVGLAAKLAICVIASTAAFFALFGYINLRLERSNSEELIKQSAYRVADVILRS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHH
THYEMLHNDRAGLHNVIQELGNETGIRRIRLFNKEGRITYSTDAAELNTVVDKKAEACYG
HHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHC
CHQQSAPLVRLHRKDRARRFTDKQGQSVLAVIQPIANAPECSNAACHEHPADRQVLGVID
CCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEE
ANLSLATVDEQIAQHQASLAYFLIGAIVFGSALAVAFIWIMVYRPVKALIDGTHRVAEGD
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC
LSYRLPVTSEDELGDLARSFNKMTVEVEGVHAEIEERVRRKTAELEKTHKVLLSTEKMAS
CEEECCCCCCHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGKLAATVAHEINNPLFGILTYARLVLRNLMKVEVEGRDEMAEQLQTIERESKRCGDLVK
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHH
NLLSFSRQAPSNREPQDLNTIVHRATLLVKHKLDMQSIELRETLAEGLPPVECDANQIQQ
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHH
VILVLMVNASEAMPKGGTLEVSTEFDKTAEQGVVRVRDTGSGIPADVLPRIFDPFFTTKE
HHHHHHHCCHHCCCCCCEEEEECCHHHHHHCCEEEEEECCCCCCHHHHHHHHCHHHCCHH
DVNRTGLGLAVAAGIVEQHTGEITVHSTPGEGTQFRVALPATAAVPSGAGQ
HCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2104615; 2509430; 9384377 [H]