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The map label for this gene is appC [H]

Identifier: 116622559

GI number: 116622559

Start: 4373447

End: 4374376

Strand: Reverse

Name: appC [H]

Synonym: Acid_3457

Alternate gene names: 116622559

Gene position: 4374376-4373447 (Counterclockwise)

Preceding gene: 116622560

Following gene: 116622558

Centisome position: 43.89

GC content: 63.01

Gene sequence:

>930_bases
ATGCTGCGGTTCTCGGTGACGGTGTTGATCCTGGCACACGCGGCGATTCTCTTCGCCGGGTATCTGGCGCCCTACGGCTA
TGCCGAGCAGCATCGTGAACTGGCCTATGCGCCGCCGACGGCGATCCACTTCGATGGATTGCGGCCGTTCGTCTATGGGG
AACGCGGTGCGCGGTACCCAATCCACTTCTTCACGGGCGGCCGGTTGTTCGGAGTAGCGGCTCCGGGTTACGTCTTCCTG
TGGGGCACGGATGCTTCGGGGCGCGACGTGTTTTCGCGCGTGCTTTACGGAGGCCGGGTCTCGCTGGCCACCGGTTTAGC
CGCCACAGTGCTGGCGCTCGGCCTGGGATTATTCTGGGGTGCGATCTCCGGGTTCTATGGCGGCTGGATAGACCGGTTGG
TGATGCGCGGCTCGGAACTTTTTCTGGCGCTGCCGTGGCTCTACCTGCTGCTGGGCGTGCGAGCCCTGCTCCCTCTGCAC
ATCGGGACCGTCCAGGCATTTTTCCTGTTGGTGGCGATCATCGGCACAGTGGGATGGGTCCGTCCGGCACGGATTATTCG
GGGCGTGGTGCTGAGCGCGCGAGAACGCGGCTTTGTGCTGGCGGCGCGCGGATTCGGAGCCGGAGCGCCCTATCTGATCC
GGCGTCACATTCTGCCGCTCACCGGGAGCGTCCTTGTGACGCAGGCGACGGTTTTGATTCCGCAGTACATTCTGGCGGAA
GTCACGCTTTCCTTCCTGGGGTTGGGGATCGGCGAACCGATTCCCAGTTGGGGCAACATGCTGGCCGAGGCCAGACAGTA
TCACTCGCTGGTTTTCCACAGTTGGATGCTAGCCCCGGGACTGGCCGCAATTCCGCTGCTCTTTGGGTACCTGATGGTGG
CCGATGCCCTGTTGGAAAGACGTCTCAAACACATGGTACGCGGCGCCTAA

Upstream 100 bases:

>100_bases
TGATTTACACGTACAAGGGACGCTCCCTCACGGTCGCGGCTCTGATGGATCTTCGCGGCATGCGAGCAGACAAATGCACA
ATAATACAGGGCTGCCAGTG

Downstream 100 bases:

>100_bases
TGGTAACGTTATCCCTCCAGTACTTTGGTTAATATCCTTTTTGCTCACAATTAGTTAAACTACTCACGAATACTTCGGAG
ACCTCCGGTTGCAGTTGTTA

Product: binding-protein-dependent transporter inner membrane component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MLRFSVTVLILAHAAILFAGYLAPYGYAEQHRELAYAPPTAIHFDGLRPFVYGERGARYPIHFFTGGRLFGVAAPGYVFL
WGTDASGRDVFSRVLYGGRVSLATGLAATVLALGLGLFWGAISGFYGGWIDRLVMRGSELFLALPWLYLLLGVRALLPLH
IGTVQAFFLLVAIIGTVGWVRPARIIRGVVLSARERGFVLAARGFGAGAPYLIRRHILPLTGSVLVTQATVLIPQYILAE
VTLSFLGLGIGEPIPSWGNMLAEARQYHSLVFHSWMLAPGLAAIPLLFGYLMVADALLERRLKHMVRGA

Sequences:

>Translated_309_residues
MLRFSVTVLILAHAAILFAGYLAPYGYAEQHRELAYAPPTAIHFDGLRPFVYGERGARYPIHFFTGGRLFGVAAPGYVFL
WGTDASGRDVFSRVLYGGRVSLATGLAATVLALGLGLFWGAISGFYGGWIDRLVMRGSELFLALPWLYLLLGVRALLPLH
IGTVQAFFLLVAIIGTVGWVRPARIIRGVVLSARERGFVLAARGFGAGAPYLIRRHILPLTGSVLVTQATVLIPQYILAE
VTLSFLGLGIGEPIPSWGNMLAEARQYHSLVFHSWMLAPGLAAIPLLFGYLMVADALLERRLKHMVRGA
>Mature_309_residues
MLRFSVTVLILAHAAILFAGYLAPYGYAEQHRELAYAPPTAIHFDGLRPFVYGERGARYPIHFFTGGRLFGVAAPGYVFL
WGTDASGRDVFSRVLYGGRVSLATGLAATVLALGLGLFWGAISGFYGGWIDRLVMRGSELFLALPWLYLLLGVRALLPLH
IGTVQAFFLLVAIIGTVGWVRPARIIRGVVLSARERGFVLAARGFGAGAPYLIRRHILPLTGSVLVTQATVLIPQYILAE
VTLSFLGLGIGEPIPSWGNMLAEARQYHSLVFHSWMLAPGLAAIPLLFGYLMVADALLERRLKHMVRGA

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787054, Length=219, Percent_Identity=37.8995433789954, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1787498, Length=220, Percent_Identity=37.2727272727273, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1787760, Length=227, Percent_Identity=34.8017621145374, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789964, Length=292, Percent_Identity=32.8767123287671, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789889, Length=230, Percent_Identity=34.7826086956522, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788505, Length=185, Percent_Identity=30.8108108108108, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787549, Length=255, Percent_Identity=29.4117647058824, Blast_Score=68, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 33647; Mature: 33647

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRFSVTVLILAHAAILFAGYLAPYGYAEQHRELAYAPPTAIHFDGLRPFVYGERGARYP
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEEECCCCCCEECCCCCCCC
IHFFTGGRLFGVAAPGYVFLWGTDASGRDVFSRVLYGGRVSLATGLAATVLALGLGLFWG
EEEEECCEEEEEECCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AISGFYGGWIDRLVMRGSELFLALPWLYLLLGVRALLPLHIGTVQAFFLLVAIIGTVGWV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RPARIIRGVVLSARERGFVLAARGFGAGAPYLIRRHILPLTGSVLVTQATVLIPQYILAE
CHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VTLSFLGLGIGEPIPSWGNMLAEARQYHSLVFHSWMLAPGLAAIPLLFGYLMVADALLER
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
RLKHMVRGA
HHHHHHCCC
>Mature Secondary Structure
MLRFSVTVLILAHAAILFAGYLAPYGYAEQHRELAYAPPTAIHFDGLRPFVYGERGARYP
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEEECCCCCCEECCCCCCCC
IHFFTGGRLFGVAAPGYVFLWGTDASGRDVFSRVLYGGRVSLATGLAATVLALGLGLFWG
EEEEECCEEEEEECCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AISGFYGGWIDRLVMRGSELFLALPWLYLLLGVRALLPLHIGTVQAFFLLVAIIGTVGWV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RPARIIRGVVLSARERGFVLAARGFGAGAPYLIRRHILPLTGSVLVTQATVLIPQYILAE
CHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VTLSFLGLGIGEPIPSWGNMLAEARQYHSLVFHSWMLAPGLAAIPLLFGYLMVADALLER
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
RLKHMVRGA
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]