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The map label for this gene is copA [H]

Identifier: 116620864

GI number: 116620864

Start: 2170625

End: 2172154

Strand: Reverse

Name: copA [H]

Synonym: Acid_1745

Alternate gene names: 116620864

Gene position: 2172154-2170625 (Counterclockwise)

Preceding gene: 116620866

Following gene: 116620860

Centisome position: 21.8

GC content: 61.37

Gene sequence:

>1530_bases
ATGGAGACCGCCCGATGTACTACGCTGAACTTCAGAGCCGCTCTTCTCGCGATCCCCATGCCTCTCTTACGTCGAAATCT
CCTCCAAGCCGCGGGCGCGCTGGCGGGGACATCCTTGCTTTCCCATACCGTTGGCTGTAAACGGCCTGCCGAACAAACGG
TACTCCCCGCCCCCGACCACACCCTCACCATCGCGGTCAAACCAGTGGAAATCGCTTCCAGGCGCACCATCACCACCACG
ACTTACAACGGGCAATTCCCCGGGCCGCTCCTCCGCTTCCAGGAAGGCCGCCCCATTACCATCGATATCCACAATCAGAC
CGACACGCCCGAGCAACTCCACTGGCATGGACAGTTTCTCTCCAGCGTTGTTGATGGCGCCGCGGAAGAAGGCACGCCCT
ACATCCCCGCGCACGGAAGCCGCCGCATCACGTTCGTACCTAAGCCTTCCGGCTTTCGCTTCTATCACACCCATGTTCGC
GCCGGCAACAATTTGAACGCGGGACAGTACACCGGCCTCGTCGGCCCCGTCTACATCGAACCGAAAAACAATCCCGGCAA
TTACGATCGCGAGGTCTTCCTCACCCTCAAGGAATTCGACGGCAGCCTCAGCCGCGGCGGCGACATGGAGGTGGACTTCC
TGCGGCCGGACACCCCGGTGGAAGCATTGAAGATCGCCGGCGACAGCGCCATGAAGGCCTCGCTCGAGAGCGGCGCGCCT
CACGGGTACGAGGTAGGGTATAGCGCCTTCACCATCAATGGCCGCATGCTGGGCACCGGCATTCCGGTGCGGGTCAAGGA
AGGGGAACGCATTCTCTTCCACATCCTCAATGGAAGCGCGACCGAGATCCGCAGTCTCGCCCTGCCCGGGCACACCTTCA
CCGTGCTCGCGATGGATGGTAATCCCATCCCCCGTCCGGTGACCGTGCCCGGACTATGGCTCGCTCCCTCCGAACGCATC
TCCGCCATCGTCGAGATGAATCAGCCCGGCGTCTGGGTCATGGGCGATCTGTCCGACGACGACCGCGGCAACGGCATGGG
TACCGTGATCGAATACGCCGGCCGGACCGGCAAGCCGGTCTGGCAGACCCCCAAGCGCTTCTACTGGAATTACGCCCAGT
TCGGAAACCCCGAAGCCAAGCTTCCCGCGCCGGATCAAATCATTGACATGACCTTCGCCAAGCAGAACGCCGCCGACGGT
GGCTTCAACCGCTGGACCATCAATGGCGTCGCCTTCTCAGACGAGCACATGCATCCCATGTTTCGCGTGAGCCAGGGAAG
ACGCTACCGCCTCCGCATGCGGAACGCCAGCGATGATACGCACCCGATGCACCTTCACCGCCACAGCTTTGAAGTAACCC
GCGTCGCCGGCCAGCCGACGTCGGGCGTCATAAAAGACGTTGTCATGCTCGGCGGCTACCAGGAAATGGAAATCGATTTC
GTCGCCGATAATCCCGGCCTCACCCTATTCCACTGCCATCAGCAACTGCACATGGATTTCGGTTTCATGGCCTTGATCGA
GTACGTGTAG

Upstream 100 bases:

>100_bases
CAACGTTGTAGAGGAAGAGAATCAGCAAAGAGCCGGACGCCGCGCTCTGGTTCATCCGCTCCGATTATCCCACCGCAAAT
ACGTGAGGCAACTTACACGC

Downstream 100 bases:

>100_bases
AACAGGCTTCGCGGCAGTCTCGCGGCTTGTTACACTAACTTGCCGCCTGGTATTACTCTGCTTTTTGTTTGCTCGCAGGC
CGCAGACATCCGCACTGTAA

Product: multicopper oxidase, type 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
METARCTTLNFRAALLAIPMPLLRRNLLQAAGALAGTSLLSHTVGCKRPAEQTVLPAPDHTLTIAVKPVEIASRRTITTT
TYNGQFPGPLLRFQEGRPITIDIHNQTDTPEQLHWHGQFLSSVVDGAAEEGTPYIPAHGSRRITFVPKPSGFRFYHTHVR
AGNNLNAGQYTGLVGPVYIEPKNNPGNYDREVFLTLKEFDGSLSRGGDMEVDFLRPDTPVEALKIAGDSAMKASLESGAP
HGYEVGYSAFTINGRMLGTGIPVRVKEGERILFHILNGSATEIRSLALPGHTFTVLAMDGNPIPRPVTVPGLWLAPSERI
SAIVEMNQPGVWVMGDLSDDDRGNGMGTVIEYAGRTGKPVWQTPKRFYWNYAQFGNPEAKLPAPDQIIDMTFAKQNAADG
GFNRWTINGVAFSDEHMHPMFRVSQGRRYRLRMRNASDDTHPMHLHRHSFEVTRVAGQPTSGVIKDVVMLGGYQEMEIDF
VADNPGLTLFHCHQQLHMDFGFMALIEYV

Sequences:

>Translated_509_residues
METARCTTLNFRAALLAIPMPLLRRNLLQAAGALAGTSLLSHTVGCKRPAEQTVLPAPDHTLTIAVKPVEIASRRTITTT
TYNGQFPGPLLRFQEGRPITIDIHNQTDTPEQLHWHGQFLSSVVDGAAEEGTPYIPAHGSRRITFVPKPSGFRFYHTHVR
AGNNLNAGQYTGLVGPVYIEPKNNPGNYDREVFLTLKEFDGSLSRGGDMEVDFLRPDTPVEALKIAGDSAMKASLESGAP
HGYEVGYSAFTINGRMLGTGIPVRVKEGERILFHILNGSATEIRSLALPGHTFTVLAMDGNPIPRPVTVPGLWLAPSERI
SAIVEMNQPGVWVMGDLSDDDRGNGMGTVIEYAGRTGKPVWQTPKRFYWNYAQFGNPEAKLPAPDQIIDMTFAKQNAADG
GFNRWTINGVAFSDEHMHPMFRVSQGRRYRLRMRNASDDTHPMHLHRHSFEVTRVAGQPTSGVIKDVVMLGGYQEMEIDF
VADNPGLTLFHCHQQLHMDFGFMALIEYV
>Mature_509_residues
METARCTTLNFRAALLAIPMPLLRRNLLQAAGALAGTSLLSHTVGCKRPAEQTVLPAPDHTLTIAVKPVEIASRRTITTT
TYNGQFPGPLLRFQEGRPITIDIHNQTDTPEQLHWHGQFLSSVVDGAAEEGTPYIPAHGSRRITFVPKPSGFRFYHTHVR
AGNNLNAGQYTGLVGPVYIEPKNNPGNYDREVFLTLKEFDGSLSRGGDMEVDFLRPDTPVEALKIAGDSAMKASLESGAP
HGYEVGYSAFTINGRMLGTGIPVRVKEGERILFHILNGSATEIRSLALPGHTFTVLAMDGNPIPRPVTVPGLWLAPSERI
SAIVEMNQPGVWVMGDLSDDDRGNGMGTVIEYAGRTGKPVWQTPKRFYWNYAQFGNPEAKLPAPDQIIDMTFAKQNAADG
GFNRWTINGVAFSDEHMHPMFRVSQGRRYRLRMRNASDDTHPMHLHRHSFEVTRVAGQPTSGVIKDVVMLGGYQEMEIDF
VADNPGLTLFHCHQQLHMDFGFMALIEYV

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=326, Percent_Identity=26.6871165644172, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 56223; Mature: 56223

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METARCTTLNFRAALLAIPMPLLRRNLLQAAGALAGTSLLSHTVGCKRPAEQTVLPAPDH
CCCCEEEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
TLTIAVKPVEIASRRTITTTTYNGQFPGPLLRFQEGRPITIDIHNQTDTPEQLHWHGQFL
EEEEEEECHHHCCCCEEEEEEECCCCCCHHEEECCCCEEEEEECCCCCCHHHHHHHHHHH
SSVVDGAAEEGTPYIPAHGSRRITFVPKPSGFRFYHTHVRAGNNLNAGQYTGLVGPVYIE
HHHHCCCHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEEEEEE
PKNNPGNYDREVFLTLKEFDGSLSRGGDMEVDFLRPDTPVEALKIAGDSAMKASLESGAP
CCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEECCCCCHHHEEECCCHHHHHHHHCCCC
HGYEVGYSAFTINGRMLGTGIPVRVKEGERILFHILNGSATEIRSLALPGHTFTVLAMDG
CCEECCEEEEEECCEEEECCCEEEECCCCEEEEEEECCCHHHHHEEECCCCEEEEEEECC
NPIPRPVTVPGLWLAPSERISAIVEMNQPGVWVMGDLSDDDRGNGMGTVIEYAGRTGKPV
CCCCCCEECCEEEECCHHHEEEEEEECCCCEEEEECCCCCCCCCCCCHHHEECCCCCCCC
WQTPKRFYWNYAQFGNPEAKLPAPDQIIDMTFAKQNAADGGFNRWTINGVAFSDEHMHPM
CCCCHHHEECHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEECCCCCCHH
FRVSQGRRYRLRMRNASDDTHPMHLHRHSFEVTRVAGQPTSGVIKDVVMLGGYQEMEIDF
EEECCCCEEEEEEECCCCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEE
VADNPGLTLFHCHQQLHMDFGFMALIEYV
EECCCCEEEEEEHHHHHCCCCHHHHHHCC
>Mature Secondary Structure
METARCTTLNFRAALLAIPMPLLRRNLLQAAGALAGTSLLSHTVGCKRPAEQTVLPAPDH
CCCCEEEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
TLTIAVKPVEIASRRTITTTTYNGQFPGPLLRFQEGRPITIDIHNQTDTPEQLHWHGQFL
EEEEEEECHHHCCCCEEEEEEECCCCCCHHEEECCCCEEEEEECCCCCCHHHHHHHHHHH
SSVVDGAAEEGTPYIPAHGSRRITFVPKPSGFRFYHTHVRAGNNLNAGQYTGLVGPVYIE
HHHHCCCHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEEEEEE
PKNNPGNYDREVFLTLKEFDGSLSRGGDMEVDFLRPDTPVEALKIAGDSAMKASLESGAP
CCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEECCCCCHHHEEECCCHHHHHHHHCCCC
HGYEVGYSAFTINGRMLGTGIPVRVKEGERILFHILNGSATEIRSLALPGHTFTVLAMDG
CCEECCEEEEEECCEEEECCCEEEECCCCEEEEEEECCCHHHHHEEECCCCEEEEEEECC
NPIPRPVTVPGLWLAPSERISAIVEMNQPGVWVMGDLSDDDRGNGMGTVIEYAGRTGKPV
CCCCCCEECCEEEECCHHHEEEEEEECCCCEEEEECCCCCCCCCCCCHHHEECCCCCCCC
WQTPKRFYWNYAQFGNPEAKLPAPDQIIDMTFAKQNAADGGFNRWTINGVAFSDEHMHPM
CCCCHHHEECHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEECCCCCCHH
FRVSQGRRYRLRMRNASDDTHPMHLHRHSFEVTRVAGQPTSGVIKDVVMLGGYQEMEIDF
EEECCCCEEEEEEECCCCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEE
VADNPGLTLFHCHQQLHMDFGFMALIEYV
EECCCCEEEEEEHHHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]