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The map label for this gene is zraR [H]

Identifier: 116623300

GI number: 116623300

Start: 5331771

End: 5333135

Strand: Direct

Name: zraR [H]

Synonym: Acid_4207

Alternate gene names: 116623300

Gene position: 5331771-5333135 (Clockwise)

Preceding gene: 116623299

Following gene: 116623301

Centisome position: 53.5

GC content: 61.32

Gene sequence:

>1365_bases
ATGGCAAGCGTAGTGGAACCAGCAACTTCAACCCGAACCAAGGGCAGAATACTCATCGTTGACGATGAGTTGGTAGTGCG
CGATTCGCTGGGCAAATGGTTTTCCAGCGAAGGCTATAGCGCGCGGCCGGTCGGCGGCGCACGCGAAGCGCTGGAGGTGA
TCCAGCATGGCGAATTCGATATCGCGCTGCTGGATATCAAGATGCCGGGAATGGACGGCATGGAGCTGCAGGCCCGTTTG
CGCGAAGCCGATTCGGACCTCACCATCATTATGATGACCGGCTATTCGAGCGTGGAGACCGCGGTCCAGGCGCTGAAGCA
GGGCGCCTACGACTACATCACCAAACCGGTGGACCCCGACGAACTCTCGCATCTCGTCTCTAACGCGCTCGAGCACAAAC
GCGCCCGCCGCGAAGTCGATCGCCTGCGCGAGAATTTGCAGGAAGTCGTGCCCGGCACCGAACTCATCGGCAAGAGCCCG
GCGATGCGCAAAGTCACGGAGCTGATCGAAATGGTGGCCCCCACCGAGGCCACCGTGCTGATCACCGGCGAAACCGGCAC
CGGCAAGGAAGTGGTGGCGCGCGCCATCCATTCCGCCGGCCCGCGGCGCTACATGCCGATGGTCACGGTACACTGCGGAG
CCCTCACCGAAACCCTGCTCGAAAGCGAGCTCTTCGGCCACGAGAAGGGAGCCTTCACCGGAGCCCAGTACCGCAAGAAG
GGCAAGTTCGAAATCGCCGACGGCGGCAGCGTCTTCCTCGACGAGATCAGCGACATCAGCCTCAAGACCCAGACCGACCT
GCTGCGCGTCCTCCAGGAAAAGGAGATCGTCCGCGTGGGCGGCAACCAGCAGCTCAAAGTCGATTTCCGCGCGATCGCCG
CCACCAACAAGAATCTCGAAACCCTGGTCAAGGCGGGCACCTTCCGTCCCGATCTTTACTACCGCCTCCACGTCTTCTGC
ATTGATCTGCCCCCGCTGCGCGATCGCCGCGAAGATATTCCGCTCCTGGTCAGCCATTTCCTCAATAAATTCTGTATGGC
CACCAGCCGTCCCGTGCCTTCGATTTCCGCCGAGGCCATGGAGATCCTGATGCGCCACGATTGGCCCGGTAACGTTCGCG
AACTCGAAAACGCCGTGGAGCGCGCCCTCGTGGTGGGCCGCGGCAATGAGGTCAAGCCGGCCGATTTCTCCTTCCAGTTC
CAGTCCGATGAAATCAAGGGCGGCAAGACCCTCGACGATATCGAACGCGTTCACATCGAACGCATCCTTAGGGAGACGCA
GCACAATCTTTCGCGCGCGGCCCGGATCCTGGACATCGATCGCACCACGCTCTACAACAAGCTGCGCCGCTACGGTCTAA
GGTGA

Upstream 100 bases:

>100_bases
AGGGTACCCAATTCAGAGTGGCGCTGCCGGCGACGGCGGCCGTGCCATCCGGGGCCGGACAGTGACAGGCAACCGTAACG
GGAACAAACGGGAGGAACCA

Downstream 100 bases:

>100_bases
AACCGATTCACCTGATTCCGCTCGCCAATGGGAGCGGTCCGCTGGAACCAGGCCTGGATGTGCTGGAGCACCTGGCGGCG
AACCTCGCACGCACCTTCCG

Product: two component sigma54-specific Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MASVVEPATSTRTKGRILIVDDELVVRDSLGKWFSSEGYSARPVGGAREALEVIQHGEFDIALLDIKMPGMDGMELQARL
READSDLTIIMMTGYSSVETAVQALKQGAYDYITKPVDPDELSHLVSNALEHKRARREVDRLRENLQEVVPGTELIGKSP
AMRKVTELIEMVAPTEATVLITGETGTGKEVVARAIHSAGPRRYMPMVTVHCGALTETLLESELFGHEKGAFTGAQYRKK
GKFEIADGGSVFLDEISDISLKTQTDLLRVLQEKEIVRVGGNQQLKVDFRAIAATNKNLETLVKAGTFRPDLYYRLHVFC
IDLPPLRDRREDIPLLVSHFLNKFCMATSRPVPSISAEAMEILMRHDWPGNVRELENAVERALVVGRGNEVKPADFSFQF
QSDEIKGGKTLDDIERVHIERILRETQHNLSRAARILDIDRTTLYNKLRRYGLR

Sequences:

>Translated_454_residues
MASVVEPATSTRTKGRILIVDDELVVRDSLGKWFSSEGYSARPVGGAREALEVIQHGEFDIALLDIKMPGMDGMELQARL
READSDLTIIMMTGYSSVETAVQALKQGAYDYITKPVDPDELSHLVSNALEHKRARREVDRLRENLQEVVPGTELIGKSP
AMRKVTELIEMVAPTEATVLITGETGTGKEVVARAIHSAGPRRYMPMVTVHCGALTETLLESELFGHEKGAFTGAQYRKK
GKFEIADGGSVFLDEISDISLKTQTDLLRVLQEKEIVRVGGNQQLKVDFRAIAATNKNLETLVKAGTFRPDLYYRLHVFC
IDLPPLRDRREDIPLLVSHFLNKFCMATSRPVPSISAEAMEILMRHDWPGNVRELENAVERALVVGRGNEVKPADFSFQF
QSDEIKGGKTLDDIERVHIERILRETQHNLSRAARILDIDRTTLYNKLRRYGLR
>Mature_453_residues
ASVVEPATSTRTKGRILIVDDELVVRDSLGKWFSSEGYSARPVGGAREALEVIQHGEFDIALLDIKMPGMDGMELQARLR
EADSDLTIIMMTGYSSVETAVQALKQGAYDYITKPVDPDELSHLVSNALEHKRARREVDRLRENLQEVVPGTELIGKSPA
MRKVTELIEMVAPTEATVLITGETGTGKEVVARAIHSAGPRRYMPMVTVHCGALTETLLESELFGHEKGAFTGAQYRKKG
KFEIADGGSVFLDEISDISLKTQTDLLRVLQEKEIVRVGGNQQLKVDFRAIAATNKNLETLVKAGTFRPDLYYRLHVFCI
DLPPLRDRREDIPLLVSHFLNKFCMATSRPVPSISAEAMEILMRHDWPGNVRELENAVERALVVGRGNEVKPADFSFQFQ
SDEIKGGKTLDDIERVHIERILRETQHNLSRAARILDIDRTTLYNKLRRYGLR

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=439, Percent_Identity=46.4692482915718, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1788550, Length=452, Percent_Identity=44.4690265486726, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1790299, Length=470, Percent_Identity=39.5744680851064, Blast_Score=322, Evalue=4e-89,
Organism=Escherichia coli, GI1788905, Length=447, Percent_Identity=36.9127516778523, Blast_Score=298, Evalue=3e-82,
Organism=Escherichia coli, GI87082117, Length=337, Percent_Identity=46.2908011869436, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI1789087, Length=352, Percent_Identity=44.0340909090909, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI87082152, Length=324, Percent_Identity=43.5185185185185, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1789233, Length=321, Percent_Identity=41.4330218068536, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI1787583, Length=343, Percent_Identity=38.7755102040816, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1786524, Length=313, Percent_Identity=41.85303514377, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI87081872, Length=242, Percent_Identity=45.4545454545455, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1789828, Length=234, Percent_Identity=35.8974358974359, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI87081858, Length=303, Percent_Identity=28.3828382838284, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790863, Length=114, Percent_Identity=35.0877192982456, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1789809, Length=107, Percent_Identity=33.6448598130841, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1787229, Length=114, Percent_Identity=37.719298245614, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=131, Percent_Identity=30.5343511450382, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790552, Length=107, Percent_Identity=30.8411214953271, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787487, Length=154, Percent_Identity=29.8701298701299, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1789402, Length=101, Percent_Identity=28.7128712871287, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI87082052, Length=218, Percent_Identity=27.9816513761468, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50879; Mature: 50748

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASVVEPATSTRTKGRILIVDDELVVRDSLGKWFSSEGYSARPVGGAREALEVIQHGEFD
CCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCE
IALLDIKMPGMDGMELQARLREADSDLTIIMMTGYSSVETAVQALKQGAYDYITKPVDPD
EEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHCCCHHHHCCCCCHH
ELSHLVSNALEHKRARREVDRLRENLQEVVPGTELIGKSPAMRKVTELIEMVAPTEATVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCCEEEE
ITGETGTGKEVVARAIHSAGPRRYMPMVTVHCGALTETLLESELFGHEKGAFTGAQYRKK
EECCCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHCC
GKFEIADGGSVFLDEISDISLKTQTDLLRVLQEKEIVRVGGNQQLKVDFRAIAATNKNLE
CCEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEEEEEEECCCCCHH
TLVKAGTFRPDLYYRLHVFCIDLPPLRDRREDIPLLVSHFLNKFCMATSRPVPSISAEAM
HHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHH
EILMRHDWPGNVRELENAVERALVVGRGNEVKPADFSFQFQSDEIKGGKTLDDIERVHIE
HHHHHCCCCCCHHHHHHHHHHHHEECCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHH
RILRETQHNLSRAARILDIDRTTLYNKLRRYGLR
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASVVEPATSTRTKGRILIVDDELVVRDSLGKWFSSEGYSARPVGGAREALEVIQHGEFD
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCE
IALLDIKMPGMDGMELQARLREADSDLTIIMMTGYSSVETAVQALKQGAYDYITKPVDPD
EEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHCCCHHHHCCCCCHH
ELSHLVSNALEHKRARREVDRLRENLQEVVPGTELIGKSPAMRKVTELIEMVAPTEATVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCCEEEE
ITGETGTGKEVVARAIHSAGPRRYMPMVTVHCGALTETLLESELFGHEKGAFTGAQYRKK
EECCCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHCC
GKFEIADGGSVFLDEISDISLKTQTDLLRVLQEKEIVRVGGNQQLKVDFRAIAATNKNLE
CCEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEEEEEEECCCCCHH
TLVKAGTFRPDLYYRLHVFCIDLPPLRDRREDIPLLVSHFLNKFCMATSRPVPSISAEAM
HHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHH
EILMRHDWPGNVRELENAVERALVVGRGNEVKPADFSFQFQSDEIKGGKTLDDIERVHIE
HHHHHCCCCCCHHHHHHHHHHHHEECCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHH
RILRETQHNLSRAARILDIDRTTLYNKLRRYGLR
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]