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The map label for this gene is moeA [C]

Identifier: 116620527

GI number: 116620527

Start: 1730889

End: 1732037

Strand: Reverse

Name: moeA [C]

Synonym: Acid_1405

Alternate gene names: 116620527

Gene position: 1732037-1730889 (Counterclockwise)

Preceding gene: 116620528

Following gene: 116620526

Centisome position: 17.38

GC content: 64.75

Gene sequence:

>1149_bases
ATGGTCCGTTCGTATCGAACTCCACCCGATACCGAGGAGGTTGCGCTGTTGGAGGTCGCGGGACGCGTGCTGGCGATGGA
TATCGCGGCCGACCGCGATTCCCCGGCGCTCGCCCGCTCCGTCCGCGACGGCTATGCGGTCCGCGCCGCCGACCTGCCCG
CGACGCTGGAAGTTATCGGCGAAGTGCGCGCCGGCGAGCGCTTCGCAGGCTTGGTAGGCCCCGGACAGGCAGTGGAGATT
ATGACCGGCGCACCCATACCCGCCGGCGCCGACGCCGTCGTCATGGTGGAGCACACCCGACGAGATGGCACCCAGGTAGT
CATCGACCGGACTGCCGAACCTCTGCAGTTCATCAATCCGAAGGGTTGCGAGGCCGCTGCTCACGACGTTGTCTTGCACG
CCGGAACCCGGCTCGACTATACCGGCATCGCCATTCTTGCCGCCTTTGGACGCTCAAAGGTTAACGTTTACCGTCGCCCC
CGCGTCGCCATTATCGCCACCGGGGATGAAATCGTCGAGGTTCACGAGCAGCCCACGGATTTCCAGATACGGAATTCCAA
CGCGTATTCCCTGGCAGCGCAGGTTACCCGCGCCGGGGGAGTGCCTGATATCCTACCGGTCGCGCGCGACGCCGTGGAAC
ATACCCGCGAGATGGTTGAGCGCGGTCTGCAGGCTGACCTTCTGCTGCTTTCGGGCGGAGTTTCCGCCGGCAAGTACGAC
ATAGTCGAAAAAGTCCTGGCGGAATTCGGCGCAGAATTCTATTTCGACCGCGTGCTTATTCAGCCCGGCCAACCCCTGGT
CTTCGGCCGCGCTTGCGGAAAGTTCTTCTTCGGCCTGCCCGGTAATCCCTCTTCGACGATGGTGACTTTCGAGATCTTCG
CGCGCGCTGCCCTGGAGCTGCTGGCCGGGCGAACAGAGTCTCCGCTCCCCATGCCGCTCGCCCGCTTGACCGCGGATTTC
CGCCACCGCTTGGGCCTCACTCGGTTTCTTCCCGCGCGGCTCAGCGACAATGGCGCGGAAGTGACTCCGGTGCCCTGGCA
CGGCTCCGCCGACATGCCCGCCCTGACGCAGGCCAACGCCTATCTGGTTGCCGACCCCGACCGCGCCGTGTACGCGCGCG
GCGAGCTTATCCGGGTACTCTACAAATGA

Upstream 100 bases:

>100_bases
TCGAGGCGCTCTTCCCAAGCCCGACCTGCCGCCCTCTCCACGCGATAATAAAAAAGTGGCGGCGTTGACATTTCCCGAAG
CTCGCGAAACCGTACTTCGC

Downstream 100 bases:

>100_bases
AAAAACTCTCGCATTTCGATTCCACCGGTAGTCCACGCATGGTCGATGTCTCCGCCAAGCAGGAGACGCGCCGCACCGCA
CGCGCGCACGCGTTTGTGCG

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MVRSYRTPPDTEEVALLEVAGRVLAMDIAADRDSPALARSVRDGYAVRAADLPATLEVIGEVRAGERFAGLVGPGQAVEI
MTGAPIPAGADAVVMVEHTRRDGTQVVIDRTAEPLQFINPKGCEAAAHDVVLHAGTRLDYTGIAILAAFGRSKVNVYRRP
RVAIIATGDEIVEVHEQPTDFQIRNSNAYSLAAQVTRAGGVPDILPVARDAVEHTREMVERGLQADLLLLSGGVSAGKYD
IVEKVLAEFGAEFYFDRVLIQPGQPLVFGRACGKFFFGLPGNPSSTMVTFEIFARAALELLAGRTESPLPMPLARLTADF
RHRLGLTRFLPARLSDNGAEVTPVPWHGSADMPALTQANAYLVADPDRAVYARGELIRVLYK

Sequences:

>Translated_382_residues
MVRSYRTPPDTEEVALLEVAGRVLAMDIAADRDSPALARSVRDGYAVRAADLPATLEVIGEVRAGERFAGLVGPGQAVEI
MTGAPIPAGADAVVMVEHTRRDGTQVVIDRTAEPLQFINPKGCEAAAHDVVLHAGTRLDYTGIAILAAFGRSKVNVYRRP
RVAIIATGDEIVEVHEQPTDFQIRNSNAYSLAAQVTRAGGVPDILPVARDAVEHTREMVERGLQADLLLLSGGVSAGKYD
IVEKVLAEFGAEFYFDRVLIQPGQPLVFGRACGKFFFGLPGNPSSTMVTFEIFARAALELLAGRTESPLPMPLARLTADF
RHRLGLTRFLPARLSDNGAEVTPVPWHGSADMPALTQANAYLVADPDRAVYARGELIRVLYK
>Mature_382_residues
MVRSYRTPPDTEEVALLEVAGRVLAMDIAADRDSPALARSVRDGYAVRAADLPATLEVIGEVRAGERFAGLVGPGQAVEI
MTGAPIPAGADAVVMVEHTRRDGTQVVIDRTAEPLQFINPKGCEAAAHDVVLHAGTRLDYTGIAILAAFGRSKVNVYRRP
RVAIIATGDEIVEVHEQPTDFQIRNSNAYSLAAQVTRAGGVPDILPVARDAVEHTREMVERGLQADLLLLSGGVSAGKYD
IVEKVLAEFGAEFYFDRVLIQPGQPLVFGRACGKFFFGLPGNPSSTMVTFEIFARAALELLAGRTESPLPMPLARLTADF
RHRLGLTRFLPARLSDNGAEVTPVPWHGSADMPALTQANAYLVADPDRAVYARGELIRVLYK

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=400, Percent_Identity=34.25, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI66932975, Length=400, Percent_Identity=34.25, Blast_Score=182, Evalue=6e-46,
Organism=Escherichia coli, GI1787049, Length=366, Percent_Identity=34.9726775956284, Blast_Score=181, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI25147659, Length=299, Percent_Identity=32.7759197324415, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17562606, Length=167, Percent_Identity=30.5389221556886, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17136978, Length=311, Percent_Identity=31.8327974276527, Blast_Score=141, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24638841, Length=311, Percent_Identity=31.8327974276527, Blast_Score=141, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 41176; Mature: 41176

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRSYRTPPDTEEVALLEVAGRVLAMDIAADRDSPALARSVRDGYAVRAADLPATLEVIG
CCCCCCCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHCCCEEEECCCCHHHHHHH
EVRAGERFAGLVGPGQAVEIMTGAPIPAGADAVVMVEHTRRDGTQVVIDRTAEPLQFINP
HHHCCCCEECCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCEEEEECCCCCHHHCCC
KGCEAAAHDVVLHAGTRLDYTGIAILAAFGRSKVNVYRRPRVAIIATGDEIVEVHEQPTD
CCCCHHHCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCEEEEEECCHHHHHHCCCCCC
FQIRNSNAYSLAAQVTRAGGVPDILPVARDAVEHTREMVERGLQADLLLLSGGVSAGKYD
EEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHH
IVEKVLAEFGAEFYFDRVLIQPGQPLVFGRACGKFFFGLPGNPSSTMVTFEIFARAALEL
HHHHHHHHHCHHHEEHEEEECCCCCEEECCHHHHHEECCCCCCCCCEEEHHHHHHHHHHH
LAGRTESPLPMPLARLTADFRHRLGLTRFLPARLSDNGAEVTPVPWHGSADMPALTQANA
HHCCCCCCCCCCHHHHHHHHHHHCCHHHHCHHHCCCCCCEEECCCCCCCCCCCCEECCCE
YLVADPDRAVYARGELIRVLYK
EEEECCCCEEECCCCEEEEECC
>Mature Secondary Structure
MVRSYRTPPDTEEVALLEVAGRVLAMDIAADRDSPALARSVRDGYAVRAADLPATLEVIG
CCCCCCCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHCCCEEEECCCCHHHHHHH
EVRAGERFAGLVGPGQAVEIMTGAPIPAGADAVVMVEHTRRDGTQVVIDRTAEPLQFINP
HHHCCCCEECCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCEEEEECCCCCHHHCCC
KGCEAAAHDVVLHAGTRLDYTGIAILAAFGRSKVNVYRRPRVAIIATGDEIVEVHEQPTD
CCCCHHHCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCEEEEEECCHHHHHHCCCCCC
FQIRNSNAYSLAAQVTRAGGVPDILPVARDAVEHTREMVERGLQADLLLLSGGVSAGKYD
EEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHH
IVEKVLAEFGAEFYFDRVLIQPGQPLVFGRACGKFFFGLPGNPSSTMVTFEIFARAALEL
HHHHHHHHHCHHHEEHEEEECCCCCEEECCHHHHHEECCCCCCCCCEEEHHHHHHHHHHH
LAGRTESPLPMPLARLTADFRHRLGLTRFLPARLSDNGAEVTPVPWHGSADMPALTQANA
HHCCCCCCCCCCHHHHHHHHHHHCCHHHHCHHHCCCCCCEEECCCCCCCCCCCCEECCCE
YLVADPDRAVYARGELIRVLYK
EEEECCCCEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]