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The map label for this gene is galK [H]

Identifier: 116622942

GI number: 116622942

Start: 4879974

End: 4881185

Strand: Direct

Name: galK [H]

Synonym: Acid_3844

Alternate gene names: 116622942

Gene position: 4879974-4881185 (Clockwise)

Preceding gene: 116622941

Following gene: 116622943

Centisome position: 48.97

GC content: 64.77

Gene sequence:

>1212_bases
TTGCGGCCTGGTCATGCTCGCCTTCGGCGCCGCCATGCTGATCGGAGCCAAAGTCTCGCCGCGCAAAGAACCATGAAGGA
TGCCTTCCGGAAACTCTTCGGGCCGGCGCACGAGATTCGCGTCTTCCGCGCCCCCGGCCGCGTCAACCTGATCGGCGAGC
ATACCGATTACAACGGTGGCTTCGTGCTTCCCGTGGCGCTCGAACTAGCCACAAGCGTCGCCACCGCCCCATCTGCAGAC
GGCAAGCTCCGCATTTATTCCGAAGACCGCAAAGAGCTCCGTGAATTCGACACTGCGGCCATCGCCACCCTCGCGCCCAC
CAGGGAGTGGACCGACTACCCGATAGGCGTAGCCCAACAACTTGCCGCCGCCGGTTTCCCCATCGCGCCGGCAAATCTCC
TGATCTGCAGCACCGTGCCCGAAGGCTCCGGCCTGAGTTCCTCCGCTGCACTGGAAGTTTCGTCCGCCCTAGCCTTTCTC
AAAGGCCGTGAGCTCGATAAATTGGAGCTGGCCAAACTCTGCCAGCGCGCCGAGCGCAATTTCGTCGGCATGCCCTGCGG
CATCATGGACCAGTACATCTCCATTTTCGGCCGCAAACACTCGGCGGTGGAAATCGATTGCCGCAGCCTGGGCCACCGCC
TGGTCCAACTTCCCGACGGCATCACTTTCATCGCCGTCAACACTATGGTGAAGCACGCGCTCTCCGGCTCCGCCTATCGG
GACCGGGTCCGTGAATGCGCCGAAGCCGCCGCTGCCATGCACGTGGAAAGCCTGCGCGACGTCTCGCCCGCGCAACTCCA
AAGTGCCGCCGCACAACTTCCGGAAGTCGTTGCGCGCCGCGCCCGCCACGTGGTCACCGAAGACGCCCGGGTCAACTGCT
TCGTCGACGCCAGCGCGCGCGCCGATGTCTCCCTCATGGGCAAACTCATGGTGGAATCCCACCGCAGCCTGCAGCATGAT
TACGAAGTAAGCTGCGAGGAGCTCGATTTTCTGGTGGATACCGCGCTCACCCTGCCAGGCGTTCTCGGCTCCCGCATGAC
CGGCGGCGGCTTCGGCGGTTGCACCGTCACCCTGCTCCGCTCGGACGCGGCCCCGGCCTTCCGCGACGCCATCGCGCAGT
CCTACAACTCCCGGTACGGCATCACTCCGGCTATCTACCCCTGCGACCCCTCCGACGGCGCCGGGGAAGTGCTCAGCGAG
CCGCGACCGTAA

Upstream 100 bases:

>100_bases
CGGGCTTCTTCTTCACCCTGATCGGCCTGATACTGGTCGCGATGGGCGTGTTCTCGCCGTCCGAACGGGCGGCGCTGACG
GATTCCAATGTGAATCTCTA

Downstream 100 bases:

>100_bases
GGGAGCGATCTACAACGCCATGCCCCGCTGGATCAATCTGGCCAACCTGTTCACCCTGGCGAGGCTTGTGCTAGTGCCTT
TCGTGGTCGGGGCCATCCTG

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MRPGHARLRRRHADRSQSLAAQRTMKDAFRKLFGPAHEIRVFRAPGRVNLIGEHTDYNGGFVLPVALELATSVATAPSAD
GKLRIYSEDRKELREFDTAAIATLAPTREWTDYPIGVAQQLAAAGFPIAPANLLICSTVPEGSGLSSSAALEVSSALAFL
KGRELDKLELAKLCQRAERNFVGMPCGIMDQYISIFGRKHSAVEIDCRSLGHRLVQLPDGITFIAVNTMVKHALSGSAYR
DRVRECAEAAAAMHVESLRDVSPAQLQSAAAQLPEVVARRARHVVTEDARVNCFVDASARADVSLMGKLMVESHRSLQHD
YEVSCEELDFLVDTALTLPGVLGSRMTGGGFGGCTVTLLRSDAAPAFRDAIAQSYNSRYGITPAIYPCDPSDGAGEVLSE
PRP

Sequences:

>Translated_403_residues
MRPGHARLRRRHADRSQSLAAQRTMKDAFRKLFGPAHEIRVFRAPGRVNLIGEHTDYNGGFVLPVALELATSVATAPSAD
GKLRIYSEDRKELREFDTAAIATLAPTREWTDYPIGVAQQLAAAGFPIAPANLLICSTVPEGSGLSSSAALEVSSALAFL
KGRELDKLELAKLCQRAERNFVGMPCGIMDQYISIFGRKHSAVEIDCRSLGHRLVQLPDGITFIAVNTMVKHALSGSAYR
DRVRECAEAAAAMHVESLRDVSPAQLQSAAAQLPEVVARRARHVVTEDARVNCFVDASARADVSLMGKLMVESHRSLQHD
YEVSCEELDFLVDTALTLPGVLGSRMTGGGFGGCTVTLLRSDAAPAFRDAIAQSYNSRYGITPAIYPCDPSDGAGEVLSE
PRP
>Mature_403_residues
MRPGHARLRRRHADRSQSLAAQRTMKDAFRKLFGPAHEIRVFRAPGRVNLIGEHTDYNGGFVLPVALELATSVATAPSAD
GKLRIYSEDRKELREFDTAAIATLAPTREWTDYPIGVAQQLAAAGFPIAPANLLICSTVPEGSGLSSSAALEVSSALAFL
KGRELDKLELAKLCQRAERNFVGMPCGIMDQYISIFGRKHSAVEIDCRSLGHRLVQLPDGITFIAVNTMVKHALSGSAYR
DRVRECAEAAAAMHVESLRDVSPAQLQSAAAQLPEVVARRARHVVTEDARVNCFVDASARADVSLMGKLMVESHRSLQHD
YEVSCEELDFLVDTALTLPGVLGSRMTGGGFGGCTVTLLRSDAAPAFRDAIAQSYNSRYGITPAIYPCDPSDGAGEVLSE
PRP

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=379, Percent_Identity=47.2295514511873, Blast_Score=285, Evalue=4e-77,
Organism=Homo sapiens, GI4503897, Length=418, Percent_Identity=32.2966507177034, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI48527957, Length=416, Percent_Identity=32.2115384615385, Blast_Score=151, Evalue=1e-36,
Organism=Escherichia coli, GI1786972, Length=380, Percent_Identity=40.2631578947368, Blast_Score=283, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI71989053, Length=406, Percent_Identity=29.8029556650246, Blast_Score=131, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6319494, Length=243, Percent_Identity=32.0987654320988, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320212, Length=241, Percent_Identity=31.5352697095436, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24661292, Length=421, Percent_Identity=27.0783847980998, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355577, Length=421, Percent_Identity=27.0783847980998, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24661285, Length=421, Percent_Identity=27.0783847980998, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 43559; Mature: 43559

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPGHARLRRRHADRSQSLAAQRTMKDAFRKLFGPAHEIRVFRAPGRVNLIGEHTDYNGG
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCCEEEEECCCCCCCC
FVLPVALELATSVATAPSADGKLRIYSEDRKELREFDTAAIATLAPTREWTDYPIGVAQQ
EEHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
LAAAGFPIAPANLLICSTVPEGSGLSSSAALEVSSALAFLKGRELDKLELAKLCQRAERN
HHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
FVGMPCGIMDQYISIFGRKHSAVEIDCRSLGHRLVQLPDGITFIAVNTMVKHALSGSAYR
CCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCHHHH
DRVRECAEAAAAMHVESLRDVSPAQLQSAAAQLPEVVARRARHVVTEDARVNCFVDASAR
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
ADVSLMGKLMVESHRSLQHDYEVSCEELDFLVDTALTLPGVLGSRMTGGGFGGCTVTLLR
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEE
SDAAPAFRDAIAQSYNSRYGITPAIYPCDPSDGAGEVLSEPRP
CCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHCCCCC
>Mature Secondary Structure
MRPGHARLRRRHADRSQSLAAQRTMKDAFRKLFGPAHEIRVFRAPGRVNLIGEHTDYNGG
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCCEEEEECCCCCCCC
FVLPVALELATSVATAPSADGKLRIYSEDRKELREFDTAAIATLAPTREWTDYPIGVAQQ
EEHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
LAAAGFPIAPANLLICSTVPEGSGLSSSAALEVSSALAFLKGRELDKLELAKLCQRAERN
HHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
FVGMPCGIMDQYISIFGRKHSAVEIDCRSLGHRLVQLPDGITFIAVNTMVKHALSGSAYR
CCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCHHHH
DRVRECAEAAAAMHVESLRDVSPAQLQSAAAQLPEVVARRARHVVTEDARVNCFVDASAR
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
ADVSLMGKLMVESHRSLQHDYEVSCEELDFLVDTALTLPGVLGSRMTGGGFGGCTVTLLR
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEE
SDAAPAFRDAIAQSYNSRYGITPAIYPCDPSDGAGEVLSEPRP
CCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA