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The map label for this gene is hisG

Identifier: 116622954

GI number: 116622954

Start: 4890429

End: 4891298

Strand: Reverse

Name: hisG

Synonym: Acid_3856

Alternate gene names: 116622954

Gene position: 4891298-4890429 (Counterclockwise)

Preceding gene: 116622955

Following gene: 116622953

Centisome position: 49.08

GC content: 60.69

Gene sequence:

>870_bases
ATGCTTCTCAAGCTTGGTATTCCGAAAGGCAGCCTGGAAAATGCGACCATCGATCTCTTCCGCCGCGCCGGATTCCAGAT
CACCACTTCCAGCCGCTCCTACTTCCCCGGCATCGATGATCCCGAGATCGAGTGCATGCTCATCCGCGCTCAGGAAATGG
CCCGCTACGTCGAAGATGGCATCCTCGACTCCGGACTCACCGGTCGCGATTGGATCGAGGAAAACGAGGCCGCCATCGTC
CCCGTCGCCGACCTCATCTACGCCAAGCAGAGCTTCGGCAAAGTCCGCTGGGTGCTCGCGGTCCCCGAAGCCTCGAGCTT
CCGCACCGTCCACGATCTCGAAGGCAAGATCATCGCCACCGAGCTTGTCGCCACCACCAAACGCTACATGGCGAAGCACG
GCGTCAAAGCCAAGGTCGAATTCAGCTGGGGCGCCACCGAAGTCAAACCGCCCGTGCTGGCTGACGCCATCGTCGAGGTC
ACCGAGACCGGCTCCAGCCTGCGCGCCAACAAACTCAAGATCATCGATACCGTGCTCGAATCCAATACCCAGCTGATCGC
CAACAAGGCCTCCTGGGAGGATCCCGAAAAGCGCCGCAAGCTCGAAGACATACGCATGCTCCTCCAGGGCGCCATCAACG
CGCTCGGCAAGGTCGGTCTCATGCTCAACGTCCATAAGGACAATCTCAAAGCGGTGCTCGGCGTGCTCCCCGCGCTCAAG
CGCCCCACCATTTCGCACCTCAGCGACGACGAGTGGCTGGCCGTCAACACCATCCTCGATGAAAGCACCGTGCGCGACAT
AATTCCCCGGCTGAAGCAGGCGGGAGGCGAGGGAATCGTGGAATACCCGCTCAACAAGATTGTCCTGTGA

Upstream 100 bases:

>100_bases
GCTACGAGAGCTGTTTTTTCCGCCGCCTGGATGCCGGCGAATGGAAGGTCGCCGACAACCCCACGTACGATCCCGGCGCC
GTGTACGGAGGCAAGTCCTA

Downstream 100 bases:

>100_bases
TCCGCATACTGGAAAGCAAAGACGTCGGCCACCTGCTGAAACGCAAGGCCGCCCGCTTCACCGAAGCCGAGGCGGTGGTG
ACGCCGATTCTAGAGGCCGT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MLLKLGIPKGSLENATIDLFRRAGFQITTSSRSYFPGIDDPEIECMLIRAQEMARYVEDGILDSGLTGRDWIEENEAAIV
PVADLIYAKQSFGKVRWVLAVPEASSFRTVHDLEGKIIATELVATTKRYMAKHGVKAKVEFSWGATEVKPPVLADAIVEV
TETGSSLRANKLKIIDTVLESNTQLIANKASWEDPEKRRKLEDIRMLLQGAINALGKVGLMLNVHKDNLKAVLGVLPALK
RPTISHLSDDEWLAVNTILDESTVRDIIPRLKQAGGEGIVEYPLNKIVL

Sequences:

>Translated_289_residues
MLLKLGIPKGSLENATIDLFRRAGFQITTSSRSYFPGIDDPEIECMLIRAQEMARYVEDGILDSGLTGRDWIEENEAAIV
PVADLIYAKQSFGKVRWVLAVPEASSFRTVHDLEGKIIATELVATTKRYMAKHGVKAKVEFSWGATEVKPPVLADAIVEV
TETGSSLRANKLKIIDTVLESNTQLIANKASWEDPEKRRKLEDIRMLLQGAINALGKVGLMLNVHKDNLKAVLGVLPALK
RPTISHLSDDEWLAVNTILDESTVRDIIPRLKQAGGEGIVEYPLNKIVL
>Mature_289_residues
MLLKLGIPKGSLENATIDLFRRAGFQITTSSRSYFPGIDDPEIECMLIRAQEMARYVEDGILDSGLTGRDWIEENEAAIV
PVADLIYAKQSFGKVRWVLAVPEASSFRTVHDLEGKIIATELVATTKRYMAKHGVKAKVEFSWGATEVKPPVLADAIVEV
TETGSSLRANKLKIIDTVLESNTQLIANKASWEDPEKRRKLEDIRMLLQGAINALGKVGLMLNVHKDNLKAVLGVLPALK
RPTISHLSDDEWLAVNTILDESTVRDIIPRLKQAGGEGIVEYPLNKIVL

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=293, Percent_Identity=26.962457337884, Blast_Score=103, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320896, Length=291, Percent_Identity=25.7731958762887, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_SOLUE (Q01ZU0)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_825110.1
- ProteinModelPortal:   Q01ZU0
- SMR:   Q01ZU0
- STRING:   Q01ZU0
- GeneID:   4426656
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_3856
- NMPDR:   fig|234267.9.peg.3665
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- PhylomeDB:   Q01ZU0
- ProtClustDB:   PRK00489
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 31952; Mature: 31952

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKLGIPKGSLENATIDLFRRAGFQITTSSRSYFPGIDDPEIECMLIRAQEMARYVEDG
CEEEECCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEEEEHHHHHHHHHHC
ILDSGLTGRDWIEENEAAIVPVADLIYAKQSFGKVRWVLAVPEASSFRTVHDLEGKIIAT
CCCCCCCCCHHHCCCCCEEEEHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHCCCCEEHH
ELVATTKRYMAKHGVKAKVEFSWGATEVKPPVLADAIVEVTETGSSLRANKLKIIDTVLE
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHCHHHHHHHHHH
SNTQLIANKASWEDPEKRRKLEDIRMLLQGAINALGKVGLMLNVHKDNLKAVLGVLPALK
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECHHHHHHHHHHHHHHC
RPTISHLSDDEWLAVNTILDESTVRDIIPRLKQAGGEGIVEYPLNKIVL
CCCHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCEEECCHHHHCC
>Mature Secondary Structure
MLLKLGIPKGSLENATIDLFRRAGFQITTSSRSYFPGIDDPEIECMLIRAQEMARYVEDG
CEEEECCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEEEEHHHHHHHHHHC
ILDSGLTGRDWIEENEAAIVPVADLIYAKQSFGKVRWVLAVPEASSFRTVHDLEGKIIAT
CCCCCCCCCHHHCCCCCEEEEHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHCCCCEEHH
ELVATTKRYMAKHGVKAKVEFSWGATEVKPPVLADAIVEVTETGSSLRANKLKIIDTVLE
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHCHHHHHHHHHH
SNTQLIANKASWEDPEKRRKLEDIRMLLQGAINALGKVGLMLNVHKDNLKAVLGVLPALK
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECHHHHHHHHHHHHHHC
RPTISHLSDDEWLAVNTILDESTVRDIIPRLKQAGGEGIVEYPLNKIVL
CCCHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA