Click here to switch to the map view.

The map label for this gene is pgsA2 [H]

Identifier: 116622943

GI number: 116622943

Start: 4881205

End: 4881753

Strand: Direct

Name: pgsA2 [H]

Synonym: Acid_3845

Alternate gene names: 116622943

Gene position: 4881205-4881753 (Clockwise)

Preceding gene: 116622942

Following gene: 116622944

Centisome position: 48.98

GC content: 59.93

Gene sequence:

>549_bases
ATGCCCCGCTGGATCAATCTGGCCAACCTGTTCACCCTGGCGAGGCTTGTGCTAGTGCCTTTCGTGGTCGGGGCCATCCT
GGATGGCCGCAACGTCGCCGCCCTGGAGCTGTTCTTCGCCGCCGCCCTCACCGACGTTATCGATGGGTTCCTGGCGCGCA
ACTTCGGCCAGGGAACCCCCTTCGGCGCATACCTCGATCCGATCGCCGATAAGCTCCTGCTGAGTGGCATTTACCTGGCG
CTCGGAGCTACCGGCGCGGTGCCCTGGTGGCTGGTCGCGCTGGTGCTCGGCCGGGACATTTACATCCTCCTCGCCGTTAT
CGGCATCATGGCGTTAACCAAAGTCAGGAGCTTCCCGCCCAGTCGGTGGGGAAAGATTTCCACTTTTGTACAGATCGCCA
CAGCGATCTGCTGGATGGTTCAAAATATCTGGCAAATCGCCCTTTTCCATGCGATTGCCGCTACCATGGTTTGGGTTTGC
GCGATTTTTACGCTCTGGAGCGGCGTCCATTACACCCTGCGCGGTACTCAATCTCTGCGGACACGTTGA

Upstream 100 bases:

>100_bases
CGGTACGGCATCACTCCGGCTATCTACCCCTGCGACCCCTCCGACGGCGCCGGGGAAGTGCTCAGCGAGCCGCGACCGTA
AGGGAGCGATCTACAACGCC

Downstream 100 bases:

>100_bases
CGAGGTGCCCGCTCGGGAGTAGTCTAAAATTAAGAACGGTCGGCATGACTCGCTATCTTCCAGCACGACATTATCGGTGG
TTTGGAATCAGCGCGGTGAT

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 182; Mature: 181

Protein sequence:

>182_residues
MPRWINLANLFTLARLVLVPFVVGAILDGRNVAALELFFAAALTDVIDGFLARNFGQGTPFGAYLDPIADKLLLSGIYLA
LGATGAVPWWLVALVLGRDIYILLAVIGIMALTKVRSFPPSRWGKISTFVQIATAICWMVQNIWQIALFHAIAATMVWVC
AIFTLWSGVHYTLRGTQSLRTR

Sequences:

>Translated_182_residues
MPRWINLANLFTLARLVLVPFVVGAILDGRNVAALELFFAAALTDVIDGFLARNFGQGTPFGAYLDPIADKLLLSGIYLA
LGATGAVPWWLVALVLGRDIYILLAVIGIMALTKVRSFPPSRWGKISTFVQIATAICWMVQNIWQIALFHAIAATMVWVC
AIFTLWSGVHYTLRGTQSLRTR
>Mature_181_residues
PRWINLANLFTLARLVLVPFVVGAILDGRNVAALELFFAAALTDVIDGFLARNFGQGTPFGAYLDPIADKLLLSGIYLAL
GATGAVPWWLVALVLGRDIYILLAVIGIMALTKVRSFPPSRWGKISTFVQIATAICWMVQNIWQIALFHAIAATMVWVCA
IFTLWSGVHYTLRGTQSLRTR

Specific function: This Protein Catalyzes The Committed Step To The Synthesis Of The Acidic Phospholipids. [C]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=207, Percent_Identity=26.5700483091787, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI10092647, Length=118, Percent_Identity=33.0508474576271, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1788220, Length=179, Percent_Identity=37.9888268156425, Blast_Score=78, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71984834, Length=185, Percent_Identity=26.4864864864865, Blast_Score=66, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71984838, Length=184, Percent_Identity=26.6304347826087, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320059, Length=210, Percent_Identity=27.1428571428571, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24650130, Length=146, Percent_Identity=33.5616438356164, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24650126, Length=146, Percent_Identity=33.5616438356164, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24650128, Length=146, Percent_Identity=33.5616438356164, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 20021; Mature: 19890

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRWINLANLFTLARLVLVPFVVGAILDGRNVAALELFFAAALTDVIDGFLARNFGQGTP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FGAYLDPIADKLLLSGIYLALGATGAVPWWLVALVLGRDIYILLAVIGIMALTKVRSFPP
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
SRWGKISTFVQIATAICWMVQNIWQIALFHAIAATMVWVCAIFTLWSGVHYTLRGTQSLR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHC
TR
CC
>Mature Secondary Structure 
PRWINLANLFTLARLVLVPFVVGAILDGRNVAALELFFAAALTDVIDGFLARNFGQGTP
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FGAYLDPIADKLLLSGIYLALGATGAVPWWLVALVLGRDIYILLAVIGIMALTKVRSFPP
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
SRWGKISTFVQIATAICWMVQNIWQIALFHAIAATMVWVCAIFTLWSGVHYTLRGTQSLR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHC
TR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036; 10889206 [H]