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The map label for this gene is hisC [H]

Identifier: 116622952

GI number: 116622952

Start: 4888091

End: 4889164

Strand: Reverse

Name: hisC [H]

Synonym: Acid_3854

Alternate gene names: 116622952

Gene position: 4889164-4888091 (Counterclockwise)

Preceding gene: 116622953

Following gene: 116622951

Centisome position: 49.06

GC content: 63.5

Gene sequence:

>1074_bases
ATGACAAAACTCCCCAAAGGCGCCATCAAACCCCGCCCCGCCGTCATCGGCATGGCTCCCTACTCGCCGCCCACCGGAGG
CCGCTCCGATAAGCTCCGCCTGGATTTCAACGAGAACACCGTCGGCTGTTCTCCCAAAGTCATCGCCGCCTTGAAGGACC
ACCTCTCCGCGCCCGCGCTCGCCGTCTACCCCGAGTACACCGCCGCCAAGGAAGCCGTGGCGCGCTACTTCCACGTCACG
CCCGACCAGTTCTGCTTCACCAACGGCACCGACGAAGCCATCCAGGTCTTCATCAACACCTATGTCGATGACGGCCAGGA
AGTGCTGGTCCTCAAGCCCGCCTACGCCATGTACCGCTTCTATGCGGAGGTCGCCGGAGCCAAAATCAGGGAAGTCGCCT
ACCCGCAGCCCGAAATGGAATTTCCGCTGCAGGAAGTGCTCGATTCCATCACGCCCGAAACCCGCGCCGTCATCCTCTCC
AACCCGAACAATCCCACCGGCACCGGACTCAGCCTGCTCGGCATCGAGCGCATTCTGGCGCGCGCCAAAAAGGCCGTCGT
CATGGTGGACGAAGCCTACTATGAATTCTCCGGCGTCACCGCGCTCACCGAAATCGAGCGCGTCCCGCACCTCCTCGTCT
GCCGGACATTCTCCAAGGTCTTCGGCATGGCCGGCATGCGTCTCGGCTGCCTCTTCTCGCACCCCGCCAACATTGAGTAT
CTGCACAAGGCGCAATCGCCCTACAGCGTGAACTCGCTTGCCGTGATCGCGGCGCAGGCCGCCGTGGAAGACACCGCCTA
CATCGAAAACTATGTCGCCGAAGTGCTCGCCGCGCGGGAGCTGCTCTGCGTCGGCTTCGAAAAGCTCGGCATCACGTACG
TGCCCAGCTCCGCGAATTTTGTGCTCGGGCATTTCGGCAAGCGGGCAATCGAAGTTCGCGACCGCCTCCGCGATCAGGCT
ATCCTGGTGCGCGACCGCAGCTACGAAGCCGCCGGCTGCGTCCGCATCACGGTCGGCACCCGCGAGCAGACGCGCCGCCT
GCTCACCGCCCTCGAAGGGATCTGGAACCAATGA

Upstream 100 bases:

>100_bases
CATCCATCACCACCCTCGCCCGCGCCGAAGGCCTCGAAGCCCACGCCCGCAGCGTCGAAGTGAGGCTCACGCGAACCGCG
ACCGTAAGGGAGCGATCTCT

Downstream 100 bases:

>100_bases
AGAAACTCATCGTATTCGACATGGATGGCGTCCTGGTGGACGTCACCGAAAGCTATCGCGAAAGCATCGCGCAGACCGTG
ACGCATTTCACCGGCCACGC

Product: histidinol phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MTKLPKGAIKPRPAVIGMAPYSPPTGGRSDKLRLDFNENTVGCSPKVIAALKDHLSAPALAVYPEYTAAKEAVARYFHVT
PDQFCFTNGTDEAIQVFINTYVDDGQEVLVLKPAYAMYRFYAEVAGAKIREVAYPQPEMEFPLQEVLDSITPETRAVILS
NPNNPTGTGLSLLGIERILARAKKAVVMVDEAYYEFSGVTALTEIERVPHLLVCRTFSKVFGMAGMRLGCLFSHPANIEY
LHKAQSPYSVNSLAVIAAQAAVEDTAYIENYVAEVLAARELLCVGFEKLGITYVPSSANFVLGHFGKRAIEVRDRLRDQA
ILVRDRSYEAAGCVRITVGTREQTRRLLTALEGIWNQ

Sequences:

>Translated_357_residues
MTKLPKGAIKPRPAVIGMAPYSPPTGGRSDKLRLDFNENTVGCSPKVIAALKDHLSAPALAVYPEYTAAKEAVARYFHVT
PDQFCFTNGTDEAIQVFINTYVDDGQEVLVLKPAYAMYRFYAEVAGAKIREVAYPQPEMEFPLQEVLDSITPETRAVILS
NPNNPTGTGLSLLGIERILARAKKAVVMVDEAYYEFSGVTALTEIERVPHLLVCRTFSKVFGMAGMRLGCLFSHPANIEY
LHKAQSPYSVNSLAVIAAQAAVEDTAYIENYVAEVLAARELLCVGFEKLGITYVPSSANFVLGHFGKRAIEVRDRLRDQA
ILVRDRSYEAAGCVRITVGTREQTRRLLTALEGIWNQ
>Mature_356_residues
TKLPKGAIKPRPAVIGMAPYSPPTGGRSDKLRLDFNENTVGCSPKVIAALKDHLSAPALAVYPEYTAAKEAVARYFHVTP
DQFCFTNGTDEAIQVFINTYVDDGQEVLVLKPAYAMYRFYAEVAGAKIREVAYPQPEMEFPLQEVLDSITPETRAVILSN
PNNPTGTGLSLLGIERILARAKKAVVMVDEAYYEFSGVTALTEIERVPHLLVCRTFSKVFGMAGMRLGCLFSHPANIEYL
HKAQSPYSVNSLAVIAAQAAVEDTAYIENYVAEVLAARELLCVGFEKLGITYVPSSANFVLGHFGKRAIEVRDRLRDQAI
LVRDRSYEAAGCVRITVGTREQTRRLLTALEGIWNQ

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507369, Length=206, Percent_Identity=26.6990291262136, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1788332, Length=353, Percent_Identity=32.2946175637394, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1788722, Length=252, Percent_Identity=25.7936507936508, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=370, Percent_Identity=28.1081081081081, Blast_Score=127, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39328; Mature: 39196

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLPKGAIKPRPAVIGMAPYSPPTGGRSDKLRLDFNENTVGCSPKVIAALKDHLSAPAL
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCEE
AVYPEYTAAKEAVARYFHVTPDQFCFTNGTDEAIQVFINTYVDDGQEVLVLKPAYAMYRF
EECCCHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHH
YAEVAGAKIREVAYPQPEMEFPLQEVLDSITPETRAVILSNPNNPTGTGLSLLGIERILA
HHHHHCCHHHHHCCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHH
RAKKAVVMVDEAYYEFSGVTALTEIERVPHLLVCRTFSKVFGMAGMRLGCLFSHPANIEY
HHHHEEEEEEHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
LHKAQSPYSVNSLAVIAAQAAVEDTAYIENYVAEVLAARELLCVGFEKLGITYVPSSANF
HHHCCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCC
VLGHFGKRAIEVRDRLRDQAILVRDRSYEAAGCVRITVGTREQTRRLLTALEGIWNQ
HHHHHCHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKLPKGAIKPRPAVIGMAPYSPPTGGRSDKLRLDFNENTVGCSPKVIAALKDHLSAPAL
CCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCEE
AVYPEYTAAKEAVARYFHVTPDQFCFTNGTDEAIQVFINTYVDDGQEVLVLKPAYAMYRF
EECCCHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHH
YAEVAGAKIREVAYPQPEMEFPLQEVLDSITPETRAVILSNPNNPTGTGLSLLGIERILA
HHHHHCCHHHHHCCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHH
RAKKAVVMVDEAYYEFSGVTALTEIERVPHLLVCRTFSKVFGMAGMRLGCLFSHPANIEY
HHHHEEEEEEHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
LHKAQSPYSVNSLAVIAAQAAVEDTAYIENYVAEVLAARELLCVGFEKLGITYVPSSANF
HHHCCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCC
VLGHFGKRAIEVRDRLRDQAILVRDRSYEAAGCVRITVGTREQTRRLLTALEGIWNQ
HHHHHCHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]