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The map label for this gene is hisI

Identifier: 116622955

GI number: 116622955

Start: 4891298

End: 4891678

Strand: Reverse

Name: hisI

Synonym: Acid_3857

Alternate gene names: 116622955

Gene position: 4891678-4891298 (Counterclockwise)

Preceding gene: 116622956

Following gene: 116622954

Centisome position: 49.09

GC content: 61.94

Gene sequence:

>381_bases
ATGAATCTCGACTTCGCTAAATCGGACGGCCTGGTCACCGCCGTCATTCAGGATCACGCCTCCGGCCGCGTCCTCATGGT
CGGCTACATGAACCAGGAGGCCTTCAACAAAACCGTGGAGACCGGCTTCGCCACTTTCTGGAGCCGCTCCCGCAAGAAGC
TCTGGCTCAAAGGCGAGAGCTCCGGCCACCGCCTCGTCGTCAAAGAGATCTCCACCGATTGCGACCTCGACGCCGTCCTC
GTCAAAGTCGAAGCGCAGGGTCCCGGCGTCTGCCATGAGGGCTACGAGAGCTGTTTTTTCCGCCGCCTGGATGCCGGCGA
ATGGAAGGTCGCCGACAACCCCACGTACGATCCCGGCGCCGTGTACGGAGGCAAGTCCTAA

Upstream 100 bases:

>100_bases
CATGCCTCCCTGCGACGGGCCGTGTCCTAATACCACTTCCAATCGATTCGGAAAGGACGCCCGCCGCGAAAAACGGCGGG
CTTTTTTATTGTTCGCAGCC

Downstream 100 bases:

>100_bases
TGCTTCTCAAGCTTGGTATTCCGAAAGGCAGCCTGGAAAATGCGACCATCGATCTCTTCCGCCGCGCCGGATTCCAGATC
ACCACTTCCAGCCGCTCCTA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 126; Mature: 126

Protein sequence:

>126_residues
MNLDFAKSDGLVTAVIQDHASGRVLMVGYMNQEAFNKTVETGFATFWSRSRKKLWLKGESSGHRLVVKEISTDCDLDAVL
VKVEAQGPGVCHEGYESCFFRRLDAGEWKVADNPTYDPGAVYGGKS

Sequences:

>Translated_126_residues
MNLDFAKSDGLVTAVIQDHASGRVLMVGYMNQEAFNKTVETGFATFWSRSRKKLWLKGESSGHRLVVKEISTDCDLDAVL
VKVEAQGPGVCHEGYESCFFRRLDAGEWKVADNPTYDPGAVYGGKS
>Mature_126_residues
MNLDFAKSDGLVTAVIQDHASGRVLMVGYMNQEAFNKTVETGFATFWSRSRKKLWLKGESSGHRLVVKEISTDCDLDAVL
VKVEAQGPGVCHEGYESCFFRRLDAGEWKVADNPTYDPGAVYGGKS

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=129, Percent_Identity=44.1860465116279, Blast_Score=108, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319819, Length=103, Percent_Identity=37.8640776699029, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_SOLUE (Q01ZT9)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_825111.1
- STRING:   Q01ZT9
- GeneID:   4426657
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_3857
- NMPDR:   fig|234267.9.peg.3666
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- PhylomeDB:   Q01ZT9
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 13895; Mature: 13895

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLDFAKSDGLVTAVIQDHASGRVLMVGYMNQEAFNKTVETGFATFWSRSRKKLWLKGES
CCCCCCCCCCEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCC
SGHRLVVKEISTDCDLDAVLVKVEAQGPGVCHEGYESCFFRRLDAGEWKVADNPTYDPGA
CCCEEEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCC
VYGGKS
CCCCCC
>Mature Secondary Structure
MNLDFAKSDGLVTAVIQDHASGRVLMVGYMNQEAFNKTVETGFATFWSRSRKKLWLKGES
CCCCCCCCCCEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCC
SGHRLVVKEISTDCDLDAVLVKVEAQGPGVCHEGYESCFFRRLDAGEWKVADNPTYDPGA
CCCEEEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCC
VYGGKS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA