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The map label for this gene is hisD2 [H]

Identifier: 116622953

GI number: 116622953

Start: 4889161

End: 4890432

Strand: Reverse

Name: hisD2 [H]

Synonym: Acid_3855

Alternate gene names: 116622953

Gene position: 4890432-4889161 (Counterclockwise)

Preceding gene: 116622954

Following gene: 116622952

Centisome position: 49.07

GC content: 67.45

Gene sequence:

>1272_bases
GTGATCCGCATACTGGAAAGCAAAGACGTCGGCCACCTGCTGAAACGCAAGGCCGCCCGCTTCACCGAAGCCGAGGCGGT
GGTGACGCCGATTCTAGAGGCCGTCCGCAAACGCGGCGATCGCGCCCTGATGGATTACGCGCGCCAGTTCGATCAACTCC
AACGCAAATCCGTCCGCGTGCCGGAAGGCGAGTTACTCGCCGCGCGCGACGGCCTCACGCCGGAATTTCGCGGCGCCATC
GAGACCGCGGCGCCGAACATCCGCGCCTATGCCGGACGTCAGATGCCGCGCGAATGGAACCGCTCCTTCGGCGCCGGCCT
GCAACTCGGGCAGCTCGTACGCCCCCTCGATGCCGTCGCCGCCTACATCCCCGCCGGGCGCTATCCGCTGCCCAGCACCG
TGATGATGACCGTGATTCCCGCGCAGGTCGCAGGCGTCCCCAACATCTGCATCGCCTGTCCCAAGCCGGTCGCCGAAGTC
TATGGCACGGCCGCCATGCTCGGCGTCCGCAACGTCTTCCAGATGGGCGGCGCGCAGGCCATCGCCGCCTTCGCCTTCGG
CACCCGCACCGTCCCGCGCGCCGACCGCATCGTCGGTCCTGGCAACATCTACGTGGCTGCCGCTAAGAAACTCCTCGCCG
GGGAAGTCGGCATCGATTTCATCGCCGGCCCCACCGAAATCCTGATCATCGCCGCCGATGGCGACCCGCGCCACTTCGCC
GCCGACATGCTCGCCCAAGCCGAACACGATGTCGATGCCTCCGCCATCCTGCTCACCACCTCCAAACGGTTGGCCGCCGC
CGTATCGCGCGAACTGGAACGTCAACTCGCCATCCTCCCCACCGCCCCCGTTGCCTCCAAATCCATCGCGAAAAACTCCG
CCATCATCCTCGTCCGCAGTCTCGACGAGGCCCTCGAAATCTCCAACCGCTTCGCCCCCGAGCACCTAAGCATCCCCGAT
GCGTCGCTGCTCCCCGGAGTCCGCCACGCCGGCAGCGTCTTCGTCGGCCCCTACAGCCCCGAAGCCGCCGGCGATTACGC
AAGCGGTCCCAACCACGTCCTCCCGACCAGCGGCGCCGCCCGCCAGCGCGGCGGCCTCAGTGTCACCGACTACGTGAAAG
TGATCTCCGTGCAAAACCTGACCGAACCCGCCCTGCGCAGGCTCGCCCCATCCATCACCACCCTCGCCCGCGCCGAAGGC
CTCGAAGCCCACGCCCGCAGCGTCGAAGTGAGGCTCACGCGAACCGCGACCGTAAGGGAGCGATCTCTATGA

Upstream 100 bases:

>100_bases
ACACCATCCTCGATGAAAGCACCGTGCGCGACATAATTCCCCGGCTGAAGCAGGCGGGAGGCGAGGGAATCGTGGAATAC
CCGCTCAACAAGATTGTCCT

Downstream 100 bases:

>100_bases
CAAAACTCCCCAAAGGCGCCATCAAACCCCGCCCCGCCGTCATCGGCATGGCTCCCTACTCGCCGCCCACCGGAGGCCGC
TCCGATAAGCTCCGCCTGGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 2 [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MIRILESKDVGHLLKRKAARFTEAEAVVTPILEAVRKRGDRALMDYARQFDQLQRKSVRVPEGELLAARDGLTPEFRGAI
ETAAPNIRAYAGRQMPREWNRSFGAGLQLGQLVRPLDAVAAYIPAGRYPLPSTVMMTVIPAQVAGVPNICIACPKPVAEV
YGTAAMLGVRNVFQMGGAQAIAAFAFGTRTVPRADRIVGPGNIYVAAAKKLLAGEVGIDFIAGPTEILIIAADGDPRHFA
ADMLAQAEHDVDASAILLTTSKRLAAAVSRELERQLAILPTAPVASKSIAKNSAIILVRSLDEALEISNRFAPEHLSIPD
ASLLPGVRHAGSVFVGPYSPEAAGDYASGPNHVLPTSGAARQRGGLSVTDYVKVISVQNLTEPALRRLAPSITTLARAEG
LEAHARSVEVRLTRTATVRERSL

Sequences:

>Translated_423_residues
MIRILESKDVGHLLKRKAARFTEAEAVVTPILEAVRKRGDRALMDYARQFDQLQRKSVRVPEGELLAARDGLTPEFRGAI
ETAAPNIRAYAGRQMPREWNRSFGAGLQLGQLVRPLDAVAAYIPAGRYPLPSTVMMTVIPAQVAGVPNICIACPKPVAEV
YGTAAMLGVRNVFQMGGAQAIAAFAFGTRTVPRADRIVGPGNIYVAAAKKLLAGEVGIDFIAGPTEILIIAADGDPRHFA
ADMLAQAEHDVDASAILLTTSKRLAAAVSRELERQLAILPTAPVASKSIAKNSAIILVRSLDEALEISNRFAPEHLSIPD
ASLLPGVRHAGSVFVGPYSPEAAGDYASGPNHVLPTSGAARQRGGLSVTDYVKVISVQNLTEPALRRLAPSITTLARAEG
LEAHARSVEVRLTRTATVRERSL
>Mature_423_residues
MIRILESKDVGHLLKRKAARFTEAEAVVTPILEAVRKRGDRALMDYARQFDQLQRKSVRVPEGELLAARDGLTPEFRGAI
ETAAPNIRAYAGRQMPREWNRSFGAGLQLGQLVRPLDAVAAYIPAGRYPLPSTVMMTVIPAQVAGVPNICIACPKPVAEV
YGTAAMLGVRNVFQMGGAQAIAAFAFGTRTVPRADRIVGPGNIYVAAAKKLLAGEVGIDFIAGPTEILIIAADGDPRHFA
ADMLAQAEHDVDASAILLTTSKRLAAAVSRELERQLAILPTAPVASKSIAKNSAIILVRSLDEALEISNRFAPEHLSIPD
ASLLPGVRHAGSVFVGPYSPEAAGDYASGPNHVLPTSGAARQRGGLSVTDYVKVISVQNLTEPALRRLAPSITTLARAEG
LEAHARSVEVRLTRTATVRERSL

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=411, Percent_Identity=40.8759124087591, Blast_Score=288, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6319819, Length=424, Percent_Identity=37.2641509433962, Blast_Score=272, Evalue=9e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45115; Mature: 45115

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRILESKDVGHLLKRKAARFTEAEAVVTPILEAVRKRGDRALMDYARQFDQLQRKSVRV
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
PEGELLAARDGLTPEFRGAIETAAPNIRAYAGRQMPREWNRSFGAGLQLGQLVRPLDAVA
CCCCEEEECCCCCHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
AYIPAGRYPLPSTVMMTVIPAQVAGVPNICIACPKPVAEVYGTAAMLGVRNVFQMGGAQA
HHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHH
IAAFAFGTRTVPRADRIVGPGNIYVAAAKKLLAGEVGIDFIAGPTEILIIAADGDPRHFA
HHHHHHCCCCCCCHHCEECCCCEEHHHHHHHHHHHCCCEEECCCCEEEEEEECCCCHHHH
ADMLAQAEHDVDASAILLTTSKRLAAAVSRELERQLAILPTAPVASKSIAKNSAIILVRS
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHEECCCCCCCHHHHCCCCEEEEEEC
LDEALEISNRFAPEHLSIPDASLLPGVRHAGSVFVGPYSPEAAGDYASGPNHVLPTSGAA
HHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCH
RQRGGLSVTDYVKVISVQNLTEPALRRLAPSITTLARAEGLEAHARSVEVRLTRTATVRE
HHCCCCCHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHCCCHHHHCEEEEEEEEEHHHHH
RSL
CCC
>Mature Secondary Structure
MIRILESKDVGHLLKRKAARFTEAEAVVTPILEAVRKRGDRALMDYARQFDQLQRKSVRV
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
PEGELLAARDGLTPEFRGAIETAAPNIRAYAGRQMPREWNRSFGAGLQLGQLVRPLDAVA
CCCCEEEECCCCCHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
AYIPAGRYPLPSTVMMTVIPAQVAGVPNICIACPKPVAEVYGTAAMLGVRNVFQMGGAQA
HHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHH
IAAFAFGTRTVPRADRIVGPGNIYVAAAKKLLAGEVGIDFIAGPTEILIIAADGDPRHFA
HHHHHHCCCCCCCHHCEECCCCEEHHHHHHHHHHHCCCEEECCCCEEEEEEECCCCHHHH
ADMLAQAEHDVDASAILLTTSKRLAAAVSRELERQLAILPTAPVASKSIAKNSAIILVRS
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHEECCCCCCCHHHHCCCCEEEEEEC
LDEALEISNRFAPEHLSIPDASLLPGVRHAGSVFVGPYSPEAAGDYASGPNHVLPTSGAA
HHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCH
RQRGGLSVTDYVKVISVQNLTEPALRRLAPSITTLARAEGLEAHARSVEVRLTRTATVRE
HHCCCCCHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHCCCHHHHCEEEEEEEEEHHHHH
RSL
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA